ML20147H395
| ML20147H395 | |
| Person / Time | |
|---|---|
| Site: | University of Virginia, 07100460 |
| Issue date: | 03/02/1988 |
| From: | Mulder R VIRGINIA, UNIV. OF, CHARLOTTESVILLE, VA |
| To: | NRC OFFICE OF ADMINISTRATION & RESOURCES MANAGEMENT (ARM) |
| References | |
| NUDOCS 8803080467 | |
| Download: ML20147H395 (2) | |
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Medical Center 54th Street and 48th Avenue South
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4 Minne.apolis MN 55417
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L K Veterans t
Administrat, ion
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Februstry 10, 1988 in Reply Ref er To: (618/115) h r
U.S. Nuclear Ibgulatory Ommiwon P
ATIN: Mr. John Madera h
Region III 799 Roosevelt Poad Glen Ellyn, IL 60137 f
SUBJ: Additional infonnation concerning the I-131 labeled monoclonal i
antibody study. Control number - 84611.
1.
Diagnostic procedure. 'Ihe patient is adnitted to the hospital and
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placed $a a private outside corner roo'n. Ile has a private bath and the bec is located in the outside corner of the roan. 5 to 50 mci of the I-131 tagged antibody is given I.V.
'Ihe dose is in 100 ml of saline nnd is dripped in over a period of 1 hour1.157407e-5 days <br />2.777778e-4 hours <br />1.653439e-6 weeks <br />3.805e-7 months <br />.
After 24 hours2.777778e-4 days <br />0.00667 hours <br />3.968254e-5 weeks <br />9.132e-6 months <br />,
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in the case of a 5 mci diagnostic dose, the patient is 1.aken to the
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Nuclear hkxlicine Department for a total body scan to detennine the 5
tumr uptake (the thyroid is blocked to prevent any free iodine uptake).
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In the case of a 50 nCi diagnostic dose, we wait 48 hours5.555556e-4 days <br />0.0133 hours <br />7.936508e-5 weeks <br />1.8264e-5 months <br /> before g
scanning the patient.
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L All patients use this roan an the ward with the stuno nursing staff. In any diagnostic dose over 5 mci, we use standard isolation and contamin-h ation/expostee procedures. 'Ihe nursing staff is supplied with pocket E
dosimeters and the readings are logged daily for each shift. Daily
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radiation readings are made at bedside, 3 feet fran bed and 10 feet frun the bed. 'Ihese readings are logged on the outside door of the roan f
along with t?..s nursing instructions. Stay time for the nurse is I
calculated not to exceed 16 mr in an 8-hour shift.
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All bedding, dishes and other articles are kept in the rocm until released or ramved by the R.S.O.
During the infusion, the drip s
bag is shielded to keep the outside of the roan 2 mr/hr or less.
'Ihe I.V. is started and nonitored by a renal department assistant, who is badged and is familiar with the procedure.
In the event that we ck) not do a therapy on the patient, he is kept in isolation and nonitored until his level has dropped 10 mC1. His roan is then decontaminated to background levels and it is then released to the wurd.
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herapy pmcedures:' Up'to this'date, we have not'excpeded a 50 mC1 therapy dose, s he same. Isolaticn and nonitoring procedures-are used as with the diagnostic procedure.. We one adjoining room to the' patients room is_ monitor'ed and if above 2 mr/hr at any. locate.n we keep the roan _enpty.
In the event we have a post-therapy patient, we _ move him to the adjoining rocm andptt the new therapy patient in
<i the corner rean.
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External radiation nonitoring data: Dcternal radiation ducts in-and around the patientWroom-depend directly on.the physical size of '
the patient. We did sis (6) patients this past year each with a-50 mci-E-
therapyLdose. Bedside levels varied from 22 mr/hr up to 60 mr/hr. -10 g~
feet frun the bed ranged from 1.5 mr/hr to 2.5 mr/hr. Rese readings were taken after the I.V. drip was empleted. he umlogy assistant attending the patient has not' received any reading on his film badge, pocket dosimeter readings for Mhe nursing staff have also been negative.
L4. Waste disposal: Our research chanist has been doing the tagging -
on the antibody using the hot lab. All solid waste has been bagged and tagged for decay storage. We patient waste is in the urine. ' Samples of urine are collected along with blood every 4 hours4.62963e-5 days <br />0.00111 hours <br />6.613757e-6 weeks <br />1.522e-6 months <br /> for 2 days and then every 12 hours1.388889e-4 days <br />0.00333 hours <br />1.984127e-5 weeks <br />4.566e-6 months <br />. he _ urine is then disposed 'of using the sanitary sewer systen.
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Patient release: he Tts 'for the activity is about 60 hours6.944444e-4 days <br />0.0167 hours <br />9.920635e-5 weeks <br />2.283e-5 months <br />. We have been keeping the patient in is1ation until his body bynjen'is 1ess than 30 mci and exiosurc,readi14;s are less than 5 mr/hrpt 3 fe6t.
J We will continue with these re fase levels. %erapy doses will exceed 150 mci without further abroval fran the N.R.C.
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