Regulatory Guide 8.9

Acceptable, Concepts, Models, Equations, and Assumptions for a Bioassay Program

ML13064A086
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Issue date:	09/30/1973
From:	US Atomic Energy Commission (AEC)
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RG-08.009
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September 1973 U.S. ATOMIC ENERGY C,,OMMIS$1OiU

OREGULATORYAR

DIRECTORATE OF 911OULATOPIY STANDARDS

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REGULATORY GUIDE 8.9 ACCEPTABLE CONCEPTS, MODELS, EQUATIONS, AND ASSUMPTIONS

FOR A BIOASSAY PROGRAM

A. INTRODUCTION

ICRP Publication 2, Report of ICRP Committee 1I

on Permissible Dose for Internal Radiation (1959)

Section 20.108, "Orders Requiring Furnishing of Bioassay Services," of 10 CFR Part 20, "Standards for ICRP Publication 6, Recommendations of the ICRP,

Protection Against Radiation," states that the Atomic 1962, Supplement to ICRP Publication 2 (1964)

Energy Commission may incorporate provisions in any license requiring bioassay measurements as necessary or JICRP Publication 9, Recommendations of the ICRP

desirable to aid in determining the extent of an 11966)

individual's exposure to concentrations of radioactive material. As used by the Commission, the term bioassay ICRP Publication 10, "Evaluation of Radiation includes in vivo measurements as well as measurements Doses to Body Tissues from Internal Contamination of radioactive material in excreta. Due to Occupational Exposure," A Report by Committee 4 (1968)

B. DISCUSSION

Analytical work involved in the planning and ]ICRP Publication 10A, "An Assessment of Internal

,conduct of a bioassay program includes (1) Contamination Resulting from Recurrenit or determination of the conditions under which bioassays Prolonged Uptakes," A Report by Committee 4 should be required; (2) selection of measurement ('1971)

techniques and quality control criteria, measurement frequency, and program participants; (3) specification of actions to be taken based on measurement results, with ICRP Publication 12, "General Principles of action points: and (4) interpretation of measurement Monitoring for Radiation Protection of Workers," A

results in terms of the location of radioactive material in Report by Committee 4 (1969)

the body, the quantity present, the rate of elimination, and the resulting dose or dose commitment. To be Commission licensees often make reference to these acceptable, any analysis of this nature requires publications when interpreting and reporting bioassay technically sound concepts, models, equations, and measurement results.

assumptions.

The International Commission on Radiological The concentrations of radioactive material in air and Protection (ICRP) has included among its publications water that appear in 10 CFR Part 20, Appendix B, are reports which contain guidance on the protection of based on concepts, models, equations, and assumptions personnel from intake of radioactive materials. Several adopted by the ICRP. Therefore a precedent exists for of these reports make recommendations which can be the acceptability of these as applied to bioassay analyses applied to bioassay measurements: nece:ssitated by Commission requirements.

USAEC REGULATORY GUIDES Copies of published guides may be obtained by request indiciting the divisions desired to the U.S. Atomic Energy Commisson. Washington, D.C. 20545.

Regulatory Guides are issued to describe and make mvailable to the oublic Attention: Director of Regulatory Standards. Comrrments and suggestions for methods acceptable to the AEC Regulatory staff of Imolemenrting specific pa"ts of improvements in these a-e encouraged and should be sent to the Secretary kuides Conmsession's regulations, to delineate tedhniques used by the st ff in of the Commission, U.. Atomic Energy Commission, Wanhsington, D.C. 2*0645

-luating specific problems or postulated accidents, or to provide guidance 1o Attention. Chief, Public Prooesding Staff.

sslicents. Regulatory Guides are not substitute for regulations and compliance with them is not required. Methods and solutions dIfferent from thos st out in The guitkss are issued in the following ton broad divisions:

the guides will be accptable if they provide a bals for the findings requisite to the issuance or continuance of a permit or license by the Commission. 1. PovwerReactors

6. Products

2. Ressarcit and Tess Reactors

7. Transpoirtaion

3. Fuels and Materials Facifitias S. Occupational Health Published guids& will be revised periodically. as eopropriate, to accommodato 4. Environmentel endSiting 9. Antitruat Review comrmnts and to reflect new iniormetlon or expsasnco. S. Materials and Plant Protection 1

C. REGULATORY POSITION

Commission requirements. For radionuclides not covered by a Regulatory Guide on bioassay, the basic It is expected that Regulatory Guides to be issued internal dosimetry concepts of the ICRP and the models, by the Commission will indicate concepts, models, equations, and assumptions derived from these concepts equations, and assumptions acceptable to the Regulatory in ICRP Publications 2, 6, 9, 10, 10A, and 12 are staff for bioassay analyss that are necessitated by acceptable to the Regulatory staff.