ML20127E516

Matls Licensing Package for Amend 1 to License SNM-1995 for Columbia Univ.Control:117138

ML20127E516
Person / Time
Site:	07003074
Issue date:	12/24/1992
From:	Elizabeth Ullrich NRC OFFICE OF INSPECTION & ENFORCEMENT (IE REGION I)
To:
References
117138, NUDOCS 9301190352
Download: ML20127E516 (19)

Text

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A i MATERIALS LICENSE Amendment No. 01 l Purs.uant to the Atomic l nergy Act of 19$4, as amended, the Energy Reorganization Act of 1974 (Public 1.aw 93-4H), and Title 80, W

Code of Federal iteful,itions Ulmpter I, Pans 30,31,32,33,34, M,39,40 arxi 70, and in rehante on statements and representations heretofore p l rnade by the biensee, a hcense is hereby hsued authorizing the htensee to recene, acymre, pou. css, and transfer byproduct, source, and special j%

nuclear material deurtwted below, to uw such material for the purgusefs) and at the place (s) designated below; to deliver or transfer such material j

to persons authorired to receive it in accordarut with the regulations of the apphcable Part(s). Uds licenre shall tv deemed to contain the conditions l i siweified in Sectinn I10 of the Atorr ic Energy Ad of 1954, as arnended, and is subject to all apphcable rules, regulations aral orderi of the Nuclear I Regulatory Cominiuion now or hereafter in effect and to any conditions specified below.

a a beenue in accordance with letter dated  !

August 21, 1992, 2 1 Columbia University 3. ucense number SNM-1995 is amended in  !

its entirety to read as follows: I l  !

l t 289 Engineering Terrace 1 500 West 120th Street <

4.%irition date August 31, 1997 New York, New York 10027 t %n n

l. t? I cket[fy070-03074;

,,en 070-00882

! f,. Byproduct, source. and/or ,V 7, Chemical and/or physical , ' B. Maximum amount that hcensee

_l special nuclear rnaterial o form k , may possess at t.ny one time J , ,

' tinder this license

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1 A. Uranium enriched 1/FUranium AhPlated electrodes in'two A. 2.37 grams 3 235 isotope to less~than '

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a 99.99% Vranium 235< er \_ ,

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0. Uranium enriched ' ..1um 2 8.ifoils f B. 286, grams i 235 isotope to le'ss-than !' > s ie

$ l l 99.99% Vranium 235" 0 u '

_ i i C. Plutonium 239 $3 ^C. Scaled nebtrony sources f' C. Not to exceed 80 grams I, p- o . i L . pef source and 363 grams 1

1. @ 7 ~ S:1 4,,k V. ! ' ' s Stotal 1

D. Plutonium 239 W O d D Plated detector ~ sources D.IO.81 grams i E. Uranium 233 v E. Liquid . .E'.70.035 grams i

A ,, i i l 9. Authorized use ~v

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B. For storage only. '  ;

1 V q C. For use in teaching and training of students; ' calibration of instruments.

i 1 0. For storage only. >N, E. For storage only. 1201,/ u~ e l}

!j COWITTORS

'(j 10. Licensed material may be used only at licensee's facilities at Columbia University i l

) in the City of New York bounded by ll4th Street and 120th Street between Broadway 1 and Amsterdam Avenues, New York, New York, Barnard College bounded by ll6th Street j and 120th Street between Broadway and Riverside Drive, New York, New York, and ,

3 Nevis Cyclotron Laboratory, Irvington, New York. [

1 1 4 11. A. Licensed material shall be used by, or under the supervision of, individuals t 1 designated by the Radiation Safety Committee, David Brenner, Ph.D., Chairman. I I A 4 B. The Radiation Safety Officer for this license is Neil Wothers poon, Ph.D. h

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( #. -. Lkenne numtet h l MATERIALS LICENSE g,, p,g, SjM-1995 lb 4 SUPPLEMENTARY SHEET q 020:030L4 P q >

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t l (Continued) CONDITIONS pl 4

q 12. A.  : Sealed sources and detector cells shall be tested for leakage and/or i contamination at intervals not to exceed 6 months or at such other intervals as .

I are specified by the certificate of registration referred to in 10 CFR 32.210, .

not to exceed 3 years.

l l B. Notwithstanding Paragraph A of this Condition, sealed sources designed to emit h-l alpha particles shall be tested for leakage and/or contamination at intervals not W i to exceed 3 months. E i

In the absence of a-o d C. certifJcat.B R E. m e from a transferor' ,.

indicating that.. test has been l made within six month?jprior to the transfer, id7aled source or vetector cell ly received from anothhfperson shall not be put into Afse until tested. >

d D. Each sealed sour abricated by the licensee shall inspected and tested for

. A construction dqfects, leakage, and contamination-prtor#to any use or transfer as >

4 asealedsourg pf l E. Sealed souredPand deteitd e1s"ne'ed)notIe7$aktested(f: k T M n,3ilor O\U

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2 l (ii) they co6Cain oplha,g'asy ji]{ ]I Jp, f'. p l (iii) the halfftfe [f th so 0 ays o Nss;orY #

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material orTgog.more thin 10picycurMst/of y e

alppa')mitting material;. )[ or l (v) they are not dilijned to emit alpha particleh are in storage, and are not f, q being used. HoweVer,wwhen they are removed from storage for use or. transfer M to another person, andIhave,,not,been t6sted within the required leak test  %

8 interval, they shall be t6sted"befdfe use or transfer. No-sealed source or d

( detector cell shall be stored for a. period of more than 10 years without h 4

being tested for leakage and/or contamination, e

o F. The test shall be capable of detecting the presence of 0.005 microcurie of radioactive material on the test sample. Records of leak test results shall- be

{ kept in units of microcuries and shall- be maintained for inspection by the .

Commission. if the test reveals the presence of 0.005 microcurie or more of' lq removable contamination, a report shall be filed.with the U.S. Nuclear. Regulatory 4 .

Commission and the source shall be removed from service and decontaminated, 4 repaired, or disposed of in accordance with Commission regulations. The report i shall be filed within 5-days of the date the leak test result is.known with the U.S. Nuclear Regulatory Ccmmission, Region I, ATTN: Chief, Nuclear Materials lt q

t Safety Branch, 475 Allendale Road, King of Prussia, Pennsylvania 19406. The q report shalli specify the source involved, the test results, and corrective action pj .-

4 taken.

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l MATERIALS LICENSE 9 ,m gg,j,y, ,MIhlS95 i SUPPLEMEf4TARY SHEET h i 070:0307.L F G h d AmendmenLNn_01 M (12'. continued) CONDITIONS g fd 4

( G. The licensee is authorized to collect leak test samples for analysis by the i licensee. Alternatively, tests for leakage and/or contamination may be performed i by persons specifically licensed by the Commission or an Agreement State to j perform such services.

l 13. Sealed sources or detector cells containing licensed material shall not be opened or i sources removed from source holders or detector cells by the licensee, d '

I 14. The licensee shall conduct a phys [ca58inOntofy]every 6 months to account for all >

sources and/or devices rece,1yed!.ahd possessed under/the license. Records of h l

, inventories shall be maintained for 5 years from the d)te of each inventory, p>

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h 15. The licensee is sexemppkfrom the requirements 24. >

4 of 10 CFR 7)4 >

1. 16. Except as specificaUy provided otherwise in this licensi, the licensee shall conduct h h

l its program in accpydance MtQthe statements, representatio65',' and procedures p y contained in the dohments includiqg any. enclosurehf, listed below. The Nuclear q

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Regulatory Commissf6n's reguhljons) shal]? govern!unless the statements,- p#

l representations and' procedures 1r[ the 1 I more restrictive th'an thesregul'at%ns =dV M,1censee'>s\

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4 in For the U.S. Nuclear Regulatory Commission fE Original Signed By:

4 ~g g( ]ggg By Elizabeth Ullrich gjDate Nuclear Materials Safety Branch 4

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NOV 241992 License No SNM-1995 Docket No. 070-03074 Control No. I17138 Columbia University ATIN: Neil Wotherspoon, Ph.D.

Radiation Safety Officer 289 Engineering Terrace 500 West 120th Street New York, New York 10027

Dear Dr. Wotherspoon:

Please find enclosed an amendment to your NRC Material License.

Please review the enclosed document carefully and be sure that you understand all conditions.

If there are any errors or questions, please notify the Region I Material Licensing Section, (215) 337-5093, so that we can provide appropriate corrections and answers.

Please be advised that you must conduct your program involving licensed radioactive materials in accordance with the conditions of your NRC license, representations made in your license application, and NRC regulations. In particular, please note the items in the enclosed, " Requirements for Materials Licensees."

Since serious consequences to employees and the public can result from failure to comply with NRC requirements, the NRC expects licensees to pay meticulous attention to detail and ,

to achieve the high standard of compliance which the NRC expects of its licensees.

You will be periodically inspected by NRC A fee may be charged for inspections in accordance with 10 CFR Part 170. Failure to conduct your program safely and in accordance with NRC regulations, license conditions, and representations made in your license application and supplemental correspondence with NRC will result in prompt and -

vigorous enforcement action against you. 'ntis could include issuance of a notice of violation, or in case of serious violations, an imposition of a civil penalty or an order suspending, modifying or revoking your license as specified in the General Policy and Procedures for NRC Enforcement Actions,10 CFR Part 2, Appendix C.

OFFICIAL RECORD COPY - G:\WPS\MLTR\LSNM1995 - 11/17/92 ML 10

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O Columbia University We wish you success in operating a safe and effective licensed program.

Sincerely, Original Signed 'By:

Elizabeth Ullrich John D. Kinneman, Chief v Research, Development and Decommissioning Section Division of Radiation Safety _

and Safeguards

Enclosures:

1. A.mendment No. 01

2. Requirements for Materials Licensees

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DRSS:RL DR Weidner/cmm Kir man 11/($/92 11 92 OFFICIAL RECORD COPY - G:\WPS\MLTR\LSNM1995 - 11/17/92

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Columbia University in the City of New York l New Yort N.Y. /0027

- ENWtot#MN TAL HE ALTH ANO SM E i V 744 S W. $Auod 500 west $20iri Street August 21,1992 ,, o 98N g# j9b Ms. Sherri Arredondo US Nuclear Regulatory Commission 475 Allendale Road King of Prussia, PA 19406

Dear Ms. Arredondo:

This is to inform you that effective August 31,1992, Dr. Leon Lidofsky will no longer Chair the Radiation Safety Committee. IIis successor will be Dr. David Brenner. His curriculum vitae is enclosed for your review.

We are, therefore, requesting the appropriate amendment to our license be made, if your have any questions regarding this matter, please feel free to contact me q at 212 854-8749.

Sincerely, RECEIVED DY LFDCB Y[Yrtd I'W /b _O --- -

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Curriculum Vitae 3

D/NID JONATHA11 BRENNER -

Date of Dirth: 9 June 1953 Place of Birth: Liverpool, England Nationality: British Status: Permanent Resident of U.S.A.

Education: 1963-1970 Herchant Taylors' School Crosby, Liverpool, England.

Examinations passed:

GCE A-levels: Mather.atics (grede A), Physics (A)

Chemistry (A), General Studies (A)

GCE S-level: Physics (distinction) 1971-1974 0xford University, St. Ednund Hall reading Physics and Philosophy Awarded Carter Physics Prize, 1974.

Degrees obtained: B.A., M.A. (II-1) 1975-1976 Medical College of St. Bartholomevs Hospital, University of London.

Degree obtained: M.Sc. In Radiation Physics (Distinction) 1976-1979 University of Surrey, Physics Department Degree obtained: Ph.D --

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Thesis Topics Pion Interactions with Light Nuclei and Applications to Radiotherapy.

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l l APPOINTMENTS l 3

1992- Associate Professor, Depttrtment of nadietion Oncology, College of Physicians & Surgeons, Columbia University 1986-92 Assistant Professor, Department of-Radiation Oncology, College of Physicians & Surgeons, Columbia University 1983-86 Associate Research Scientist, Rediological Research Laboratorf, College of Physicians & Surgeons, Columbia University 1981-83 Staff Member, Los Alamos National Laboratory 1979-81 Postdoctoral Fellow, Los Alamos Scientific Laboratory.

AVARDS Vinner, 1992, NCRP Moseley Prize.

Vinner, 1991 Radiation Research Society Annual Research Award P.I. of American Cancer Society Research Grant "On the Problem of High vs Lov Dose Rate for Cervical Carcinoma", 1991-1994.

P.I. of NIH grant " Radon, Bronchial Morphometry and Occupational Health",

1991-1993.

P.I. of NCI Nev Investigator Resecrch Grant 1985-1989:

"Early Effects of Radiation-Induced Radicals" 0xford University Carter Physics Prise, 1974.

HEMBE; SHIPS and COMMITTEES Associate Editor, International Journal of Radiation Biology.

Consultant, ICRP/ICRU Committee on the Quality Factor, 1984-Hember, IAEA Advisory Group on Nuclear and Atomic Data for Radiotherapy and Radiobiology (1985)

Consultant, Los Alamos National Laboratory,1987-Hember, NCI Site Reviev Committees, University of Rochester, 1983, University of Visconsin, 1990; Memorial Sloan-Ketterin.;, 1991. .

Member,-Radiation Research Society Membership Connittee,'Avards Committee Member of Program Committees for 34th and 36th Annucl Meetings of Radiation Research Society, 1986, 1983.

• Member of Program Committee for 9th International Congress of Radiation Research, Toronto, 1991.

! Member of Program Committee for Vorld Space Congress, 1992, r

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9 9 COLUMBIA UNIVERSITY ACTIVITIES Teaching undergraduate course Cl450 Radiation and Life Teacher of annua'lly.

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Columbia University Biology Department, 24 lectures, (jointly with H. Lieberman).

Teacher of graduate ccurse F9321, Current Perspectives on the biological Effects of Radiation - Columbia University School of Fublic Health, 24 hours2.777778e-4 days <br />0.00667 hours <br />3.968254e-5 weeks <br />9.132e-6 months <br />, annually (jcintly with M. Zaider).

Lecturer in Radiobieloov for Eesidents in Radiation Oncology (Columbia-PresbyteriaH W dical CenterJ.

Lecturer in core graduate course P6300 Environmental Sciences --

Columbia University School of Public Health.

Lecturer in graduate course P8308 Molecular Toxicolocy --

Columbia University School of Public Health.

Lecturer in graduate cource F8312 Systemic Toxicolocy_-- Columbia University School of Public Health.

Academic advisor to A. Ong, doctoral student in the School of Public Health.

Other teaching Course Faculty for Annual UCSF (University of California, San Francisco) Radiation Oncology Course: Approaches to Radiation Oncology, Biology and Physics. _

Teacher of Radiation Bioloav for Residents in Radiation Oncology (St. Barnabas Hospital, New Jersey)

Teacher of course scattering Theory, Surrey University, 1978-1979 Columbia University Committeon Member: Columbia University Senate, 1985-1987.

Member, senate Libraries and Computing Committee, 1985-1987.

Member, Columbia University Comprehensive cancer Center Computer Committee.

Co-Chair, Howard Hughes Medical Institute Computing Advisory Committee.

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o- o sylected Invited Conference Talks Workshop on the Interfaco Between Radiation Chemistry and Radiation-Physics (Argonne, 1982)

" Analysis Techniques and Results of Monte-Carlo Simulation of 9toton and Electron Tracks" 31st Radiation Research Scciety Annual Meeting (San Antonio, 1983)

"Looking Inside the Black Box: Monte-Carlo Transport Codes" International Sympesium on Science With Soft X Rays (Brockhaven, 1983)

" Soft X rays revisited" Workshop on Electronic and Ionic Collision Cross Sections Needed in the Modelling of Radiation Interactions with Matter (Argonne, 1983)

"The Transport of Low-Energy Electrons in Water and some Physico-Chemical Implications" IAEA Advisory Meeting on Nuclear and Atomic Data for Radiotherapy and Related Radiobiology (Rijswijk, 1985)

" Cross Sections for Neutron Interactions with Carbon and Oxygen above 14 MeV" Gordon Conference on Radiation Chemistry (New Hampshire, 1986)

" Stochastic Effects in early Radiation Chemistry" 35th Radiation Research Society Annual Meeting (Atlanta, 1987)

"Hard Facts from Soft X rays" International Symposium on X-ray Microscopy (Brookhaven, 1988)

"The Use of Soft X rays to Probe Mechanisms of Radiobiological Science" NATC Advanced Research Workshep: Early Effects of Radiation on DNA (San Miniato, Italy, 1990) _

" Links Between Track Structure Radiochemical Species and Cell ~

Survival" 38th Radiation Research Society Annual Meetino (New Orleans, 1990)

" Death Undor the Floorboards? An Overview of Ehe Radon Problem" Second International Brachytherapy and Remote Afterloading Sy:apo sium (St. Louis, 1990)

"The Application of Radiobiological Principles to Brachytherapy" Ninth American Statistical Association Conference on Radiation and Health (Colorado, 1990)

" Modifying factors in Biological Response: Radiation Quality and Dose Rate" Ninth International Congress on Radiation Research (Toronto, 1991)

" Biological Effects of Highly-Fractionated Effects of Protons in the South-Atlantic Anomaly World Space Congress (Washington DC, 1992)

" Radiations in Space" SO'd L26 t-9126 01 533 CYa dito WOdd 90:ST E66T-EO d35

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" Radon. Risk and Remedy", D. J. Brenner (V. B. Freeman, Nev York, 1989).

PEER-REVIEVED PAPERS

1. Brenner, D. J. and Smith, F. A. Dose and LET Distributions due to Neutrons and Photens Emitted from Stopped Negative Pions. Phys. Med. Biol.

23, 451 465 (1977).

2. Brenner, D. J. and Reading, D. H. A Method for Heasuring Neutron Spectra in a Stopping Pion Field, Nucl. Instr. Meth. 153, 137-144 (1978).

3. Jackson, D. F. and Brenner, D. J. Nuclear Inteiactions for Medical Purposes, Prog. Part. Nucl. Phys. 5, 143-204 (1981).

4. Brenner, D. J. Monte Carlo Self-shielding Corrections for Use with Neutron Spcetrum Unfolding Codes, Nucl. Sci. Eng. 78, 175-177 (1981).

5. Zaider, M., Dicello, J. F., Brenner, D. J., Takai, M., Raju, M. R. and Hovard, J. Microdosimetry of Range-Modulated Beams of Heavy Ions I.

Determination of the Yield of Projectile Fragments from Microdosimetric Spectra for Neon Beams. Radiat. Res. 87, 511-520 (1981).

6. Brenner, D. J., Dicello, J. F. and 2 aider, M. An Interpretation of Some Biological Results Obtained in Range-Modulated Negative Pion Beams, Int.

J. Radiat. Oncol. Biol. Phys. 8, 121-126 (1982).

7. Brenner, D. J. Calculation of Ioni:ation Distributions in a Tissue-Equivalent Cloud Chanber Gas Mixture. Radiat. Res. 89, 194-202 (1982).

8. Zaider, M., Brenner, D. J., Hanson, K. and Minerbo, G. N. An algorithm for determining the proximity distribution from cose-averaged lineal energies. Radiat. Res. 01,95-103 (1982).

9. Zaider, M., Brenner, D. J. and Wilson, V. E. The application of track calculations to radiobiology. I. Monte Carlo simulation of proton tracks. Radiat. Res. 95, 231-247 (1983).

10. Atari, N. , Malik, S. R. , .Brenner, D. J. , Hilko, R. and Bradbury, J. N. A Lyoluminescent tissue-equivalent dosemeter for pion therapy beams. '

Phys. Med. Biol. 28, 493-502 (1983).

11. Brenner, D. J. and Zaider, M. Soft x-rays as a tool to investigate radiation-sensitive sites in cammalian cells. Proc. SPIE 47, 172-179 (1983).

12. Goodhead, D. T. and Brenner, D. J. Estimation of a single physical property of lov LET radiations which correlates with their biological effect. Phys. Med. Biol. 28, L85-492 (1983).

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13. Subramanian. T. S. , Roacro, J. L. , Brady, F. P. , Vatson, J. V. ,

, Fitzgerald, D. H. , Garrett, R. , Needham, G. A. , Ullman, J. L. .

Zanelli, C. I. , Brenner, D. J. and Prael, R. E. Double differential inclusive hydrogen and helium spectra from neutron induced reactions on carbon at 27.4, 39.7, and 60.7 MeV. Phys. Rev. C28, 521 (1983).

14. Brenner, D. J. and Zaider, H. The application of track calculations to radiobiology.-II. Calculations of microdosimetric quantities.

Radiat. Res. 9_8, 14-?)5 (1984).

15. Zaider, M. and Brenner. D. J. The application of track calculations to radiobiology.--III. Analysis of the molecular beam experiment results.

Radiat. Res. 100, 213-221 (1984).

16. Zaider, M. and Brenner, D. J. On the stochastic treatment of fast chemical reactions. Radiat. Res. 13,245-256(1984). _.

17. Brenner, D. J. and Prael, R. E. The C(n,n')3a Cross-Section up to 60 MeV. Nucl. Sci. Eng. 88,97-101 (1984).

18. Brenner, D. J. Neutron ker:ta values above 15 HeV calculated with a nuclear model applicable to light nuclei. Phys. Med. Biol., 29, 437-441 (1984).

19. Brenner, D. J. and Zaider, M. A computationally convenient parameterisation of experimental angular distributions of lov energy electrons elastically scattered off water vapour. Phys. Med. Biol.,

p,443-447(1984).

20. 2 aider, M. and Brenner, D. J. Cocments on 'V79 Survival following simultaneous or sequential irradiatinn by 15-MeV neutrons and Co photons' by Higgins et al. [Radiat. Res. 95, 45-56 (1983)).

Radiat. Res. 99, 438-441 (1984).

21. Zaider, M. and Brenner, D. J. Modification of the theory of dual J-radiation action for attenuated fields.--I. Basic formalism.

Radiat. Res. 90, 484-491 (1984)

22. Brenner, D. J. and Zaider, M. Modification of the theory of dual r adiation action for attenuated fields.--1I. Appplication to the analysis of soft x-ray results. Radiat. Res. 99, 492-501 (1984).

23. Zaider, M. and Brenner, D. J. On the Microdosimetric Definition of Quality Factors. Radiat. Res. 103, 302-316 (1985).

24. Brenner, D. J. and Zaider, M. Stochastic and Deterministic Treatnents of the Time Decay of Species Created by Heavy--Charged Particle Interactions. Radiat. Prot. Dosimetry 13, 127-131 (1985)

25. Hoshi, M., Goodhead, D. T., Brenner, D. J., Bance, D. A., Chmielevski, J. J., Paciotti, M. A. and Bradbury, J. N. Dosimetry Comparison and Characterisation of an Al K Ultrasoft x-ray Beam from an MRC Cold-cathode Source. Phys. Med. Biol., 30,0 1029-1041 (1985)

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26. Zaider, M. and Brenner, D. J. Evaluation of a Specific Quality Function

. for Mutation Induction in Human Fibroblasts. Rad. Prot. Dosim., 15, -

79-82 (1986).

27. Subramanian, T. S. , Romero, J. L. , Brady, F. P. , 'w'a t s on , J. V. ,

Fitzgerald, D. H. , Garrett, R. , Needhat, G. A. , Ullman, J. L .

Zanelli, C. I. , Brenner. D. J. and Prael, R. E. Double Differential Inclusive Hydrogen and Helium Spectra fron Neutron-Induced Reactions at 27.4 39.7, and 60.7 MeV II. Oxy,,en and Nitrogen. Phys.- Rev. C 34, 1580-1586 (1986)

28. brenner, D. J. , Zaider, M. , Coyne, J. J. , Men: el, E. G. and Prael, R. E.

'.'he Evr?.uation of Non-Elastic Neutron Cross-Sections on Carbon above 14 W.' . Nucl. Sci. Eng. M , 311-315 (1987)

29. Brenner, D. J., Bird. R. F., Zaider, M., Goldhagen, P., Kliauga, T. J.

and Rossi, H. H. Inactivation of Synchronized Mancalian Cells with l Lov-Energy X rays-- Results and Significance. Radiat. Res. 110. l 413-427 (1987)

30. Brenner, D. J., Geard, C. R., Zaider, M. and Georgsson, M. A. Cell Survival and Plating Efficiency. Radiat. Res. 111, 572-576 (1987)

31. Brenner, D. J. Concerning the Nature of the Initial Dacage Required for the Production of Radiation-Induced Exchange Aberrations. Int. J.

Radiat. Biol. 3,805-809(1987)

32. Miller, R. C., Brenner, D. J., Ceard, C. R., Kc atsu, K., Marino, S.

A., and Hall, E. J. Oncogenic Transformation by Fractionated Doses of Neutrons. Radiat. Res. 114, 569-598 (1988)

33. Brenner, D. J . On the Probability of Interaction 3etween Elementary Radiation-Induced Chromosomal Injuries. Rad. Environ. Biophys. 27,

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189-199 (1988)

34. Brenner, D. J. Stochastic Calculations of the Fast Decay of the Hydrated Electron in the Presence of Scavengers -- Tests of Model Consistency.

Rad. Phys. Chem. M , 157-162 (1988)

35. Zaider, M., Brenner, D. J., Hall, E. J. and Kliauga, P. J. The link between physics and biology. Am. J. Clin. Oncol. M, 212-219 (1988).

36 Hei, T. K., Chen, D. J., Brenner, D. J. and Hall, E. J. Mutation induction by charged particles of defined 12T. Carcinogenesis 9, 1233-1236 (1988).

37. Brenner, D. J. Precision and Accuracy in Radiotherapy. Radiotherapy &

Oncology M 159-162 (1969)

38. Miller, R. C. , Geard, C. R., Brenner, D. J., Komatsu, K., Marino, S.

A. and Ball, E. J. Heutron-energy-dependent oncogenic transformation of C3H 10T1/2 cells. Radiat. Res. 117, 114-127 (1989)

ents on "kt is Time

39. Brenn'er, D.' J., C to Re n the Question of Thresholds in Radiation Exposure Rosponses" by J. R. Totter (Rad. Res. 114, 1-2 (1988)]. Radiat. Res. M , 172-174, (1988).

40. Brenner, D. J. and Prael, R. E. Calculated differential secor.dary- par t ! cle production cross sections after non-elastic neutron interactions with carbon and oxygen between 10 and 60 MeV. atomic Data Nucl. Data Tables ,4_1,,71-130 (1989)

41. Brenner, D. J., Appropriate uses of the prope.;ed ICRU 40 quality factor, Q(y). J. Radio 1. Prot. 9, 51-52 (1989)

42. Vorgul, B. V. , Merriam, G. R. , Jr. , Medvedovsky, C. and Bronner, D. J.,

Accelerated heavy particles and the lens: III. Cataract enhancement by dose fractionation. Rad. Res. 118 93-100 (1989).

43. Brenner, D. J. and Anols, U.I. Enhanced risk from lov-energy screen-film aammography x rays. Brit. J. Radiol. 62, 910-914 (1989). -

44 Drenner, D. J. The effectiveness of single alpha particles. In Lov Dose Radiation: Eiological Bases of Risk Assessment (Ed. Lancashire, J.) pp 4//-480, l'aylor and Francis, London and Nev York (1989)

45. Hoshi, M. Yokoru, K., Savada, S., Shi:uma, K., !vatani, K., Hasai, H.,

Oka, T., Morishica. H. and Brenner, D. J. Europium-152 activity induced by Hiroshina atomic-boab neutrons: Comparison vith the 32p, 50Co and 152Eu activities in Dosimetry System 1986 (DS86). Health Physics H , 831-837 (1989).

46. Brenner, D. J., Geard, C. R. and Hall, E. J. Mossbauer Cancer Therapy Doubts. Nature 339, 185-186 (1989).

47. Hall, E. J., Brenner, D. J., Hei, T. R. and Miller, R. C. The Microdosimetric link between oncogenic transformation data vith neutrons and with charged particles. Radiat. Prot. Dosim., 31,

~

275-278 (1990).

48. Marchese M.J., Goldhagen, P.E., Zaider, M., Brenner, D.J. and Hall, E. J. The relative biological effectiveness of encapsulated iodine-125 photon radiation in human cells. I. Normal diploid fibroblasts. Int.

J. Radiat. Oncol. Biol. Phys. 18, 1407-1413 (1990).

49. Marino, S. A., Harvey, J. R., Brenner, D. J. and Rossi, H. H.

Measurements of the distribution of the separatiens between paired icas after passing through mylar. Radiat. Prot. Dosim., 31, 77-80 (1990).

50. Brenner, D. J. and Quan, H. Confidence Limits for Lov Induced Frequencies of Oncogenesis in the Presence of a Background. Int. J.

Radiat. Biol., 57, 1031-1046 (1990).

51. Geard, C. R. and Brenner, D. J. Chromosomal changes per cell nucleus per charged particle. Radiat. Prot. Dosim., H , 283-290 (1990).

I 60'd LE6r9tE6 01 53d GSd MMO WOdd 60:st 566t-30-d35

. A y

52. Brenner, D. J. The microdosimetry of radon daughters and its significance. Radiat. Prot. Desim., 31. 399-404 (1990).

53. Brenner, D. J . and Hall, E. J., The Invorse Dose-Rate Effect for Oncogenic Transformation by Neutrons and Charged Particles: A Plausible Interpretation Consistent with Published Data. Int. J. Radiat. Biol

] M , 745-758 (1990).

54. Miller, R.C., Brenner, D. J., Randers-Fehrson, C., Marino, S.A. and Hall. E. J., The Effects of the Temporal Dictribution of Dose on Oncogenic Transformation by Neutrons and Charged Particles of Intermediate LET. Radiat. Res. 124, S62-68 (1990)

Track Structure, Lesion Development and Cell Survival.

] 55. Brenner, Radiat.

D. J.

Res. 124, 529-37 (1990)

56. Brenner, D. J. and Quan, U. Graphs of Confidence Limits for Binonial Proportions - Pearson and Hartley Revisited. The Statistician 39 ~

391-397 (1990).

57. Brenner, D. J, On the use of distributions of stopping pions as an

~}

indicator of the spatial distribution of the high-LET doce in negati_ve pion radiotherapy. Phys. Med. Biol., 35, 1585-1591 (1990).

58. Geard, C.R., Brenner, D. J., Randers-Pehrson, G. and Marino, S.A.,

Single-Particle Irradiation of Mammalian Cells at the Radiological Koscarch Accelerator Facility: Induction of Chromosomal Changes. Nucl.

Instr. Meth. B54, 411 416 (1991).

59. Brenner, D. J. and Hall, E. J., Conditions for the Equivalence of Continuous to Pulsed Lov Dose Rate Brachytherapy. Int. J. Radiat.

Oncol. Biol. Phys. 2_0, 181-190 (1991).

60. Brenner, D. J. The Contribution of Neutrons to the Health Effects at Hiroshima. Health Physics 60, 439-442 (1991).

61. Brenner, D. J. and Hall. E. J. Fractionated high dose rate versus lov dose rate regimens for intracavitary brachytherapy of toe cervix. I.

General considerations based on radiobiology. British Journal of Radiology 64, 133-141 (1991).

62. Brenner, D. J. , Martel, M. K. and Ball, E. J. Fractionated Regimes for stereotactic radiotherapy of recurrent tumors in the brain.

International Journal of Radiation Oncology, Biology, Physics 2_1_,

819-824 (1991).

63. Hall, E. J., Miller, R. C. and Brenner, D. J. Neoplastic transformation 127, and the inverse dose rate effect for neutrons. Radiat. Res.

S75-80 (1991).

Mcdonald,J. C., Pederson, R. A., Brenner, D. J. and Dobson,

64. Straume, T.,

R.L. Biroshima-like neutrons from A-bomb replica: Physical basis for their use in biological experiments. Radiation Pescarch 128, 133-142 (1991).

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65. Brenner, D. J., Medvedovsky, C., Muang, Y., Morriam, G. R., and Vorgul, 3 B. V. Accelerated-heavy particles and the lens VI. RBE studios at lev-

, doses.- Radiat. Res. 128, 73-81 (1991).

66. Hall, E. J. and Brenner, D. J., The Dose-Rate Effect kevisited -

Radiobiological Considerations of Importance in Radiotherapy. Int. J.

Radiat. Oncol. Biol. Phys. 21, 1403-1413 (1991).

67. Brenner, D. J. and Hall, E. J., fractionated High Dose-Rate versus Lov Doce-Rate Regimens for Intracavitary Brachytherapy of the Cervix. II.

Equivalent Regimes for Combined BrachytLnapy and 2xternal Radiation.

Int. J. Radiat. Oncol. Biol. Phys. _ 21, 1415-1423 (1991).

68. Hall, E. J. Astor, M., and Brcr.ner, D. J., Biological Intercomparison of Neutron Bears Used for Radiotherapy Generated by p'->Be in Hospital-Based Cyclotrons. British Journal of Radiology g, 66-71 (1992).

69. Brenner, D. J. Radon - Current Challenges in Cellular Radiobiology.

Int. J. Radiat. Biol, g , 3-13 (1992)

70. Hall, E. J. and Brenner, D. J., The Dose Rate Effect in Interstitial Brachytherapy -

A Controversy Resolved. British Journal of Radiology g,242-247(1992).

71. Brenner, D. J. and Hall, E. J., Radiation-induced _ oncogenic transformation: the interplay betveen dose, dose protraction, and radiation quality. To be Published in Advan. Radiat. Biol. (1992).

72. Brenner, D. J. and Vard, J. F. , Cons traints on Energy Deposition and Target Size of Multiply-Damaged Sites Associated with DNA Double-Strand Breaks. International Journal of Radiation Biology, 61, 737-748 (1992).

73. Hall, E.J. and Brenner, D.J., Needles, Vires and Chips - Advances in Brachytherapy. Clin. Oncol., 4, 249-256 (1992).

7_4 . Brenner, D. J. Dose, volune and tunor-control predictions in radiotherapy. To be Published _ in _ Int. J. Radiat. Oncol. Biol.

Phys.

(1992)

75. Brenner, D. J.

Correlations between a/S and T1/2: implications for clinical biological modelling. To be Published in Brit. J.- Radiol.

(1992).

76. Brenner, D. J., Medvedovsky, C., Euang, Y., and Vorgul, B. V.

Accelerated heavy particles and the lens VIII. Comparison betveen the effects of iron ions (190 key /um) and argon ions (88 kev /um). To be Published in Padiation Research (1992).

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o PAPERS SUBMITTED FOR PUBLICATION

1. Brenner. D. J. The Influence of Cell Killing on Radiation Oncogenesis:

Fossible Implications for High-LET Risk Assessment at Medium Doses.

Submitted to Radiation Research (1992).

2. Brenner, D. J., llall, E. J., Randers-Fehrson, G. and Hiller, R. C. Model Considerations on the Dosc-Rate /LET Dependence of Oncogenic Transformation by Charged Particles. Submitted to Radiation Research (1992).

3. Brenner, D.J. and Sachs, R.K., Generalized Microdositetric Calculations of Cell-to-Cell Variance. Submitten to Radiat. Protec. Dosia.

(1992).

4. Sachs, R.K. and Brenner,D.J., The Production and Variance of Dicentric Chromosomal Aberrations: I. A Possible Role for Long-Lived DNA Double Strand Breaks. Submitted to Int. J. Radiat. Biol. (1992)

5. Brenner, D.J.and Sachs, R.K., Characteristic Molecular " Fingerprints" from Densely-Ionizing Radiation. Submitted to Science (1992).

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rROCEEDINGS AND BOOK CHAPTERS

1. Brenner, D. J. and Jackscn, D. F. A Cluster Approach to Stopped Pion Absorption on Oxygen and Carbon, A.I.P. Conference Proceedings, ~47, 622 ~

(1978).

2. Brenner, D. J. Pion Interactions with Light Nuclei and Applications to Radiotherapy, Rutherford Laboratory Report RL-79-032 (1979).

3. Dicello, J. F., 2 aider, H. and Brenner, D. J. ' Dosimetry of Pions' In Advances in Radiation Protection and Dosimetry in Hedicine, Thomas, ET~B. and~ferez-Mendei, V., Eds., Plenum Press, Nev~ York, (1980),

4. Brenner D. J., Zaider, M., Dicello, J. F. and Bichsel, H. Theoretical Approaches to Energy Deposition in Small Sites. In Proceedings, 7th Synposium on Hierodosimetry, Booz, J., Ebert, H. G. and Hartfiel, H. D., Eds., Commission of the European Communities-(1981).

5. Brenner, D. J., Prael, R. E., Dicello, J. P. and Zaider, H. Improved Calculationc of Energy Deposition fren Fast Neutrons. In, Proceedings, Fourth Symposium on Neutron Dosimetry, Berger, C. and Ebert, H. G,.,

Eds., Commission of the European Communities (1981).

6. Dicello, J. F., Brenner, D. J., Zink, S., Berardo, P. A. and Rosen, I. I. A Method for the Direct Measurement in the Treatment Volume of Neutron Dose from Pion Stars. In, Proceedings, Fourth Symposium on Neutron Dosimetry, Berger, G. and Ebert, H.-G., Eds., Commission of-the European Communities (1981).

7. Dicello, J. F. and Brenner, D. J. Radiation Quality of Beams of Negative Pions, in Pions and Heavy Ion Radiotheracy: Preclinical and Clinical Studies, (L.D. Skarsgard~ed.)~Elsevier Biomedical (1982).

8. Zaider, M and Brenner, D. J. Computational details of the Monte-Carlo simulation of proton and electron tracks. In Proceedings of workshop on the interface between radiation chemistry and radiation physics, Argonne Na tional Laboratory ANL-82-88 (1983).

9. Brenner, D. J. and Zaider, M. The soft x-ray experiment revisited. 'A theoretical analysis. In Froc. of the 8th Symp. on Microdosimetry, Julich, Fed. Rep. of Germany (J. Booz and H. Ebert, eds.), EUR 8395, pp. 639-649 (1983).

- 10. Goodhead, D. T. and Brenner, D. J. The Mechanism of Cadiation Action and the Physical Nature of Biological Lesions. In Proc. of the 8th Symp. on Microdosimetry, Julich, Fed. Rep. of Germany (J. Boot _ and H. Ebert, eds.), EUR 8395 (1983).

11. Brenner D. J. , Zaider, H. and Bradbu ry , J. N. Investigation of mechanisms of radiation action using track structure calculations for heavy ions. In Proc., 7th Int. Congress of Radiation Research (J. J.

Broerse, G.V. Barendsen, H.B. Kal and -A. J. Van der Kogel Eds.),

Martin Nijhoff, p.El-05 (1983).

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, 12. Zaider, M. and Brenner, D. J. Hierodosimetry and Radiation Chemistry.

In Proc., 7th Int. Congress of Radiation Reccarch, (J. J. Broerse, C. V. Barendsen, H. B. Kal, and A. J. Van der Kogel, Eds.), Hartin Nijhoff, p. El-22 (1983).

13. Brenner, D. J. and Eaider, M. Some analysis techniques and results of the Monte-Carlo simulations of proton and electron tracks. In proceedings of Vorkshop on the Interface between Radiation Chemistry and Radiation Physics, Argonne National Laboratory ANL-82-88 (1983).

14. Brenner, D. J. enc Zaider, M. The transport of lov energy electrons in vater and some physico-chetical implications. In Proc. Vorkshop on Electronic and Ionic Collision Cross-Sections Needed in the Modelling of RaClation Interactions eith Matter. Argonne Laboratory Report ANL-84-28 (1984)

15. Brenner, D. J. and Frael, R. E., Non-elastic Cross-Sections for Neutron ,

Interactions vith Carbon and Oxygen above 14 MeV. In ' Nuclear and Atomic Data for Radiotherapy ap Related Radiobiology' (Ed. ~C Ulia~ mo,c to) International Atomic Energy Agency, Vienna (1987).

16. Srenner, D. J., Prael, R. E. and Little, R. C., Neutron charged-particle cross sections and their incorporation into Monte-Carlo neutron transport codes. Los Alamos National Laboratory Report LA-UR-87-3337 (1987).

17. Brenner, D. J. and Geard, C.,R,, The use of roft X rays to probe mechanisms of radiobiological damage. In 'X-ray microscopy II' (Ed, D.

~-

Sayre) Springer-Verlag, Heidelberg (1988).

18. Miller, R. C. , Geard, C. R., Brenner D. J., Komatsu, K.,

Randers-Pehrson, G., Marino, S. A. and Hall, E. J. The effects of I- temporal distribution of dose on neutron-induced oncogenit transformation. In Cell Transformation and Radiation-Induced Cancer.

l Eds., K. B. Chadvick, C. Seymour and B. Barnhart, Hilger Fublishers, pp 357-362 (1989).

19. Brenner, D. J. and Geard, C. R. Links betteen radiation track l

l structure, radiochemical species and cell survival. In The E Jarl l Effects of Radiation on DNA. Eds., E.

H. Fielden and P. O' Nel u ,

Springer Verlag, pp 3T',b~T1991).

20. Hall, E. J. and Brenner, D. J., The Radiobiological Basis of Recent Innovations in-Brachytherapy. Activity 5_, 91-93 (1991).

l

21. - Brenner, D. J. and Ball, E. J., Practionated High Dose Rate -Versus Low Dose Rate Regimens for Brachytherapy of the Cervix: A Non-Mathematical Guide for the Perplexed. -Activity, Supplement 2, 11-14 (1991).

22. Brenner, D. J., Potential cnhanced risk for Space-Station astronauts exposed to highly fractionated doses of fast protons. In Radiation

! Research. A Tventieth-Century Pespective. Vol. II, Eds.,~ V. C.

bevey, M. ~Edington, R.J.M Fry. Academic Press, San Diego, 1992.

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