ML20135F682

Matls Licensing Package for Amend 6 to License SNM-0200 for South Dakota State Univ.Control:466224

ML20135F682
Person / Time
Site:	07000218
Issue date:	12/05/1996
From:	Burks J NRC OFFICE OF INSPECTION & ENFORCEMENT (IE REGION IV)
To:
References
466224, NUDOCS 9612130218
Download: ML20135F682 (35)

Text

,

_ m m ,unu: T T T T T r m. w a A u.s. *~- necVLA tor Y CoMMisMoM 1 3

t MATERIALS LICENSE *kmendme~iiNo.' 06 " in

' Cale of Federal Regulations. Chapter I. PartsPursuant to the Atomic nude by the licenwe, a license is30hereby 31.amended.

32

. 33 issued the Energy Reorganization Act of 1974 (P b

, tonuclear material persons authorized designated to receise authorizing the licensee to receise, acquire it in accord below ; to use such material for the purposet o ore p posse s) a at the place (s) designated below; to ca deliver or f'lRegulatory specified innow Section . 183 ofshall the theAtomi q

Comminion or hereafter in etfectance with regulation $

i i i

and to any conditions speciGed below. This license be deemed ns i to co U "" n orders of the Nuclear !

l k l1 IF F

South Dakota State University October 7, 1996In accordance with letter da F

3. Ucense number ftE

2.

its entiretySNM-200 is follows:n amended i P.O. Box 2202 ;E:

Brookings, South Dakota to read as i 57007-2298 f

4. Expiration date M Y)i k[6. Byproduct, source, and/or June 30, 1995 S special nudear material feren e No 070-00218

7. Chemical and/or physical form j it' B. Maximum amount that !Icensee q A. may possess at any one time @

t' , Plutonium-239 under this beense jP 4 A.

4; Sealed neutron A. 80 grams sources (Monsanto .E

{A; Serial Nos. M495, M496, M497 /lp; and M499) , M498,  :

4 F. Authorized use i

l' A.

i g For use in experiments and demonstrati l! activation analysis of biological and envions for student~instruction j1 i

a F

ronmental samples. 1

' ~

10. CONDITIONS '

l Engineering Hall, South Dakota State UniLicensed mat i

~ l

11. A.

versity, Brookings, South Dakota.e lice t Licensed material shall only be used by l

.Ph.D.,

individuals Chairperson. designated by the Radiation Safety Co, or under th 1 B. mmittee, Gary L. Yarrow, l;

12. A.

The Radiation Safety Officer for this li  !

Sealed sources and detector cells shall bcense is Gary L. Yarrow, l Ph.D contamination at intervals not to exceed tested6 for leakage and/or i

B.

specified by the certificate of registratioe Notwithstanding Paragraph A of this n Creferred to in 10 CFR 32.21 not to exceed 3 months. alpha particles shall be tested for 130014 and/or contamination at intervals >

P n

ICIAL RECORD COPY y {

9612130218 961205 PDR C ADOCK 07000218 l PDR m w w-= " " >

" " " " w "MLA0 "v"""*t

gwwwwwwwwAwAW********************####

NRC For.M 374A pcGes l PAGE 2 3 N U.S. NUCLEARJGULAToRY CoMMISSloN of B - Lgense Number SNM-200

! ll gj MATERIALS LICENSE g SUPPLEMENTARY SHEET owket or gaggr }E! '

jE W

Amendment No. 05 N

fs j E

N E N C. In the absence of a certificate from a transferor indicating that a leak test E N has been made within 6 months prior to the transfer, a sealed source or U N detector cell received from another person shall not be put into use until E p tested. E N

E y D. Sealed sources need not be leak tested if: E B

g (i) they contain only hydrogen-3; or IE jE 9

y (ii) they contain only a radioactive gas; or h

E lN E

g. (iii)the half-life of the isotope is 30 days or 'less; or i jE

N' g b (iv) they contain not more than 100 microcuries of beta.and/or gamma ,E

'g- emitting material or not more than 10 microcuries of alpha emitting

,g material; or f,E B

g (v) they are not designed to emit alpha particles, are in storage, and are not h

,E y being used. However, when they are removed from storage for use or jE

!y transferr~ed to another person, and have not been tested within the E g required leak test interval, they shall be tested before use or transfer. ;E j No sealed source or detector cell shall be stored for a ' period of more

g than 10 years without being tested for leakage and/or contamination. ylE E.

@@ The leak test shall be capable of detecting the presence of 0.005 microcurie of radioactive material on the test sample. If the test reveals the presence of I l g 0.005 microcurie or more of removable contamination, a report shall be filed !g with the U.S. Nuclear Regulatory Commission in accordance with I

g

' 10 CFR 30.50(b)(2), and the source shall be removed immediately from service !g and decontaminated, repaired, or disposed of in accordance with Commission

regulations. The report shall be filed within 5 days of the date the leak test Ig t

l g result is known with the U.S. Nuclear Regulatory Commission, Region IV, 611 Ig L Ryan Plaza Drive, Suite 400, Arlington, Texas 76011, ATTN: Director, Division f of Radiation Safety and Safeguards. The report shall specify the source g l%, N i involved, the test results, and corrective action taken. 'g F.

Tests for leakage and/or contamination shall be performed by the licensee or by other persons specifically licensed by the Commission or an Agreement State to i perform such services.

j jN J@)

13 IE f

Sealed sources or detector cells containing licensed material shall not be opened or 3 lM sources removed from source holders by the licensee. E ig E

l3 14 The licensee shall conduct a physical inventory every 6 months to account for all E sources and/or devices received and possessed under the license.

l E

llIsy E E

in lg E E

hrrr.mrmrm m m m m7srm- arm- m m m m m m m m m_m m m m m "m"m' m "

===m

NRC FORM 374A U.S. NUCLEAR REGULATORY COMMISSION (7 " *

• PAGE 3 OF 3 PAGES l Lkense Numbre y SNM-200 Ej y MATERIAL S LICENSE Docket or Reference Number (i

g SUPPLEMENTARY SHEET 070-00218 ,E i N E y Amendment No. 05 ;E p

B W ,E l

y

15. In addition to the possession limits in Item 8, the licensee shall further restrict the possession of licensed material to quantities below the minimum limit specified '

g

, in 10 CFR 30.35(d) for establishing decommissioning financial assurance, lg N

16. Except as specifically provided otherwise in this license, the licensee shall N

N conduct its program in accordance with the statements, representations, and g N

procedures contained in the documents, including any enclosures, listed below. The g N

U.S. Nuclear Regulatory Commission's regulations shall govern unless the statements, g representations, and procedures in the licensleetCapplication and correspondence are y more restrictive than the regulations. '%

'// y E A. Application dated September 30, 1983 '

jE N 8. Application dated January 12, 1989 - E B C. Letter dated June 2, 1995 ,.

E E 0. Letter dated November 22, 1996 E N

E B ;E N.

E p'

E

.B E

'n' E N

I

,E B

E ls!

3, }E iE

)!! 'E E

3 E

5 E

13' E

!N' E B

.E

<B E

3. E B

FOR THE U.S. NUCLEAR REGULATORY COMMISSION E

9 Odginal Signed By E B .

Eme!ine D. Burks E N Date DEC 5m By .E

,B Jacqueline D. Burks E W Nuclear Materials Licensing Branch E lB.

l Region IV E l3 Arlington, Texas 76011 E it E IN 5

lN E

N E

N E

)N E

!Nmm =rurm m m m m m moinne - m m m m m m m m m = = = = = = = = = = = m = = = = = = = = = = =

Pruued on recycled paper

, - . . . . . - _ - . . _ , - - - . _ - . . - - - - ~.- - ~ . . . - . . . .

gDa otog ' UNIT E D STATES r

+

s',  % NUCLEAR REGULATORY COMMISSION

\

sg j

, g.

. e REGloN iv 0, ' & 611 RYAN PLAZA oRivE. SulTE 400 ARLINGTON, TEXAS 76011-8064

% . . . . * ,o ,

i December 5,1996 l

South Dakota State University ATTN: Robert T. Wagner, President i P.O. Box 2202 Brookings, SD 57007 2298 )

SUBJECT:

LICENSE AMENDMENT Please find enclosed License No. SNM 200. You should review this license carefully and be sure that you understand all conditions. If you have any questions, you may contact ,

the reviewer who signed your license at 817 860 8132.

NRC expects licensees to conduct their programs with meticulous attention to detail and a

high standard of compliance. Because of the serious consequences to employees and the l public which can result from failure to comply with NRC requirements, you must conduct your program involving radioactive rnaterials in accordance with the conditions of your NRC license, representations made in your license application, and NRC regulations. In particular, note that you must

1. Operate in accordance with NRC regulations 10 CFR Part 19, " Notices, instructions j and Reports to Workers: Inspection and investigations," 10 CFR Part 20, l " Standards for Protection Against Radiation." and other applicable regulations.

I

2. Possess radioactive material only in the quantity and form indicated in your license.

3. Use radioactive material only for the purpose (s) indicated in your license.

4 Notify NRC in wnting of any change in mailing address (no fee required if the l l location of radioactive material remains the same). I

5. Request and obtain written NRC consent before transferring your license or any l ,

right thereunder, either voluntarily or involuntarily, directly or indirectly, through transfer of control of your license to any person or entity. A transfer of control of I l your license includes not only a total change of ownership, but also a change in the j j controlling interest in your company whether it is a corporation, partnership, or '

l other entity. In addition, appropriate license amendments must be requested and l obtained for any other planned changes in your facility or program that are contrary I

to your license or contrary to representations made in your license application, as well as supplemental correspondence thereto, which are incorporated into your license. A license fee may be charged for the amendments if you are not in a fee-

exempt category.

i 6. Maintain in a single document decommissioning records that have been certified for completeness and accuracy listing all the following items applicable to the license:

South Dakota State University l

• Onsite areas designated or formerly designated as restricted areas as defined in 10 CFR 20.3(a)(14) or 20.1003.

• Onsite areas, other than restricted areas, where radioactive materials in quantities greater than amounts listed in Appendix C to 10 CFR 20.100120.2401 have been used, possessed, or stored.

• Onsite areas, other than restricted areas, where spills or other unusual occurrences involving the spread of contamination in and around the facility, equipment, or site have occurred that required reporting pursuant to 10 CFR 30.50(b)(1) or (b)(4), including areas where subsequent cleanup procedures have removed the contamination.

I + Specific locations and radionuclide contents of previous and current burial areas within the site, excluding radioactive material with half lives of 10 days or less, depleted uranium used only for shielding or as penetrators in unused

munitions, or sealed sources authorized for use at temporary job sites.

• Location and description of all contaminated equipment involved in licensed operations that is to remain onsite after license termination.

7. Submit a complete renewal application with proper fee, or termination request at least 30 days before the expiration date on your license. You will receive a reminder notice approximately 90 days before the expiration date. Possession of radioactive material after your license expires is a violation of NRC regulations.

l 8. Request termination of your license if you plan to permanently discontinue activities l involving radioactive material. l

)

You will be periodically inspected by NRC. Failure to conduct your program in accordance with NRC regulations, license conditions, and representations made in your license application and supplemental correspondence with NRC will result in enforcement action l

against you. This could include issuance of a notice of violation; imposition of a civil .

I penalty; or an order suspending, modifying, or revoking your license as specified in the I

" General Statement of Policy and Procedure for NRC Enforcement Actions" (Enforcement l Policy), 60 FR 34381, June 30,1995.

i i

South Dakota State University Thank you for your cooperation.

Sincerely, 0:ir,nal Signed By Jr.aueline D. Burks Jacqueline D. Burks Health Physicist Nuclear Materials Licensing Branch Docket: 070-00218 License: SNM-200 Control: 466224

Enclosures:

As stated

DEC 5 1996 l

South Dakota State University l I l l

l l

l l

l

)

l l

l l

t

=

l l

l l

l I

DOCUMFJ4T N AME: P:\MLCOVER\ LETTER'.SDSUSNM.MLC To receive a copy of this document, indicate in the boa "C' - Copy wchout anachmenvenclosure "E" . Copy with attachment / enclosure "N* - No Copy RIV:NMLB N JDBurks(O[Rt)(fN 12/$/96 0FFICIAL RECORD COPY l

l I

I i

l t

i -

m/6*/4 offs of the Presdient l < q r

Souta Daiota

• m m, pj i T SDSU State Um'versity -- eo 5-e Phone 605-688-4,11 l

FAX 605-688-4443 l { -

l SDSU l

l November 22,1996 5

{<$@$fl8@' _ _

! ~~ DEC I2 1996 a l United States Nuclear Regulatory Commission Regi on IV l Attention: Jacqueline D. Burks

! 611 Ryan Plaza Drive; Suite 400 REGION IV l Arlington, Texas 77011-8064

Subject:

License Amendment l

Reference:

License: SNM-200 Docket: 070-00218 Control: 466224 The attached material is provided in response to your request for additional infoimation on the training and experience of Dr. Gary L. Yarrow relative to his qualifications to be Radiation Safety Officer. It should be noted that the same individual will serve as RSO for licenses SNM-200 and 40-02194-17. Dr. Yarrow's training and experience makes him an excellent candidate for RSO at South Dakota State University. Additional information on any specific item can be supplied if needed.

Cordially,

/ff/M Robert T. Wagner Preefdent C%cument\ Rad-Lic\RsONominitr quad

. l

. 1 l

'.* QUALIFICATIONS OF DR. GARY YARROW TO BE RADIATION SAFETY OFFICER l AT SOUTH DAKOTA STATE UNIVERSITY (SNM-200) I F November 22,1996 l

1. Formal Training Dr, Yarrow has been involved in three formal training programs. Each course dealt extensively with the topics listed under " Training" in your letter of October 29,1996. Course i outlines are attached.

A. Radioisotopes Techniques - Chemistry 660 l This was a four semester-credit graduate level course taken at South Dakota State

University (Brookings) in 1980. It consisted of approximately 42 clock hours of ,

lecture and approximately 40 clock hours in the laboratory.

B. Biochemistry 8-225, Tracer Techniques j This was a five quarter-credit graduate level course taken at the University of Minnesota in 1982. It consisted of approximately 30 clock hours oflecture and approximately 40 clock hours in the laboratory.

C. Radiation Safety OfIicer Training Course l

This was a five day non-credit basic overview of radiation safety presented at i Madison, Wisconsin, October 16-20,1995, by Engelhardt and Associates. It consisted of approximately 40 clock hours oflecture. l

2. "On-The-Job-Training" In the course of using radionuclides in various laboratories, Dr. Yarrow received instruction in

, various aspects of radiation safety.

A. Certification as a Radiation Worker As the result of short-term (less than one day) training courses by the Radiation Safety Oflicer, Dr. Yarrow was approved as a Radiation Worker at South Dakota State l

, University (Brookings), the Ohio State University (Columbus), University of Minnesota (St. Paul), and University of Wisconsin (Madison). This training encompassed the requirements of 10 CFR Part 19.

Dr. Yarrow also completed the short term training by the RSO for Authorized Users at South Dakota State University in 1995 aller he was employed as Assistant Environmental Regulatory Compliance Officer.

l l

1

4 I

l B. Ph.D. Research at the University of Minnesota (St. Paul)

Dr. Yarrow was designated as the person responsible for radiation safety in his research group for one year. Duties included ordering radionuclides, performing smear tests, training new workers, maintaining radionuclide records and arranging for disposal of radioactive wastes. For two years, Dr. Yarrow was responsible for calibration and maintenance of the liquid scintillation counter.

C. Research Associate, University of Wisconsin (Madison)

Dr. Yarrow served for one year as the responsible user for the radionuclides in his laboratory while the Authorized User was on sabbaticalleave in Europe. He wrote the special exemption request, which was granted by the University, for use of radionuclides in field studies. For two years he was responsible for calibration and maintenance of the liquid scintillation counter.

3. Description of Radioactive Materials Usage Table I summarizes Dr. Yarrow's experience with unsealed radionuclide sources. The nuclides used in the instructional laboratories are sat included. 1 Dr. Yarrow has had limited experience with sealed Pu/Be neutron sources. He has assisted in making the semi-annual leak tests of the five sources covered by license SNM-200. The sources are used in the instructional program of the Physics Department. An experienced professor of Physics is designated as the Authorized User responsible for the utilization and storage of the sources.

Dr. Yarrow used Electron Capture Detectors with Ni-63 foils for four years while working on his Ph.D. degree at the University of Minnesota (St. Paul).

For the past 2.5 years, as Assistant Enviromnental Regulatory Compliance Officer, he has been involved with the leak testing and storage of the sealed Co-60 sources under the control of the Radiation Safety Officer. The activity of these sources are 850 mci,0.83 mci, and 0.01 mci. He has been involved in the leak testing of six Am-Be neutron moisture probes and 10 Ni-63 Electron Capture Detector foils. During this time, Dr. Yarrow has developed an l understanding of the NRC concern for maintenance of control of all sealed sources.

CMocument\ Rad-Lic\RSonomutatn I

t 2

_.._..._...-._.._..._.._...._._._--.~.m-. - . _ - - _ _ . - - -

i ._ _ *_ _ _ _

l,

1 TABLE 1. Unsealed Radionuclide Source Usage

~

~

Maximum Activity Length Nuclide (mci) Location of Use of Use Description of Use j H-3 5 University of Minnesota 4 years Plant hormone identification tracers.

(St. Paul) Translocation tracers for plant hormones, amino acids, carbohydrates.

.C-14 10 University ofMinnesota 4 years Plant hormone identification tracers.

(St. Paul) Translocation tracers for plant hormones, amino acids, carbohydrates H-3 2 University of Wisconsin 3 years Biochemistry and translocation of (Madison) plant hormones in growth chamber ,

greenhouse- and field-grown barley ,

plants.

C-14 5 University of Wisconsin 3 years Biochemistry and translocation of l (Madison) plant hormones in growth chamber , )

greenhouse- and field-grown barley l plants.- l l

l l

1 l

l l

! ChmenMad-Uc\RSonomin.atn lt 3 l

l l

l l

l

• lt RADIOISOTOPE TECHN8 QUES - Chem 660 l ,

Course Outline i ..

I. He Code of Federal Regulations, Title 10, Chapter 1 - ENERGY l

i a) discussion of Parts 19, 20, 30, 31 and 71 b) problem sheet hand-out; calculations specifically calling attention to details j .in Part 20 II. An Introduction to the Radioisotope l a) historical considerations ,

l 1) the structure of matter l 2) pioneer scientists in this field l b) particles l j

l 1) radiations from radioactive nuclei

2) theories about atomic structure and the atomic nucleus  !

I l 3) rest mass and relativistic mass III. Nuclear Equations and Nuclear Energetics IV. Nuclear Stability 1

a) neutron-proton ratios and decay modes b) binding energy and packing fraction c) the naturally-occurring radioactive elements and series d) determination of disintegration rate

1) half-life; decay constant j

2) biological half-life l

i V. Characteristics of Ionizing Radiations

! a) alpha particle interactions with matter b) deuteron interactions with matter c) proton interactions with matter l d) anti-proton interaction with matter -

i e) neutron interactions with matter f) meson interactions with matter g) beta particle interactions with matter and measurement of beta energies l 1) backscatter; sidescatter; self-absorption h) gamma ray interactions with matter

1) absorption and energy of gamma photons VI. Radiation Detection Methods a) methods based on ion collectic ?

1) ionization chambers - dosime.urs - certain survey instruments

2) vibrating reed electrometer l 3) the proportional region and pri portional counters

~

4) the Geiger region and Geiger ._ 11er counters b) methods based on scintillation

1) fluors: alpha, beta and gamma l

2) photomultipliers '

i 3) gamma ray spectrometry

4) liquid scintillation techniques and corrections for quench c) autoradiography l

VII. Preparation of Counting Samples VIII. Errors in Measurements

~

1) indeterminate

2) determinate (continued on next page)

1 1

I

IX. Design and Execution of Radiotracer Experiments a) basic features of experimental design l , b) basic assumptions implied in radiotracer studies

\

l.

X. Analysis by Isotope Dilution i l XI. Neutron Activation and Activation Analysis l XII. Safe-llandling of Radioisotopes a) ionizations and free radicals formed in water and tissue b) measurement of the radiation effect l

' 1) basic units c) radiosensitivity of cells i d) biological effects of radiation for various tissues

(Throughout the semester, problem sheets emphasizing calculations of decay, l half-life, radiation levels, shielding, instrument calibration, absorbed dose, activation time, and compliance with items in Title 10, Chapter 1 CFR Part 20 l will be distributed.)

1 l

l 4

I i

l

i e Chem 560/660 - RADIO!SOTOPE TECHNZQUES

Spring Semester - 1983 l

4 t

LABORATORY EXPERIMENTS i

~

j Ifednesday Friday l Jan. 19 Determination of the Operating Potential Jan. 21 l l

of a Geiger-Maller Counter I

Resolution of an Unknown Mixture of Two j Independently-Decaying Activities Jan. 26 Determination of the Half-Life of Jan. 28' j Phosphorus-32 l Decontamination Experiment l j Feb. 2 Backscatter Feb. 4 l Feb. 9 Determination of the Resolving Time of a Feb. 11 l Geiger-Muller Counter i

! Feb. 16 Quantitative Analysis Using a Radioisotope Feb. 18 i

Feb. 23 Uptake of Labeled Phosphate in the Rat Feb. 25 Mar. 2 Statistical Considerations i ionssays Mar. 4 i

Mar. 16 Blood Volume Mar. 18 Mar. 23 Biosynthesis of Cholesterol from Acetat Mar. 25 l Mar. 30 Anion Uptake by Resting Yeast Cells April 8 i

l April 6 In, Vitro Incorporation of Radioactive Glycine April 15 l into a Protein Fraction of Rat Spleen i

l April 13 Uptake of Orthophosphate by Seedling Plants April 22 1

I April 27 Incorporation of a Radioactive Amino Acid April 29

into Protein Using Anino Acid-Activating l Enzymes from Yeast i

j (Note: all lab reports due by May 6th) l Wednesday lab group meets at 2:30 to 4:20 pm:

l Tron Bandy, Bret Batchelder, Carla Cass, i Duane Flemmer, Linda Reilly-Gergen, Omar 1 rafawin and Smart Oruseibio i

Friday lab group meets at 1

30 to 3:20 pm:

Cecil Andraos, Rod Bindert, Jeff Lias, j! ~

Joe MacDonald, Doug Raynie and Hui Chich ifang 1

i a

l j ll &

• W '

4 Biochemistry 0-225, Tracer Techniques i., Syllabus - " rinc om r'.cr. 1^'?

l. LECTURE TOPICS:

Saf ety in use of radioisotopes: f actors af fecting radiation exposure f rom external source and f rom internal source, general laboratory technique for l handiing radloisotopes.

Definitions: units of radioactivity, ef ficiency, specific activity.

Review of atomic and nuclear structure: atomic particles, stable and unstable nuclIdes, nuclear binding forces.

Characteristics of radioisotopes: type of ionizing radiation, energy of ionizing radiation, half-life.

Characteristic radioisotope decay diagrams: negatron emission, positron emission, electron capture, gamma decay, iscrneric transition, Internal l conversion, alpha particle emission.

Mass-energy relationship: mass dif ference, rest mass, kinetic energy, neutrinos.

I interaction of ionizing radiation with matter Beta particles: lon pair formation, bremstrahlung.

Alpha particles: len pair formation, nuclear disintegration.  !

Gamma rays: photoelectric ef fect, Compton ef fect, pair production, nuclear transformation.

Range of ionizing radiation, specific ionization.

Detection of radioactivity:

Radicautography Gas ionization: without gas amplification, lonization chambers; with gas amplification, proportional counting, Geiger-Mueller counting, coinci-dence losses, sample self-absorption, quenching.

Scintillation detectors: scintillation crystals, liquid scintillation, photomultiplier tube, coincidence circultry, discriminator and amplifi-cation controls, pulse height analysis, pulse summation, block diagrams of commercial liquid scintillation spectrometers, liquid scintillation systems, solvents, flours, and solubilizers, quenching, chemiluminescence, Cerenkov radiation.

r Ef ficiency detemination; quench correction:

Internal standardization, channels ratio, automatic external standard.

Simultaneous detemination of two radioisotopes; derivation of equations for calculations, quench correction with two radioisotopes in multichannel liquid scintillation spectrometer.

2-

/.. Errors:

General survey of sources and magnitude of possible errors in laboratory work involving radioisotopes, chemical, radiochemical and radioisotopic purity of commercial radiochemicals.

Statistical considerations of radioactivity determigations: everage error, standard deviation, probable error, coef ficient variation, contribution of error in background to error of net sample count rato.

Radiat' ion hazard:

1 Units of radiation dosage: roentgen, rad. rem, RBE, maximum permissible dose. ]

l Radiation damage: somatic ef fects, genetic ef fects, radiation syndrome, l natural sources of radiation and approximate dose. )

l l Radiation mo'nitoring methods: film badge, pocket dosimeter, survey meter, I laboratory bonch swipe method for contamination.

)

1 Procurement end use of radioisotopes:

l General licensing and purchasing procedures, storage, use, radioactive waste collection and disposal.

1 Safety in uso of radioisotopes: factors af fecting radiation exposure f rom external source and f rem internal source, general laboratory technique for handiIng radloisotopes.

Production of radionuclides by nuclear reactions: neutron bcmbardment, proton bombardment, deuteron bombardment, alpha particle bombardment, high energy l gamma _ ray bombardment, production cf cerrler-f ree radionuci Ides neutron l activation analysis. generation of environmental background of bHand14C.

/S'ynthesis of specific radioisotopically labeled compounds; organic synthesis,

! l biological synthesis in vivo or in vitro, the Ulizbach procedure, use of l carrier to facilitate purification, crystallization to constant specific activity.

Instability of radioisotopically labeled ccmpounds: Modes of decomposition:

primary internal and external, sscondary, chemical.

Means of maximizing stability during storage: low temperature, low specific activity, thin films for 14 , non-equeous C solvents.

Isotope dilution techniques:

Derivation of equation, reverse isotope dilution to determine radiochemical purity, derivative dilution, saturation enalysis.

l Isotope effects: minimal extent in chemical separations, reaction rates and

! stereochemical effects in enzyme catalyzed reactions.

Radioimmunoassays.

s?

. /

11. PROBLEM SETS:  %( J, h $odoJL 1

Several problem sets are provided which provide controlle'd circumstances for computations involving radioisotopes. Problems deal with specific activities, correction of radioactivity for decay of short half lived radioisotopes, maximum l possible specific activities, molecular weights of radioisotopically labeled com- l pounds, radiocarbon dating analysis, quench analysis in liquid scintillation l counting,' determination of two radioisotopes in one sample by liquid scintillation I spectremetery and isotope dilution.  ;

111. LABORATORY EXERCISES'AND EXPERIMENTS: l l

. Laboratory radioisotope records. Each student is to keep a record of the kin s and amounts of radioisotopes received as well as of the kinds a'nd amounts of radioisotopes discarded in radioactive waste. Two laboratory Icications are to be monitored for possible contamination at the beginning, middle and end of the quarter by the laboratory bench swipe procedure. Any areas showing contamination must be prcrnptly decontaminated.

rometer. Observation of the spectrum of energies OperationofliquidscintllationspegPthroughmanipulationofdiscrimina-of beta particles of H, 4 C and j tor and amplification controls. Introduction to quenching. '

3 Iquid clntillation sample preparation. Several methods of preparing aq ous and 4 C samples for liquid scintillation counting are to be evaluated in l terms of visual observation of the phase condition of the sample end the apparent j

' / counting efficiency.

-tt #[ 4.t/In vitro preparation of uridine diphospho-[g4 ]C glucose frcm [I4 ]C glucose by V' enzymes Tsolated frcm yeast cells. The student is to prepare a partially purified M f raction of uridine diphosphoglucose pyrophosphorylase f rcm yeast cells. Ccemerc ia l preparations of hexokinase, phosphoglucomutase and inorganic pyrophosphatase are l supplied. The student must determine reaction conditions which will provide maximum conversion of [14C ] glucose to UDP-[l4C ] glucose, so that he may subsequently 9 obtain a maximum yield of UDP-[l4C]giucose frem the 2 pCI of [l4 C] glucose which is 9 supplied. This experiment requires a large block of time but introduces the use of j go/

Lang-Levy micropipettes, radicautography, the radiochromatogram scanner, the use of /

partially purified enzymes to preparc a labeled compound. /

5. Administration of [I# C]CO2to a Soybean Plant. [ C]C02 is generated and administered to a leaf of a soybean plant. Residual CO 2 is trapped and discarded.

The plant is given time for translocation to occur and an attempt is made to deter-O/.e mine quantitatively the distribution of the 14 C-labeled materials in leaf, rcot and stem tissues. Major considerations of this experiment are the handling of radio-Isoto in the vapor phase and the mothods of quantitation in tissue samples.

% 6. Preparation and characterization of glucose-t- P f rom starch and [ 2 P ]In-

1. / organic phosphate by potato phosphorylase. A crudo gxtract'~oT)oTafo homogenate is incubated with 100 pCi of 32P to yield glucose 1 22P This compound is purified l by Ion exchange column chrcmatography and identified by crystallization to constant

! specific activity after the addition of authentic carrier.

l The student must work with sizeable quantitles of an energetic beta emitter.

Lapses in laboratory technique are easily detected by monitoring the working area with a survey meter. Crystallization to constant specific activity illustrates a powerful method of identification of a radioactively labeled compound.

- . - ... - _ - . ~ . __ - - . . .. -.- . . . - . . . - . - . - _ , . -

t .

t !. 7. Effect of antibiotics on nucleic acid synthesis in Escherichia coll. A

! thymine r is grown in a culture supplemented with [3H] thy-mine and [guiring mutantphosphate.

2P] Inorganic of E. coli Replicate cultures are treated with rif ampicin 2

(Inhibits RNA synthesis), mitemycin C (inhibits DNA synthesis) and sodium azide (an inhibitor of ATP production), respectively. Samples of the cultures are removed

! periodically and the cells are washed f ree of the radioisotopes of the culture

! medium. The cells are solubilized in IIquid scintillation vials and eventually counted in a multi-channel liquid scintillation spectrometer. Standard samples of H P quench correction

[3 ]. water curves. Theand [32 is] Inorganic student to calculatephosphate arq used the [ M] thymine and [ to generajgP] phosphate inco into total nucleic acids, into DNA and into RNA and to observe the differential ef fect of the antibiotics and general inhibitor.

This experiment clinches the material presented in the lecture about computat.lon of activities of two radioisotopes in one sample with opportunity for quench correc-tion as well .

I 1

)

l i

o l

i I s

l l

l l

h~d I

f k

w u

a 1 B

3 E o o C o 5 E 2 m 2 Q E

o $o?

x m 8 r C

_a S

O D o O 3 c: m g

$a mC 0 o C

O d B

ac rEo oZ4 0 E Oo m E =O %p o uso SE _c=

E c c84 SS o@5 Q a S o o o O a0 o - =m $ E-w 3

2 3 o 3 jhe 3 0 cod

, cE

$C S $joS2

~, ccryf O $0 -

E <O D av6 oc aO _86 r o22cE o . j

< o h br8 COEg ob bCEchd l b Z m -

v 3 3 oZOc eO

- >ou=Dy o 03 e h L() $ 0 O D o a p>jo dd 3

0 O cd 9 c

5d6OE udEurox 3 o

.o.

w

@y _[yy O o ct Vcf V e 7 <. O 3 =C S ev- ec gc Oc2 OOm o O

l i

• C $" E 2 2a=eeeg E=r E$5 ?8E??89 Om O . -o a e es3e3 3.

S, _< ue uee> o -e O 'O m< 3m 3 OVo oO-oo y-eyyya V cccco c

< oo S

> C) O 3 < < c

.- CN .u_) o o c coC O C C C-oZ o aux <xow C

x5o Z Z DEOUDU" Z "

$b$

o- -

M w C ch O s ODE

~

u m

gz 4 m gg

• Oy O -m 2

>o

.O *o" ~O u

c 20 w : 5 2- 6o o em Vn2 v 3

$ On O _o cf c a

c cg n=

gCu

. a c

U 2 o

4 6 ov 2 S Sr >oE iO d

m oO

$S $80 eUn 3 o a 5 O 33 5m h 2"50 a

S

> n m

c 6-g S33 v3 cE

-cB c o"g 3 e

3 mc Eg O

- o c g-S Oc m

.. S e o y O o 2 EGEE o y.

o 3Or c -0 50oOCEG Q O eo 3g =o =cr3 e km o=uc ec c

, m u o4m e_ o > g @) 70 gegcyo a h

hd e o S $ENE O O cOcE~hS S c O 0335ZOwo EPS$"U o<amm u S-6 =

-a o e o o 2 x v 0 3 -

ro o O S O -V o = e 3 e O 5a c o o E O 3O oo c

i m S,,..5 " C e.. 5 c.....

O O O ..

E E 2 a o e g o n

o 5 8 8.. e 88 aa a5 ..

b' go77N .o oo c 888 o , 5 O o e 8 o n no 0 E 8.'.8.'.

>. 80 ? -

6 O D5 0 e o e Q o o o $ 8" A:6 - v l .

Breok NA 01:50- 02.00 Know methods used for rodlollon Dee 02:00- 03:20 Rod!atlon Protection Stovo Storr

. Time, distonco, shtoldin0 protraction (e.g., timo, distance.

. Inverso squoro (colculollon) shield!n0, contomination contto0.

Know NRC dose limits,

. Types of dosimeters; how they work Knowwhat ALARAis and how to

. Rules for protection from implement.

rodlotion (includin0 oppare0 Know the dectored proOnont worker proarom.

. Postino (510ns.lobots)

- Allowoblo exposure limits

. ALARA

. Declared prognant worker Breok NA 03:20- 03:30 See alloched All 03:30- 04:30 Group Sossions I

DayTwo Description Objectives Trainer (s)

C8.00- 08:30 cm ContinentalBreokfast NA 08:30- 09:00 How Radiction is Used Know common uses of rod!ation in Sue

. Medical uses industry, research, and medicine. Steve Industrial uses Academic uses 09:00-11:00 Rod!allon Detection Equipment Understand how to select and operate Rolph

. Types of equipment detection equipment for the different (10 min break) . Appropriate uses types of :odlollon.

Demonstrollon of equipment Understand the basic design principles

. Self-reading dostmeiers of vor!ous detectors.

11:00- 12:00 Group Sessions See attached All 12:00 - 01:00 pm Lunch NA 01:00- 01:50 Sources of Radiation Exposure Understond typicallevels of radiction Sue Naturaloccurring medico!, exposure from common sources (e.0., Ro!ph work, life style background, medicol).

Risk vs. benefit Understand perceived vs. real risk.

01:50 - 02:00 Brook NA 02:00- 03:00 Rodlotion Biology Understand the biological effects of Sue

. Cellular effects, tissue effects, rodlotion exposure and the dose levels Steve systematic effects where these effects occur.

Delayed effects, early somatic effects Acute rodlotion syndrome

. Rodlotion hormesis, threshold vs.

non-threshold 03:00- 03:10 Breok NA 03:10- 04:10 Group Sessions See ottoched All

.. .~

• Day Three Description Objectives Trainer (s) 08:00 - 08:30 cm Continental Breakfast NA 08:30- 10:00 Regulatory issues / Principles of Use Know common types of NRC licenses Sue

. Device registrollons and scope of each. Steve (10 min breok) - Gouging, medlcol, ocodemic, blotechnology requirements

. Generalvs. specific Ilconses 10:00-11:30 Rodlotion Sofety Programs Know key elements of a rodlotion safety Dee

. Written rodlotion safety program. Steve ,

programs Know how to develop on effective

. Key elements written program. '

(10 min brook) . Trotning Know requirements for and how to

. Rodlotion mon!!oring (surveys, develop a Quality Management teok tests) Program (medicol).

. Instrument colibrollons

. Shipping, receiving rodlocctive material ,

. Recordkeeping

. Annual reviews

. Quality Monagement Progroms 11:30-12:00 Responsibillfles for Radiation Safety Understand the various responsibilities All

. Who is responsible for rodlotion safety.  ;

I - Legollssues 12:00 00 pm Lunch NA N

01:00- 02:00 Group Sessions See ottoched All 02:00- 02:30 Rodlocctive Waste Management Understond waste management Sue

. Options for dlsposal strategles (e.g., minimization, DIS, Dee

. Minimization vs. volume sewer).

reduction Know rodlooctive waste disposal

. Trotn!ng requirements options. i

. DOT transportation Understand rodlooctive waste storage Storo0e requirements (e.g., shielding, facility needs).

_ ELERRER.5%ER.A4EEAEAREE:

j

L _J Undorstand the do's and don'ts when Suo 02:30-03:20 Writing a Ucense Steve

+ New. renewal omendment writing a licenso.

. NRC Form 313 or equivalent for Know what references are ovoltobte for assistanco (e.g.. NRC regulotory Agreement stotes

. Content guldes).

+ Fees NA 03:20- 03:30 Breok See ottoched All 03:30- 04:30 Group Sessions n

L i

i 4

l

Doy Four D:scription Objectives Trainer (s) 08:00 - 08:30 cm Continental Breakfast NA 08:30- 10:20 Emergencies Understand the RSO's role in planning Judy Grunewald Types of emergencies (gou00, for and preventing accidents.

(10 min brook) medical, ocodemic) Know how to develop on emergency Procedures plan.

. Source lookoge, loss of source

. Emergency personnelas responders Performance based trotning, continuing educollon Interactions with the pub!!c.

media, and employees 10:20- 10:30 Break NA 10:30- 11:00 Laborofory Preparation Prepare for labororatory actMiles. Sue 11:00- 12:00 Lunch NA 12:00 - 12:30 pm Transportation to the Faraday Center NA 12:30- 04:00 Laborofory Workstotlons (Honds-On) See ottoched

. Source room -look tests, scatter Bob, Ralph rodlotion surveys. collbrallons Laborofory room - surveys. wipe Judy, Dee, Steve tests, decontamination Solid scintillation detectors - Bruce Gregg MCA, pulse height onclysis

. Liquid scintillation detectors -

Ron Verm!!ye microplate. LSC, etc.

. Specific gouco operations Sue 04:00- 04:30 Transportation to the Rodisson inn NA

MER D 0.E 3 3 0 0 E E oleta a a n k; I

Day Five Description Objectives Trainer (s) 08:00 - 08:30 cm Continentot Breokfast NA 08:30- 10 20 NRC Regulations Know critical provisions of applicoble Sue

. Ports 19 and 20 NRC regulations (e.g., Ports 19,20 ond Steve (10 min break) . Ports 30-35(Types of Ucenses) 35).

. Specloi requirements (guages and licenses) 10:20-10-30 Break NA j 10:30-11:30 NRC/ State inspections and Reporting Know NRC requirements for reporting All

. How to prepare incidents and misodministrollons

. How to dealwith inspectors (medicol).

. What to do if yourinspection is Understand the inspection process.

going badly Know how to prepare for and respond 4 . What to do if co!!ed for on to enforcement actMiles.

enforcement conference ,

i 11:30 - 12:30 pm Lunch NA l

12:30- 01:00 Interactions with the Public and Medlo Understand the NRC's media Sue

. Discussion of media contacts notificotton criterlo.

and pub!!c Information on the Know key ospects of conducting i

sensitive issue of rodlotion Interviews with the public and medio.

01 01:30 Trotning and Continuing Educotton Understond importonce of Steve

. RSOs, employees, anci!!ary staff performance based and compentency Judy based trotning.

01:30- 01:40 Break NA 01:40-02:30 Examination Complete exam and score 80% or All better.

02:30- 03:00 Wrap-up NA I

0

PERFORMANCE OBJE CTIVES FOR THE 5 DAY RADIATION SAFETY SEMINAR

. BREAKOUT SESSIONS 2

i Dov One: Afternoon Session:

. Calculations and discussions of radioactive decay and attenuation of adionuclides used in medicine.

. Discussion of regulatory agencies and how the regulations are structured

. Examples of physics and interactions of radiation and matter

. Calculation of dose.

• Demonstration of time, distance, shielding principles

• Discussion on ALARA concepts.

Dov Two: Momina Session:

. Discussion and demonstration of the types and uses of different types of survey meters.

. Review of postings and measurements to demonstrate how the postings are used.

• Leak tesiing and how the procedure is done.

. Wipe testing and how the procedure is done.

Dov Two: Afternoon Session:

. Discussion of risk vs benefit; description / discussion of patient release l from hospitals after nuc medicine procedures vs non-release of radioactivity from the research setting.

• Demonstration of threshold vs non-threshold impact of radiation l exposure.

• Discussion of the dose from nuclear medicine procedures vs the dose  ;

needed for a measurable bioiogical effect to occur. (

~

Dov Three: Early Afternoon Session:

• Medicallicense requirements and issuance of medicallicenses.

. Responsibilities of the RSO for the radiation safety program.

• Effective auditing techniques.

. Types of training that is needed.

. Development of a radiation safety program for a hospital setting.

Dov Three: Late Aftemoon Session:

. Hands-on development of a license for a medical facility.

. Setting up a decay in storage program for radioactive waste management.

. How to receive / ship a package from Nuclear Medicine.

. _ _ . .. . _ ~ _ _ _ _ . _ _ _ _ _ .. . _ . _ . _ _ - . _ _ _ . . _._ _._ _ .. _ . _ _ _ _ _ . _ _ _ . . .___._

1 1-s y

4t Dov Four: Aftemoon Session: NOTE-This is o Laboratorv .

. Calibrate a survey instrument.

• Use a survey instrument to detect radiction exposure E

. Wipe test on area for contamination and cleanup of the i contamination. -

Operoflon of a liquid scintillation counter; when useful and when it is l

' not. '

1

. Operation of solid scintillation detectors.

. Emergency handling of contaminated persons. l l <

Demonstration of the halflife of a radioactive material.

l i . Performance of leak tests on a Cs-137 calibration source.

! . Detection and mitigation of scatter radiation. ,t

- -- -M M

j i

g@w I. _____f0 [I !a i Y.! 0 II l

' I [ DEC ' 2 FA6 -

f L 4

REGION IV -

i ___

}

l l

! a l

s P

1 l ..,

l i

i et n -

W %9U)

EUIW WUON WUU 9996 SDSU REG.'CoMPL. @ 002 I

i Enwonmental Regratory

,/,

SOllth DakOla "w"'s*.,-

eo

- - cr.m,% re g ,

tale n1versity ums, Boz 2202. SFvpwd HA 153 Brochngs. SO 57007M96 Phcne 605 688-4264 F AX 605 469 6364 CnOT T E rret. ERCo e erg s#se-ecu 011O U l

l 1

i

..~~~~n...

-~~m-n~:~ .<--~m***~~~~wev++~~vvva-w-~~-

MSYSea.

m a m~=- teesna:.: +hir??a::rd.,=:

q rim

• iEEE==t mr-~n: n=: EEsnE ns. s.ca:an=li!E!Sf5305E?I!E251Ei1 2_1m.a. p=u:===m.ww=:x.:m =~pm=5L=w ! 5;: =

~

BE:2 =========Lf;.2==

a;==*=i=:g) c 7._ggg:g2.g3_m: p= n=3E:~m:w===:=======:==nn m n r.-:======wmm=mu=m:n:n:=rcm=:gr

._~.

l m:g q;====:mm4eenr:wr = c=rml -- m a r. m e ~ m - - - n m e m m p p ic t

i l

l November 25,1996 United States Nuclear Regulatory Commission Region IV Attention: Jacqueline D. Burks 611 Ryan Plaza Drive; Suite 400 Arlington, Texas 77011-8064 l

Subject:

License Amendment j l Reference; License: SNM-200 l Docket: 070-00218 Control: 466224 l

l President Robert T. Wagner is sending, today by US Mail, a response to your letter of October l 29,1996, regarding the qualifications of Dr. Gary L. Yarrow to serve as Radiation Safety Officer.

If the material does not arrive in a few days, please contact me.

Sincerely, f

l Leo H. Spir -

Radiation Saf ty O[Iicer C%cumcat%&UdRSONomin.itr 1

1 I

l l

I t

l I

. - . . . .--. = . - . ~ . .. . - - - - .

l 1 l

l j>a 28G0 9 UNITED STATES k

gi

• NUCLEAR REGULATORY COMMISSION

, j REGloN IV

! $.* 2

%4 0 g 611 RYAN PLAZA drive, SulTE 400 AR LINGToN, TEXAS 760114064 I 4*...*# g October 29,1996 1 1

1 South Dakota State University l ATTN: Robert T. Wagner, President l

P.O. Box 2202 i

Brookings, SD 57007-0896 l

SUBJECT:

LICENSE AMENDMENT i l

We have reviewed your letter dated October 7,1996, requesting an amendment to your l special nuclear materiallicense to use sealed sources. Before further action can be taken,  !

we will need the following additional information. l l

1. Before Dr. Gary L. Yarrow can be authorized as Radiation Safety Officer (RSO) and l Chairperson of the Radiation Safety Committee (RSC) for license number SNM-200, I the following information should be provided: I

• Resume of the training and experience of Mr. Yarrow. The resume should include the type (on-the-job or formal course work), location, and duration of training.

Training should cover:

l

a. Principles and practices of radiation protection,

b. Radioactivity measurements, standardization, and monitoring techniques and instruments.

c. Mathematics and calculations basic to the use and measurement of radioactivity.

i

d. Biological effects of radiation.

• Description of the use of radioactive materials which should include:

l

a. Specific isotopes handled. j

b. Maximum quantities of material handled,

c. Where experience was gained.

d. Duration of experience,

e. Type of use.

1 South Dakota State University l 1

l NOTE THAT THE QUALIFICATIONS, TRAINING, AND EXPERIENCE SHOULD BE COMMENSURATE WITH THE MATERIAL AUTHORIZED IN LICENSE NO. SNM.

200. ,

1 l

l Amend the application to provide the additional information.

Reference:

ltem 4.4 of Regulatory Guide (RG) 10.3.

If we do not receive a reply from you within 30 calendar days from the date of this letter,

we shall assume that you do not wish to pursue your application. Please reply in duplicate and refer to the license, docket, and control number specified below. If you have questions or require clarification on any of the information stated above, we encourage you  !

l i to contact us at (817) 860-8132.

l Sincerely, I l l

' Original Signed By Jacqueline D. Buths l

Jacqueline D. Burks Health Physicist I Nuclear Materials Licensing Branch License: SNM 200 Docket: 070-00218 Control: 466224

Enclosure:

Regulatory Guide 10.3, " Guide i For The Preparation of Applications For Special Nuclear Material Licenses Of Less Than Critical Mass Quantities,"

April 1977 l

i I

1

OCT 301370 l l South Dakota State University l 1

1

> l l

l l

l l

i l

DOCUMENT NAME: P:\DEF1CIEN\SDSUSNM.DEF To receive a copy of this document, indicate in the box "C" - Copy without attachmenuenclosure 'E' Copy with attachment / enclosure "N* . No Copy

! RIV:NMLB N JDBurks([hiphy' I

10/d//9d a

BEWEEM:  !  ! I!

LicensefeegnagementBranch. ARM gramCg: 22120 Regional Licensing Sections :eeCgrg[g

. . . . o. m. E. . . ". k. !. d. u. . . . . . h. f. . . .

LICDiSE FEE T NSMITTAL A. REGIO.

c g DAKOTA STATE UNIVERSITY NSe :

M'"kionType.: nt t /

ur 1%Ang B. LICENSE FEE MANAGEMENT BRANCH (Check when' mil [ston[gh[9bntEYtdr

~

1. fee Category and Amount: bk'[h I"P h h )$?=bi

2. O n{eePai,dAplicationmaybeprocessedfo'r: ", 5

'~ '"'"

g,, c gg :c,,, ,~ e gjp \

, ~_

wE' efu[j"s i t 12

,- _f.

a . ---.. . ..__

CD

...[ ,

[?,y..t-_...------

" " te Ccmp:cted _/O /_ / 7 b.

r-c>

N 1.2 b

office of the President L 4' '

Souta Dawta _,

State University  :- e-e .

Phone 605-688-411l l

FAX 605-688-4443 l

l l

SDSU October 7,1996 7 I g United States Nuclear Regulatory Commission Q-@@0$$

! Region IV Nuclear Materials Licensing Branch f OCT l 51996 C.

611 Ryan Plaza Drive; Suite 400 ,

A i

~

Arlington, Texas 76011-8064 HEGIONN a l L

RE: License Number: 40-02194-17 Docket Number: 030-13079 License Number: SNM-200 Docket Number: 070-00218 l Gentlemen: l Dr. Leo H. Spinar has been Radiation Safety Oflicer under the referenced licenses since 1983.

In anticipation of his pending retirement from the University, it will be necessary to appoint a

~

new Radiation Safety Officer for South Dakota State University.

This is a request for NRC approval of the appointment of Dr. Gary L. Yarrow as Radiation Safety Officer at a time that is mutually agreeable to the University, Dr. Spinar and Dr. Yarrow.

l The NRC will be notified at least 30 days in advance of when Dr. Yarrow assumes the position provided NRC approval has been received.

l Dr. Yarrow's training and professional experience are described in the attached material.

Your consideration of this request is appreciated.

! Cordially,

//NlW Robert T. Wagner President RTW:gm Attachment cao uo=ncaa-tm I

466224

l .

I Amendment to NRC Licenses 40-02194-17 and SNM-200 Proposed Change in Radiation Safety Omcer October 7,1996 Item 7.1 Radiation Safety Officer Dr. Gary L. Yarrow, Assistant Environmental Regulatory Compliance Omcer and Environmental Scientist, has assisted the Radiatior. Safety Omcer since June,1994. Dr. Yarrow reports directly to the Radiation Safety Omcer at South Dakota State University.

Education l

t B.S.: Botany, South Dakota State University (Brookings),1977.

M.S.: Botany, The Ohio State University (Columbus),1979.

The M.S. degree was in Physiological Plant Anatomy, under the direction of Dr.

Richard Popham. Course work included laboratory studies using Carbon-14 as a carbohydrate tracer and emphasized safety while using such nuclides.

Ph.D.: Plant Physiology and Plant Biochemistry, University of Minnesota (St. Paul) 1985.

The Ph.D. degree, under the direction of Drs. W.A. Brun and M.L. Brent',:r, was l in plant hormone biochemistry and translocation and included formal cos.rse work j in radionuclide techniques and safety. Research work focused on the ure of Carbon-14 and Hydrogen-3 as plant hormone identification tracers in high perfonnance liquid and gas chromatography and as translocation tracers for plant I hormones, amino acids and carbohydrates. Research included extensive use of gas-liquid chromatography equipped with Ni-63 detectors. During 1983-1984, Dr.

Yarrow was the laboratory person responsible for radionuclide safety in his research group. These duties included ordering radionuclides, performing wipe

, tests, training new laboratory workers on university and labo:atory rules, i maintaining radionuclide records, and arranging for disposal of radionuclide waste.

From 1982-1984 Dr. Yarrow was responsible for maintaining and calibrating the Agronomy Department's scintillation counter. Typical quantities of Carbon-14 were <10 mci and Hydrogen-3 was <5 mci.

Other Experience 1979-1980; Research Associate, South Dakota State University (Brookings). Certified as i si$sidiary user of radionuclides (including attending safety class) and formal class in rdioNotope techniques and safety.

i j

Amendment to NRC Licenses 40-02194-17 and SNM 200 Proposed Change in Radiation Safety Officer October 7,1996 Page 2 1984-1887: Research Associate, Department of Agronomy; University of Wisconsin-Madison. Dr. Yarrow studied the biochemistry and translocation of plant hormones in growth chamber, greenhouse and field grown barley plants. These studies extensively used Carbon-14 and Hydrogen-3 as tracers. Dr. Yarrow wrote a successful special exemption, by the University, for use ofradioisotopes in field studies. . From Nov.1985 to Oct.1986, Dr. Yarrow was laboratory P.I. for use of radioisotopes in two laboratories, while his supervisor was on sabbatical leave in Europe. During this time he wrote a successful application for radioisotope recertification of two laboratories (Phosphoms-32, Sulfur-35, Carbon-14 and Hydrogen-3.) During 1986-1987 he was responsible for calibration and maintenance of a Packard liquid scintillation counter.

1987-1993, Associate Scientist / Scientist, The Quaker Oats Company (Barrington, IL).

Project manager for a large biotechnology and molecular biology research consortium of seven universities, two private companies and two federal agricultural agencies.

Responsibilities included assessing technological abilities, coordinating the different research groups' responsibilities, negotiating contracts, coordinating patent and other legal issues, organizing quarterly meetings and annual conferences.

1994-present, Assistant Environmental Regulatory Compliance Officer, South Dakota State University. As a part of this position, duties include assisting in the operation and administration of South Dakota State University's radiation safety program. These duties include logging and delivery of radionuclides, confirmatory snipe tests and survey of laboratories using radionuclides, inspection oflaboratories, assisting in GM meter calibrations, assisting in sealed source testing, developing and maintaining radionuclide databases, collecting and disposing of radionuclide wastes, responding to accidents and

' assist in training of radionuclide users. Dr. Yarrow has been certified as both a subsidiary u ter of radionuclides (under the supervision of the RSO) and as a Principal Investigator, w tich required successfully completing two different training sessions. On October 16-2( ,1995, Dr. Yarrow attended a 5-day Radiation Safety Officer Training Course conducted by Engelhardt and Associates, Inc. (Madison, WI.). Dr. Yarrow is a plenary member of the Health Physics Society and a member of the North Central Health Physics Society. .He actively participates in regional and national radiation safety officers and health physics meetings.

! q l

i 9@@@05 D

L $y OCT15996b a

REGION 1V o 466224

- -- .- . _ _