ML15187A234
| ML15187A234 | |
| Person / Time | |
|---|---|
| Site: | University of Missouri-Columbia |
| Issue date: | 04/27/2015 |
| From: | Univ of Missouri - Columbia |
| To: | Research and Test Reactors Branch B |
| Lynch S, NRR/DPR, 301-415-1524 | |
| Shared Package | |
| ML15187A033 | List: |
| References | |
| Download: ML15187A234 (25) | |
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Providing quality nuclear research, education and service to a global community University of Missouri Research Reactor, Nordion and General Atomics Collaborating to Develop a New and Reliable Supply of Mo-99 for the Future A Canadian-US partnership has been announced to create a "new, reliable supply" of medical isotopes for use worldwide.
The MURR research reactor (Image: University of Missouri)
Canada's Nordion and its US parent company Sterigenics International signed partnership agreements on 20 February with the USA's General Atomics (GA) and the University of Missouri Research Reactor Center (MURR).
Todays meeting is to present and discuss the approach to NRC Licensing at MURR related to this project April 27, 2015
Providing quality nuclear research, education and service to a global community University of Missouri-Columbia Research Reactor http://www.murr.missouri.edu
Providing quality nuclear research, education and service to a global community Improving the Quality of Life Reactor Operations Education Products Services Research Development Our core missions are Research & Education Our core missions are Research & Education 3
Providing quality nuclear research, education and service to a global community Research and Development
- Life Sciences Radiopharmaceutical Research Trace Element Epidemiology Boron Neutron Capture Therapy Radioisotope Tracers
- Social Sciences Archaeometry
- Material Sciences Triple Axis Spectrometer Neutron Reflectometer Multi-detector Powder Diffractometer High Resolution Powder Diffractometer 4
Providing quality nuclear research, education and service to a global community Hidden Treasures of Rome Archaeometry Research 5
Providing quality nuclear research, education and service to a global community Carrier free lanthanides Indirect production (Lu-177, Pm-149 and Ho-166)
DOE Advanced Nuclear Medicine Initiative Electromagnetic isotope separation (Sm-153)
DOE SBIR Mo-99 n, gamma production for novel generator technologies Industry partnership with NorthStar Fission production with uranium recycle Industry partnership with Northwest Medical Isotopes Rh-105 Carrier free from uranium fission using selective gas extraction Subcontract with General Atomics/DOE Isotope Program Re-186 Accelerator production and separations for high specific activity DOE Isotope Program As-72, As-77 and Cu-67 Production of high specific activity with target recycle DOE Isotope Program Isotope Research Activities 6
Providing quality nuclear research, education and service to a global community Lutathera 177Lu from MURR is currently being evaluated in over 30 clinical applications for radiotherapy of cancer.
Metastatic prostate cancer Non-hodgkins lymphoma Neuroendocrine tumors Ovarian cancer Metastatic bone cancer Colon cancer Lung cancer Phase III Clinical Trials in Europe and U.S.
Metastatic gastro-entero-pancreatic neuroendocrine tumors Survival benefit of 40 to 72 months Nuclear Medicine Diagnostics AND Therapy New Isotopes for Cancer Treatment 7
Providing quality nuclear research, education and service to a global community Epigallocatechin-gallate (EGCg) functionalized radioactive gold nanoparticles administered intratumorally resulted in 80% reduction of tumor volumes after 28 days.
Nuclear Medicine Diagnostics AND Therapy Radioactive Gold Nanoparticles 8
Providing quality nuclear research, education and service to a global community Isotope Activities Isotopes Supplied by MURR in 2014 Au-198 Ir-192 Sb-122 Au-199 Kr-79 Sb-124 Ba-131 Mo-99 Sc-46 Ca-45 Na-24 Se-75 Cd-115 P-32 Sm-153 Ce-141 P-33 Sn-117m Co-60 Pd-109 Sr-89 Cr-51 Po-210 W-181 Cu-64 Rb-86 Y-90 Fe-59 Re-186 Yb-169 Lu-177 Ru-103 Zn-65 Hg-203 S-35 Zr-95 ATR Isotopes Co-60 HFIR Isotopes Se-75 Cf-252 W-188 Ra-223 Np-237 9
Providing quality nuclear research, education and service to a global community Preparing the Next Generation Neutron Scattering for the Science and Engineering of the 21st Century
$3M National Science Foundation 10
Providing quality nuclear research, education and service to a global community Introduction to Radiochemistry lecture/lab course -
the nations largest Intensive MU summer course for Missouri high school science teachers (3 graduate credits in nuclear engineering, 30 years running)
Host for Nuclear Chemistry Summer School for undergraduates, featuring lectures, labs and field trips covering aspects of nuclear science, medicine, particle physics and radiochemistry Nuclear Workforce Development Radiation Protection Technician program - DOL grant to develop and disseminate curriculum to more than 20 technical colleges Nuclear Quality Control Technician program - NRC grant to develop QC curriculum for nuclear power industry Preparing the Next Generation 11
Providing quality nuclear research, education and service to a global community University-operated Research Reactors 12 Facility Power Level Kansas State University 250 kW Reed College 250 kW University of California-Irvine 250 kW University of Maryland 250 kW Missouri University of Science and Technology (Rolla, MO) 200 kW University of Arizona 100 kW University of Florida 100 kW University of Utah 100 kW Purdue University 1 kW Idaho State University 5 W University Of New Mexico 5 W Rensselaer Polytechnic Institute 100 W Facility Power Level University of Missouri, Columbia (MURR) 10 MW Massachusetts Institute of Technology 6 MW University of California-Davis 2 MW Rhode Island Nuclear Science Center 2 MW Oregon State University 1 MW University of Texas, Austin 1 MW North Carolina State University 1 MW Pennsylvania State University 1 MW Texas A&M University 1 MW University of Massachusetts-Lowell 1 MW University of Wisconsin 1 MW Washington State University 1 MW Ohio State University 500 kW
Providing quality nuclear research, education and service to a global community History July 1963 Ground broken at the reactor site October 13, 1966 MURR achieves initial criticality at 18:14 (5 MW license)
June 1967 Reactor reaches 5 MW July 1969 Reactor starts 5 MW, 100 hours0.00116 days <br />0.0278 hours <br />1.653439e-4 weeks <br />3.805e-5 months <br /> per week operating schedule August 1971 Reactor upgraded to 6.2 kg uranium aluminide fuel core July 1974 Reactor upgraded and licensed to 10 MW September 1977 Reactor starts 10 MW, 100 hours0.00116 days <br />0.0278 hours <br />1.653439e-4 weeks <br />3.805e-5 months <br /> per week operating schedule October 1981 First beryllium reflector replaced (occurs approximately every 8 years thereafter)
April 1984 100,000 hours0 days <br />0 hours <br />0 weeks <br />0 months <br /> of operating time achieved August 2006 Facility relicensing application submitted to NRC December 2006 Primary and pool coolant heat exchangers replaced February 2010 300,000 hours0 days <br />0 hours <br />0 weeks <br />0 months <br /> of operating time achieved January 2012 Cooling tower replaced 13
Providing quality nuclear research, education and service to a global community 14
Providing quality nuclear research, education and service to a global community Key Reactor Parameters MURR is a pressurized, reflected, heterogeneous, open pool-type, which is light-water moderated and cooled:
- Maximum power: 10 MWth
- Peak flux in center test hole: 6.0E14 n/cm2-s
- Core: 8 fuel assemblies (775 grams of U-235/assembly)
- Control blades: 5 total - 4 BORAL shim-safety, 1 SS regulating
- Reflectors: beryllium and graphite
- Forced primary coolant flow rate: 3,750 gpm (237 lps)
- Primary coolant temps: 120 °F (49 °C) in, 136 °F (58 °C) out
- Primary coolant system pressure: 85 psia (586 kPa)
- Forced pool coolant flow rate: 1,200 gpm (76 lps)
- Pool coolant temps: 100 °F (38 °C) in, 106 °F (41 °C) out
- Beamports: three 4-inch (10 cm), three 6-inch (15 cm) 15
Providing quality nuclear research, education and service to a global community Reactor Core Assembly 3D View Reactor Core Assembly 2D View 16
Providing quality nuclear research, education and service to a global community Reactor Design and Programs
- Reactor design is modular, where all components are replaceable, including the reactor pressure vessels.
- Spare reactor pressure vessel is on hand, including stock material to fabricate additional vessels, if needed.
- Beryllium reflector is replaced every 26,000 MWd (approximately 8 years); prior to the combined stresses
[1H3, 2He3, and thermal] reaching the berylliums yield point.
- Reactor pool is designed such that the entire reactor pool and pool liner are above the elevation of the beamport floor and not in contact with any soil. With the exception of the base, all areas of the reactor pool are visible and accessible.
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Providing quality nuclear research, education and service to a global community Renewal and Relicensing Projects
- Replacement of Graphite Reflector Elements
All 12 graphite reflector elements were replaced with new ones
- Radioactive Liquid Waste System Modification
System was modified such that all radioactive drain piping is accessible for inspection, monitoring and maintenance
- Installation of a Fire Protection System
A Detection System that consists of heat, smoke, and remote manual devices, and a Suppression System that incorporates a normal sprinkler system with a pre-action system used in areas with sensitive electrical equipment
- Replacement of the Primary & Pool Coolant System Heat Exchangers
Shell and tube-type heat exchangers were replaced with plate-type heat exchangers and flow measurement instrumentation upgraded 18
Providing quality nuclear research, education and service to a global community Renewal and Relicensing Projects
- Replacement of the Reactor Plant Make-up Water Tanks
Replaced two 7,000 gallon phenolic-lined carbon steel demineralized water storage tanks with two stainless steel tanks of the same capacities
- Replacement of major facility Electrical Distribution Transformers and Motor Control Centers
Installed two new 300-kVA transformers and distribution panels to increase the facilitys 120/208V load capacity Replaced and upgraded the facilitys main 1000-kVA transformer with a new 2000-kVA transformer
Replaced and upgraded the cooling tower 500-kVA transformer with a 1500-kVA transformer
Replaced and upgraded the Secondary Coolant Pump Motors from 125 to 150 HP with variable speed drives
- Replacement of the Cooling Tower
Replaced and upgraded an old-style 3 cell, wood-framed 10 MW cooling tower with a new 3 cell stainless steel 15 MW cooling tower 19
Providing quality nuclear research, education and service to a global community MURR in Summary
Purpose:
Multi-disciplinary research and education facility also providing a broad range of analytical and irradiation services to the research community and the commercial sector.
- MURR operates 24 hours2.777778e-4 days <br />0.00667 hours <br />3.968254e-5 weeks <br />9.132e-6 months <br /> a day, seven days a week, 52 weeks a year
- 165 full-time employees 20
Providing quality nuclear research, education and service to a global community University of Missouri Research Reactor, Nordion and General Atomics Collaborating to Develop a New and Reliable Supply of Mo-99 for the Future A Canadian-US partnership has been announced to create a "new, reliable supply" of medical isotopes for use worldwide.
The MURR research reactor (Image: University of Missouri)
Canada's Nordion and its US parent company Sterigenics International signed partnership agreements on 20 February with the USA's General Atomics (GA) and the University of Missouri Research Reactor Center (MURR).
April 27, 2015 While maintaining MURR Core Missions of Research and Education
Providing quality nuclear research, education and service to a global community Process Reactor Process Facility Mo 99 Irradiated Target Transported to Processing Facility Radioactive Waste New Target Typical Molybdenum-99 Project
- In the GA/Nordion Project target remains in the reflector region for >one year 2
Providing quality nuclear research, education and service to a global community GA Mo-99 GA Mo-99 Simplified Reactor Plan View Hot Cells Outside of Biological Shield Gaseous Extraction Lines exit biological shield through abandoned pneumatic tube penetrations 3
Heat Exchanger Heat Exchanger Secondary Coolant System to Colling Tower
24 Selective Gas Extraction Process Overview Hot cell #1 Product packaging
& shipping Hot cell #2 Extraction system MoO2Cl2 Waste Spent target after
~1 year service Collection system Target assembly Helium heating line waste Neutron flux Mo-99 control system Passive safety heat exchanger Reactor core Target cooling system Extraction gas line Facility cooling tower MURR control room MoO2Cl2 Extraction Gas MURR pool
Providing quality nuclear research, education and service to a global community 25 BREAK Proprietary Session