ML20129A928

Amend 21 to License SNM-159 for Case Western Reserve Univ. Control:301681

ML20129A928
Person / Time
Site:	07000145
Issue date:	10/03/1996
From:	Kevin Null NRC OFFICE OF INSPECTION & ENFORCEMENT (IE REGION III)
To:
References
301681, NUDOCS 9610220286
Download: ML20129A928 (13)

Text

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RC FORM 374 PAGE OF PAGES U.S.NUCd.EAF REGULATORY COMMISSION Arrendment No. 21

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hJ MATERIALS LICENSE {

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I Pursuant to the Atomic Energy Act of 1954, as amended, the lhergy Reorganization Act of 1974 (Public Law 93-438), anJ Title 10, Code of ,

l Federal Regulations, Chapter 1, Parts 30,31,32,33,34,35,36,39,40, and 70. and in reliance on statements and representations heretofore made I

! by the licensee, a license is hereby issued authorizing the hcensee to receive, acquire, possess, and transfer by product, source, and special nuclear C(g d material designated below; to use such material for the purpose (s) and at the place (s) designated below; to deliser or transfer such material to "j persons authorized to receive it in accoidance with the regulations of the appheable Part(s). This license shal "l specified in Section 183 of the Atomic Energy Act of 1954, as amended, and is subject to all applicable rules, regulations, and orders of the ' ;$

", Nuclear Regula:ory Commission now or hereaf ter in effect and to any condinons specifi-d below. s J f f

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j Licensee In accordance with letter dated 6 j July 31, 1996 E I 1. Case Western Reserve University 3. License Namber SNM-159 is amended in (

Department of Occupational & its entirety to read as follows: F Environmental Safety E

2. 10900 Euclid Avenue i Cleveland, OH 44106 4. Expiration Date January 31, 2002 E s

5. Docket or Reference No.

070-00145 2 2

6. Byproduct, Source, and/or 7. Chemical and/or Physical 8. Maximum Amount that Licensee 2

Special Nuclear Material Fonn May Possess at Any One Time 5 y

Under This License 3 E

$ A. Plutonium-239 A. Sealed Pu-Be neutron A. 16 grams f f; sources (Mound)  ;

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lh B. Uranium-235 B. Any B. 70 milligrams s ifj E

l 5 l3 9. Authorized Use: E l3 s lh A. To be used for research and training. (

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B. To be used for radiometric tracer studies. (

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CONDITIONS l .

l 10. Ohio. Licensed material shall be used only at Case Western Reserve University, Cleveland, j j s I

11. Licensed material shall be used by, or under the supervision of, individuals 2 I

designated by the University Radiation Safety Committee, Christopher David Town, Ph.D., Chairperson.

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12. A. The Radiation Protection Officer for the activities authorized by this license 2 is W. David Sedwick, Ph.D. j l

B. The Assistant Radiation Protection Officer for the activities authorized by this license is Karl Von Ahn.  !

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y MATERIALS LICENSE Docket or Reference Number y k SUPPLEMENTARY SHEET 070-00145 g B

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13. A. (1) The source (s) specified in Item (s) 7.A. shall be tested for leakage and/or N N

5 contamination at intervals not to exceed 6 months. Any source received E from another person which is not accompanied by a certificate indicating E I E

that a test was performed within 6 months before the transfer shall not be I i 5 put into use until tested. 'N l 3

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H (2) Notwithstanding the periodic leak test required by this condition, any N '

licensed sealed source is exempt from such leak tests when the source E 3

contains 100 microcuries or'less?ofibeta and/or gamma emitting material or .E N

y 10 microcuries or lesk' of alpha' emitting

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N 8. Any source in storage *and not being used need noPb ,s tested. When the source E M is removed from storage for use or transfer to anothe~rlperson, it shall be  %

l3 tested before use:or transfer. E 3

J E l B C. The test shall be capable of detecting the presence of 0.005 microcurie of N B radioactive material on the" test sample. If,the test reveals the presence of M H 0.005 microcurie or more of removable contaniination, the source shall be E 5 removed from service and decontaminated', repaired, or disposed of in accordance E l B with Comniission regulations. A report -shalb b'e filed within 5 days of the date E H the leak test result is known with the U.S. Nuclear Regulatory Commission, E B Region III, 801 Warrenville Road, Lisle, Illinois 60532-4351, ATTN: Chief, E Nuclear Materials Safety Branch. The report shall specify the source involved, 3

E y the tcst results, and corrective action taken. Records of: leak test results E i

s shall be kept in units of microcuries and shall be maintained for inspection by p jy the Commission; Records may be disposed of following Commission inspection. R j D.

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Tests for leakage and/or contamination shall be performed by the licensee or by E

y y other persons specifically licensed by the Commission or an Agreement State to (

13 perform such services.

p I3 E y 14. Sealed sources containing licensed material shall.not be opened. (

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@a15. The licensee shall maintain records of information important to safe and effective g y decommissioning at Case Western Reserve University, 10900 Euclid Avenue, Cleveland, g y Ohio per the provisions of 10 CFR 30.35(g) until this license is terminated by the g y Commission, g

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16. Except as specifically provided otherwise in this license, the licensee shall k

conduct its program in accordance with the statements, representations, and N 8

8 procedures contained in the documents, including any enclosures, listed below. The 5 U.S. Nuclear Regulatory Commission's regulations shall govern unless the statements, E 8

representations, and procedures in the licensee's application and correspondence are more restrictive than the regulations. !R S

E A. Application dated June 17, 1991 (with attachments, including Radiation E 3 Protection Procedures Manual); and Cm E N . ., ,w e '- L-b /r, N 9 B. Letters dated November 27,"1991, August 20, 1993', July 25, 1994, July 7, 1995,  %

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LICENSE FEE MANAGEMENT BRANCH, ARM  : PROGRAM CODE: 22120 O AND  : STATUS CODE: 0 REGIONAL LICENSING SECTIONS  : FEE CATEGORY: EX 1D

EXP. DATE: 20020131 O  : FEE COMMENTS: 170.11(A)(4) EFF. 7/

DECOM FIN ASSUR REGD: N LICENSE FEE TRANENITTAL O A. RECION

1. APPLICATION ATTACHED O AreLICANT< LICENSEE: CASE WESTERN RESERVE UNIVERSITY RECEIVED DATE: 960802 DOCKET NO: 7000145 CONTROL NO.: 301681 O LICENSE NO.: SNM-159 ACTION TYPE: AMENDMENT

2. FEE ATTACHED O AM0uNT: ~~~~

CHECK NO.: _~_

3. COMMENTS SIGNED .

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1. FEE CATECORY AND AMOUNT: ___ _ _ _ _ _ _ _ _ /, _ _ _ _ _ _ _j_l _______

N O 2. CORRECT FEE PAID PPLICATION MAY BE PROCESSED FOR' AMENDMENT ~~~~~~~~~~~~~~ -

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CASEWESTERN RESERVE UNIVERSITY

)uly 31,1996 Materials Licensing Branch US Nuclear Regulatory Commission, Region III 801 Warrenville Road Lisle, Illinois 60532-4351 Re: Case Western Reserve University NRC License Nos.

34-00738-04,34-00738-07 34-00738-09,34-00738-10, SNM-159

Dear Sirs,

i This is a request to approve two new Radiation Safety Committee members for the licenses above.

4 The first approval request is for Dr. Thomas H. Large (curriculum vitae enclosed) as a voting Radiation Safety Committee member for Case Western Reserve University. We request that Dr. Large be approved for a three year term, starting

, August 8,1996, and will replace Dr. Susan Payne.

The second approval request is for Dr. Hue-Lee Cheng Kaung (curriculum vitae enclosed) as a voting Radiation Safety Committee member for Case Western Reserve University. We request that Dr. Kaung be approved for a three year term, starting August 30,1996, and will replace Dr. Carole Liedtke.

If you have any questions, please call me at 216-368-2906.

Sinc r6fy, 7

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D avid Se wick Raaiation Safety Officer cc: Dr. Agnar Pytte, President of CWRU Dr. Christopher Town, Chairperson RSC g Kenneth Basch, Assistant Treasurer -

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Karl Von Ahn, Asst. RSO - - =

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1. $ 191996 oep rirnent or occup.:x>n. a environ,neni.i s.<ety Jvgg

"="l,tmeserve C university 2220 Circle Onve. First Floor

=;; g:gry;L, t"  := RECEIVED Cleveland. Ohio 44106-7227 g}_

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1965 129 i UCSF Medkal School 1 Possdoctoral Pellowship i

j 1960 1985

i. Northwestem University, Evanston, Blinois i

. 3'hD N"*65'%Y *ad Phy'80308Y 19 4 1979

Northwestern University, Ryanston, Illinois l Dual Major: Integrated 5 dance Program and Biology 1

Heness i

McKnight Award, Finalist

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j NIH Postdoctoral Pellowship j NIMH Pre <loctoral Fellowship FeDowship in Reproductive Biology l

g Northwestern University Teaching Feuuwship

Honors / Masters Programin Biology NSP Undergraduate Iruegrated Science Program p, s- saa.1 rue. 4 - -

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July 1992

' Assistant Professor prescmt Division of General Medkal bdences (Oncology)

Case Western Reserve Unhersity School of Medidne January 1990 -

Assistant Prufessor present DepartmentofNeurcedenare Case Western Reserve University School of Medkku Cleveland, Ohio 44106 4V75 June 1986- Associate Dec1989 I Howard Ilughes MudkalInsttrute Univ. of Cammia Medical School SenFrancisco.Califomia 94143 August 19es. rotdutor.1p.n w  !

May 1986 Dvpt. of Physiology Univ. of Cammia Medka! School s.tue.J M.=h=%=

i 1994 1996 1994 1995 Ad hoe and regular ausnber, NLS-1 Study Section Ad hoe memhae, NIIVieC Study Soetion 1994

• Ad hoc meneur, NICHD Site Visits 1994 Ad hoe reviewer for NSF 1991-1996 American Heart Assodation Study Section 1991 ,

Ad hoc member, N!A/NINDS Alh8 Disease Study Section mmviewer far temmales 5dence Neman J.NE _ A Developinenal B6 ology Newoedance1 steers Endocrirwiegy J. Ce5 Biology c .. . -

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1 4 TRAININGRECORD CumntPoebloc6etalFellows:

voet. Matt: 1991 -

i MD 1987 Univ.of Pennsylvania 1 Phyelcian Scientist Awaal l King, Paul,1994-MD 1992 TempleUniv.

Cunent ProdoctoralStudents:

4 Gamar, Andrew (MD/PhD); 1990-

BA 1989 % .rt .r,re 7 MSTP Tranning Grant l 4

Erry Menegay (PhD): 1991 -

1 BA 1988 AkronUniv.

i j

Krletwi Beeshore (PhD): 1W3- i BA 1992 LebanonValleyCollege '

i, Past Postdoctoral Fellows:

);

Xie, Xiao.Yi; 1991 - 1992 PhD 1990 Univ. of Miami School of Medicirw i American Wart Association Fellowship t Bethea, Jahru IW1 1994 j

PhD 1991 Univeralty of Alabama, Birmingham ,

NRSA 4

McKeon, Robert;1991 1994 PhD 1989 University of Vermont j (co sponsored by Jerry Silver) 1 Past Undergraduates

Dalla Elkhairi; 1990 - 1993 currendy MD student, Ohlo $ tate

Venus Paxton;1991 1994 cur +ently reeaarch associate, CWRU j Past Minodty Students

Cynthia Long currently MD student,CWRU j

Victoria Prlbley currently MD student, CWRU Nate Russell currundy MD student, CWRU WkkMarvin-currently aduate i lasonRees currvedyi unte TennishlaGoggare currendyundergraduate i .

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l Past Suppoit A) NIH (NRSA award to John Bethea, Phu) I

8) "F.ffect of NT4 Cene AKnockout on Mouw Development.- l Q 11/1/92 10/31/M D) $45,000'IDC A) Bristol Meyers

8) Sponsor,0% effort Squibb Fellowship Pro 8mm for Minority Medical Studane (Cynthia 1.o Q 6/1A/95 12/31/93

• D) 96,000 TDC A) Gilatech,Inc.

B) *1dentification and Expression of NGF-related Trophk Factors.*

Q 1/1/91 6/30/93 ,

D) 5100,000 TDC  !

i A) Spunsor,0%

B) American effort Heart Association Postdoctoral Pellowship (Xiao YL Xie, PhD) j Q 7/1/91 6/30/93 U) 542,000 TDC;$21,000 ADC '

1 l

A)Sponsor,0%

B) American eMort Cancer Sodcty Joseph S. Silber Student Fellowship (Venus Paxton) 1 Q 6/1/92 8/31/92 D) $1,5001DC . )

I A) Association R) Sponsor,0% effortfor Academic Minority Phydcians/Merck Summer Pellowship (Victoris Fribleyi O 6/1/92- 8/31/92 i

D) $5,0M1DC Rehted to Nerve Growth Factor *A) Research Initiation Grant (Ohio Regents): *1dentificah n) 0% elfort Q06/01/90 m/31N1 D) 85,000 TDC i

Training Granta:

DevelopmentalNeutology FI:fkory 1.andis, Dept.of Neumtelences

1. NS07115 7/1/89 6/30/90 2 pre /4 post Normal and Abnormal Development - P!: Urs Rutishauser, Dept. of Genetics

1. HD07104 7/1/91 6/30/96 6 pre / 3 post Ceti and

1. GM00056 Molecular blogy - Pts I' ritz Rottman, Dept. of Microbiology and Moleenlar Biology 7/1/92-A/M/97

)

8prodoco i j Pharmacology. PT: John N!! son, Dept. of Pharmacology 1

Pend q Research Oncology Training Grant . Nathan Berger, Ireland Cancer Center

1. CA43700 7/1/93 6/30/96 3/4postdoes 1

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Barke, P.A, Miller, F.D.,1sp, T.H. and Murphy, llA. (1991) N Schwarm ceNierival trunca6ed bem the NGF receptor arises from post translational processing. Soc. Nammi. Abstr.17,11E Ignatius. M.)., targe, T.H., Houde, M., Taws. J.W., Barton, A., Carbonetto, S. and Rekhardt, LP. (1991)

Molecular 17,207. cloning of the rat integrin alpha.1 subdt: A recepinr fne laminin and co!!agen Soc. Newosci. Als r.

Ignat4us, M.J Large, T.H, Houde, M Tawlt J.W,1 arton, A, Esch, F., Carbonetto, S. and Reichardt, LP.

i (1990) 111,142a.Molecular cloning of the retintegrin alpha.1 subunit: A receptor forIsmwn and coUagen. ASC3 Aker.

Rohack,J.D Downen M., Lee, HJ, Zucker, J.,1.arge, T.H Otten, U. and Wainer, BR (1990) NGF and NGF ruptur

.Ostr. 16,90s. expression in primary reaggregate cultures derived from the embryonne mouse septum. Sne. Namri.

Robeck,J.D Large, T.H., Otten, U. and Walner, B.H. (1989) Expression of NGF mRNA and peotein in the develoging Nppocampus in vitro. Soc. Namaci. A6str.15,364.

Large,T.N Weekamp, G. and Rekhardt, LP. (190s) Structure and developmental expresesan of the NGP ravptur in cNck brain. Soc. Neurosef. Abstr.14,902. i lae, H.J., Hammond, D.N., Large, T.H. and Walner, D.H. (1988) Expression ut NGF by permanent cell lines '

derived from postnatalMppocampus. See.Namef. Aktr.14,368.

Roback, J.D., Watner, BE and large, TE (1968) The expression of NGF protein in the developing Nppm.p s in resagregate culture. Soc. Nrwasci. Abfr.14,305.

Hammand, D.N., Walner, RE, Heller, A., large, T.H. and Ratchardt, LF. (1987) Clonal hybrid ccil lines  ;

derived fium primary Nppocampal cells express nerve growth factor (NGF) mRNA and Prntain. IBRO Akfr. '

Large, T.H, Bodary, S.C., Clegg, D.0, We , G, Otten, U. and Reichardt, LP. (1966) Regulattun of nerve growth factne vnRN A and protein levels in the eloping rat brain. Soc. Neurosci. Abtr.12,587.

j Largw, TE, Rauh,J.J., Cho, N.], Skorupa, A.P. and Klein, W.L (1985) Mr 72,0U0 and Mr 116.000 forms of muscadnic ACh receptors in avian CNS: Shiftin predominant form during development. Soc. Naurund. Abtr.

11,655. l Large, T.H., Rauh, )., and Klein, W.L (1964) Molecular alteration of muscarinic acetylcholine receptors during synaptogenesis. Soc.Neurosef. Abir. 10,1042.

tarse, T.H., Cho, NJ., and luein, W.L (19m) Muscarinic ruponses in avian retina develop prior to togenesis. Soc. NeuroscL Abstr. 9,693.

M.A, large, T.H., and KleirkW.L(1983) Develo binding in the rat olfactory bulb. Soc. Neurosci. Abstr. 9, M9. pment of muscarinic acetykholine receptor Large, T.H., Chin, II., Raithel, D.}., and Klein, W.L (1981) Separation and characteriaation of nicotink receptors using bromoacetylcholine. Soc. Newesel. A6str. 7,497.

Targe, T.H., Siman, R.C., and Klein, W.L (1980) Um o( 3H.bromoacetylcholine to label nkodak acetylcholine receptors from the central nervous system. Soc. Neurosef. A6str. 6,754.

SUPPORT

1) Present:

A) NIH

9) PYO6865 02 " Role of Nerve Grov,th Fwtur in Retinal Development."

C) 12/1/90 11/30/96 (5 years)

D) $500A00 TDC A) NIH (PSA awsed James M. Voef) i D) AG0053$.01 *"Neurotrophin 4: Characesitaation of a Novel Neurotrophk Factor."

C) 7/1/91 6/30/96 (5 years)

D) $375400 TDC '

A) NIH (Pmgram Project, Nathan Berger, PI)

B) 1 P20 CA6017101 " Receptor Targeted Proseln Toxins for Brain Tumor Therapy.' I C) 4/1/93 3/31/96 (3 years)

D) smannToC forsubpmject 1

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i lage, T.R. Boduy, S.C., Gegg, D.0, Wabmp, G.,0ttn, U. ud Rekh gene exprisskin in the developing rat brain. Scicner 234,352 355.

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Large. TR, Cremillion, M.A., and IQeln, W.L (1966) Cholinersk development in t Parallel development nf choline acetyltransfernac and muscarinic acetylcholine 44, 671 680.

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i turnover by histamine and acetylcholine receptors in the N1 66,31 M. .

{ Large, T.H, Rauh, J.J., DeMello, FG. and Klein, W.L 1%$) Two molecular wcight forms acetylcholine of synapses. Proc. Nati. Acad. receptors Sef. IMA 82,in the avian central nervous sy(stem: Switch in pre 4785-8789.

j j targe. TE, Cho, NJ, DeMallo, F.C., and Klein, W.L (1985) Molecular aheretion of a muscarink acetylcholine receptor system duttng synaptopneels. J. blogleal Chemiwy 260, 8873 6881.

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the.= mad.Razia1sas 1 i Reichardt. LF., Bossy, B., Kmmett, E., Lefcort, F., Hall, D.,1gnatius, M., Larp, T., Neugebaue

{ Napohtano, E. aml Tomaselli, K., (1990) Neumnel glycoproteins that regulate axon extens I

Spring Harbor Symposium on Qunnlitativ Biology vol. LV, pp. 341350.

i t Clegg, D.0, Bodary, S.C.,14rse, TR, Shelum, D.L and 1teichardt, LP. (1989) Quantitative m

') nerve and Sons,growth Chichester,factor mRNA England. p. 255 275.in SAO Naneook Scrics. Neruc Growtfi Factors. (Rush, R.A.

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l Ahahneta decreased responsiveness to NT3 e6mulatinn in fibroblasts. Soc Oakley, R.A., Camer, A.S., Large, TR and Frank E. (1996) Target dependant and trkc transcripts in developing sensory neurons. Soc. NeuroscL Almer. 21,.

Oakley, aptnaf gangua. R.A.,

soc.large, NeumectTR and alsk. Frank,ii. (1994) Differential distribution of irkC-poettive sens 20,856.

retinas. Soc. Neumsci. Alwir.19,722.Voct, JE, McKeon. RJ. and Larp, TR (1993) Retr Gamer, A.S. end Large, TR outgrowth from survival. Soc. Naansci. Abstr. 19, 1477.

(1993) Altemate spucing of the trtC ryrosine kinase disenc Johnson, J.E., Wang, S.W. Bovahore, K., Gamer, A.S., Larp, T.H., McKay, S.I. an .

in sffil nybridlaation of frkB in the developing chkk visual system and brain. Soc. 19,1298. Pamud. Abstr.

McKay, S.E., Herzog, KE, Garrwr, A., Tucker, R.P. Oppenheim, R.W. and large,T BDNF 19,516. and trtB during the development of the neuromuscular system in the chick embryo Oukley, neuroru in opinal R.A.,

gangGamer, A.S.,A6Large, 11a. Soc. Neussed. err.19,1300.T.H. and Frank, E. (1993) Differential distribution u McKeen, and after cortkallrqury. R.L $Uver, J. and Abstr.

Soc.Neuroset imege, 19,1477.TX (1993) Identifkation of trkD receptur mRNA in astrocy retina. Soc. Neuroset A8str.18,12u9. Ale, X.-Y,, Garner, A.S., Voci, JX and lary, TR (1992)

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Camer, chkk. A.S. and Soc. Neuronel Large, T.lt (1992) bidance for kinaseless and altamate 5' tenninal fonns o Abetr.18,950.

Voci, Nosoress J.M. and large, TX (1992) Cloning of chick RDNP. Tectal factor and potential altam Abetr.18,615. . .

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\ $$$G OaBey, R.A., Gamer, A.S. brgo, T.H. and Frank. E. (1996) Target depen trkC in the dorwl root gang!!a of the chick embryo. (in prop)

! McKeon, Pr*P)- R., $11ver, J. and Large, T.H. 096) Ranctive astrocyte expreston of full leng i

i Neu.>otrophin bindhg ard transport by sensory and motor e Vuct, J.M., Menegay, HL Xie, X. Y., Johnson,11 and Large, TR (1996) Retruviral delivery o anbryonic eye recum tatset deprived reenal gangilon rans. f. Newwdmes (submitted).

isoforms in the developing evian visual16,system, 1740 1752.

f. NeurosdenceGamer, A.S, V McKay, S.E., Gamer, A., Caldero,I, Tucker, R.P., Large, TE and Oppenheim, R.W. (19 enrpression in the developing neuromuscular syskm ut the chick embryo, 1)codopment 122, 715 724.

Mcnlon, P.D., Garner, AJ.,large,TR and Weston,J.A. (1995) TrkC mediated NT3 sign the early development of a subpopulation of neurogenic neural crest172, cells. Drodopmenfel R 602 413.

Oakley, R.A., Garner A.% iarge, TR and Prank, E. (1995) Neurotrophin4 deprivation selecti the death of serwoty neuruns that supply muscle spirdisa. Dreeformast 121, 1341 1350.

Garner, A.S. and targe, T.H. (1W4) Isofnrms of the avian erkC roccptor: A novel kinase inserti transformation and process out 6 rowth frum survival. Neuron 13,457 472.

Roback, J.D., Diede, S., Downen, M., Lee, H.J., Kwon, J., large, TR, Otten, U. and Walner, B Expression cultures: of neurotrophins and the low-affinity NGP receptor in septal and hippocampa 70,123-133.Local phystobgleal effects of NCF sptheslied in the septal region. Decelopmental #refn Anaeren Barker, P.A., Miller, F.11, Large, TR arwi Murphy, R.A. (1991) Generatlun of the truncated form of receptor by rat $dswann cells: Evidence for prat translational processing. f.266, Biol. CArm.

19113 19119.

Ignatius, M.1.,1.Arge TR, Hotde, M, Tawit, J.W, Barton, A., Esch, F., Carbunetso, S. and Reichardt, L (1990) Molecular cloning of the rat integrin a 1 subunit: '

111, 709 720. A receptor for laminin and collagen, J. Cdl D&gy i

Lee, HJ., t Hammond, D.N., Large, T.H., Roback,1.D., Sim, J.A Bmwn, D.A, Otten, U. and W Neuronal wopertim mice,f.Neurwcience 10. 1779and 1787.trophk activities of immortall:.ed hippucampel cells from embryonic a Lee, H.J., Hammend, D.N, large, TE and Wainer, BE (1990) Immortalized young adult neurons' from th medial septal region:

Generation and characterization. Developmentel 3rsin Research 52, 219 228.

hippocampus leoldted in vitro. Droelopmental 137, 451 455. #fologyRoback,).D., targe, T.H. O large, T.H., Weskamp, G., Helder, J.C., Racieke, M, Misko, T, Shooter, E.M. and Reichardt, L.F. '

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developmental expression of the twrve growth factor receptor in the chickan central nerv Clegg, D.O., large, TR, Dodary, S.C. and Reichardt, L.F. (1989) Regulation of NGF mRNA levels in I developing rat heart ventricle is not altered by sympathectomy. Dvoelopmental 134, 30 37. Biology l

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O BIOGRAPIIICAL SKETCII NAME: Kaung, Hue-lee Cheng EDCATION National Taiwan University, Taipei, Taiwan BS 1962 Zoology University ofIowa, Iowa City, Iowa MS 1964 Zoology University ofIowa, Iowa City, Iowa PhD 1971 Zoology POSTDOCTORAL TRAINING Postdoctoral fellow, USPHS Diabetes Research Training Grant, Department of Anatomy, University ofMinnesota ACADEMIC APPOINTMENTS Assistant Professor, Department of Anatomy, University of Minnesota, 1974-1984 Assistant Professor, Department of Pediatrics, Case Western Reserve University,1984-present Assistant Professor, Joint Appointment, Department of Anatomy, Case Western Reserve University, 1984-present PROFESSIONAL SOCIETY The endocrine society RESEARCH INTEREST Comparative studies of endocrine pancreas in vertebrates Development of endocrine pancreas Pancreatic islet cell line developmem MAJOR TEACIIING EXPERIENCE Lecturer and laboratory instructor, Human IIistology for medical students, Department of Anatomy, University of Minnesota. 1974-1984 Course director, Human Anatomy and Physiology for allied health sciences students, Department of Anatomy, University of Minnesota. 1978-1980 Lecturer and laboratoy instructor, Human Ilistology, Medical student curriculum Phase I and II.

Department of Anatomy, Case Western Reserve University 1984-Present RECENT PUBLICATIONS Vadlamudi S, Hiremagalur BK, Tao L, Kalhan S, Kalaria R Kaung HC and Patel MS 1993 Long-term effects on pancreatic function of feeding a high-carbohydrate formula to rats during the preweaning period. Am. J. of Physiology E565-E571.

Kaung HC 1994 Growth dynamics ofpancreatic islet cellpopulations during fetal and neonatal development of the rat. Dev. Dynamics 200:163-175 Kaung, HC, Xu S, Wang C, Jacobergger J and. Chen W 1996 Rat islet cell lines produced by.

retroviral transduction of SV40 T antigen. In Vitro Cell. Dev. Biol. -Animal 32:197-203.

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OCT 0 31996 W. David Sedwick, Ph.D.

' Radiation Safety Officer Case Western Reserve University Department of Occupational and i

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