ML20245E665
| ML20245E665 | |
| Person / Time | |
|---|---|
| Site: | 05508347 |
| Issue date: | 04/21/1989 |
| From: | Bordenick B NRC OFFICE OF THE GENERAL COUNSEL (OGC) |
| To: | ACOSTA, M.P. |
| References | |
| CON-#289-8513 TAC-68699, TAC-68700, NUDOCS 8905020085 | |
| Download: ML20245E665 (23) | |
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g5/3 April 21, 1989 P. ELATED CORRESPONDUtCA
[TLvlifD In v ,
UNITED STATES OF AMERICA NUCLEAR REGULATORY COMMISSION '89 APR 25 PS :48 BEFORE THE ATOMIC SAFETY AND LICENSING BOARD mr r B.ir In the Matter of )
MAURICE P. ACOSTA, JR. Docket No. 55-08347
)
Operator License No. 6010-2 )
NRC STAFF'S SECOND FURTHER RESPONSES TO MR. ACOSTA'S FIRST SET OF INTERROGATORIES AND REQUEST FOR PRODUCTION OF DOCUMENTS I. INTRODUCTION The NRC staff (Staff) hereby further supplements its responses to Interrogatories I and 2 of Mr. Acosta's First Set of Interrogatories to the Staff. This Second Further Responses to Interrogatories is being provided by Staff Counsel.
II. INTERROGATORY RESPONSES INTERR0GATORY 1 State the full name, business address, and telephone number, of any person the NRC presently intends to call as a witness in this proceeding.
RESPON1E The Staff intends to call Dr. Edward J. Cone as a witness in this preceeding. Dr. Cone's business address is Chief, Laboratcry of Chemistry end Drug Metabolism, Addiction Rtsearch Center, National Institutes of DruT Abuse., P.O. Box 5180, Baitinore, t1D 21224. His work phone number is 301 -550-1507.
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8905020085 090421 SECY LICSS OSbo 7
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INTERROGATORY 2 )
With respect to any person listed in response to Interrogatory No. 1, state the following:
- a. the details of that person's education;
- b. employment history; !
- c. asserted area of expertise; and, 4
- d. the subject of that person's testimony. i
RESPONSE
l The information requested in subparts a-c of Interrogatory 2 is set forth in the attached "Curriculm Vitae" prepared by Dr. Cone.
With respect to subpart d of Interrogatory 2, the subject of Dr.
Cone's testimony is 1) drug testing techniques and 2) passive inhalation.
Respectfully submitted, M
ernard M. Bordenick Counsel for NRC Staff Dated at Rockville, Maryland this 21st day of April, 1989.
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4 CURRICULlM VITAE Namg: Edward Jackson Cone Phone (301)550-1507, Work Date and Place of Birth: 17 Septenber 1942, Mobile, Alabama Family Information: Married (2-16-63) to Eleanor Elizabeth Bray (b. 9-15-45)
Children: Randall Edward . . b. 12-28-68 Jennifer Lynn ..b. 7-22-70 Education:
B.S., Mobile College, Mobile, Alabama, 1967.
Ph.D. (Chemistry), University of Alabama, University, Alabama,1971.
Post-doctoral Appointment, University of Kentucky, Lexington, Ky.,
1971-1972.
Professional Experiengg:
Chemist, Shell Oil Conpany, Norco, La., 1966-1967.
Instructor, University of Alabama, Department of Chemistry, 1971.
Chemist, NIDA Addiction Research Center, July 9, 1972 to present.
Chief, Chemistry Section, ARC, NIDA, 1981.
Chief, Laboratory of Chemistry and Drug Metabolism, ARC, NIDA, 1984-present.
Societies:
American Chemical Society, 1968.
Sigma Xi 1977.
American Society of Pharmacology and Experimental Therapeutics, 1977.
International Society for the Study of Xenobiotics, 1981 The International Association of Forensic Toxicologists, 1988.
Society of Forensic Toxicologists,1989.
I Honors and Fy g dg. 4 Icademic Scholarshiper Mobile College, 1965 and 1966.
Fellowship, University of Alabama, 1957-1970.
Alpha Gmmu Epsilon Chenical Honorary,1969.
Listed in " Outstanding Young Men of America", 1971.
Listed in American Men of Science, 1977-1981. )
Outstanding Service Medal, HHS, PHS, March 17,1987. ]
Erofessignal Activi.tigg:
Associate Professor (adjunct), Division of Pharnaceuties ard )
Pharmeeutical Analysis, School of Pharmacy, thiversity of Kentucky, ;
1975 to 1985.
Menber of the Fditorial Board of Drug Metebolism and Disposition,1977 to 1987.
Reviewer for Journal of Pharmaceutical Science, 1979 to present.
Member of the Editorial Board of Journal of Analytical Toxicology 1987 to present.
Reviewer for Journal of Chromatography, 1982 to present.
Reviewer for Journal of Medicinal Chemistry,1981.
Reviewer for Clinical Pharmacology and Therapeutics, 1986 to present. .
Special consultant to Preclinical Psychopharmacology Research Review Comittee, NIMH, 1978-1979.
Bimedical Review Comittee, NIDA,1982.
EEO Counselor, 1979-1984.
Additional Trainina and Experience:
Jan., 1973 - Five day course on " Theory and Practice of Computerized Gas Chromatography / Mass Spectrometry". Finnigan Corp.,
Sunnyvale, CA.'
h,1977 - Five day course on " Applications of High Pressure Liquid Chromatography", Perkin Elmer Corp., Norwich, NJ.
Cpljpae Courses at the University of Kentucky:
Course Title Semester hours Grade Xgar Pharmacology 2 A 1974 Biology I,II 5, 5 A,B 1978-79 Pharmacy Practice I,'II 4, 3 A,A 1979-80 Physiology Basis for Therapeutics I, II 4, 3 A, B 1980-81 1981 - Five day course on " Basic EEO Counseling", Office of Personnel Management, Atlanta, GA.
1986 - Three day course on " Rapid Drug Detection", Toxi-Lab, Washington, DC.
1988 - NIDA Laboratory Inspector Trainina Course, San Diego, CA, Apr. 15-18, 1988. Performed three labora*;ory inspections during 1988.
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Edward J. Cone received his B.S. in chemistry from Mobile College in 1967. He earned his Ph.D. in organic chemistry in 1971 from the University of Alabama. From 1971 to 1972 he held a post-doctoral appointment in the Department of Chemistry, University of Kentucky, under the direction of Professor Ellis Brown. In the summer of 1972 he joined the staff of the Addiction Research Center, National Institute on Drug Abuse, where he currently serves as Chief of the Laboratory of Chemistry and Drug Metabolism. From 1977 to 1985 he also served as a menber of the adjunct faculty in the Division of Pharmaceutics and Pharmaceutical Analysis, School of Pharmacy, University of Kentucky. He was a menber of the editorial board of the Journal of Drug Metabolism and Kinetics from 1977-1987 and is presently serving on the editorial staff of the Journal of Analytical Toxicology. Dr. Cone has written numerous chapters and over a hundred papers on the analysis of drugs in biological media. His major research interests are in the disposition and metabolism of drugs of abuse and the relationt. hip of drug levels to dmg-induced effects. Presently, he is pursuing research on the dweloptent of drug tests related to behavior and performance. He has published in tla area of organic synthesis, gas chromatography mass spectrometry (GC/MS),
analytical toxicology, pharmacokiaetics, drug metabolism, and the phannacology of drugs of abuse.
s RDCENT PRESENTATIONS (Since 1987)
" Effects of Passive Inhalation of Marijuana Smoke", IBM Medical staff, Gaithesburg, FD, March 4, 1987
" Substance Abuse Testing Workshop", IBM medical staff Fishkill, NY, March 11, 1987.
Endicott, NY, March 17, 1987.
Burlington, VI, April 8,1987.
Rochester, MN, April 15, 1987.
Lexington, KY, May 15, 1987.
Research Triangle, NC, May 19, 1987.
" Substance Abuse Testing", Ford Motor Company medical staff,
- World Headquarters, Detroit, MI.
" Substance Abuse Testing", ASIS, Wilmington, DE, Nov.15, 1987.
" Substance Abuse Testing", Maryland Chanber of Coramerce, Dec.3, 1987.
"Pharmacokinetics and Testing of Cocaine", University of Maryland, School of Medicinc, Baltimore, MD, March 2, 1988.
' " Drug Testing" Campus Law Enforcement Administration, Pesearch Triangle Institute, Research Triangle Park, NC, Feb.25, 1988.
"The Pharmacokinetics and Pharmacodynamic Aspects of Cocaine" Scientific Consensus Conference: Clinical Pharmacologic Implications of Urine Screening for Illicit Substances of Abuse, Anerican Society for Clinical Pharmacology and Therapeutics, March 7-8, 1988, San Diego, CA.
"Pharmacokinetics and Studies of Drugs of Abuse" Division of Forensic Pathology, School of Medicine, University of Maryland, Baltimore, MD., April 13, 1988.
" Drugs of Abuse-Pharmacology, Metabolism, Kinetics and Testing",
Drugs of Abuse Workshop, Dupont Co. Medical Staff, Wilmington, DE, May 4, 1988.
k "Sabstance Abuse-The Problem", Pfizer Inc., World Headquarters, New York, NY:
June 7, 3988 September, 14, 1988
" Drug Testing and Arbitration", American Gas Association, Las Vegas, NE, Cct. 6,1988.
" Marijuana Effects and Urinalysis After Passive Inhalation and {
Oral Ingestion", NIDA Technical Review Meeting, Research I Fingings on Smoking Abused Substances, Rockville, MD, Ibv.10, '
1988.
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" Basics of Drugs in Hair" and " Controlled Dosages and Hair
' Absorption Rates *, National Institute on Justice, Workshop on
' Hair Analysis for Drugs of Abuse, Crystal City, Jan. 9-10, 1989..
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l BIBLIOGRAPHY Edward J. Cone, Ph.D.
Published Papers Cone, Edward J.: Investigations on synthetic routes to structural moieties related to the nonadride class of mold metabolites. Ph.D. Dissertation, University of Alabama, 1971.
Cone, Edward J.: Ring inversion in 2,4-cyclooctadienone systems. Tetrahedron Letters No. 1, 57-60, 1972.
Cone, Edward J.: Spectral studies on cyclic enamino ketones.
J. Org. Chem. 37:(26) 4436-4439, 1972.
Cone, E. J.: Human metabolite of naltrexone (N-cyclopropylmethylnoroxymorphone) with a novel C-6 isomorphine configuration. Tetrahedron Letters No. 28, 2607-2610, 1973.
Cone, Edward J., Gorodetzky, Charles W. and Yeh, S. Y.: The urinary excretion profile of naltrexone and metabolism in man.
Drug Metab. Disp. 2:(6) 506-512, Nov-Dec, 1974.
Cone, E. J., Gorodetzky, C. W. and Yeh, S. Y.: Biosynthesis, isolation and identification of 6-beta-hydroxynaltrexone, a major human metabolite of naltrexone. J. Pharm. Sci.14: (4) 618-621, 1975.
Cone, Edward J. and Gorodetzky, Charles W.: Analytical controls in drug metabolic studies: A Commentary. Drug Metab. Disp.
3.:(5) 417-418. 1975.
Cone, E.J.: A General Procedure for the Isolation and Identification of 6-alpha- and 6-beta-Hydroxymetabolites of Narcotic Agonists and Antagonist with a Hydromorphone Structure. J. Chromatogr. 129: 355 (1976).
Co'ne, E. J. and Gorodetzky, C. W.: Metabolism of Naltrexone and Naloxone, Bulletin, Problems of Drug Dependence, pp. 338-347, Washington, D. C., 1975.
Jasinski, D. R., Pevaick, J. S., Griffith, J. D., Gorodetzky, C.
W., and Cone, E. J.: Progress Report on Studies from the Clinical Pharmacology Section of the Addiction Research Center, Bulletin, Froblems of Drug Dependence, pp. 112-148, Washington, l D. C. ,1976. l Cone, E. J., Phelps, B. A., and Gorodetzky, C. W.: Urinary Excretion of Hydrxorphone and Metabolites in Man, Rat, Dog, l Guinea Pig, a:id Rabbit. J. Phatn. Sci. Es: 1709 (1977).
Cone, E. J.: The Metaoolism of Azidomorphine in a Single Human Subject. Xenobiotics 8: 301-304, 1978.
Cone, E. J. and Darwin, W. D.: Simultaneous Determination of i Hydromorphone, Hydrocodone and Their 6-alpha- and l 6-beta-hydroxymetabolites in Urine Using Single Ion Recording with Methane Chemical-Ionization. J. Biomed. Mass Spect. 5.: 291 i (1978).
1 Cone, E. J. and Darwin, W. D., Gorodetzky, C. W., and Tan, T.:
Comparative Metabolism of Hydrocodone in Man, Rat, Guinea Pig, i Rabbit and Dog. Drug Metab. Dispos. J.: 488 (1978).
Cone, E. J., Gorodetzky, C. W., Darwin W. D., Carroll, F. I.,
Brine, G. A., and Welch, C. D.: The Identification and Measurement of Two New Metabolites of Naltrexone in Human Urine. Res. Comun. Chem. Path. Pharmacol. 2Q: 413 (1978).
Cone, E. J., Risner, M. E. and Neidert, G. L.: Concentrations of Phenethylamines in Dog Following Single Doses and During Intravenous Self-Administration. Res. Commun. Chem. Path.
Pharmacol. 22.: 211 (1978).
Cone, E. J., Darwin, W. D. and Gorodetzky, C. W.: Comparative Metabolism of Codeine in Man, Rat, Dog, Guinea Pig and Rabbit:
Identification of Four New Metabolites. J. Pharm. Pharmacol.
21: 314 (1979).
Cone, E. J., Yousefnejad, D. and Shannon, H.: Measurement of Phenylethylamine, Phenylethanolamine and Their N-Methyl Homologs in Plasma by Gas-Liquid Chromatography with Flame Ionization Detection. Anal. Letters ll: 313 (1979).
Cone, E. J., Darwin, W. D., Yousefnejad, D. and Buchwald, W.
F.: Separation and Identification of Phencyclidine Precursors, Metabolites and Analogs by Gas and Thin-layer Chromatography and Chemical Ionization Mass Spectrometry. J. Chromatogr. 122.: 149 (1979).
Cone, E. J., Buchwald, W. F. and Vaupel, D. B.: Phencyclidine:
Detection and Measurement of Toxic Precursors and Analogs in Illicit Samples. J. Anal. Toxicol. 4: 119 (1990).
Darwin, F. D. and Cone, E, J.: Fluorescence Propertica of Pseudrorphine and Conge'1ers - a Structure-activity Relationship Study. J. Pharm. Sci, f9: 253 (1980).
Su, T.-P, Cons, E. J., Shannon, H., VGupel, D. B.: Relative Pomeieu of rhercyclidine and Analogs in the Oplate Receptor Binding Assay: Correlation with Relative Potencies Determined l
- 10. yJya in Mouse and Rat. Res. Cormun. Substance Abuse 1: 85 (1980).
Cone, E. J., Buchwald, W. and Yousefnejad, D.: Simultaneous Determination of Phencyclidine (PCP) and Monohydroxylated Metabolites in Urine of Man by Gas Chromatography - Mass Fragmentography with Methane Chemical Ionization. J.
Chromatogr. 223: 331 (1981).
9 Shannon, H. E., Cone, E. J. and Yousefnejad, D.: Physiologic Effects and Plasma Kinetics of Phenethanolamine and its IHnethyl Homolog in the Dog. J. Pharmacol. Exp. Ther. 2E, 379 (1981) .
McQuinn, R. L., Cone, E. J., Shannon, H. E. and Su, T.-P.:
Structure Activity Relationships of the Cycloalkyl Ring of Phencyclidine. J. Med. Chem. 21: 1429 (1981).
Carroll, F. I., Brine, G. A., Boldt, K. G., Cone, E. J.,
Yousefnejad, D., Vaupel, D. B. and Buchwald, W. F.:
Phencyclidine Metabolism: Resolution, Structure and Biological Activity of the Isomers of the Hydroxymetabolite, 4 phenyl-4-(1-piperidinyl) cyclohexanol. J. Med. Chem. 24: 1047 (1981).
Cone, E. J., Vaupel, D. B. and Yousefnejad, D.: '
Monohydroxymetabolites of Phencyclidine (PCP): Activities and Urina*y Excretion by Rat, Dog and Mouse. J. Pharm. Pharmacol.
21: 197 '1981).
Cone, T. J., Gorodetzky; C. W.. Veh, 5. Y., Darwin, W. D. and Buchwal b W. F. ; Detection and Measurement of Opium Alkaloids and Metabolites in Urine of Opium Eaters by Methane Chemical Ionization Mass Fragmentography. J. Chromatogr. 230_: 0 57 (1982).
Shannon, H. E., Cone, E. J. and Yousefnejad, D.: Physiologic Effects and Plasma Kinetics of Beta-Phenylethylamine and its N-Methyl Homolog in the Dog. J. Pharmacol. Exp. Ther. 221: 190 (1982).
Cone, E. J., Buchwald, W. F. and Darwin, W. D.: Analytical Controls in Drug Metabolism Studies II. Artifact Formation During Cholroform Extraction of Drugs and Metabolites with Amine Substituent. Drug Metab. Dispos. 10: 561 (1982).
Cone, E. J., Darwin, W. D. and Buchwald, W. F.: Assay for Codeine, Morphine and Ten Potential Urinary Metabolites by Gas Chromatography-Mass Fragmentography. J. Chromatogr. 275: 307 (1983).
Cone, E. J., Gorodetzky, C. W., Darwin, W. D. and Buchwald, W, F. Stability of the 6,14-EDd2ethanotetrahydrooripavine Analgesics: Acid Catalyzed Rearrangement of Buprenorphine. J.
Pharm. Sci. 71: 243 (1984)
Shannon, H. E. , McQuinn, R. L., Vaupel, D. P- arri Cene, E. J.:
! Effects of Cycloalkyl Ring Analogs of Phencyclidine on Behavior in Rodents. J. Pharmacol. Exp. Ther., 214: 327 (1983). ,
Shannon, H. E., Coner E. J. and Gorodetzky, C. W.:
Morphine-like Diecriminctive Stimulun Effects of Buprenorphine and Demethoxybuprenorphine in Rats: Quantitative Antagonism by Naloxone. J. Pharnacol. Exp. Ther., 221: 768 (1984).
Cone, E. J., Darwin, W. D,. and Buchwald, W. F.: Oxymorphone l
Metabolism and Urinary Excretion in Human, Rat, Guinea Pig,
} Rabbit and Dog. Drug Metab. Dispos. H: 446 (1983).
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.Vaupel, D. B., McCoun, D. and Cone, E. J.: Phencyclidine Analogs and Precursors: Rotarod and Lethal Dose Studies in the Mouse.
J. Pharmacol. Exp. Ther., 2 M: 20 (1984).
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-Cone, E. J. McQuinn, R. L. and Shannon, H. E.: Structure -
Activity Relationship Studies of Phencyclidine Derivatives in Rats. J. Pharmacol. Exp. Ther., 228: 147 (1984).
Cone, E. J., Gorodetzky, C. W., Yousefnejad, D., Buchwald, W. F. j and Johnson, R. E.:- The Metabolism and Excretion of '
Buprenorphine in Humans. Drug Metab. Dispos., 12: 577 (1984).
l Cone, E. J. Gorodetzky, C. W., Yousefnejad, D. and Darwin, W.
D.: A 63N; Electron Capture Gas Chromatographic Assay for Buprenorphine and Metabolites in Human Urine and Feces. J.
Chromatogr. 331:291 (1985)).
Risner, M.E., Jackson-Smith, P.A., and Cone, E.J.:
Discriminative Stimulus Properties and Schedule Effects of-Fencamfamine in Rats. Pharmacol. Biochem. Behav. 21:449 (1985).
Risner, M.E., Goldberg, S.R., Prada, J.A. and Cone, E.J.:
Effects of Nicotine, Cocaine and Some of Their Metabolites on Schedule <ontrolled Responding by Beagle Dogs and Squirrel Monkeys. J. Pharmacol. Exp. Ther, 2M:113 (1985).
Cone, E.J. and Johnson, R.E.: Contact highs and urinary cannabinoid excretion after passive exposure to marijuana smoke.
Clin. Pharmacol. Exp. Ther., 10_:247 (1986).
Cone, E.J., Johnson, R.E., Moore, J.D. and Roache, J.D.: Acute effects of smoking marijuana on hormones, subjective effects and performance in male human subjects. Pharmacol. Biochem. Behavior, 21:1749 (1986).
Cone, E.J., Yousefnejad, D. , Buchwald, W.D. and Kumor, K. :
Determination of ketocyclazocine in human plasma by gas chromatography-negative ion chemical ionization mass j spectrometry. J. Chromatogt., 331:15 8(1986).
Preston, K.L., Griffiths, Cone, E.J., Darwin, W.D., Gorodetzky, C.W.: Diazepam and methadone blood levels followina concurrent administration of diazepam and methadone. Drug Alc. Dap.c 11:195(1986). )
i Risner, M.E. and Cone, E.J.: Intravenous self-aininit,tration of fencamfamine and cecaine by beagle oogs under fixed-retlo and progressive-rstio schedults of reinfUrcem nt. Drug Alc. Dep. 17: ,
93 (1986).
Moore, J.D., Cone, E.J2, Jaffe, J.H., Alexander, S.S.: IfrLV-III seropositivity in 1971-72 parenteral drug abusers - a case of false positives or evidence of viral exposure. N.E.J.M., 3M:1387 (1986).
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Risner, M.E., Cone, E.J., Benowitz, N.L. and Jacob III, P.:
Effects of the stereoisomers of nicotine and nornicotine on schedule-controlled responding and physiological parameters of dogs. J. Pharnacol. Exp. Ther., 244:807 (1988).
Thompson, L.K., Yousefnejad, D., Kumor, K., Sherer, M. and Cone, E.M.: Confirmation of cocaine in human saliva after intravenous use. J. Anal. Toxicol., H:36 (1987).
Jacob III, P., Benowtiz, N.L., Copeland, J.R., Risner, M.E. and Cone, E.J.: Disposition kinetics of nicotine and cotinine entantiomers in rabbits and beagle dogs. J. Pharm. Sci., 21:396 (1988).
Cone, E.J., Johnson, R.E., Darwin, W.D., Yousefnejad, D., Mell, L.D., Paul, B.D., Mitchell, J.: Passive inhalation of marijuana smoke: urinalysis and room air levels of .
delta-9-tetrahydrocannabinol. J. Anal. Toxicol., H:89 (1987). !
Cone, E.J. and Lange, W.R., Clonidine partially blocks the physiologic effects but not the subjective effects produced by smoking marijuana in male human subjects, Pharmacol. Biochem.
Behav., 21:649 (1988).
Thompson, L.K. and Cone, E.J., Determination of delta-9-tetrahydrocannabinol in human blood and saliva by high performance liquid chromatography with amperometric detection, 1 J. Chromatogr., 421:91 (1987).
E .J. and Menchen, S.L., Lack of validity of KDI Quik Cone bDrug Screen for detection of benzoylecgonine in urine, Test J. Anal. Toxicol., H:276 (1987).
Cone, E.J., Menchen, S.L. and Mitchell, J., Validity testing of the 'IDxR Cocaine Metabolite Assay with human specimens obtained after intravenous coceine administration, Forensic j Science International, 21:265-275 (1988).
Lange, W.R., Cone, E.J. and Jaffe, J.H., Study of Haitian boat people shows prevelance of HSV and HIV markers, Public Health Reports, 101:98-99(1988).
Cone, E.J., Kumr, K. , Thcapon, L.K. and Sherer, M.
Correlation of salive cocaine levels with plasma levele and with pharmacciogic effects after inravenous cocaine administration in hunan subjects, J. Anal. Toxicol., H:200 (1988).
Cone, E.J., Menchen, S.L., Paul, B.D., Mell, L.D. and Mitchell, J. Validity testing of concercial cocaine metabolite assays. I.
Assay detection times, individual excretion patterns and kinetics aftet cocaine administration to humans, J. Forensic Sci.,34:xx-xx,1989.
Cone, E.J., and Mitchell, J., Validity testing of comercial' cocaine metabolite assays. .II. Sensitivity, specificity, accuracy and confinnation by gas chromatography / mass spectrometry, J. Forensic Sci., M:xx-xx, 1989.
Cone, E.J., Johnson, R.E., Mell, L.D., Paul B.D. and Mitchell, J. Marijuana-laced brownies: Behavioral effects, physiologic effects and urinalysis in humans following ingestion, J. Anal.
Toxicol,11:169 (1988).
Cone, E.J. and Menchen, S.L., Stability of cocaine in saliva, Clin. Chem., M:1508 (1988).
Kumor, K., Sherer, M., Gomez, J., Cone, E. and Jaffe, J.H.,
Subjective response during continuous infusion of cocaine, Phannacol. Biochem. Behavior, in press,1988.
Della Puppa, A., Ford-Rice, F. Snyder, F.R., Cone, E. and London, E.D. Time course of verapamil interaction with morphine effects on physiological parameters in rats. J. Pharm.
Pharmacol., in Press, 1989.
Sherer, M.A., Kumor, K.M., Cone E.J. and Jaffe, J.H.
Suspiciousness Induced by Four-Hour Intravenous Infusions of Ccaine. Arch. Gen. Psychiatry. M:673-677, 1988.
Kumor, K., Sherer, M., Thompson, L. Cone, E., Mahaffey, J. and Jaffe, J.H. Lack of Cardiovascular Tolerance During Intravenous Cocaine Infusions in Human Volunteers. Life Sciences.
41:2063-2071, 1988.
Higgins, S.T., Preston, K.L. Cone, E.J., Henningfield, J.E. and Jaffe, J.H. Supersensitivity to Naloxone Following Acute Morphine Treatment in Humar.s: Hormonal, Physiological and Behavioral Effects. Submitted, JPET,1989.
Cone, E.J. Validity Testing of Commercial Urine Cocaine Metabolite Assays. III. Evaluation of an ELISA Assay for Detection of Cocaine and Cocaine Metabolite. J. Forensic Sciences, in press, 1989.
Cone, E.J. and Henningfield, J.E. Preanier ' Smokeless Cigarettes' Can Be Used 'lb Deliver Crack. JANA,261:41, 1989.
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Chapters Gorodetzky, C. W., Martin, W. R., Jasinski, D. R., Mansky, P.
A., and Cone, E. J.: Human pharmacology of naltrexone. In Senay, E., Shorty, V, and Alksne, H. (Eds.): Developments in the Field of Druo Abuse (National Drug Abuse Conference), 1974, 749-753, Canbridge, Schenkman Publishing Company,1975.
Cone, E. J.: The Urinary Excretion Profile of Naltrexone and Naloxone in Man and Several Laboratory Animal Species. In:
Critical Concerns In The Field of Drug Abuse. Marcel Dekker, Inc., New York, 1978.
Cone, E. J.: Analysis of Drugs in Biological Samples by Conbined Gas Chromatography-Mass Spectrometry. In:
Phantaceutical Analysis - ModeIn Methods, Vol. I, Marcel Dekker, Inc., New York, (1981), pp.143-228.
Jasinski, D. R. , Shannon, H. E., Cone, E. J. , Vaupel, D. B. ,
Risner, M. E., McQuinn, R. L., Su, T.-P., and Pickworth, W. B.:
Interdisciplinary studies on phencyclidine. In PCP-Historical _.
and Current Perspectives, ed. E. F. Domino, NNP Books, (1980),
pp 331-400.
Vaupel, D. B. and Cone, E. J.: A Pharmacologic Comparison between Phencyclidine, Its Precursor, Metabolites, and a Quaternary Derivative in the Dog. In Problems of Druo Rependence 1980, NIDA Research Monograph No. 34, U.S. Government Printing Office, Washington, D. C. pp. 180-186.
Gorodetzky, C. W., Cone, E. J., Croughan, J. L., Goldberg, S.
R., Risner, M. E., Shannon, H. E., Su, T.-P and Yeh, S. Y.:
Progress Report from the NIDA Addiction Research Center (Preclinical Laboratory), Lexington, Ky., In Problems of DR g_
Dependence,1981, NIDA Research Monograph, U. S. Government Printing Office, Washington, D. C., pp. 53-59.
Cone, E. J., Shannon, H., Vaupel, B., Su, T.-P. and McQuinn, R.: A Structure Activity Relationship Study of the Cycloheryl and Aromatic Rings of Phencyclidine (PCP), In Problens of Druo Dependence. 1981, NIDA Research Monograph, U. S. Government Printing Office, Washington, D. C., pp. 126-133. !
Gorodetzky, C. W. , Cone, E. J., Goldberg, S. R., Herling, S.,
Risner, M. E., Shannon, H. E. and Vaupel, D. B.: Progress I Report from the NIDA Addiction Research Center (Preclinical l Laboratory), Lexington, KY. In Problems of Drug Dependence, 1 1982, NIDA Research Monograph 43, U. S. Government Printing I Office, Washington, D. C., 1983, pp. 85-91. l
i Gorodetzky, C. W., Cone, E. J., Johnson, R. E., Risner, M. E.,
l Su, T.-P and Yeh, S. Y.: Progress Report from the NIDA Addiction Research Center (Preclinical Laboratory), Lexington, l
Ky. In Problems of Drug Dependence 1983, NIDA Research Monograph, U.S. Government Printing Office, Washington, D.C.,
1984, pp. 52-58.
Cone, E.J., Roache, J.D. and Johnson, R.E. Effects of passive exposure to marijuana smoke. In Problems of Drua Dependence 12Hfi, NIDA Research Monograph, No. 76 U.S. Government Printing Office, Washington, D.C. 1986, pp. 150-156..
Cone, E.J., Menchen, S.L. and Mitchell, J., Validity testing of the 'IDxR Cocaine Metabolite Assay with human F'ecimens obtained after intravenous cocaine administration. In Proceedings of the TIAFT'87 Meetina, 1987, in press.
Higgins, S., Preston, K., Cone, E., Henningfield, J. and Jaffe, J., Behavioral, Physiological and Hormonal Effects of a Naloxone Challenge Following Acute Morphine Retreatment in Humans. In Problems of Drua Dependence,1987, NIDA Research Monograph, No.??, U.S. Government Printing Office, Washington, D.C. 1987, in press.
Fudala, P.J., Cone E.J., Dorbert, A.I. and Johnson,R.E.,
Physiological and Behavioral Effects of a Rapid Dose Induction of Buprenorphine in Heroin-Dependent Volunteers. In Problerrs of Drug Dependence,123.E, NIDA Research Monograph, No.??, U.S.
Government Printing Office, Washington, D.C., 1988, in press.
h
Symposia "New Analytical Methods for Drug Studies", E. Cone and S.
Spector, ASPET, Portland, Oregon, August 1979.
" Stereochemical Probes of the Phencyclidine Receptor Surface",
R. McQuinn and E. Cone, 17th National Medicinal Chemistry Symposium, Rensselaer Polytechnic Inst., Troy, N. Y., June 15-18, 1980.
" Buprenorphine: Pharmacology and Clinical Uses--Chemistry and Metabolism", E. Cone, ASPET, Louisville, Kentucky, August, 1982.
"The Newer Opiate Agonist and Antagonists", C. W. Gorodetzky and E. J. Cone, Toxicology Section of the American Academy of Forensic Sciences, Cincinnati, Ohio, Feb. 17, 1983.
"The Pharmacodynamics of Single Intravenous Doses of Cocaine",
Association for Medical Education and Research in Substance Abuse, Washington, DC, Dec. 11, 1986.
"The Kinetic and Pharmacodynamic Aspects of Cocaine", E.J. Cone, Scientific Consensus Conference: Clinical Pharmacologic Implications of Urine Screening for Illicit Substances of Abuse, American Society for Clinical Pharmacology and Therapeutics, San Diego, CA, March 7-8, 1988.
Abstracts Cone, E. J.: Spectral studies on enamino ketones.
Southeast-Southwest Meeting, American Chemical Society, 1970.
Cone, E. J.: Reactions of 2, 3-dicarbamethoxy-3-cycloheptenone. Southeast Regional Meeting, American Chemical Society, June, 1972.
Cone, E. J.: The crystal structure of 4-bromo-2, 341carbomethoxy-2-cycloheptenone. Southeast Regional Meeting, American Chemical Society, Novent>er 1972.
Cone, E. J., Yeh, S. Y. and Gorodetzky, C. W.: Human metabolism of naltrexone. Pharmacologist H: 242, Fall, 1973.
Cone, E. J., Gorodetzky, C. W. and Yeh, S. Y.: Biosynthesis, isolation and identification and of 6-beta-hydroxynaltrexone.
Pharmacologist H: 225, Fall, 1974.
Kullberg, M. P., Gorodetzky, C. W. and Cone, E. J.:
Identification of etorphine (E) in human urine after a single 100 miorogram dose. Pharmacologist H: 193, 1974.
Cone, E. J. and Gorodetzky, C. W.: New metabolites of naltrexone and naloxone in man and several laboratory animal specie.s. Fed. Proc. H: 469, 1976.
Gorodetzky, C. W. and Cone, E. J.: Plasma levels of propoxyphene (P) and metabolites after single oral doses of propoxyphene hydrochloride (PH) and propoxyphene napsylate (PN) in man. Pharmacologist H: 121, 1976.
Cone, E. J., Darwin, W. D., Tan, T. and Gorodetzky, C. W.:
Biotransformation of hydrocodone (HC) in mano Pharmacologist H: 142, 1977.
Cone, E. J., Darwin, W. D., Tan, T. and Gorodotzky, C. W.: j comparative metabolism of codeine in man and several laboratory 1
- animal species. Fed. Proc. E: 693, 1978.
Fraser, H. F. , Jasinski, D. R., Sharpe, L. G., Cone, E. J. and Neidert, G. L.: The value of the experienced narcotic addict in assessing morphine-like euphoria of opiates. Pharmacologist R:
242, 1978.
Cone, E. J., Su, T.-P alx3 McQuinn, R.: Phencyclinine: Chemical ]
and Analytical Studies at the Addiction Research Center, l Technical Review on the Chemistry and Pharmacology of PCP and )
its Analogues, NIDA, Washington, D.C., March 14, 1979. J Cone, E. J., Buchwald, W. F., Gorodetzky, C. W. and Vaupel, D. ;
B.: Evidence for toxic precursors in illicit phencyclidine 1 preparation. Fed. Proc. H: 435, 1979.
i
Cone, E. J., Vaupel, D. B. and Yousefnejad, D.: Metabolism of phencyclidine (PCP) and relative potencies of two hydroxylated metabolites. Fed. Proc. 22: 302, 1980.
Jasinski, D. R. , Shannon, H. E. , Cone, E. J., McQuinn, R. L. ,
Pickworth, W. B., Risner, M. E., Su, T.-P. and Vaupel, D. B.:
Interdisciplinary studies on phencyclidine at the Addiction Research Center, Lexington, Kentucky. Psychopharmacology Bull.
16.: 79, 1980.
Gorodetzky, C. W., Cone, E. J. and Johnson, R. E.: Tine course of detection of oxymorphone, oxycodone, hydromorphone, hydrocodone, naloxone and naltrexone in human urine by RIA and EMIT opiate screening tests. Pharmacologist 22: 170, 1980.
Darwin, W. D. and Cone, E. J.: Drug Assay DeveloEnent. I.
Gas-liquid chromatographic analyses with short (36 cm) glass columns, 33rd Southeastern Regional Meeting, American Chemical Society, Lexington, Ky., Nov. 4-6, 1981.
Yousefnejad, D. and Cone, E. J.: Drug Assay Development. II.
Analysis of phencyclidine and metabolites by gas chromatography with a nitrogen detector. 33rd Southeastern Regional Meeting, American Chemical Society, Lexington, Ky., Nov. 4-6, 1981.
Buchwald, W. F. and Cone, E. J.: Drug Assay Develognent. III.
Artifact formation druing chloroform extraction. 33rd
-Southeastern Regional Meeting, American Chemical Society, Lexington, Ky., Nov. 4-6, 1981.
Cone, E. J., Gorodetzky, C. W., Darwin, W. D. and Buchwald, W.
F.: Drug Assay Develognent IV. Analyses of " opium eaters" urine for opium alkaloids by chemical ionization-Irass fragmentography (CI-MF). 33rd Southeastern Regional Meeting, American Chemical Society, Lexington, Ky., Nov. 4-6, 1981.
Darwin, W. D., Buchwald, W. F. and Cone, E. J.: Drug Assay Development V. Stability Studies of Buprenorphine and Other 6,14-EDd gethanotetrahydrooripavine Analgesics. 34th Southeast Regional Meeting, American Chemical Society, Birmingham, Ala.,
Nov. 3-5,1982.
Yousefnejad, D., Darwin, W. D., Gorodetzky, C. W. and Cone, E.
J.: Drug Assay Develognent VI. Analyses of Buprenorphine and Metabolites in BioFluids by Gas Chromatography (GC) with Electron Capture Detection (ECD). 34th Southeast Regional Meeting, American Chemical Society, Birmingham, Ala., Nov. 3-5, 1982.
Cone, E. J., Darwin, W. D. and Buchwald, W. F.: Drug Assay Develognent VII. Identification and Measurement of Oxymorphone and Metabolites in Urine by Methane Chemical Ionization-Eass Fragmentography (CI-MP). 34th Southeast Regional Meeting, American Chemical Society, Birmingham, Ala., Nov. 3-5, 1982.
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Cone, E. J.,'Gorodetzky, C. W., Darwin, W. D. and Buchwald, W.
F.: Acid-Catalyzed Rearrangement of Buprenorphine (B) and Other 6,14-Endoethanotetrahydrooripavine Analgesics. Fed. Proc. 11:
1044 (1982).
Shannon, H. E.,. Cone, E. J. and Gorodetzky, C. W.: Behaviora)
Effects of Buprenorphine (B), Demethoxybuprenorphine (DMB) and Morphine (M) in Rats. Fed. Proc. 11: 1044 (1982).
Cone, E. J., Darwin, W. D. and Buchwald, W. F.: Metabolism and Urinary Excretion of Oxmorphone (OM) in Man and Laboratory i Animals. Fed.. Proc. 12: 1293 (1983).
Cone, E. J.: Species Trends in the Metabolism of 6-Keto-opioid Narcotic Agonists and Antagonists by Humans and Laboratory Animals. '18th Annual Meeting of the Commissioned Officers Association of the U.S. Public Health Service, Crystal City, VA, May 29 - June 1, 1983.
Cone, E. J. and Risner, M. E.: The Reinforcing Properties of Fencamfamine hcl . (F, " Fake Cocaine") in the dog. Pharmacologist H: 199 (1983).
Risner, M. E., Goldberg, S. R. and Cone, E. J.: Effects of
-Nicotine, Cocaine and Metabolites on Schedule-Controlled Behavior of Dogs and Monkeys.. Pharmacologist H: 221 (1983).
Gorodetzky, C. W., Cone, E. J. and Johnson R. E.: Validity of EMIT and RIA for Detection in Urines of Marijuana Cigarette (MC)
Smoking. Pharmacologist H: 270 (1983).
Johnson, R. E., Yaeger, D. M., Jasinski, D. R., Cone, E. J. and Gorodetzky, E. W.: Detection of Cannabinoid Metabolites in ;
Human; Urine Following Passive Inhalation of Marijuana (M). )
Pharmacologist H: 271 (1983).
Yousefnejad,.D., Buchwald, W. P. and Ccne, E. J.: Drug Assay
>: Develognent VIII. Identification of Metabolites of Phencyclidine Derivatives by Gas Chromatography / Mass .
I Spectrometry (GVMS) with Methane Chernical Ionization (CI).
35th Southeast Regional Meeting, American Chemical Society, Charlotte, NC., Nov. 9-11, 1983.
Darwin, W. D., Cone, E. J. aad Buchwald, W. F.: Drug Assay Develognent IX. Gas Chromatographic Analysis of Urinary Oxycodone and Metabolites. 35th Southern Regional Meeting, Arrarican Chemical Society, Charlotte, NC., Nov. 9-11, 1953.
Cone, E. J., and Gorodetzky, C. W.: Extraction ard Measurement ,
of Beta-Endorphin-Like Inununoreactivity (ELI) in Micro-Volume Plasma Samples of Human Centenarians. Pharmacologist, 25.: 138 (1984).
Vaupel, D. B. and Cone, E. J.: Stereospecific Effects of the 1-Isomer of Ketocyclazocine (KC) in the Dog. Pharmacologist, 26.: 161 (1984). ;
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Moore, J. D.,' Cone, E. J. and Gorodetzky, C. W.: The Lexington Addicts--Demographic Characteristics and Prevelance of Infectious Diseases. Pharmacologist,26: 198 (1984).
Cone, E. J., Darwin, W. D., Buchwald, W. F., and Gorodetzky, C.
W.: Comparative Metabolism and Excretion of Oxycodone in Man and Laboratory Animals. Fed. Proc., 11: ? (1984) .
Darwin, W. D., Cone, E. J. and Gorodetzky, C. W.: Drug Assay Development X. Gas and Liquid Chromatographic Analyses of Methadone, Diazepam and Metabolites in Human Plasma. American Chemical Society Meeting, Raleigh, N.C., Oct. 24-26, 1984.
Darwin, W. D., Cone, E. J. and Johnson, R.E.: Drug Assay Development XI. Collection and Measurement of Delta-9-Tetrahydrocannabinol in Marijuana Cigarette Smoke.
Americal Chemical Society Meeting, West Long Branch, N.J., May 21-23, 1985.
Vaupel, D.B., Cone, E.J. and Johnson, R.E. An Enkephalin-like Pentapeptide (BW942C) with Partial Kappa Agonist Activity, Neuroscience, 1985.
Risner, M.E., Cone, E.J. Benowitz, N.L. and Jacob, III, P.
Effects of the Stereoisomers of Nicotine and Nornicotine on Schedule-controlled Behavior and Physiological Parameters of Dogs. Pharmacologists,22:258 (1985).
Jacob, III, P., Benowitz, N.L., Copeland, J.R., Risner, M.E.,
and Cone, E.J. Synthesis and Metabolic Studies of Nicotine and Nornicotine Enantiomers, Pharmacologist, 22:119 (1985).
Cone, E.J., Johnson, R.E., and Moore, J.D. Subjective and Hormonal Responses After One and Two Marijuana Cigarettes, Pharmacologist., 22:233 (1985).
Berning, R.I., Pickworth, W.B,, Kumor, K., Sherer, M. and Cone, E.J. Cocaine improves information processing in heavy users:
Electrophysiologic evidence. Pharmacologist, 3:1539 (1985).
Cone, E.J. and Johnson, R.E. Passive inhalation of marijuana l smoke. I. DiIT results. Pharmacologist, 3:235 (1985).
l Johnson, R.E. and Cone, R.J. Passive inhalation of marijuana l smoke. II. Subjective Effects. Pharmacologist. R:235 (1985).
Noe, D.A., Kumor, K.M., Sherer, M.A. and Thwpson, L. A l I
pharmacodynamic model of the chronotropic effect of iv cocaine (c) in man after bolus doses with or without subsequent infusion. Pharmacologist, M:205 (1986).
- 1. .
e I
Sherer, M.A., Kumor, K.M., DeBorja, J., Cone, E. and Jaffe, J.H. Psychiatric effects of 4 hr. infusions of cocaine.
American Psychiatric Association Meeting, Washington, D.C.,
1986.
Sherer, M.A., Kumor, K.M., Thompson, L., Cone E. and Jaffe, J.H.
i Psychopharracologic and cardiovascular responses after two methods of cacaine administration: Cocaine bolus versus cocaine bolus with continuous infusion. American College of Neuropsychopharmacology Meeting, Maui, Hawaii, 1986.
Thonpson, L.K. and Cone, E.J. Drug assay developent. XII.
Identification and determination of delta-9-tetrahydrocannabinol I (THC) in human plasma, serum and saliva by high performance liquid chromatography with amperometric detection. 20th Middle Atlantic Regional Meeting, American Chemical Society, Baltinore, MD, Sept 2-4, 1986.
Thompson, L.K. and Cone, E.J. Drug assay development. XIII.
Detection of phencyclidine in human plasma, saliva and urine by high performance liquid chromatography with amperometric detection. 20th Middle Atlantic Regional Meeting, American Chemical Society, Baltimore, MD, Sept 2-4, 1986.
Darwin, W.D. and Cone, E.J. Drug assay developent. XIV.
High-performance liquid chromatographic analysis of methylenedioxymethamphetamine (MDMA "Ectasy"). 20th Middle Atlantic Regional Meeting, American Chemical Society, Baltimore, MD. Sept 2-4, 1986.
Johnson, R.E. and Cone, E.J. Ingestion of marijuana-laced brownies. I. Subjective and physiological effects.
Pharmacologist, 21, 157 (1987).
Cone, E.J., Thompson, L.K. and Johnson, R.E. Ingestion of marijuana-laced brownies. II. Urine screening and physiological effects. Pharmacologist, 29, 157 (1987).
Core, E.J., Menchen, F. and Mitchelly J. Volidity testing of the 2DxR Cocaine Metabolite Assay wi+h hipun specirens obthned arter intravenous cocaine adm.d.n1stration.
International Association of Fo:ensic Toxicologists, July 28-31, 1907, Dariff, Alberta, Canada.
Lange, W.R. , Cone, E.J., Kaczaniuk, M.A., Snyder, F.R. and Saffe, J. Potential BIV Seropositivity in 1971-72 Parenteral Drug Abusers - A fo11oN2p study. Swenty Second Annual Meeting USPHS Professional Association, Nov. 8-12, 1987, Los Vegas, Nevada.
Cone, E.J., Menchen, S. and Mitchell, J., Validity assessment of corrercial cocaine metabolite assays. American Association for Clinical Chemistry, July 24-28, 1988, New Orleans, Louisiana Darwin, W.D., Yousefnejad, D. and Cone, E.J. Drug assay development. XV. Solid phase extraction (SPE) of cocaine from human saliva. 22nd MARM, ACS, May 22-24, 1988, Millerville, PA.
Yousefnejad, D., Darwin, W.D. and Cone, E.J. Drug assay develogient. XVI. Determination of cocaine in human saliva by capillary gas chromatography with ion trap detection or nitrogen ;
(NPD). 22nd MARM, ACS, May 22-24, 1988, Millerville, PA. I Menchen, S.L. and Cone, E.J., Drug assay development. XVII.
Detection of cocaine in human saliva by radioimunoassay. 22nd MAPN, ACS, May 22-24, 1988, hillerville, PA.
Cone, E.J., Yousefnejad, D., Darwin, W.D. and f.enchen, S.
Detection of morphine and cocaine ir, human saleva by Coat-A-CountR radioimmunoassays. The Internaton Association of Forensic Toxicologists, June 27.30, 1988, Groningen, The Netherlands.
Ford-Rice, F. , Della Puppa, A. , Snyder, F., Cone, E. and Lordon, E.D. Interactions between verapamil injection time and morphine effects on physiological parameters in rats. Neuroscience, in press, 1988.
Ritz, M.C., Cone, E.J., Sharkey, J. and Kuhar, M.J. Structure activity relationship of cocaine and related compounds in binding to dopamine transporters. Neuroscience, in press, 1988.
Welch, P., Radzius, A., Henningfield, J. and Cone, E.J. Use of a new optical assessment device temeasure opioid-induced changes in pupils. Pharmacologist, in press, 1988.
Cone, E.J., Menchen, S. and Mitchell, J. Specificity and accuraq of comercial urine screening assays for the detection of cM:a'ne use. Pharmacologist, in press,1988.
l
O : ,,
UNITED STATES OF AMERICA' x-NUCLEAR REGULATORY COMMISSION ' ' m '-
BEFORE THE ATOMIC SAFETY AND LICENSING BOARD.89. A In the Matter of cp g n-gocu .. . , . , .m MAURICE P. ACOSTA, JR. Docket No. 55-08347 / C Operator License No. 6010-2 CERTIFICATE OF SERVICE I hereby certify that copies of " NOTICE OF APPEARANCE" and "NRC' STAFF'S SECOND FURTHER RESPONSES TO MR. ACOSTA'S FIRST SET OF INTERROGATORIES AND, REQUEST FOR PRODUCTION OF DOCUMENTS" in the above-captioned proceeding have been. served on the following by deposit in the United States mail, first class, or as indicated by an asterisk through deposit in the Nuclear Regulatory Comission's internal mail system, this 21st day of April,'1989:
'B. Paul Cotter, Jr., Chairman
- Atomic Safety Licensing Appeal Administrative Judge Panel (5)*
Atomic Safety and Licensing Board U.S. Nuclear Regulatory Comission U.S. Nuclear. Regulatory Comission Washington, DC. 20555 Washington, DC 20555 Adjudicatory File
- Dr. Harry Foreman Atomic Safety and Licensing Board Administrative Judge- U.S. Nuclear Regulatory Comission 1564 Burton Avenue Washington, DC 20555 St. Paul, MN 55108 Docketing and Service Section*
Dr. Jerry R. Kline* Office of the Secretary Administrative Judge U.S. Nuclear Regulatory Comission
. Atomic Safety and Licensing Board Washington, DC 20555 U.S. Nuclear Regulatory Comission
, Washington, DC 20555 Michael B. Blume, Esq. !
U.S. Nuclear Regulatory Comission Mr. Maurice P. Acosta, Jr. Regional Counsel, Region V-193 Santa Maria Court 1450 Maria Lane, Suite 210 Vista, CA 92083 Walnut Creek, CA 94596 Charles R. Kocher, Esq. Atomic Safety and Licensing .
James A. Beoletto, Esq. Board (1)* i Southern California Edison, Co. U.S. Nuclear Regulatory Comission 2244 Walnut Grove Avenue Washington, DC 20555 Rosemad, CA 91770 Robert B. Rothman, Esq.
110 West C. St., Suite 2000 San Diego, CA 92101
%hpli Bernard M. Bordenick Counsel for NRC Staff