ML20054D947

From kanterella
Jump to navigation Jump to search
Rebuttal Testimony of Ji Fabrikant on Contention 8/9.Refutes Idj Bross Assessment of Validity of Biostatistical Techniques & Elimination of Risk in Beir III Rept.Prof Qualifications & Certificate of Svc Encl
ML20054D947
Person / Time
Site: Waterford Entergy icon.png
Issue date: 04/20/1982
From: Fabrikant J
CALIFORNIA, UNIV. OF, SAN FRANCISCO, CA, LOUISIANA POWER & LIGHT CO.
To:
Shared Package
ML20054D911 List:
References
NUDOCS 8204230533
Download: ML20054D947 (59)


Text

r y V EI

,; . M " 4/20/82 v =

,9 UNITED STATES OF AMERICA NUCLEAR REGULATORY COMMISSION Before the Atomic Safety and Licensing Board In the Matter of )

)

LOUISIANA POWER & LIGHT COMPANY ) Docket No. 50-382

)

(Waterford Steam Electric )

Station, Unit No. 3 ) )

APPLICANT'S REBUTTAL TESTIMONY OF JACOB I. FABRIKANT ON CONTENTION 8/9 Question:

Please state your name, your academic qualifications, your areas of professional training, responsibilities, interests and activities.

Answer:

My name is Jacob I. Fabrikant. I hold a Bachelor of Science degree in chemistry and mathematics, McGi.'.1 University; a Doctor of Medicine degree and a Master of Surgery degree, both from McGill University; and a Doctor of Philosophy degree in biophysics, University of London. I am a Fellow of the American College of Radiology. I did post-doctoral training in surgery and pathology at Duke University Hospital, and trained 1 -

8@04230533

s in radiology at The Johns Hopkins Hospital. I am certified by the American Board of Radiology in diagnostic radiology, therapeutic radiology and nuclear medicine. I have been Professor and Head of the Department of Radiology, University of Connecticut School of Medicine; and Professor and Chairman, Department of Diagnostic Radiology, McGill University Faculty of Medicine. I am presently Professor of Radiology, University of California School of Medicine at San Francisco; Staff Senior Scientist at Lawrence Berkeley Laboratory, University of California, Berkeley; Physician-in-charge of the Donner Pavilion, Cowell Memorial Hospital, University of California, Berkeley; and Member of the Graduate Biophysics Group, Department of Biophysics and Medical Physics, University of California, Berkeley. I devote all my professional and academic activities to patient care, primarily in diagnostic and therapeutic radiology and nuclear medicine; to research in the radiological sciences, primarily cancer research; and to teaching in radiology and biophysics, primarily in the radio-logical sciences in the medical school and in the graduate 5-school at the University of California. These are all docu-mented in my curriculum vitae which is attached to this testimony.

l 1

1

i o

3 Question:

Have you ever been appointed to or served or do you presently serve on any recognized national or international committees, commissions, or groups dealing with the radiolog-ical sciences in general, and radiation and health in particu-lar?

Answer:

Yes.

I have served on five committees of the National Academy of Sciences - National Research Council, including the BEIR I, BEIR II and BEIR III. I presently serve on a National Academy of Sciences committee on a NIOSH study of the Portsmouth Naval Shipyard Workers, and I am consultant to the National Academy of Sciences Board of Radioactive Waste Management.

I was the Director of Public Health and Safety of The President's Commission on the Accident at Three Mile Island. I have served on advisory scientific committees of the President's Commission, USPHS, NIH, NCI, BRH, NASA, American College of Radiology, the NRPB of Canada and England, and other bodies dealing with radiation and health and cancer research.

I am a member of the International Commission on Radiological Protection.

Question:

Have you ever published in the scientific literature dealing with medicine, cancer research, radiation and health?

Answer:

Attached to my testimony is a complete bibliography of my I publications. My publications now number in excess of 200 scientific articles, reports, chapters and reviews in the open

literature. They are all in the fields of radiological sciences, medicine and surgery, radiobiology, radiation and health, cancer biology, and related disciplines.

Question:

Have you reviewed the testimony of Dr. Irwin D. J. Bross which appears in the transcript of March 30 and 31, 1982, in this proceeding?

Answer:

Yes.

Question:

Directing your attention to Dr. Bross's answer to Question 19 in his prefiled testimony, do you share his assessment of the validity of the biostatistical techniques and the estimation of risk in the BEIR III Report?

Answer:

No. Dr. Bross fails to recognize that the BEIR III Report is a Committee Report of the National Academy of Sciences -

National Research Council that responded to a particular task proposal. The task before the BEIR III Committee was specified in detail in an agreement accepted by the National Academy of Sciences on September 30, 1976 (NAS-BEIR III Report: 1980, p.9). Two provisions of the task included: (1) review the current state of knowledge on somatic and genetic effects of ionizing radiation, and (2) make recommendations on the potential risks from ionizing radiation as may be justified on the bcsis of current published scientific information.

s Accordingly, a group )f 25 scientists with established scientific reputations in the fields of biology, genetics, cytogenetics, embryology, mathematics, biostatistics, epi-demiology, experimental medicine, pathology, radiology, nuclear medicine, oncology, public health, cancer research, envi-ronmental medicine, biophysics, cell biology, and radiobiology, constituted the working committee.

The Committee's report had a due date; a Committee decision was made to end review of all current published scientific information by the beginning 'f 1979 in order to provide the final report to the National Research Council in a responsive and timely manner for review by the National Academy of Sciences prior to final publication. By that time many hundreds of published references considered important to the task of the Committee had been carefully reviewed and recorded.

Appendix B to Chapter V of the BEIR III Report (pp. 455 to 475) is a " Review and Analysis of Selected Studies on Record," and includes the published or available reports of Mancuso, Stewart and Kneale; Bross; Najarian and Colton; Sternglass; and Frigerio, Archer, and others. Eighty-six references are cited in this Appendix B, and these include all of Dr. Bross's published (and some unpublished) papers and letters relevant to the problems of low-level radiation and risk estimation available to the Committee.

l l

The BEIR III Committee used biostatistical techniques and methods extant and considered applicable and appropriate for l

l

=

analysis of the epidemiological data for estimation of risk coefficients for cancer. The techniques and methods are those used in radiation epidemiology and biostatistics as well as in other related areas of epidemiology and biostatistics by national and international groups, committees, universities and institutes, including biostatistics and epidemiology depart-ments in universities such as Harvard, Johns Hopkins, Oxford, Cambridge, Paris, London School of Hygiene and Tropical Medicine, Stanford, Rochester, New York, Cornell, and many more; national agencies and groups, such as NIH, NCI, EPA, NCRP and NAS-NRC in the U.S.A., and others abroad, e.g., NRPB (UK)

(National Radiological Protection Board) and NRPB (Canada); and international agencies and groups such as ICRP and UNSCEAR.

There has been no published criticism from any of the above-mentioned institutions or groups to warrant the conclu-sion that the biostatistical techniques or methods for risk estimation used by the BEIR III Committee, or the risk estimates for radiation-induced cancer in the illustrative examples provided or derived from the scientific literature, were inappropriate, inaccurate, incorrect, or otherwise biased.

The sets of data and interpretations of data which have recently played a role in the public controversy over the potential risk of low-level radiation, particularly those tending to indicate that low-level radiation may be more hazardous than thought, were carefully reviewed by the BEIR III Committee (BEIR III Report: 1980, pp. 455 to 475). The overall conclusion is that none of these reports, individually or collectively, changes appreciably or even significantly the evaluations of possible low-level radiation effects that have been made by the BEIR III Committee and by the several other authoritative national (e.g., NCRP, NRPB (UK)), and interna-tional (e.g., ICRP, UNSCEAR) groups.

The ICRP, Committee I, of which I am a member, constantly reviews these published " controversial" reports as they become available in the scientific literature. At the most recent meeting of the ICRP in December, 1981, all current published reports to date which are considered relevant, were reviewed.

No additional information, data, interpretations, or current reports of low-level .adiation carcinogenic (cancer-induction) or genetic effects, were introduced to alter the conclusions of the BEIR III Report. Those centroversial reports reviewed in the Appendix B to Chapter V of the BEIR III 1980 Report can still be seriously faulted, and none is considered by any of the national or international groups to constitute reliable evidence at present for use in risk estimation for various reasons, including inadequate sample size in some instances, inadequate statistical analysis, and unconfirmed results.

Dr. Bross states that "[e] xtrapolation beyond the range of data is unacceptable, from a statistical standpoint . . . .

The BEIR III Committee chose not to extrapolate beyond the available human epidemiological data, where there is "little reliable information concerning the consequences of exposure to

l lower doses, especially those low doses to which a human population might be exposed." (NAS-BEIR III 1980 Report,

p. iii.

l The BEIR III Committee after three years of deliberation and careful perusel of available scientific evidence found that its "most difficult task has been to estimate the carcinogenic risk of low-dose, low-LET, whole-body radiation. It recognized that the scientific basis for making such estimates is inadequate, but it also recognized that policy decisions and the exercise of regulatory authority require a position on the probable cancer risk from low-dose, low-LET radiation.

Accordingly, the Committee decided that emphasis should be placed on the assumptions, procedures, and uncertainties involved in the estimation process, and not on specific numerical estimates." (NAS-BEIR III 1980 Report, pp. 2 to 3).

Finally, I note that at other points in his testimony (e.g., page 1523-24 of the transcript), Bross displays an ignorance of the BEIR III Report, which he finds "unaccepta-ble." E3ross apparently does not know the difference between DEIR II and BEIR III. It appears he assumes, incorrectly, that the 1979 edition of the BEIR III Report was the BEIR II Report.

Had he read BEIR III, he would have known the history of the Committee's reports (see BEIR III 1980 Report, p. 9). I quote:

"The BEIR Committee produced its report in November 1972: The Effects on Populations of Exposure to Low Levels of Ionizing  ;

Radiation (BEIR I) . . . . The Committee completed its I

[second] report in 1976, and it was published in 1977:

Considerations of Health Benefit-Cost Analysis for Activities Involving Ionizing Radiation and Alternatives (BEIR II). Page iii of the Report, President Philip Handler's letter, transmits the most recent Report, "'The Effects on Populations of Exposure to Low Levels of Ionizing Radiation [:1980]'. . . .

familiarly known as BEIR III (after its authorizing Committee on the Biological Effects of Ionizing Radiations). . . .

Furthermore, contrary to Dr. Bross's statement, there was no disagreement in the BEIR II Report on the linear hypothesis.

Only the linear hypothesis was used for risk estimation and cost-benefit analysis in the BEIR II Report.

Further, "another report" (tr. 1524, line 15) of BEIR II did not come out; it was BEIR III. The 1980 BEIR III did not attempt "to paper over the differences between members of the BEIR Committee" but rather (quoting from President Handler's letter of transmittal, p. iii), "The report presents all of these views [of the Committee members], in balanced fashion.

The committee as a whole, despite individual preferences, has agreed that the report treats each of the possible inter-pretations [of dose-response models for estimating risk) in a fair manner."

o Question:

Do you agree with Dr. Bross's reply to Question 28, which appears in his prefiled testimony, " Qualitatively how does the health risk from low-level radiation exposure compare to the risk from high level exposure"?

Answer:

No. In recent years, a general hypothesis for estimation of excess cancer risk in irradiated human populations based on theoretical considerations, extensive laboratory animal studies, and available reliable epidemiological surveys, suggests various and complex dose-response relationships between radiation dose and observed cancer incidence. (BEIR III Report, 1980; UNSCEAR Report, 1977; NCRP Report No. 64, 1980). By far, the most widely considered dose-response model for cancer-induction by radiation is a multicomponent, non-threshold, dose-response curve which contains: (1) initial upward curving linear and quadratic functions of dose at low and intermediate levels of dose, and (2) a downward-curving function in the high-dose range (BEIR III Report, 1980; p.23).

For risk-estimation, the BEIR III Committee used a variety of dose-response functions that could be applied to the observed epidemiological data. (BEIR III 1980 Report, p. 21).

These included the linear, the pure quadratic, and the linear-quadratic (quadratic with a linear term) dose-response models.

The BEIR Committee preferred, for risk estimation of low-dose, low-LET, whole-body radiation, the linear-quadratic dose-response model. "Wherever possible, in estimating the cancer s

risk from low doses of low-LET radiation, the [BEIR III]

Committee has used a linear-quadratic dose-response model that is felt to be consistent with epidemiologic and radiobiologic data, in preference to more extreme dose-response models, such as the linear and the pure quadratic." (BEIR III Report, 1980, p.2).

In the application of the linear-quadratic dose-response model forms, "the [BEIR III) Committee recognizes that some experimental and human [ epidemiological] data, as well as theoretical [ mathematical and biophysical] considerations, suggest that, for exposure to low-LET radiation at low doses, the linear model probably leads to overestimates. of risk of most cancers, but can be used to define the upper limits of risk." (BEIR III 1980 Report, p.2). This overestimate of risk is particularly the case at lower doses. Therefore, it must be concluded from the scientific evidence that insofar as radia- i tion mutetion and cancer induction are concerned, the risk per unit (low-LET) radiation dose at low-dose levels is less than the risk at high-dose levels.

And finally, there is little evidence of reliable and reproducible epidemiological dose-response date for cancer-induction at doses below 50 rad of low-LET radiation. Thus, the shape of the dose-response curve cannot be determined directly from observed human data, and "the available human  ;

data fail to suggest any specific dose-response model and are not robust enough to discriminate among a priori models

suggested by theoretical and experimental work." (BEIR III Report, 1980, p. 142).

It is of considerable importance to note that " [ t] he [BEIR III] Committee was in general agreement that, for most radiation-induced solid cancers, the dose-response relationship for low to intermediate doses of low-LET radiation is best described by a linear-quadratic function of dose with nonnega-tive curvature. Nevertheless, there are arguments in favor of other models, especially the linear and the quadratic, which lead to widely divergent [ risk) estimates. For these reasons, and because of the basic uncertainty associated with the choice of a single [ dose-response] model, the [BEIR III] Committee decided to present an envelope of [ risk] estimates bounded by the linear and the pure quadratic models, with the linear-quadratic [model] providing intermediate [ risk] values." (BEIR III Report, 1980, p. 142). The scientific evidence, therefore, compels the conclusion that for low-LET radiation the risk from low-dose exposure is less than from high-dose exposure, and that the risk per unit radiation dose is less from low-dose than from high-dose levels.

Question:

Do you agree with Dr. Bross's explanation of mechanisms of radiation and chemicals causing ill-health in humans as described in response to Question 20 in his prefiled testimony?

Answer:

No. Dr. Bross by training is a statistician. His testimony overall reflects very limited understanding of biology, biophysics, genetics, medicine, and radiation biology at any level to explain the theories of mechanisms of mutagen-esis and/or carcinogenesis at the cellular level and how these mechanisms manifest cancer-induction and/or genetically-related ill-health in the human. His understanding of biological mechanisms and factors of radiation and chemical carcinogenesis as indicated by his testimony is naive and confused. The problems involving both are extremely complex, highly scientific, and in large measure subject to great uncertainty.

Question:

Do you agree with Dr. Bross's assessment, expressed at page 1391 of the transcript, regarding the role of "the members of the radiation protection community" in relation to their review of his scientific articles submitted in the open literature?

Answer:

No. There are two matters here. First, Bross describes a

" radiation protection community," suggesting a group of individuals with some unyielding dogma or doctrine foreign to the norm and malevolent in intention. Second, Bross describes a response to his articles that suggests deliberate and malicious intention to thwart the peer-review process and deny publication of meritorious scientific research in the open literature. Neither situation exists.  ;

l l

l

s The " radiation protection community" that Bross describes does not exist. There is, however, a large number of outstanding scientists, epidemiologists, statisticians, and physicians in the radiological sciences. The most outstanding of these are asked to serve, without compensation, on the editorial boards or review committees of scholarly scientific journals in their disciplines. It is an honor. to serve. Their role is to evaluate profferred scientific articles and to recommend their suitability for publication in the open scientific literature. Speed of review and publication is -

essential; pressure for rapid review and publication comes from the fact that the volume of profferred papers is large, and the space for publication is limited. I am unaware of any intent ,

to maliciously deny or delay publication of Bross's or anyone else's work. Most profferred papers are ultimately published in the scientific journals because the work is meritorious. If Bross cannot get his profferred articles published in one of the very many available scientific journals in the United States, Canada and Europe, only one conclusion can be drawn:

many scientists throughout the world consider Bross's proffer-red papers lacking in scholarship and essentially worthless, and these many scientists recommend that Bross's papers not be publi-:hed in the journals they serve.

, It is not a conspiracy--it is the most meritorious function of the peer-review process.

Question:

Would you agree with Bross's assessment at page 1419 of the transcript that he was the only scientist at the Yale Symposium in May, 1980?

Answer:

As I understand it, Bross is a statistician. He has never been on a science faculty in a university other than for statistical support. He has never done scientific research in a biology, physics, or chemistry laboratory. He has never carried out a scientific experiment in a biology, physics, L

chemistry or medical laboratory. He merely helps others treat and evaluate data which the others accumulate and interpret.

Statistical methods aid in the experimental scientific method, but do not substitute for it.

The Yale Symposium had a number of outstanding scientists participating who are well-recognized by their peers in the fields ol' physics and biology. These scientists included Professor Merrill Eisenbud, of the Institute of Environmental Medicine, New York University, School of Medicine; Professor Harold Rossi of the Department of Radiology of Columbia University College of Physicians and Surgeons; Professor Warren

, 'Sinclair of the University of Chicago School of Medicine and President of the NCRP; Professor Bernard Cohen of the University of Pittsburgh School of Public Health; Professor Rowe of Georgetown University and Director of the Institute of Risk Analysis; Professor Robert Schulz of the Department of Radiation Oncology, Yale University School of Medicine; and Professor Jan Stowjvak of the Department of Epidemiology and Public Health, Yale University School of Medicine. I was a participant in the Yale Symposium; my scientific credentials and contributions are listed in my curriculum vitae and bibliography.

Question:

Directing your attention to page 1450 of the transcript, would a method of identifying susceptible individuals in the population prior to leukemia incidence permit the definition of a dose-response curve for leukemia?

Answer:

No. BEIR III considered the matter of sensitive subgroups l

with increased susceptibility to DNA damage and increased cancer risk after exposure to ionizing radiation. "The role of constitutional susceptibility to cancer induction is not well enough understood, however, for it to be used as a factor to modify risk estimates [ based on dose-response relationships].

Inasmuch as the [ cancer] risk estimates developed for this

[BEIR III] report are averages for large populations that presumably include many genotypes, it is unlikely that these risk estimates would be notably altered if data representing very small subsets of abnormally radiosensitive persons could be recognized and excluded from the calculations. If pop-ulation subsets can be identified as being at substantially greater risk of radiation carcinogenesis, their risk will require separate estimation." (BEIR III 1980 Report, p. 4).

The experience of the scientists and statisticians on the BEIR Committee (BEIR III 198'O Report), the ICRP, and the NCRP i

(Report 64, 1980), is that it is unlikely that the best shapes to the dose-response curves in man can ever be resolved by statistical analysis alone, and this is particularly the case in the low-dose region below 50 rad. To the present time, analysis has to depend on attempting to estimate the risks of low-level radiation by determining how the effects of low doses are related to those higher doses. The BEIR III Report explains (p. 27, BEIR III 1980 Report) that what is needed for defining the dose-response curve in the low-dose region is a better understanding of the fundamental mechanisms by which cancers are induced by radiation. Bross's testimony demon-strates his shallow knowledge of even the most rudimentary biological processes of genetic mutagenesis and carcinogenesis.

Insofar as host factors in radiation carcinogenesis are concerned, the BEIR III Committee devoted considerable time and attention to this important area (see pp. 26-27, 141-148, 149-175 in BEIR III Report 1980). Attention and discussion was directed to initiating and promoting stages, hormonal influ-ences, cell proliferation, immunologic surveillance and host defense mechanisms, irritant chemicals, vitamin deficiencies, viral infections, age, sex, etc. However, at no time did there arise any theory, hypothesis or scientific evidence that would support Bross's concSp of " pre-existing genetic damage."

Question:

Do you agree with Bross's estimate, discussed at pages 1596 and 1598 of his transcribed testimony, that the doubling dose concept for leukemia-induction is about 5 rem and that for some individuals (with Bross's " pre-existing damage") it is substantially lower, perhaps in the range of 1 rem?

Answer:

No. The concept of " doubling-dose for cancer induction" was not used in the BEIR III 1980 Report in estimating cancer risks of exposure to low-dose, low-LET, whole-body irradiation, since the BEIR III Committee considered the concept obsolete and could not be applied to all cancers, all tissues, and all ionizing radiations. Accordingly, it chose to use risk projection models only in the above situation to estimate thc cancer risk in exposed human populations.

Furthermore, Bross's risk estimates are not borne out by experience. If there is, as Bross estimates, a doubling dose of 5 rem for myeloid leukemia on the basis of diagnostic X-ray studies, and an " increased susceptibility due to pre-existing genetic damage" in individuals (as yet unrecognized) who would have a doubling dose of perhaps 1 rem, then from diagnostic X-ray experience we would expect an epidemic of myeloid leukemia due to diagnostic medical radiation in the United States and Europe, with decreasing incidence due to improved low-dose imaging procedures in modern medicine. This has not occurred. We do not have an epidemic of myeloid leukemia. We do not have a substantial change in incidence with a decreased l leukemia rate resulting from improved low-dose diagnostic l

l i

l t

I .

imaging radiological techniques. Bross's hypothesis fails to support experience or statistics for both natural background radiation and artificial man-made radiation.

Question:

Do you agree with the criticisms cited in critiques of Dr.

Bross's studies by various authors in the scientific literature and discussed by Dr. Bross during his testimony at pages 1604 through 1637 of the transcript?

Answer:

Yes. Bross invariably uses a number of techniques and procedures to alarm the public that low-level radiation is more hazardous than the majority of scientists believe it to be.

While Bross lacks appropriate scientific basis for his theses, scientific experimentation, epidemiology, radiobiological theory, and other information from a myriad of scientific disciplines form the scientific bases for our present under-standing of the potential hazards to health resulting in human populations exposed to low-level radiation. Bross consistently exploits spurious techniques and unconventional statistical methods to analyze selected data, introduces confounding biases, and creates unfounded hypotheses to arrive at his alarming conclusions. He remains detached from the wealth of i

modern scientific knowledge which continually disproves and discredits his theses and his conclusions. The findings of all his studies differ so sharply from the results of all the major studies existing that if the risks and hazards of ill-health he believes to occur were shown to result from radiation exposure i

I

alone, then modern biology, physics and medicine would require a radical change in theories of mutagenesis, carcinogenesis, and the molecular biology of the human hereditary and constitu-tional structure and function.

I concur completely with the severe criticisms of Bross's studies as documented in the BEIR III 1980 Report (pp.

458-461); in NCRP Report 64, 1980 (pp. 160-162); in the i Interagency (Libassi) Report 1979 (pp. 36-38); and in the critiques by Boice and Land, 1979 AJPH, by Oppenheim, by Rothman, and by Smith, Pike and Hamilton, 1973. Bross remains discredited; none of his studies is sufficiently extensive, complete, or free of serious methodologic complications to provide conclusive, or even reliable, information at the present time on the health effects of radiation at low doses.

Question:

Do you agree with Bross's description, at pages 1637 through 1651 of the transcript, of the " radiation protretion community" and the expertise and qualifications Bross describes of the members of the national (e.g., NCRP and NAS-BEIR) and international (e.g., ICRP and UNSCEAR) groups and committees concerned with the sciences of radiation protection?

Answer:

No. I draw three conclusions from his statements: (1) he holds in great contempt virtually all those scientists who have dedicated their professional skills and capabilities to the understanding of radiation and health end preventive medicine--if they are or have been associated with recognized scientific bodies on a national or international level; (2) he

has concluded - that a conspiracy exists, ar.d remains a cohesive force, among perhaps 500-1000 internationally-known scientists in the fields of radiation and health, at all levels of science, in perhaps 20 nations throughout the world including the U.S.S.R, China, and the countries of Europe and the United States, that an official administrative policy was developed in the White House to agree that low-level radiation was harmless, and that the of ficial doctrine has been supported and defended by all subscribing scientists and countries to this day; and finally, (3) he believes that a conspiracy exists to suppress all scientific evidence--by a community of designated scientific administrators--of the potential or real health effects of low-level radiation. This conspiracy he believes is now directed toward him and his peers who be believes have also demonstrated these low-dose health effects exist in a malicious attempt to discredit him so that the doctrine of the safety of low-level radiation is preserved and spread throughout the world.

It is regrettable that Dr. Bross holds such views; they simply do not square with reality.

Question:

Do you agree with Dr. Bross's claim (page 1402 of tran-script) that his Yale Journal article was peer-reviewed by a group of scientific peers for quality and scientific suitabil-ity for publication in the Yale Journal of Biology and Medicine?

l Answer:

No. One requirement (established by Professor Robert Schulz, the organizer of the Yale Symposium) of all the Yale Symposium participants was to submit the texts of their presentations for publication in the Yale J. Biol. Med. Thus the papers were invited for publication in the Yale Journal. I have been informed by Professor Schulz, who inquired of the Editor of the Journal to what extent these papers were reviewed prior to acceptance for publication, that all papers were briefly reviewed by a general biomedical editorial board of faculty members and students who were not necessarily experts or peers in epidemiology, biostatistics, public health, or radiation and health. Furthermore, Professor Schulz has informed me that the editorial board merely reviewed each paper for quality of writing, language, completeness, references, tables and charts, and appropriateness for the Yale Journal; the board did not necessarily review it for scientific content or scientific quality. Indeed, that editorial board accepted my paper verbatim, but it requested that I add a very few definitions of the complex radiation science abbreviations or acronyms that a broad and non-specialized readership of the Journal would not understand unless defined. I conclude, therefore, that that is not scientific peer review of my article.

On the other hand, I have been told by Professor Schulz that Bross's paper, invited for publication in the Yale Journal as part of the Symposium, was rejected by that editorial board on first review by the board for a number of non-scientific reasons, including poor and contentious writing and language, and incompleteness of content, references, citations and tables. That editorial board did not have the expertise to judge the scientific quality of the paper. On the second or later submission by Bross, I have been told by Professor Schulz, Bross's article was accepted foc publication in the Journal since he had complied with some of the requests by the board (but not all) to improve the quality of the writing and presentation. This can in no way be construed as scientific peer review of the Bross article in the Yale Journal.

Question:

Have you read the testimony of Dr. Carl Johnson which appears in the transcript of April 1, 1982, in this proceeding?

Answer:

Yes.

Question:

Directing your attention to pages 1914-16 of the tran-script of Dr. Johnson's testimony, do you know whether there was controversy over the statement which appears at page 268 in BEIR III regarding synergistic effects in uranium miners who smoke?

i Answer:

There was no controversy regarding that statement in the BEIR III report.

l l

- CURRICULUM VITAE JACOB 1. FABRIKANT Bi rth February 9,1928 New York, New York Education 1948-52 McGill University, Montmal B.Sc. (magna cum laude; Chemistry)

- Faculty of Arts and Science 1952-56 McGill University, Montmal M.D., C.M.

Faculty of Medicine 1961-64 University of London, England Ph.D. (Biophysics)

Faculty of Science 1978 American College of Radiology Fellow (F. A.C.R. )

Academic Appointments 1956-57 Duke University Hospital and Intern in Surgery School of Medicine, Durham 1957 Duke University Hospital and Assistant in Pathology School of Medicine 1957-58 Duke University Hospital and Fellow in Surgery School of Medicine 1958-61 The Johns Hopkins Hospital, Resident in Radiology Baltimore 1958-61 The Johns Hopkins University Fellow in Radiology School of Medicine, Baltimore 1961-64 Department of Physics Advanced Fellow in Academic Institute of Cancer Research Radiology of the James Picker University of London, England Foundation, National Academy of Sciences-National Research Council 1964-65 The Johns Hopkins University Advanced Fellow in Acacfemic School of Medicine and School Radiology of the James Picker of Hygiene and Public Health, Foundation, National Acadenty of Baltimore Sciences-National Research Council 1964-68 The Johns Hopkins University Assistant Professor of Radiology School of Medicine 1964-70 The Johns Hopkins Hospital Radiologist

JAC'0B I. FABRIKANT Academic Appointments (cont.)

1965-68 The Johns Hopkins University Assistant Professor of School of Hygiene and Public Radiological Science Heal th 1968-70 The Johns Hopkins University Associate Professor of Radiology

. School of Medicine 1969-70 The Johns Hopkins University Associate Professor of School of Hygiene and Public Radiological Science I Heal th 1970-75 The University of Connecticut Professor and Head School of Medicine, Farmington Department of Radiology 1973-75 The Royal Society Special Consultant for the London, England Advisory Committee on the Biological Effects of Ionizing Radiations, National Academy of Sciences-National Research Council, U.S. A.

1973-75 Royal Postgraduate Picker Sabbatical Study Year Medical School James Picker Foundation University of London, England National Academy of Sciences-National Research Council, U.S. A.

1973-75 Royal Postgraduate Visiting Colleague Medical School Department of Diagnostic Radiology University of London, England 1973-75 Hammersmith Hospital Honorary Consul tant Radiologist Royal Postgraduate Department of Diagnostic Radiology Medical School London, England 1975-78 McGill University Professor of Diagnostic Radiology Faculty of Medicine Department of Diagnostic Radiology Montreal, Canada 1975-78 The Montreal General Hospital Diagnostic Radiologist-in-Chief Montreal, Canada Department of Diagnostic Radiology 1976-78 McGill University Professor & Chairman Faculty of Medicine Department of Diagnostic Radiology Diagnostic Radiologist-in-Chief ,

1978- University of Califomia Professor of Radiology School of Medicine San Francisco, California

3.

JAC0'B I. FABRIVANT Academic Appointments (cont.)

1978-80 University of California, Staff Scientist Berkeley Research Medicine and Radiology Donner Laboratory Di rector, 1979 President's Commission on the Public Health and Safety Accident at Three Mile Island, The White House, Washington, D.C.

k980- University of California, Staff Senior Scientist Berkeley Lawrence Berkeley Laboratory 8

e =

8

4.

JACOB I. FABRIKANT Academic and Professional Organizations American College of Radiology,1972-; Member, 1972-78; Fellow,1978-Society of Chairmen of Academic Radiology Departments, 1970-75, 1976-78 Association of University Radiologists,1967-British Institute of Radiology,1961-Society of Nuclear Medicine, The Academic Council,1970-Canadian Association of Radiologists, 1975-80; Committee on Basic Research 1975-78 The New England Roentgen Ray Society, 1972-78

- Radiological Society of Connecticut, 1971-75 Association for Radiation Research (U.'K.),1964-Radiation Research Society,1965-; Councillor in Medicine, 1973-76 Sigma Xi,1971-Cell Kinetics Society,1978-Connecticut State Medical Society, 1971-75 The Johns Hopkins Medical and Surgical Association,1965-Maryland Medical and Chirurgical Society, 1958-70 American Association for the Advancement of Science, 1966-75 American Institute of Biological Sciences, 1968-75 Alpha Omega Alpha,1955-Nu Sigma Nu Medical Fraternity,1953-Academic Honors Alpha Omega Alpha Honorary Medical Society, McGill University Faculty of Medicine, Montreal , 1955 -

Wood Gold Medal, McGill University Faculty of Medicine, Montreal,1956 Advanced Fellow in Academic Radiology of the James Picker Foundation, National Academy of Sciences-National Research Council, 1961-65 Special Consultant, Committee on the Biological Effects of Ionizing Radiations, National Academy of Sciences-National Research Council, The Royal Society, London, England, 1973-75 Picker Sabbatical Study Year Award of the Janes Picker Foundation, National Academy of Sciences-National Research Council, 1973-75 Visiting Colleague in Diagnostic Radiology, Royal Postgraduate Medical School, England, 1973-75 Fellow of the American College of Radiology (F. A.C.R.),1978 Visiting Professorship _s_

Visiting Professor of Radiology, Bowman Gray School of Medicine,1968 Visiting Professor of Oncology, Clinical Cancer Program, Georgetwon University School of Medicine and Hospital,1969 Visiting Radiation Biologist, American Institute of Biological Sciences, 1969-75 William O'Brien Professor of Radiation Science, University of Minnesota School of Medicine and Hospitals,1970 6

5.

JACOB 1. FABRIKANT Visiting Professorships _ (Continued)

Visiting Professor of Radiology, University of Vermont College of Medicine, 1970, 1977-78 Visiting Scientist, Gray Laboratory, Cancer Research Campaign, Mt. Vernon Hospital, England,1971 Visiting Lectumr, Cambridge University Medical School, Addenbrooke's Hospital, England,1971 Visiting Professor of Radiology, University of Southem Florida College of Medicine, 1973 Visiting Professor of Radiology, University of Montmal, Faculty of Medicine,

~

Montreal ,1977  !

- Visiting Lecturer, Oxford University Medical School, The Radcliffe Infirmary, 0xford, England,1979 Visiting Lectumr, University of London, Institute of Cancer Research, London, England,1979 Visiting Professor of Radiation Medicine, Brown University,1979 Scientific Advisory Committees Comission on Radiation and Infection, Armed Forces Epidemiological Board, Liaison Member, 1965-66 Comittee on Radiology, Division of Medical Sciences, National Acadergy of Sciences-National Research Council, Member, 1967-74 X-Ray Image Production and Related Facilities Advisory Comittee, DHEW, USPHS, Membe r, 1968-69 Medical Radiation Advisory Comittee, Bureau of' Radiological Health, DHEW, USPHS, Member, 1969-74 Long-Tenn Radiation Effects Advisory Committee, DHEW,' USPHS, Member, 1969-74 Neurology A Study Section, National Institutes of Health, DHEW, Member, 1969-72 Comittee on the Biological Effects of Ionizing Radiations, National Academy of Sciences-National Research Council, Member,1973-;

Vice-Chai rman , 1973-77; Subcomittee on Medical Radiation, Member, 1973-77 Subcomittee on Somatic Effects, Member,1977-Ad hoc Subcomittee on Somatic Effects, Chairman,1979-Comittee on Genetic and Carcinogenic Effects, Division of Radiotherapeutic Researth, Comission on Radiation Therapy, American College of Radiology, Member, 1972-76 Comittee on Medical Uses of Radiation and the Radiation Exposure of Patients, National Radiological Protection Board, United Kingdom, Member, 1974-75 Associate Comittee on Scientific Criteria for Environmental Quality, Sub-committee on Physical Energy, National Research Council, Canada, Member, 1976-78 Committee on Radiation Risks to Space Workers (Space Powered Satellite), .

National Aeronautics Space Administration, Member,1979-Comittee on Federal Research into the Biological Effects of Ionizing Radiation, National Institutes of Health, DHEW, Member,1979-President's Comission on the Accident at Three Mile Island, The White House, Washington, D.C. ; Director, Public Health and Safety,1979 International Comission on Radiological Protection, Comittee 1 on Radiation Effects, Member,1980-

6.

j JACOB 1. FABRIKANT l

Extramural Research and Education Review Committees National Acadeny of Sciences-National Research Council, Committee on Radiology, Division of Medical Sciences, Member, 1967-74 U.S. Atomic Energy Commission, Division of Biology and Medicine, Consultant, 1968-75 National Science Foundation, Division of Developmental Biology, Consultant, 1970 State of Connecticut, Commission on Higher Education, Standing Committee on

- Accreditation, Connecticut Council on Higher Education, Consultant, 1971-73

. Connecticut Cancer Epidemiological Program, Planning Committee, Secretary, 1972-73 American Cancer Society, Connecticut Division, Board of Directors, Member, 1972-73 National Academy of Sciences-National Research Council Assembly of Life Sciences, Division of Medical Sciences, Consultant, 1972-75 U.S. Energy Research and Development Agency, Consultant, 1975-76 McGill University, University Senate Senator, 1976-78 McGill University, Faculty of Graduate Studies and Research, Faculty Council, The Graduate Council, Councillor, 1975-78 McGill University, Faculty of Medicine, Postgraduate Training Committee, Member, 1975-78 McGill University Faculty of Medicine, Department of Diagnostic Radiology, Postgraduate Training Committee, Program Director, 1976-78 Scientific Journal Review Cell and Tissue Kinetics,1968-; Member, Editorial Board,1972-Investigative Radiology,1973-; Member, Editorial Board, 1973-76 ,

Journal of the Canadian Association of Radiologists,1976-; Member, Editorial Boa rd,1976-78 McGill Medical Journal, 1952-56; Managing Editor, 1954-55; Editor, 1955-56 ,

Cancer Research,1968-Journal of the National Cancer Institute,1969-Biology of Reproduction,1970-Radiology, 1970-Science, 1970-Medicine ,1970-Bioscience, 1970-Cancer,1971-Radiation Research,1972-International Journal of Applied Radiation and Isot, opes,1973-

7.

JAGOB I. FABRIKANT Hospital Appointments 1964-70 The Johns Hopkins Hospital Radiologist Baltimore, Maryland 1970-73 University of Connecticut Hospital Head, Department of Radiology Hartford, Connecticut 1973-75 University of Connecticut Hospital Attending Radiologist Hartford, Connecticut

- 1970-73 Veterans Addiinistration Hospital Acting Chief, Department of

. Newington, Connecticut Radiology; Consultant in Radiology 1971-75 New Britain General Hospital. Consultant in Radiology New Britain, Connecticut 1971-75 William W. Backus Hospital Consultant in Radiology Norwich, Connecticut 1972-75 Hartford Hospital ' Consultant in Radiology Hartford, Connecticut 1972-75 Mount Sinai Hospital Consultant in Radiology Hartford, Connecticut 1973-75 Hamersmith Hospital Honorary Consultant Radiologist London, England Department of Diagnostic Radiology 1975-78 The Montreal General Hospital Diagnostic Radiologist-in-Chief Montreal, Canada Department of Diagnostic Radiology 1975-78 The Montreal General Hospital Director, Department of Montreal, Canada Diagnostic Radiology 1978- Cowell Memorial Hospital _

Physician present University of California, Berkeley 1978- University of California Medical Radiologist, Clinical Faculty present Center, San Francisco an i

. 8.

JACOB I. FABRIKANT Certi fication 1962 American Board of Radiology

' Medical Licensure 1957- National Board of Medical Examiners (No. 36999)

"1958 Maryland (No. D 1511)

~ 1971 Connecticut (No.14808) 1973-75 Great Britain 1976-78 Quebec, Canada (No.76-033) 1978 California (No. G 36656)

Military Service World War II, Veteran, United States Navy Marital Status Irene B. Fabrikant, Wi fe B.Sc. (McGill University)

M.Sc. (McGill University, Bacteriology and Immunology)

Ph.D. (University of Maryland, Microbiology) 1966-70 Instructor, Department of Microbiology l'iiversity of Maryland School of Medicine 1970-75 issistant Professor of Medicine, Department of Medicine lae University of Connecticut School of Medicine 1973-75 emnorary Research Fellow (Immunology)

Lslartment of Zoology and Comparative Anatomy Uni versity College, London, England 1975-78 Assistant Professor, Departnent of Microbiology & Immunology Facul ty of Medici ne, McGill University, Montreal 1977-78 Executive Secretary, McGill University Biohazards Committee McGill Cniversity, Montreal 1978-79 Research Fellow, U.S. Public Health Service, DHEW .

Center for Disease Control, San Juan Laboratories, Puerto Rico 1979- Researth Associate, University of California, Berkeley, School of Public Health, Department of Biomedical & Environmental Health Sciences . .

9.

JACOB I. FABRIKMT BIBLIOGRAPHY

1. Fabrikant, J.I. The Osler Society. (Editorial) McGill Med. J. 24:128, 1955.
2. Fabrikant, J.I. The Dean. (Editorial) McGill Med. J. 24:180, 1955.

Fabrikant, J.I. A concept of the term " anxiety". McGill Med. J. 24:201-207, 3.

1955.

r Pediatric problens in clinical practic. (Book Review) McGill

4. Fabrikant, J.I.

- Med. J. 24:114-115,1955.

5. Anylan, W.G. , Delaughter, G.D. , Jr. , Fabrikant , J.I. , Sullenberger, J.W. and Weaver, W.T. The nanagement of acute venous thromboembolism. JAMA 168:

725-729, 1958.

Anyl an , W.G. , Baylin , G.J. , Fabrikant, J.I. and Trumbo, R.B. Studies in 6.

coronary angiography. Surgery 45:8-18, 1959.

7. Fabrikant, J.I. Colostomy--A short review. Il. Quart. 2:23-33, 1959.

Sullenberger, J.W. , Weaver, W.T. , Fabrikant, J.I. and Anylan, W.G. A study 8.

of the pressor effects of serotonin and its possible role in massive thromboembolism. Surgical Forum 9:127-130, 1959.

9. Fabrikant, J.I. Reflections on illness. II. Quart. 3:6-8, 1959.

Fab ri kant , J. I . , Anlyan , W. G. , Bayl in , G.J . and T rumbo , R. B. A comparison 10.

of various techniques for a safe and reliable method of coronary arterio-graphy. Surgical Forum 9:233-237, 1959.

11. Fabrikant , J.I . , Anlyan , W.G. and Creadi ck, R.N. The management of radiation injuries to the intestines. South. Med. J. 52:1186-1191, 1959.
12. Fabri kant, J. I . The ileal bladder. II. Quart. 3:43-47, 1959.

Fabrikant, J.I. , Anlyan, W.G. , Baylin , G.J. and Trumbo, R.B. A comparison 13.

of techniques for visualization of the coronary arteries. Ame r. J .

Roentgenol. Rad. Therapy and Nuclear Med. 81:764-771, 1959.

14. Fabrikant, J.I. The wet colostomy. Il. Quart. 4:1-5, 1959. .
15. Koehler, P.R. , Fabri kant, J.I . and Dana, E. R. Gastric retention during oral cholecystography due to underlying lesions of the stomach and .

duodenum. Surg. Gynec. and Obstet. 110':409-412, 1960.

16. Fabrikant, J.I. , Anlyan, W.G. and Creadick, R.N. Management of intestinal l Modern Med. 28:117-118, 1960.

! injuries caused by pelvic irradiation.

I 17. Fabrikant, J.I. An improved ileostomy appliance. AMA Arch. Surg. 89:416-418, 1960.

l

JACOB I. FABRIKANT 10.

18. Anlyan, W.G. , Baylin, G.J. , Fabrikant, J.I. and Trumbo, R.B. Studies in coronary arteriography. (In) Year Book of Radiology, Eds. , Holt, J.F. ,

Whitehouse, W.M. , Jacox, H.W. and K11 german, M.M. , pp. 123-125, Year Book Medical, Chicago, 1960.

19. Fab ri kan t , J. I . Specialists at your service: The radiologist. II. Quart. 5:

29-32, 1961.

20. Fabrikant, J. I. , Ri chards , G.J. , Jr. , Brack, C.B. and Goodwin , P.N. A

_r vaginal applicator for radium therapy of carcinoma in the vagina.

. Radiology 77:987-989, 1961.

21. Fabrikant, J.I. , Cockey, T.B. and Goodwin, P.N. A simple pituitary localizer for radiation therapy. Amer. J. Roentgenol. , Rad. Therapy and Nuclear Med. 86:649-650, 1961.
22. Fabrikant, J.I. Reflections upon illness. Nursing News 12:3-5, 1961.
23. Fabrikant, J.I. , Anlyan, W.G. , Baylin, G.J. and Isley, J.K. Isotope studies for the evaluation of venous disease of the lower extremity. J. Nuclear Med. 2:136-148,1962.
24. Koehler, P.R. , Fabrikant, J.I. and Dickson, R.J. Observations on the behavior of testicular tumors with conments on racial incidence. J. Urol . 87:

577-579, 1962.

25. Fabrikant, J.I. , Richards, G.J. , Jr. , Tu.cker, G.F. , Jr. and Dickson, R.J.

Contrast laryngography in the evaluation of laryngeal neoplasms. Amer.

J. Roentgenol. , Rad. Therapy and Nuclear Med. 87:822-835, 1962.

26. Fabrikant, J.I. , Richards, G.J. , Jr. , Tucker, G.F. , Jr. and Dickson , R.J.

Aid to diagnosis of laryngeal cancer. Modem Med. 31:212, 1962.

27. Fabrikant, J.I. Radiological changes in experimental animals following the administration of bone-seeking radionuclides. (ab) Intem. Congr.

Radiation Res. 2:212, 1962.

28. Fabrikant, J.I. Cellular response and cell population kinetics under con-tinuous irradiation. Radiologic changes in bone following irradiation.

(In) James Picker Foundation, Annual Report, pp. 23-25, New York,1962.

29. Fabrikant, J.I. and Dickson , R.J. Contrast cinefluorographic studies of the la rynx. (ab) Intem. Congr. Radiology 10:261, 1962.
30. Fabrikant, J.I. and Dickson, R.J. Clinical observations on radiation carci-nogenesis. (ab) Intem. Congr. Radiology 10:243, 1962.
31. Fabrikant, J.I. and Smith, C.L.D. Radiological changes in experimental animals following the administration of bone-seeking radionuclides. (In) l Radiation Effects in Physics, Chemistry, and Biology, Eds. , Ebert, M.

l and Howard, A. , p. 472, North-Holland, Amsterdam,1963.

.i

JACOB I. FABRIKANT - 11.

32. Fabrikant, J.I. Regenerating liver. (In) Report of the Institute of Cancer Resea rch: Royal Cancer Hospital, Annual Report, p.122, London,1963.
33. Fabrikant, J.I. , Richards , G.J. , Jr. , Brack, C.B. and Goodwin, P.N. Vaginal  !

applicator for radium therapy of carcinoma in vagina. (In) Year Book of Radiology, Eds. , Holt, J.F. , Whitehouse, W.M. , Jacox, H.W. and K11 german, M.M. , p. 315, Year Book Medical, Chicago,1963.

34. Fabrikant, J.I. Studies of ~ cellular reponse and cell population kinetics under continuous irradiation. (In) James Picker Foundation, Annual  ;

Report, pp. 26-27, New York, 1963.

I 35. Fabrikant, J.I. Cell proliferation studies in normal, continuously irradiated and malignant tissues. Regenerating liver. (In) Report of the Institute of Cancer Research: Royal Cancer Hospital, British Empire Cancer Cam-I paign for Resean-h, Annual Report 41:152-153, 1964.

Fabrikant, J.I. and Smith, C.L.D. Radiographic changes following the admini-i 36.

stration of bone-seeking radionuclides. Brit. J. Radiol . 37:53-62, 1964. l

37. Fabrikant, J.I. and Roylance, P.J. Cinefluorographic anatorqy of the larynx and hypopharynx. Proc. Anat. Soc. Great Britain and Ireland 33:25, 1964.
38. Fabrikant, J.I. Investigrtion of cellular reponse and cell population kinetics in tissues oder continuous irradiation. (In) James Picker Foundation, Annual Rs ort, pp. 28-29, New York,1964.
39. Fabrikant, J.I. Studies of cell proliferation in the regenerating liver and the effect of prior continuous irradiation. Ph.D. Thesis, University of London, 1964.
40. Fabrikant, J.I. , Dickson, R.J. and Fetter, B.F. Mechanisms of radiation carcinogenesis at the clinical level. Brit. J. Cancer 18:459-477, 1964.
41. Fabrikant, J.I. and Dickson, R.J. The use of cinefluorography for the radio-logical examination of the: larynx and hypopharynx in cases of suspected carcinoma. Brit. J. Radiol . 38:28-38, 1965.
42. Fabrikant, J.I. and Roylance, P.J. Cinefluorographic functional anatorqy of the nonnal and diseased larynx. J. Anat. 99:209,1965.
43. Fabrikant, J.I. and Koburg, E. R$ntgen-Kontrastuntersuchungen von Larynx und Hypopharynx in Verbindung mit Bildverst5rkung. HNO Wegw. f. fach.

Praxis 13:16-19, 1965.

L

44. Fabri kant, J.I. and Lamerton, L.F. The effect of prior continuous irradiation . ..

on cell proliferation in the regenerating liver. Exc. Med. Intern. . *:

Congr. 89:347,1965.

45. Fabrikant, J.I. , Dickson, R.J. and Fetter, B.F. Mechanisms of radiation car-cinogenesis at clinical level. (In) Year Book of Radiology, Eds. , Holt, J.F. , Whitehouse, W.M. and Latourette, H.B. , pp. 384-386, Year Book Medical, Chicago, 1966.

1

l 12.

JACOB I. FABRIKANT

46. Fabrikant, J.I. Cell cycle of regenerating hepatocytes after continuous irradiation. (ab) Intern. Congr. Radiation Res. 3:79, 1966.
47. Fabrikant, J.I. Cell population kinetics in the regenerating liver in nonnal and continuously irradiated mice. (ab) Intem. Congr. Radiation Res. 3:

80, 1966.

48. Fabrikant, J.I. Radiation-induced chromosome aberrations in the regenerating

- liver under continuous irradiation. (ab) Intern. Congr. Radiation Res. 3:

. 80, 1966.

Fabrikant, J.I. and Dickson, R.J. Use of cinefluorography for radiologic

~ 49.

examination of larynx and hypopharynx in cases of suspected carcinoma. 384-387, (In) Year Book of Cancer, Eds. , Clark, R.L. and Cumley, R.W. , pp.

Year Book Medical, Chicago,1966.

50. Fabrikant, J.I. The spatial distribution of parenchymal cell proliferation during mgeneration of the liver. J. Hopkins Med. J. 120:137-147, 1967.

51 . Fabri kant, J.I. The effect of prior continuous irradiation on the G 2, M and S phases of pmliferating parenchymal cells in the regenerating liver.

Radiation Res. 31:304-314, 1967.

JAMA 200:201-202, 1967.

52. Fabrikant, J.I. Radiation sterilization in man.
53. Fabrikant, J.I. The kinetics of cellLlar proliferation in conditional cell renewal systems under continuous irradiation. (ab) Assn. Univ. Radiolo-gists 15:24, 1967.
54. Fabrikant, J.I. The accumulation of chromosome damage under continuous low dose-rate exposure. Radiology 88:767-774, 1967.

Fabrikant, J.I. The ileal bladder. Colorado St. Dept. Public Health, Suppl . ,

55.

pp.1-4, Denver,1967.

56. Lamerton, L.F. and Fabrikant, J.I. Repair of cellular radiation injury in the liver of continuously irradiated C578L mice. (ab) Radiation Res. 31:

664-665, 1967.

57. Fabrikant, J.I. The effect of radiation-free intervals after continuous exposure on the yield of chromosome aberrations in the regenerating liver.

(ab) Radiation Res. 31:665, 1967.

58. Fabrikant, J.I. Cell proliferation in the regenerating liver of continuously irradiated mice. Brit. J. Radiol. 40:487-495, 1967. , ,
59. Fabrikant, J.I. and Wisseman, C.L., III. Cell proliferation in no malignant tissues. I. In vitm incorporation of thymidine-Hpal

. (ab) and Radiol . Soc. N. Amer. 37:41, 1967.

l f

13.

JACOB I. FABRIVJJiT

60. Fabrikant, J.I. Cell proliferation in the mgenerating liver and the effect Radiation Res. 32:804-826, 1967.

of prior continuous irradiation.

61. Fabrikant, J.I. , Peterson, W.E. and Donner, M.W. Biographical note. (In)

Russell H. Morgan, A Tribute. Eds. , Fabrikant, J.I. and Donner, M.W. ,

pp. xi-xii, duPont, Wilmington, Delaware,1967.

62. Fabrikant, J.I. The analysis of cell population kinetics (In) in a conditional Russell H. Morgan, A mnewal system under continuous irradiation.

-" Tribute. Eds. , Fabrikant, J.I. and Donner, M.W. , pp.93-100, du Pont, Wilmington, Delaware,1967.

Kinetic analysis of hepatic regeneration. Growth 34:311-

63. Fabrikant, J.I.

315, 1967.

Ossified arytenoid

64. Morreels, C.L. , Jr. , Cherry, J. and Fabrikant, J.I.

cartilage masquerading as a famign body; A case report. Ame r. J.

Roentgenol. , Rad. Therapy and Nuclear Med. 101:837-838, 1967.

65. Fabrikant, J.I. The kinetics of cellular proliferation in regenerating liver. J. Cell. Biol. 36:551-565, 1968.
66. Fabrikant, J.I. and Wisseman, C.L. , III. In vitro incorporation of tri-Radiology 90:361-tiated thymidine in normal and neoplastic tissues.

363, 1968.

Morreels, C.L. , Jr. , Cherry, J. and Fabrikant, J.I. Masquerader. (ab) 67.

Modem Med. 36:103, 1968.

68. Fabrikant, J.I. Rate of cell proliferation in the regenerating liver.

Brit. J. Radiol . 41:71, 1968.

69. Foster, B.R. and Fabrikant, J.I. Studies on lymphoid cell proliferation in the nomal and continuously irradiated mouse thymus by repeated labeling with tritiated thymidine. (ab) Radiation Res. 35:486, 1968.
70. Fabrikant, J.I. Cell proliferation during lymphopoiesis in normal and continu-ously irradiated mice. (ab) (In) Symposium on the Effect of Radiation on Cellular Proliferation and Differentiation, IAEA, Vienna, SM-103/41, 1968.
71. Fabrikant, J.I. Radiation effects on a conditional cell renewal systrem under continuous low dose rate exposure. Amer. J. Roentgenol . , Rad. Therapy and Nuclear Med. 102:811-821, 1968.

(Iri) ',

72. Fabrikant, J.I. Cell proliferation in normal and malignant human tissues.

James. Picker Foundation, Annual Report,1967, New York, pp. 44-45, 1968.

73. Fabri kant, J. I . Cell proliferation during lymphopoiesis in ncemal and continu-ously irradiated mice. (In) Symposium on Effects of Radiation on Cellular i

Proliferation and Differentiation, SM-103/41, pp.1-24, I AEA, Vienna, 1968.

C

14.

. JACOB. I. FABRIVANT Fabrikant, J.I. Influence of cell cycle stage on radiation response in vivo.

74.

(ab) Assn. Univ. Radiologists, 16:27, 1968.

75. Fabrikant, J.I. Cell proliferation in the regenerating liverBrit. of continuously J. Radiol . ,

irradiated mice; effect of a radiation-free interval.

41:369-374, 1968.

The kinetics of cellular

76. Fabrikant, J.I. , Vitak, M.J. - and ' Wisseman, C.L. , III . Nucleic acid synthesis and the c proliferation in human tissues. IV.

-r cycle in relation to normal, inflamatory and neoplastic growth. (ab)

- Radiol. Soc. N. Amer., 54:47, 1968.

77. Hoopes, J.E. and Fabrikant, J.I. Objective evaluation of cleft palate speech.

~

i Plast. Reconstr. Surg., 42:214-224, 1968.

78. Fabrikant, J.I. The kinetics of lymphoid cell proliferation under continuous irradiation. (ab) Radiol. Soc. N. Amer., 54:149, 1968.
79. Knudson, D.H. and Fabrikant, J.I. Radiographic evaluation of x radiation induced bone tumors. (ab) Radiol. Soc. N. Amer., 54:180, 1968.
80. Fabrikant, J.I. Cell proliferation during lymphopoiesis in the thymus of continuously irradiated mice. (In) Effects of Radiation on Cellular Proliferation and Differentiation, pp. 269-393, I.A.E.A., Vienna, 1968.
81. Fabrikant, J.I. , Wisseman, C.L. , III, and Vitak, M.J. TheAnkinetics in vitro of cellular method II.

proliferation in normal and malignant tissues.

for incorporation of tritiated thymidine in human tissues. Radiology 92:1309-1320, 1969.

82. Fabrikant, J.I. Studies on cell population kinetics in regenerating liver.

30:169-183, (In) Human Tumor Cell Kinetics, Nat. Cancer Inst. Monogr. No.

1969.

83. Fabrikant, J.I. and Cherry, J. The kinetics of cellular proliferation in normal and malignant tissues. III. Cell proliferation in the larynx.

Ann. Otol . , Rhinol . , Laryngol . , 78:326-341, 1969.

84. Hoopes, J.E. , Dellon, A.L. , Fabrikant, J.I. and Soliman, H. The locus of levator veli palatini function as a measure of velopharyngeal incompetence. Plastic Reconstr. Surg., 44:155-160, 1969.

Fabrikant, J.I. and Foster, B.R. The kinetics of lymphoid cell proliferation

85. Radiation Res., 39:544, during radiation lymphomogenesis in C57BL mice.

1969. -

86. Fabrikant, J.I. and Cherry, J. The kinetics of cellular proliferation in normal and malignant tissues. V. Analysis of labeling indices and potential doubling times in human tumor cell populations. J. Surg.

Oncol . , 1 : 27-51, 1969.

Size of proliferating pools in regenerating liver. Exp.

87. Fabrikant, J.I.

Cell Res., 55:277-279, 1969.

l r

15.

' JACOB I. FABRIKANT

88. Fabrikant, J.I. Radiation response in relation to the cell cycle in vivo.

Amer. J. Roentgenol. , Rad. Therapy and Nuclear Med. 105:734-745, 1969.

89. Fabrikant, J.I. Studies on cell population kinetics in radiation leukemo-genesis. Assn. Univ. Radiologists 17:88, 1969.
90. Fabrikant, J.I. and Foster, B.R. Cell cycle of lymphocytes in mouse thymus.

Die Naturwissenschaften' 57:567,1969.

- '91. Fabrikant, J.I. Cell proliferation in continuously irradiated mammals;

~

Effect of age. (In) Radiation Biology of the Fetal and Juvenile Mamal,

- Sikov, M. and Mahlum, D.D., eds. USAEC, CONF. 690501, pp. 621-628, Oak Ridge, Tenn. ,1969.

92. Hoopes , J.E. , Dellon , A.L. , Fabrikant, J.I. , Edgerton , M.T. and Soliman , A.H.

Cineradiographic definition of the functional anatomy and pathophysiology of the velopharynx. (ab) Intern. Congr. Cleft Palate, 42, Houston, Texas, 1969.

93. Fabrikant, J.I. The kinetics of cellular proliferation in the seminiferous epithelium under continuous irradiation. XII Intern. Congr. Radiology 12:98, 1969.
94. Fabrikant, J.I. Radiation effects on lymphopoiesis under continuous low dose-rate exposure. Radiology 93:887-893, 1969.
95. Hoopes, J.E. and Fabrikant, J.I. Objective evaluation of cleft palate speech.

(ab) Cleft Palate J. 6:181, 1969.

96. Fabrikant, J.I. Research on cell proliferation in normal and malignant human tissues. (In) James Picker Foundation Annual Report,1968, pp. 45-50, 1969.
97. Fabrikant, J.I. The kinetics of cellular proliferation in normal and malignant tissues. VIII. Studies on cell population kinetics in normal, inflammatory and neoplastic tissues in man. (ab) XII Intern.

Congr. Radiology 12:442, 1969.

98. Fabrikant, J.I. Cell proliferation in normal and malignant human tissues.

(In) James Picker Foundation Annual Report,1969, pp. 40-42,1969.

99. Fabrikant, J.I. and Wisseman, C.L. , III. In vitro incorporation of tritiated thymidine in normal and neoplastic tissues. (In) Year Book of Radiology, Holt, J.F. , Whitehouse, W.M. and Latourette , H.B. , eds. ,

pp. 383-384, Year Book Medical, Chicago,1969. .

100. Fabrikant, J.I. The kinetics of cellular proliferation in human tissues.

IX. Estimation of DNA synthesis time in normal and malignant tissues.

(ab) Radiol. Soc. N. Amer. 55:44, 1969.

l l

16.

JACOB.I. FABRIKANT 1 01. Fabrikant, J.I. Tumor cell population kinetics during radiation lymphomo-genesis. (ab) Radiol. Soc. N. Amer. 55:124, 1969.

102. Hoopes, J.E. , Dellon, A.L. , Fabrikant, J.I. and Soliman, A.H. Cineradio-graphic assessment of combined island flap pushback and pharyngeal flap in the surgical management of submucous cleft palate. Brit. J.

Plast. Surg. 23:39-44, 1970.

Fabrikant, J.I. and Kovar, D.S. $pennatogonial cell renewal under continu-103.

-e ous irradiation at 1.8 rads / day. (ab) Radiation Res. 18:233, 1970.

5 04. Dannenberg, A.M. , Jr. , Shima, K. , Chandrasekhar, S. and Fabrikant, J.I.

Macrophage proliferation, maturation, and function in rabbit BCG lesions. (ab) Fed. Proc. 29:501,1970.

105. Fabrikant, J.I. Thymus cell population studies during radiation leukemo-genesis. Amer. J. Roentgenol. , Rad. Therapy and Nuclear Med.108:

729-735, 1970.

106. Fabrikant, J.I. The kinetics of cellular proliferation in normal and malig-nant tissues. XI. Estimation of DNA synthesis time in human tissues.

Radiology 95:691-693, 1970.

107. Hoopes , J.E. , Dellon , A.H. , Fabrikant, J. I . and Soliman , A.H. Idiopathic hypernasality: Cineradiographic evaluation and etiologic considera-tions. J. Speech Hearing Dis. 35:44-50, 1970.

108. Fabrikant, J.I. The kinetics of cellular proliferation in normal and malignant tissues. IV. Nu::leic acid synthesis in human tissues. (ab)

Invest. Radiol . 5:281, 1970.

109. Hoopes , J.E. , Dellon , A.L. , Fabrikant, J. I . and Soliman , A.H. The locus of levator palatini function as a measuna of velopharyngeal incompetence.

(ab) Cleft Palate J. 7:357, 1970.

110. Fabrikant, J.I. and Cherry, J.I. The kinetics of cellular proliferation in normal and malignant tissues. X. Cell proliferation in respiratory epithelium of the nose and adjoining cavities. Ann. Otol., Rhinol.,

Laryngol. 79:572-578, 1970.

111. Fabrikant, J.I. Environmental radioactivity: Inclusion at the cellular level. Envi ronmental Radioactivity Symposium, Clopton, J.C. , ed. ,

pp.35-106, The Johns Hopkins University Press, Baltimori, Md. ,1970.

112. Fabrikant, J.I. Report of the United Nations Scientific Connittee on the -

Effects of Atomic Radiation. Supplement 13, 1969. (Book Review) ,

Social Biol. 17:238-241, 1970.

113. Fabri kant, J. I . Radiation response in relation to the cell cycle in vivo.

(ab) Radiology 94:247, 1970.

I7-

' JACOB 1. FABRIKAfR 114. Fabrikant, J.I. Human tumor cell kinetics. (In) Time and Dose Relation-ships in Radiation Biology as Applied to Radiotherapy, Bond, V.P. ,

Suit, H.D. and Marcial, V. , eds. , pp. 334-337, BNL 50203(C-57) Brook-haven National Laboratory, Upton, N.Y. ,1970.

115. Hoopes , J.E. , Dellon , A.L. , Fabrikant , J.I. , Edgerton , M.T. and Soliman ,

A.H. Cineradiographic definition of the functional anatonty and patho-physiology of the velopharynx. Cleft Palate J. 7:443-454, 1970.

- '116. Fabrikant, J.I. Cell proliferation in the seminiferous epithelium under continuous irradiation. (ab) IV Congr. Intern. Radiobiol. Physico-

- Chimie Rayon. 4:68, 1970.

117. Fabrikant, J.I. Effects of rapidly and slowly proliferating cell renewal systems. Sixth Annual San Francisco Cancer Symposium, (ab) 5:26, 1970.

118. Dannenberg, A.M. , Jr. , Shima , K. , Kambara, T. , Meyer, 0.T. , Esterly, J.R.

and Fabrikant, J.I. Imunity in tuberculosis, illustrated by its pathogenesis. (ab) Tuberculosis Conference, NIAID, US-Japan Program, 7, 1970.

119. Hoopes, J.E. , Dellon , A.L. , Fabrikant , J.I. and Soliman, A.H. Cineradio-graphic definition of the anatomical variables responsible for cleft palate speech. Brit. J. Plast. Surg. , 24:158-162, 1971.

120. Fabrikant, J.I. Radiation response in relation to the cell cycle in vivo.

(In) Year Book of Radiology, Holt, J.F. , Whitehouse, W.M. and Latourette, H.B. , eds. , p. 392, Year Book Medical, Chicago,1970.

121. Fabrikant, J.I. The kinetics of cellular pmliferation in human tissues.

VII. Determination of duration of DNA synthesis using double labeling autoradiography. Brit. J. Cancer 24:122-127, 1970.

122. Fabrikant, J.I. Thymus cell population studies during radiation leukemo-genesis. (ab) Radiology 97:742, 1970.

123. Fabrikant, J. I. Radiation effects on cell renewal systems. (ab) (In)

Frontiers of Radiation Therapy and Oncology, Vaeth, J.M. , ed. , 5:6-8, 1970.

124. Fabrikant, J.I. The kinetics of cellular proliferation in normal and malignant tissues. XII. In vitro label. (In) The Growth Kinetics of Solid Tumors , Williambsburg, Va. , February 8-11, 1971, Sumary Report of the Meeting. Mendelsohn, M.L. and Shackney, S.E. The growth kinetics of solid tumors. Cell Tissue Kinet. 3:401-414, 1971. .

J 125. Fabrikant, J.I. The kinetics of cellular proliferation in nonnal and malignant tissues. XV. A review of methodology and the analysis of cell population kinetics in human tissues. Amer. J. Roentgenol . ,

Rad. Therapy and Nuclear Med. 111:700-711, 1971.

8 18.

JACOB I. FABRIKANT l

126. Fabrikant, J.I. Spematogonial cell renewal. (In) Symposium on Cell Renewal Systems. (ab) Radiation Res. 19:46-47, 1971.

127. Delahunty, J.E. and Fabrikant, J.I. Experimental laryngeal arteriography.

Ann. Otol . , Rhincl . , Laryngol . 80:744-749, 1971.

128. Fabrikant, J.I. Cell population kinetics in thymus lymphocytes under con-tinuous irradiation. (In) Biological Aspects of Radiation Protection, Sugahara, E. and Hug, 0. , eds. , pp. 74-80, Igaku Shoin, Tokyo,

" Japan ,1971.

. 129. Fabrikant, J.I. Biological effects of small doses of radiation. (ab)

Amer. Assn. Physicists Med. Quart. Bull. 5:115, 1971.

130. Fabrikant, J.I. Spermatogonial cell- renewal under continuous low dose i rradiation. Invest. Radiol. 6:343, 1971.

1 31 . Fabrikant, J.I. Radiation Biology of the Fetal and Juvenile Mammal. Proc.

Ninth Ann. Hanford Biol. Symposium. (Book Review). Radiology 97:

659-660, 1970.

132. Fabrikant, J.I. and Foster, B.R. The cell cycle and growth kinetics during radiation leukemogenesis in C578L mice. (ab) Radial. Soc. N. Amer.

57:244, 1971.

133. Chandrasekhar, S. , Shima , K. , Dannenberg, A.M. , Jr. , Kambara, T. , Fabrikant, J.I. and Roessler, W.G. Radiation, infection and macrophage function.

IV. Effect of radiation on the proliferative abilities of mononuclear phagocytes in tuberculosis lesions of rabbits. Infection and Inununity 3:254-259, 1971.

1 34. Fabrikant, J.I. and Cherry, J. The kinetics of cellular proliferation in nomal and malignant tissues. XIII. Doubling times in primary and metastatic tumors in the same patient. (ab) Radiol. Soc. N. Amer. 57:

46, 1971.

135. Fabrikant, J.I. , Wisseman, C.L. , III and Vitak, M.J. The kinetics of cellular proliferation in normal and malignant tissues. VI. Nucleic acid metabolism in mlation to the cell cycle in human tissues. Growth 36:

173-183, 1972.

136. Fabrikant, J.I. The effects of small doses of radiation. (In) Reduction of Radiation Dose in Diagnostic X-Ray Procedums, pp. 3-32. Proceedings of a Symposium held in Houston, Texas, July 8,1971. Amer. Assoc.

Phys. Med. , USDHEW Publ . No. (FDA) 73-8009, Bureau of Radiological ,

N Health, Rockville, Md. ,1972. ,

137. Fabrikant, J.I. Spermatogonial cell mnewal under continuous low dose i rradiation. Amer. J. Roentgenol . , Rad. Therapy and Nuclear Med.

114:792-802.,1972.

l l

l

  • 19.

JACOB I. FABRIKANT I

L 138. Fabrikant, J.I. Radiation effects on rapidly and slowly proliferating cell renewal systems. Discussion. Front. Radiation Ther Oncol. 6:524-526, 1972.

139. Hsu, T.H.S. and Fabrikant, J.I. Spermatogonial Kinetics cell renewal under continu-of cellular depopulation ous low level irradiation. VII.

under 45 rads per day. (ab) Radiation Res. 51:544, 1972.

140. Fabrikant, J.I. and Foster, B.R. Lymphoid cell renewal under low-level

- irradiation. XI. The cell cycle and growth kinetics during radiation  :

i - c- leukemogenesis of C578L mice. Radiology 104:203-204, 1972.

141. Fabrikant, J.I. Radiation effects on rapidly and slow ~ly proliferating cell renewal systems. (In) Frontiers of Radiation Therapy and Oncology, '

i Vaeth, J.M., ed., Vol. 6, pp. 57-78, Karger, Basel, 1972.- \

Medical Radiation Biology. ~(BookReview)'.' Radiology 105:

~

142. Fabrikant, J.I. l 434, 1972.

Fabrikant, J.I. Cell population kinetics in ~the semini' ferous epithelium l 143.

under continuous low dose rate irradiation.~ (_In)' Advances'.in Radiation r

Research. Biology and Medicine. Vol . II. Duplan, J.F. and Chapiro, i

A. eds. pp. 805-814, Gordon and Breach, New York, 1972.

144. Fabrikant, J.I. and Foster, B.R. Cell population kinetics in mouse and  !

rat thymus. J. Hopkins Med. J. 130:208-215, 1972. ,

Fabrikant, J.I. Lymphoid cell renewal under low level irradiation. XII.

i 145.

' Regulation of thymus cell proliferation under continuous exposure.

(ab) Radiation Res. 51:471, 1972.

146. Fabrikant, J.I., Hsu, T.H.S., Knudson, D.H. and Smith, C.L.D. Effect of ,

LET on radiation carcinogenesis. Comparison of single and fractionated '

i doses of plutonium-239, americium-241, phosphorus-32 and x-rays on the production of osteosarcomas in rats. (ab) 12th Hanford Biology Symposium on Radionuclide Carcinogenesis, Richland, Wash., May 11-13, 1972. i Fabrikant, J.I. and Cherry, J. The kinetics .of cellular proliferation in l

147.

normal and malignant tissues. XIV. Analysis of tumor cell kinetics  !

in primary and metastatic lesions. (ab) Assn. Univ. Radiologists 20:

34, 1972. Invest. Radiol. 7:436-437, 1972. ,

148. Fabrikant, J.I., Hsu, T.H.S., Knudson, D.H. and Smith, C.L.D. LET and  !

radiation carcinogenesis. The effects of fractionation of dose of plutonium-239, americium-241, phosphorus-32 and x-rays o'n the produc-

  • tion of osteosarcomas in rats. (.In) Radionuclide Carcinogenesis, 12th Hanford Biology Symposium, pp. 322-346, C.L. Sanders, R.H. Busch, J.E.

Ballou, D.D. ~ Mahlum, eds. CONF-720505, USAEC Oak Ridge., Tenn. 1973. ,

149. Fabrikant, J.I. Public health considerations of the biological' effects of l small doses of medical radiation. .(ab)_ Health Physics Society, j San Juan, P.R., 7:4, 1972. ,

f i

I

I

.JAC0B I. FABRICANT 20.

150. Fabrikant, J.I. Radiation dosimetry of heavily irradiated sites in patients treated for ankylosing spondylitis. (In) The Effects on Populations of Exposure to Low Levels of Ionizing Radiation. Report of the Advisory Comittee on Biological Effects of Ionizing Radiations, pp.

190-195. National Academy of Sciences-National Research Council, Washington, D.C., 1972.

151. Fabrikant, J.I. The kineties of cellular proliferation in normal and malignant tissue. XVI. Cell population kinetics in primary and

-- metastatic tumors. (ab) Europ. Soc. Radiation Biol . , Rome, 9:47, 1972.

_ l52. Fabrikant, J.I. Lymphoid cell renewal under low level irradiation. XIII.

Homeostatic control of cell mproduction under continuous exposure.

(ab) Europ. Soc. Radiation Biol. , Rome, 9:48, 1972.

153. Fabrikant, J.I. and Hsu, T.H.S. Spermatogonial cell mnewal under low level irradiation. VII. Cellular response and cell population kinetics in the seminiferous epithelium during mcovery after continuous exposum at 45 rads / day. (ab) Europ. Soc. Radiation Biol . , Rome , 9:49, 1972. .

154. Shima, K. , Dannenberg, A.M. , Jr. , Ando, M. , Chandrasekhar, S. , Seluzicki, J.

and Fabrikant, J.I. Macrophage accumulation, division, maturation, and ,

digestive and microbial capacities of tritiated thymidine and their Amer. J. Path. 66:143, 1972.

content of lysomal enzymes and bacilli. l 155. Delahunty, J.E. and Fabrikant, J.I. Experimental laryngeal arteriography.

Radiology 103:227, 1972.

156. Fabrikant, J.I. Lymphoid cell renewal under continuous low level irradiation.

XIV. Regulation of cell proliferation and differentiation. (ab)

Radiol . Soc. N. Amer. 58:47, 1972.

157. Hsu, T.H.S. and Fabrikant, J.I. Spermatogonial cell renewal under low level i rradiation. X. Cellular response and cell population kinetics during recovery of the testes after continuous irradiation at 45 rads / day.

(ab) Radiation Res. 55:560, 1973.

158. Fabrikant, J.I. and Foster, B.R. Lymphoid cell renewal under low level ,

i rradiation. XVII. Cell kinetic analysis of radiation leukemogenesis.

(ab) Radiation Res. 55:587, 1973. l 159. Fabrikant, J.I. Public health considerations of the biological effects of small doses of medical radiation. (In) Health Physics in the Healing l Arts, pp. 31-42, DHEW Publication (FDA) 73-8029, Food and Drug Admini-stration, Bumau of Radiological Health, NTIS, Springfield, Va.,1973.

160. Fabrikant, J. I. , Hsu, T.H.S. , Kovar, D.H. and Smi th, C.L.D. Radiation-induced osteosarcomas in rats. Delayed effects of bone-seeking radio-nuclides and x-rays. Invest. Radiol. 8:269, 1973.

l 1 61. Fabrikant, J.I. Tumor cell population kinetics under continuous irradiation.

i -(In) Symposium on the Radiobiological Effect and RBE of Minimum Doses I of Radiation. (ab) Proc. XIII Intern. Congr. Radiology, p. 473,. Madrid, l Spain , 1973. -

l l

- c

21.

' JACOB I . FABRIKANT l

l Lymphoid cell renewal under low level irradiation. XIV.

162. Fabrikant, J.I.

(In) Symposium Regulation of lymphopoiesis under continuous exposure.

on Long-Tenn Effects--Low Level Radiation Doses. Proc. XIII Intema-tional Congress of Radiology, p. 518, Madrid, Spain,1973.

163. Hsu, T.H.S. , Fabrikant, J.I. and Kovar, D.S. Spermatogonial cell renewal under low level irradiation. XII. Effect (ab) of dose rate on cellular J. Hopkins Med. Surg. Assn.,

response under continuous exposure.

Radiology Sec. , Baltimore , Md. ,1973.

164. Fabrikant, J.I. The cell cycle in lymphoid tissues. (ab) (In) The Cell

- Cycle in Malignancy and Immunity. Thirteenth Hanford Biology Symposium, Richland, Wash. 13:59-60, 1973.

165. Hsu, T.H.S. , Kovar, D.S. and Fabrikant, J.I. Spermatogonial cell mnewal under low level irradiation. XI. Analysis of stem cell population kinetics in mice. (ab) Radiat. Res. Soc. Work-in Pmgress Session, Twenty-third Ann. Mtg. , St. Louis , Mo. , May 1,1973.

166. Fabrikant, J.I. Some implications of the 1972 Report of the Advisory Com-mittee on the Biological Effects of Ionizing Radiations (The BEIR Report) of the National Academy of Sciences-National Research Council.

(In) Report of the Eleventh Meeting of the Medical Radiation Advisory Comittee, Bureau of Radiological Health, FDA, DHEW, Rockville, Md. ,

September 13-14, 1973.

167. Fabrikant, J.I. The cell cycle in lymphoid tissues and the immune response.

(In) The Cell Cycle in Malignancy and Immunity, Hampton, J. , ed. ,

Thirteenth Hanford Biology Symposium, pp. 504-530, _ (CON F-731005) .

NTIS, Springfield, Va. ,1974.

168. Fabrikant, J.I. The biological effects of low levels of radiation dose:

Implications for diagnostic radiology. (ab) Postgraduate Weekend Course, The Faculty of Radici siirts, London, England, May 1974.

169. Hsu, T.H.S. and Fabrikant, i ' 3 'nnatogonial cell renewal under continu-aus irradiation. XII .a ti ' renewal. (ab) V. Intern. Congr.

Radiation Res. , SeattQ, Wau.. , July 1974.

170. Fabrikant, J.I. Tumor cell population kinetics under continuous irradiation.

Proc. XIII International Congress of Radiology, Madrid,1973, pp. 585-589, Excerpta Medica, Amsterdam,1975. .

1 71. Fabrikant, J.I. Medical Radiation. Second Report to the Advisory Committee on the Biological Effects of Ionizing Radiations, National Academy of .

N Sciences-Nationai Research Council , 59 pp. , Washington, D.C. ,1974.

172. Fabrikant, J.I. Concepts : Cost-Benefit Analysis and Medical Radiation.

Report to the Advisory Comittee on the Biological Effects of Ionizing Radiations, National Academy of Sciences-National Research Council, 18 pp. , Washington, D.C. ,1975.

e L

22.

JACOP I. FABRIKANT 173. Hsu, T.H.S. and Fabrikant, J.I. Spermatogonial cell renewal under continu-(In) Proceedings of the ous irradiation at 1.8 and 45 rads per day.

Symposium on Low Level Radiation, International Atomic Energy Agency, IAEA-SM-202/214, Chicago, Ill . ,1975.

174. Fabrikant, J.I. The significance to diagnoscic radiology of the effects

  • _ of exposure to low levels of ionizing radiations. Clinical Radiol.

33:172-179, 1975.

475. Fabrikant, J.I. Benefit-Risk-Cost Analysis for Medical Radiation. Chapter

- VI. (In) Considerations of Health Benefit-Risk-Cost Analysis for Activities Involving Ionizing Radiation Exposure and Altematives.

Report of the Advisory Connittee on the Biological Effects of Ionizing Radiations, National Academy of Sciences-National Research Council, 147 pp. , Washington, D.C. ,1976.

176. Hsu, T.H.S. and Fabrikant, J.I. Spermatogonial cell renewal (In) under con-Biological tinuous irradiation at 1.8 and 4.5 rads per day.

Vol. 1, pp. 157-and Environmental Effects of Low-Level Irradiation.

4 168, I AEA-SM-202/214, International Atomic Energy Agency, Vienna,1976.

177. Fabrikant, J.I. and Hsu, T.H.S. Spermatogonial cell renewal under low-level irradiation. XVI. Stem cell proliferation. (ab) Radiat. Res.

> 70:620, 1977.

178. Hsu, T.H.S. and Fabrikant, J.I. Kinetics of spermatogonial cell renewal under continuous irradiation at 1.8 and 4.5 rads per day. (ab)

Radiat. Res. 70:620, 1977.

179. Fabrikant, J.I. and Hilberg, A.W. Benefit-cost analysis for medical radia-ti on. (ab) Radiat. Res. 70:670-671, 1977.

i 180. Fabrikant, J.I. Benefit-cost analysis in diagnostic radiology. (In) Panel on Efficiency, Cost-Benefit Analysis and Health Resource Allocation in Radiology. James Picker Foundation Conference, The Radiologist in Society--Prospects and Problems for the 1980s. Kay Biscayne, Florida, April 1977.

181. Fabrikant, J.I. and Hsu, T.H.S. Spermatogonial cell renewal under low-level i rradiation. XV. Stem cell proliferation in the seminiferous epi-thelium under 1.8 rads per day. (ab) XIV International Congmss of Radiology, Rio de Janeiro, Brasil,1977, In Press. ,

Fabrikant, J.I. and Hilberg, A.W. Benefit-cost analysis for diagnostic l

! 182.

radiology in medicine. (In) Symposium on Risks and Benefits in Medical '

Radiation Applications. XIV International Congress of Radiology, t,

Rio de Janeiro, Brasil,1977, In Press.

183. ' Fabrikant, J.I. and Anderson, N.D. Immunchematopoietic cell mnewal under low level irradiation. XVIII. Hematopoietic stem cell kinetics. (ab) l XIV (In) Symposium on Immunological Consequences of Radiotherapy.

International Congress of Radiology, Rio de Janeiro, Brasil,1977, In Press.

/

23.

. JACOB 1. FABRIKANT 184. Fabrikant, J.I. and Hilberg, A.W. The effects of low level radiation dose to human populations; The significance for diagnostic radiology. (ab) XIV International Congress of Radiology, Rio de Janeiro, Brasil,1977, In Press.

185. Fabrikant, J.I. Lymphoid cell renewal under low level irradiation. XIX.

Cell proliferation in the spleen germinal center during the primary imune reaction under 45 rads per day. (ab) XIV International Congress of Radiology, Rio de Janeiro, Brasil,1977, In Press.

Fabrikant, J.I. and Hilberg, A.W. Mamorgraphy: Benefit-cost analysis of 186.

mass screening procedures. (ab) XIV Intemational Congress of Radiology, Rio de Janeiro, Brasil,1977, In Press.

187. Fabrikant, J.I. Respiratory function in ischemic rqyocardial disease: The value of pulmonary radiology. (ab) XIV International Congress of Radiology, Rio de Janeiro, Brasil,1977, In Press.

188. Fabrikant, J.I. Radiation protection and safety in diagnostic ultrasound.

(ab) XIV International Congress of Radiology, Rio de Janeiro, Brasil, 1977, In Press.

189. Fabrikant, J.I. Safety in Diagnostic Ultrasound. (In) CRC Critical Reviews in Diagnostic Imaging, Wang, Y. , ed. CRC Press, Inc. , Vol .10, pp. 219-234, 1977.

190. Fabrikant, J.I. Perspectives of decision.-making and estimation of risk in populations exposed to low levels of ionizing radiation. (In) Symposium on Epidemiology Studies of Low level Radiation Exposure. AAAS Annual Meeting, Houston, Texas, January 1979. Lawrence Berkeley Laboratory Report LBL-8667, pp.1-40, Lawrence Berkeley Laboratory, University of California, Berkeley, California, January 1979.

Fabrikant, J.I . Cell cycle of spennatogonia in mouse testes. Invest.

191.

Radiol. 14:189-191, 1979.

1 92. Fabrikant, J.I. The 1979 Report of the Advisory Committee on the Biological Effects of Ionizing Radiation (The BEIR Report). The Effects on Populations to Exposure to Low Levels of Ionizing Radiation. Implications for Nuclear Energy and Medical Radiation. (In) Symposium on Known Effects of Low Level Radiation Exposures, (National Cancee Institute),

Pittsburgh, Pennsylvania, April 1979, Lawmnce Berkeley Laboratory Report, LBL-9084, pp.1-42, In Press.

Fabrikant, J.I. and Anderson, N.D. Immunchematopoietic cell renewal under f 193. -

low level irradiation. XI X. CFU stem cell kinetics. (ab) VI Inter- '

national Congress of Radiation Researth, Tokyo, May 13-19,1979, p. 309, '

1979.

Fabrikant, J.I. Spermatogonial stem cell renewal following irradiation. (In) 194.

Symposium on Radiation and Stem Cells, (ab) VI International Congress of Radiation Research, Tokyo, May 13-19,1979, p. 44,1979.

./

24.

JACOB I. FABRIKANT 195. Fabrikant, J.I. Spermatogonial stem cell renewal following irradiation.

(In) Symposium on Radiation and Stem Cells. VI International Congress of Radiation Research. Proceedings of the Congress, Tokyo, May 13-19,1979, LBL-8667,1979.

196. Fabrikant, J.I. and Hilberg, A.W. Benefit-risk analysis for diagnostic radi ology. (ab) VI International Congress of Radiation Research, Tokyo, May 13-19,1979, p.183,1979.

197. Lyman, J.T. and Fabrikant, J.I. Estimation of absolute risk of leukemias and cancers of heavily irradiated sites in single-course radiotherapy patients treated for ankylosing spondylitis in England and Wales. (ab)

~

VI International Congress of Radiation Research, Tokyo, May 13-19, 1979, p.180,1979.

198. Tobias, C. A. , Benton , E.V. , Holley, W.R. , Fabrikant, J.I. , and Henke, R.P.

Heavy-ion computed tomography. (ab) VI International Congress of Radiation Research, Tokyo, May 13-19,1979, p.135,1979.

199. Vitak, M.J., Hsu, T.H.S., Kovar, D., and Fabrikant, J.I. Lymphoid cell renewal under low level irradiation. XX. B-cell population kinetics of the cellular imune response. (ab) VI International Congress of Radiation Research, Tokyo, May 13-19,1979, p. 212,1979.

200. Fabrikant, J.I. Degeneration and regeneration of the spermatogonial stem-cell system after exposure to ionizing radiation. Lawrence Berkeley Laboratory Report No. LBL-8850, pp.1-25, University of California, Berkeley, California, February 1979.

201. Fabrikant, J.I. Perspectives of decision-making and estimation of risk in populations exposed to low levels of ionizing radiations. (In) Sym-posium on Epidemiology Studies of Low-Level Radiation Exposure, AAAS Annual Meeting, Houston, Texas, January 3-8, 1979; Lawrence Berkeley Laboratory Report LBL-8667, pp.1-40, January 1979.

202. Fabrikant, J.I. Fertility. (In) Chapter V. Somatic Effects: Effects Other Than Cancer: The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980. Report of the Committee on the Biological Effects of Ionizing Radiations, pp. 493-498, National Academy of Sciences-National Research Council, Washington, D.C., 1980, Lawrence. Berkeley Laboratory Report LBL-8704, January 1979.

203. Fabrikant, J.I. Salivary Glands. (In) Chapter V. Somatic Effects: Cancer.

The Effects on Populations of Exposure to Low Levels of lonizing Radiation: 1980. Report of the Committee on the Biological Effects of Ionizing Radiations, pp. 392-396, National Academy of Sciences-National Research Council, Washington, D.C.,1980, Lawrence Berkeley -

Laboratory Report LBL-8708, January 1979.

t

r

, JACOB I. FABRIKANT 25.

I 204. Fabrikant, J.I. and Lyman, J.T. Estimates of radiation doses in tissues and organs in the single-course radiotherapy patients treated for ankylosing spondylitis in England and Wales. (In) Chapter V. Somatic Effects: Cancer. The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980. Report of the Committee on the Biological Effects of Ionizing Radiations, pp. 160-167, National Academy of Sciences-National Research Council, National Academy Press, Washington, D.C.,

1980, Lawrence Berkeley Laboratory Report LBL-8708. January 1979.

~ 305. Fabrikant, J.I. and Land, C.E. Pancreas. (In) Chapter 5. Somatic Effects:

Cancer. The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980. Report of the Committee on the Biological Effects of Ionizing Radiations, pp. 384-389, National Academy of Sciences-National Research Council, Washington, D.C. ,1980, Lawrence Berkeley Laboratory Report LBL-8710. January 1979.

206. Fabrikant, J.I. Pharynx, hypopharynx, and larynx. (In) Chapter V. Somatic Effects: Cancer. The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980. Report of the Committee on the Biological Effects of Jonizing Radiations, pp. 389-392, National Academy of Sciences-National Research Council, Washington, D.C.,1980, Lawrence Berkeley Laboratory Report LBL-8711. January 1979.

207. Fabrikant, J.I. Somatic Effects - Cancer. II. Introductory Material.

A. Mechanisms of Radiation Carcinogenesis. B. Concepts of Somatic Effects. (In) The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980. Report of the Comm ttee on the Biological Effects of Ionizing Radiations, National Academy of Sciences-National Research Council, Washington, D.C., pp.1-14, Lawrence Berkeley Laboratory Report LBL-8715. January 1979.

I 208. Fabrikant, J.I. Ovary. (In) Chapter V. Somatic Effects: Cancer. The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980 Report of the Comittee on the Biological Effects of Ionizing Radiations, pp. 406-409, National Academy of Sciences-National Research Council, Washington, D.C.,1980, Lawrence Berkeley Laboratory Report LBL-8743.

January 1979.

209. Fabrikant, J.I. Degeneration and regeneration of the spermatogonial stem-cell system after exposure to ionizing radiation. Presented at the Symposium on Radiation and Stem Cells. VI Intern. Congr. Radiation Res., Tokyo, Japan, May 13-19, 1979. Lawrence Berkeley Caboratory Report LBL-8850, pp. 1-25. February 1979.

210. Fabrikant, J.I. Health Effects of low-level ionizing radiation. Presented ,

before the U.S. Senate Committee on Human Resources, Subcommittee on Health and Scientific Research. Official Record ofLawrence the U.S. Senate Berkeley Hearings of April 4,1979, GP0, Washington, D.C. l l

Laboratory Report LBL-9018. April 1979.

JACOB I. FABRIKANT 26.

211. Fabrikant, J.I. Applications of dose-response functions to observed data.

(In) Chapter II. Scientific Principles of Radiation Effects. The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980.

Report of the Comittee on the Biological Effects of Ionizing Radiations, pp. 21-23, National Academy of Sciences-National Research Council, Washington, D.C., 1980.

21 2. Fabrikant, J.I. Perspectives of decision-making and estimation of risk in populations exposed to low levels of ionizing radiation. Presented at the AAAS Annual Meeting. Symposium of Epidemiology Studies of Low-Level Radiation Exposure, Houston, Texas. January 3-8, 1979. Report LBL-8667, pp.1-40, Lawrence Berkeley Laboratory, University of California, Berkeley, California, January 1979.

213. Tobias, C. A. , Fabrikant, J.I. , Holley, W.R. , and Benton, E.V. Heavy-ion radiography. Lawrence Berkeley Laboratory Report, LBL-10022, UC-48, pp. 63-67,1979.

214. Holley, W.R., Henke, R.P., Gauger, G.E., Jones, B., Benton, E.V., Fabrikant, J.I., and Tobias, C.A. Heavy particle computed tomography. (In) Sixth Symposium on Computer Radiology, 1979 IEEE, pp. 64-70, June 1979.

21 5. Fabrikant, J.I. Summary of the Public Health and Safety Task Force Report to The President's Commission on the Accident at Three Mile Island.

(In) Public Health and Safety Task Force Report to The President's Comission on the Accident at Three Mile Island. (Fabrikant,J.I.,Ed.)

32 pp. Government Printing Office, Washington, D.C., October 1979.

21 6. Axel rod, D. , Bluestone, M. , Densen, P.M. , Fabrikant, J.I. , Fowinkle, E.W. ,

Johnson, K.G. , Jones, E.W. , and Seltser, R. Technical Staff Analysis Report on Public Health and Epidemiology. (In) Public Health and Safety Task Force Report to The President's Comission on the Accident at Three Miles Island. (Fabrikant, J.I., Ed.) 147 pp. Government Printing Office, Washington, D.C., October 1979.

217. Abrahamson, S. , Bair, W.J. , Bender, M. A. , Bloom, A.D. , Bond, V.P. , Casarett, G.W., and Fabrikant, J.I. Technical Staff Analysis Report on Report of the Radiation Health Effects Task Group. (In) Public Health and Safety Task Force Report to The President's Comission on the Accident at Three Mile Island. (Fabrikant, J.I., Ed.) 98 pp. Government Printirig Office, Washington, D.C., October 1979. .

218. Fabrikant, J.I. The BEIR-III Report and the health effects of low-level radiation. (In) Symposium on Nuclear Reactor Safety: A Current Per-spective. AAAS, San Francisco, 1980. Science. Lawrence Berkeley 3

Laboratory Report LBL-10383. January 1980.

t 9

JACOB 1. FABRIKANT 27.

219. Fabrikant, J.I. The 1979 Report of the Advisory Committee on the Biological Effects of Ionizing Radiation (The BEIR Report). The Effects on Popula-tions of Exposure to Low Levels of Ionizing Radiation. Implications for Nuclear Energy and Medical Radiation. (In) Kncwn Effects of Low Level Radiation Exposure Health Implications of TMI Acciden (Shrivastava, P.N. , Ed. ) pp.79-104. Division of Cancer Control and Rehabilitation of the National Cancer Institute, Mideast Center for Radiological

_ ,. Physics, Pittsburgh, Pennsylvania, April 25, 1979, NIH Publication 80-2087.

Lawrence Berkeley Laboratory Report LBL-9084. 1980.

~

'220. Fabrikant, J. I. The BEIR-III Report and its implications for radiation protection and public health policy. (In) Proceedings of the Inter-national Radiation Protection Association, Fifth International Congress, Jerusalem, March 9-14, 1980. In press. Lawrence Berkeley Laboratory Report LBL-10494,1980.

221. Fabrikant, J.I., Tobias, C.A., Benton, C.V., and Capp, M.P. Heavy ion imaging applied to medicine, (ab.). (In) Proc. SPIE, IEEE, Medicine VIII, p. 64, Las Vegas, Nevada. April 1980.

222. Fabrikant, J.I. Current understanding of the relation between radiation exposure and the induction of developmental disabilities. Presented at Symposium on Prevention of Mental Retardation: Opportunities and Obstacles 1980, III. Environmental Hazards; Special Concerns, American Association on Mental Deficiency,104th Annual Meeting, San Francisco, May 14, 1980, in press.

223. Fabrikant, J. I., Tobias, C.A., Capp, M.P., Benton, E.V. and Holley, W.R.

Heavy-ion imaging applied to medicine. SPIE Vol. 233, Application of Optical Instrumentation in Medicine VIII, pp. 255-263, 1981. Lawrence Berkeley Laboratory Report LBL-10543,1981.

224. Fabrikant, J.I. Health effects of the nuclear accident at Three Mile Island.

Presented at Conference on Environmental Regulation of the Nuclear Industry: A new Decade. Atomic Industrial Forum, San Francisco, California, May 18-21, 1980, in press.

225. Fabrikant, J.I. The BEIR-III controversy. Radiation Research Society, New Orleans, Louisiana. June 1,1980. University of California, LBL-11268, June 1980. .

226. Fabrikant, J. I . , Tobias, C. A. , Capp, M.P. , Benton, C.V. , and Holley, W.R.

Heavy-ion imaging applied to medicine. Amer. J. Roentgenol . , Nuclear Medicine and Rad. Therapy, 1981, in press.

227. Tobias, C.A., Fabrikant, J.I., Benton, E.V. and Holley, W.R. Projection radiography and tomography. (In) Biological and Medical Research with Accelerated Heavy Ions at the Bevalac 1977-1980. (Pirruccello, M. and Tobias,C.A.,eds.) pp. 335-346. Lawrence Berkeley Laboratory Report LBL-11220, 1980.

28.

JACOB I. FABRIKANT 228. Fabrikant, J. I. , Tobias, C. A. , Capp, M.P. , Holley, W.R. , Woodruff, K.H. and Sickles, S. A. Heavy-ion mammography and breast cancer. 1977-1980.

and Medical Research with Accelerated Heavy Ions at the BevalacLawrence Berkel (Pirruccello, M. and Tobias, C.A., eds.) pp. 347-357.

Laboratory Report LBL-ll220.1980.

229. Chen, G.T.Y., Fabrikant, J.I., Holley, W.R., Tobias, C.A. and Castro, J.R.(In)

- e Heavy-ion radiography applied to charged particle radiotherapy.

Biological and Medical Research with Accelerated Heavy Ions at thepp. 359 Bevalac 1977-1980. (Pirruccello, M. and Tobias, C.A., eds.)

Lawrence Berkeley Laboratory Report LBL-ll220.1980.

Active 230. Llacer, J. , Chu, W.T. , Tobias, C. A. , Fabrikant, J.I. , and Alonzo, J.R.(In) Bio heavy-ion radiography and computerized tomography. 1977-1980.

Medical Research with Accelerated Heavy Ions at the BevalacLawrence Berkeley (Pirruccello, M. and Tobias, C.A., eds.) pp. 367-374.

Laboratory Report LBL-ll220.1980.

231. Fabrikant, J.I., Budinger, T.F., Tobias, C.A., and Born, J.L. Focal lesions in the central nervous system. (In) Biological and Medical Research with Accelerated Heavy Ions at the Bevalac 1977-1980. (Pirruccello, M. and Tobias, C.A., eds.) pp. 399-405. Lawrence Berkeley Laboratory Report LBL-11220.

232. Fabrikant, J.I. , Beebe, G.W. , Bender, M. A. , Brill , A.R. , Land, C.E. ,

Moeller, D.W. , and Webster, E.W. Estimating the Total Cancer Risk of Low-Dose, Low LET, Whole-Body Radiation. Chapter V, Section 3, pp. 176-226. (In) The Effects on Populations of Exposure to Low Levels of Ionizing Radiation, 1980. Report of the Committee on the Biological Effects of Ionizing Radiations, National Academy of Sciences-National Research Council, Washington, D.C., 1980.

233. Fabrikant, J.I. Health effects of the nuclear accident at Three Mile Island.

Health Phys. 40:151-161, 1981. Lawrence Berkeley Laboratory Report LBL-ll297, 1980. .

Fabrikant, J.I. The BEIR-III controversy. Radiat. Res. 84:361-368, 1980.

234.

235. Holley, W.R. , Tobias, C. A. , Fabrikant, J.I. , Llacer, J. , Chu, W.T. and Eenton, E.V. Computerized heavy-ion tomography. SPIE Vol. 27.3, Application of Optical Instrumentation in Medicine IX, pp. 283-293, 1981. Lawrence Berkeley Laboratory Report LBL-12304.

236. Fabrikant, J.I. The contribution of modern medical imaging technology to radiation health effects in exposed populations. IEEE Transactions on Nuclear Science, Vol . NS-28, No.1, pp. 40-46, February 1981. Lawrence Berkeley Laboratory Report LBL-ll728, November 1980.

l

I

. l 29.

JACOB I. FABRIKANT 237' Fabrikant, J.I. The BEIR-III Report: Origin of the controversy. AJR 136:209-214, 1981. Lawrence Berkeley Laboratory Report LBL-13409,1981.

l f 238. Fabrikant, J.I. and Lyman, J.T. Estimates of absolute risk of excess leukemias and cancers arising in heavily irradiated sites in the single-course l radiotherapy patients treated for ankylosing spondylitis in England and Wales. Brit. J. Radiol., in press.

239. Fabrikant, J.I. Public health implications and decision-making during nuclear reactor accidents---the Three Mile Island experience. (In)

Symposium on Preparing for the Issues of the 1980's. Annual Meeting, Association of State and Territorial Health Officials, Atlanta, Georgia, April 1980. To be published.

240. Fabrikant, J.I. , Tobias, C. A. , and Pirruccello, M.C. Medical imaging using heavy-ion radiography. (In) Proceedings of the Conference on Biological Imaging, Scripps Clinic and Research Foundation, La Jolla, California, November 1980. To be published. Lawrence Berkeley Laboratory Report LBL-12517,1981.

241. Fabrikant, J.I. Risk estimation and decision-making: Implications of the 1980 BEIR-III Report. (In) Proceedings of the Conference on Radiation Exposure on Pediatric Dentistry, American Academy of Pedodontics, Cincinnati, Ohio, April 1981. Pediatric Dentistry, 1981. In press.

Lawrence Berkeley Laboratory Report LBL-13407.

242. Fabrikant, J.I. Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: Nuclear explosions and medical radiation. (In) Proceedings of the Symposium on Effects on Humans of Exposure to Low Levels of Ionizing Radiation, Yale University School of Medicine, New Haven, Connecticut, May 1981. Yale Journal Biol . Med. ,1981.

In press. Lawrence Berkeley Laboratory Report LBL-13416.

243. Fabrikant, J.I. The effects of low-level radiation on human health: Epidemio-logical studies. The Walter W. Herbert Pemorial Symposium: Is Low-dose Radiation Harmful? (In) Diagnostic Radiology 1981. (Margulis,A.R.and Gooding,G.A.,eds.) pp. 451-455. University of California, San Francisco 1981.

244. Fabrikant, J. I. and Tobias, C. A. Heavy-ion radiography and. cancer. Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, PUB-5051. February 1981.

245. Fabrikanti J.I. Controversial issues confronting the BEIR-III Committee---impli-,

cations for radiation protection. Thirteenth Annual National Conference on Radiation Control, Little Rock, Arkansas, May 1981. To be published.

Lawrence Berkeley Laboratory Report LBL-13444.

30.

JACOB 1. FABRIKANT 246. Fabrikant, J.I. Impact of the 1980 BEIR-III Report on low-level radiation:

Risk assessment, radiation protection guides, and public health policy.

(In) Proceedings, Selected Topics in Reactor Health Physics, Fourth Annual HPS Sumer School, Lexington, Kentucky, June 1981. To be published, 1981. Lawrence Berkeley Laboratory Report LBL-13408.

247. Fabrikant, J.I. Biological effects of ionizing radiation: Epidemiological surveys and laboratory animal experiments. Implications for risk evaluation and decision processes. (In) Proceedings of the Seminaire

- des Evaluations des Risques et Processus de Decision, National Academy of Sciences-National Research Council (USA) and Mouvement Universel de la Responsibilite Scientifique-Academie Francais, Orsay, France, December 17-19, 1980. To be published,1981. Lawrence Berkeley Laboratory Report {

LBL-12555.

248. Fabrikant, J.I. Nuclear energy, public health and public policy. Amer.

Jour. Public Health,1981. To be published. Lawrence Berkeley Laboratory Report LBL-13469.

249. Fabrikant, J. I. Influence of dose and its distribution in time on dose-response relationships for low-LET radiations. NCRP Report 64, National Council on Radiation Protection and Measurements (Book Review). Health Physics,1981, in press.

1 9

a

~

JACOB I. FABRIKANT BOOKS AND CHAPTERS

1. Fabrikant, J.I. Studies on Cell Proliferation in the Regenerating Liver Ph.D. Thesis, and the Effect of Prior Continuous Irradiation. i University of London, London,1964.
2. Fabrikant, J.I. and Donner, M.W. , Eds. Russell H. Morgan, A Tribute duPont, Wilmington, Delaware,1967.

Fabrikant, J.I. The Effec'ts of Continuous Irradiation.

(In) Pathology of 3.

Irradiation. Berdjis, C.C., Ed., Chapter 4, pp. 50-85, Williams and Wilkins, Baltimore, Maryland,1971.

I 4. Fabrikant, J.I. The Effects of Irradiation on the Kinetics of Proliferation in Cell Renewal Systems. (In) CRC Critical Reviews in Radiological Sciences. Wang , C. , Ed. Vol . 2, pp. 525-576, CRC Press Inc. Cleveland, Ohio, 1971.

5. Fabrikant, J.I . Radiobiology Year Book Medical Publishers, Chicago, Illinois,1972.
6. Fabrikant, J.I. The Kinetics of Cell Proliferation in Normal Tissue, Malignant Tumors of the Upper Air Passages. (In) The Biological and Clinical Basis of Radiosensitivity. Friedman, M. , Ed. , Chapter 13, pp. 274-313, Charles C. Thomas Publishers, Springfield, Illinois,1974.
7. Fabrikant, J.I. Safety in Diagnostic Ultrasound. (In) CRC Critical Reviews in Diagnostic Imaging. Wang, C., Ed. Vol. 10, pp. 219-234, CRC Press Inc., Cleveland, Ohio, 1977.
8. Fabrikant, J.I. Summary of the Public Health and Safety Task Force Report to The President's Commission on the Accident at Three Mile Island.

~

32 pp. Government Printing Office, Washington, D.C., October 1979, in press.

9. Axelrod, b. Bluestone, M. , Densen, P.M. , Fabrikant, J.I . , Fowinkle, E.W. ,

Johnson, K.G. , Jones , E.W. , and Seltser, R. Technical Staff Analysis Report on Public 'iealth and Epidemiology. (In) Report of the Public Healti, and Saf.cy Task Force Report to The President's Commission on The Accident at Three Mile Island.132 pp. Government Printing Office, Washington, D.C. , October 1979, in press.

10. Abrahamson, S. , Bair, W.J. , Bender, M. A. , Bloom, A.D. , Bond, V.P. , Casarett, G.W. , and Fabrikant, J.I . Technical Staff Analysis Report on Report of the Radiation Health Effects Task Group. (In) Report of The Public Health and Safety Task Force Report to The President's Commission on The Accident at Three Mile Island. 98 pp. Government Printing Office, .

Washington, D.C., October 1979.

11. Auxier, J. A. , Berger, C.D. , Eisenhauser, C.M. , Gesell , T.F. , Jones, A.R. ,

and Masterson, M.E. Report of the Task Group on Health Physics and Dosimetry. (In) Report of the Public Health and Safety Task Force to The President's Commission the Accident at Three Mile Island 1 (Fabrikant, J.I., Ed.) 196 pp. Government Printirg Office, Washington, i D.C. , October 1979.

l l

32 o

JACOB I. FABRIKANT Dohrenwend, B.P. , Dohrenwend, B.S., Kasl, S.V. and Warheit, G.J. Technical  !

12. (In) Report of the Public Staff Analysis Report on Behavrioral Effects.

Health and Safety Task Force to The President's Commission on the Government Accident at Three Mile Island. (Fabrikant, J.I., Ed.) 81 pp.

Printing Office, Washington, D.C., October 1979.

13. Fabrikant, J.I. , Beebe, G.W. ,. Bender, M. A. , Brill , A.R. , Land, C.E. , Moeller, D.W., and Webster, E.W. Estimating the Total Cancer Risk of Low-Dose,

- o- Low LET, Whole-Body Radiation. Chapter V., Section 3. (In) The1980. Effects on Populations of Exposure to Low Levels of Ionizing Radiation:

Report of the Committee on Biological Effects of Ionizing Radiations, pp. 176-226, National Academy of Sciences-National Research Council, Washington, D.C., 1980.

4 h

April 20, 1982, n1:27 82 s 21 UNITED STATES OF AMERICA NUCLEAR REGULATORY COMMISSION f

BEFORE THE ATOMIC SAFETY AND LICENSING BOARD j In the Matter of )

)

LOUISIANA POWER & LIGHT COMPANY ) Docket No. 50-382

)

(Waterford Steam Electric Station, )

Unit 3) )

CERTIFICATE OF SERVICE I hereby certify that copies of the following listed documents were served upon the parties identified on the attached Service List by Express Mail, except those parties designated by a single asterisk (*) were served by hand delivery and those parties designated by a double asterisk (**) were served by deposit in the United States mail, first class, postage prepaid, this 20th day of April, 1982.

(1) Applicant's Testimony of Robert G. Azzarello, Alexis Tsaggaris, and Ronald J. Perry on Radiological Emergency Response Plans, Contentions 17/26 (1) (a) , (c), (d), (e) and (f).

(2) Applicant's Testimony of Kevin P. Twine on Radiological Emergency Response Plans, Conte'ntion 17/26 (1) (b) .

(3) Testimony of John M. Lucas on Radiological Emergency Response Plans.

(4) Testimony of Bertram Paul Madere on Radio-  ;

. logical Emergency Response Plans.

(5) Testimony of Robert William Myers on Radio-logical Emergency Response Plans.

(6) Applicant's Testimony of John J. Mauro on the Use of Potassium Iodide as a Thyroid Blocking l Agent.

1 (7) Applicant's Rebuttal Testimony of George B. I Hutchison on Contention 8/9.

l (8) Applicant's Rebuttal Testimony of Jacob I.

Fabrikant on Contention 8/9.

(9) Applicant Exhibit No. 6. Wallace Laboratories Patient Package Insert for Thyro-Block (Potassium Iodide).

(10) Applicant Exhibit No. 7 Department of Health, Education, and Welfare (Food and Drug Administration)

Notice, Request for Submissions of New Drug Applications, Potassium Iodide as a Thyroid-Blocking Agent in a Radiation Emergency. 43 Fed.

Reg. 58,798 (Dec.15, 197 8) .

(11) Applicant Exhibit No. 8. Memorandum dated March 26, 1981 to William J.

Dircks, NRC Executive Director for Operations, from Samuel J. Chilk, NRC Secretary, with attachments.

BrYce W. D urchill Dated: April 20, 1982 i

t l

~ . .

UNITED STATES OF AMERICA 4

NUCLEAR REGULATORY COMMISSION Before the Atomic Safety and Licensing Board .

In the Matter of )

)

LOUISIANA POWER & LIGHT COMPANY ) Docket No. 50-382

)

(Waterford Steam Electric )

Station, Unit 3) )

SERVICE LIST Sheldon J. Wolfe, Esquire .Lynan L. Jones, Jr., Esquire Administrative Judge Post Office Box 9216 Chairman, Atomic Safety and Metairie, LA 70055 Licensing Board U.S. Nuclear Regulatory Luke B. Fontana, Esquire -

Commission 824 Esplanade Avenue Washingt;n, D.C. 20555 New Orleans, LA 70116 Dr. Harry Foreman ** Atomic Safety and Licensing Administrative Judge Board Panel Director, Center for U.S. Nuclear Regulatory Population Studies Commission Box 395, Mayo Washington, D.C. 20555 University of Minnesota Minneapolis, MN 55455 ** Atomic Safety and Licensing Appeal Board Panel Dr. Walter H. Jordan U.S. Nuclear Regulatory Administrative Judge Commission 881 West Outer Drive Washington, D.C. 20555 Oak Ridge, TN 37830 ,

  • ** Docketing & Service Section (3)

Sherwin E. Turk, Esquire (4) Office of the Secretary Office of the Executive U.S. Nuclear Regulatory Legal Director Commission U.S. Nuclear Regulatory Washington, D.C. 20555 Commission Washington, D.C. 20555 l

l I

. _ . . ._- __. -- . _ _ _