ML20148A855
| ML20148A855 | |
| Person / Time | |
|---|---|
| Site: | 07000817 |
| Issue date: | 07/16/1987 |
| From: | Burke H CHESTNUT HILL COLLEGE, PHILADELPHIA, PA |
| To: | Glenn J NRC |
| Shared Package | |
| ML20148A805 | List: |
| References | |
| 107554, 24542, NUDOCS 8801220614 | |
| Download: ML20148A855 (3) | |
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July 16, 1987
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j License No. SNM - 771 I*
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Uocket No. 070-00817 5,
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John E. Glenn, Chief M u;.T kt;J..k t h f
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Nuclear Materials Safety Section B
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Dear Mr. Glenn:
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The following information is in support of the application for amending Special Nuclear Materials License No. SNM-771.
The below numbered items refer to the numbers found in NRC form 313, Application for Material License.
5.
Radioactive Material-C(14)
(5 millicuries), H(3)(50 millicuries), P(32) (20 millicuries),
and S(35) (1 millicuries).
The chemical forms of the above isotopes will be either carbohydrates, nucleotides or amino acids or their derivatives.
6.
Purpose for which licensed material will be used -
The purpose of the above material is to conduct basic biochemical research in the field of nucleotide metabolism, including Isotope Effect Studies, metabolic pathway studies, and molecular biology studies on enzymes important in the metabolism of purine nucleosides and nuclectides.
7.
The individual responsible for radiation safety program and his training and experience -
David W. Parkin, Ph.D., Assistant Professor of Chemistry, Research Associate-Biochemistry Department Temple University School of Medicine Academic Training - Ph.D. in Chemistry, University of Nebraska-Lincoln, 1982.
Postdoctoral Trainee - Temple University School of Medicine with Vern L. Schramm, 1981 - 1983.
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- p. 2 Training and Experience Extensive training on the use of the above listed Isotoper: was received while working on Ph.D. under the guidance of Dr. Robert B. Johnston.
Experience was obtained in the use of various C(14) and tritium labeled amino acids; also experience was obtained in the use of P(32) in the assay of Tyrocidine Synthetase.
Labeled pyro-phosphate was synthesized chemically from P(32) inorganic phosphate.
Further training and experience was obtained in the laboratory of Vern L. Schramm during postdoctoral training.
Several specifically radiolabeled nucleotides such as C(14), H(3) AMP's and ATP's were syn-thesized by Dr. Parkin.
Also S(35) was used in labeled S-adenosylmethionine.
These compounds were used in the Kinetic Isotopat Studies on AMP nucleo-sidase and S-adenosylmethionine synthetase.
Items 8-10 will remain the same as described in the original application.
1 11.
Waste management-j All materials will be divided into the following categories containing C(14) and or H(3); samples containing S(35); and samples P(32).
All P(32) and S(35) samples will be allowed to decay until levels are accept-able for either liquid or solid disposal.
All liquid samples containing C(14) and or H(3) will be diluted to levels as described in 10 CER Part 20 pp 20.301 -20.305 and disposed of via the sanitary sewer system.
All solid waste or liquid which will not be disposed of in the sanitary sys-tea will be transferred to Teledyne Isotopes of Westwood, New Jersey.
They are presently on contract for the inspection of the Pu-Be source.
Sincerely yours,
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Sister Helen Burke, S.S.J., Ph.D.
Chairwoman, Chemistry Dept.
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h ww w e BETWEEN:
C. James Holloway, Chief 3[90 license Fee Management Branch Office of Resource Management John E. Glenn, Chief Nuclear Materials Safety & Safeguards Section B Division of Radiation Safety and Safeguards LICENSE FEE TRANSMITTAL A.
REGION 1.
APPLICATION ATTACHED Applicant / Licensee:
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hb 7/ / M /77 Application Dated:
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Control No.:
107554
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fA' h/ 7 License No.:
2.
FEE ATTACHED Amount:
Check No.:
3.
COMMENTS Signed M
Date
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B.
LICENSE FEE MANAGEMENT BRANCH 1.
Fee Category and Amount:
8M
/N 7 O ' // b J
2.
Correct Fee Paid. Application may be processed for:
Amendment Renewal e
License
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'l LV/97
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REGION I FORM 213 (MARCH 1987)
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