ML20092C819

Catholic Univ of America Chemical Matls Safety Manual

ML20092C819
Person / Time
Site:	05000077
Issue date:	01/11/1989
From:	CATHOLIC UNIV. OF AMERICA, WASHINGTON, DC
To:
Shared Package
ML20092C810	List: ML20092C808 ML20092C812 ML20092C815 ML20092C819 ML20092C823
References
PROC-890111, NUDOCS 9202120109
Download: ML20092C819 (80)

Text

{{#Wiki_filter:. a

w. a u,,n < cn n.c.. o y o r ame ri e.,

l.icense R-ji p,. c o nim i r, t i on i n y, P l an llocke t h)-77 Appendix H TIIE CNrHOLIC UNIVERSITY OF AMERICA CLLA a = = au: .s, v CHEMICAL MATERIALS SAFETY MANUAL /\\ /%sqy x@o N The Content of this Procedure Mariual Does Not Constitute a Contract 9202120109 920206 PDR ADOCK 05000077 P PDR

t. pir, Eh1ERGl:NCY 'ITLI.PflONC Ntiht!!EltS i,.ar.. o we.,i M,nui Ne i.e S c...., i,e in,. e g

e. n tilEhllCAL hlATI:HI ALS January 11,19M i

_SA)1:1Y h1ANUAL I:htl'HGl:NCY TI:1.El'llONI; NUhllti.l(S i 11Ril/AhlilVLANCE' ............. 9 911 CAht PUS PO LI CE......................... $111 !!NVlltONht ENTAL SAI ETY OITICl!.................................. 6112 STUDENT ilEALTil SERVICE 4 5744 POISON CONT:tOL CENTER..... .................. 625 33 33 RA D I ATI O N S A F ETY................................................... 5?rt. Campus Police must be noeified imme<diately after any call for fire or emergency assist.mcc. EhlERGENCY PROCEDURES FOR CliEh11 CAL SPILLS ARE FOUND IN SECTION 8.17, 11EGINNING ON PAGE 23 OF Tills MANUAL

r - I' Chapt (t ACKNO%1EDGEMENT twe oi 9.ue on unos o m ni he,iuon niinn e, ige page CllEMICAL NIATTR.lAl Si january 11,1989 il SAITTY MAAUAL P ACKNOI.WEDGEMLNT 1 This manual u based on a similar manual which was developed by the University of Delaware's Department of Occupational Her th and Safety. It bas been edited to reflect the differences betweet. the two universities and the procedures which have been adap'ed by each. We wish to give credit to the liniversity of Delaware for the work that has gone imo tL' manual. We wish to give our { appicciation to the George Washington University, Office of Safety a.d Security, for providing an automated version of this manual, ar{ 80 thank tF- ' ministrations of both institutions for giving us permission to adapt it at The Catholic tJniversity oi. nerica. 4 K - i me*N _M Au v

'4 mg C UA s*= "o"cv them n,uew mns o.at w %,n a i% r.ve r qe CllDilCAL M ATERIALS January 11,1989 iii SAFETY ',' ANUAL SAFETY POLICY The policy of the University is to provide the University community with a safe and healthful work environment. Serious attempts will be made to mitdmite recognizable hazards. It is the intent of the University to comply with all occupational helh, safety, and fire regulations and recommended practices. The University Safety Maiaal contains general safety information fm University employees, faculty and students. More specific safety information is contained in the following manuals: Laboratory Safety; Radiation Safety; 13ichazard Safety; and in this Chemical Materials Safety Manual. Other safety manuals cu y be published to proside safety information. Each of these manuals should be issued to, used and referred to by employees, facuhy and students whose work is related to any of these safety areas. The implementation of this policy is the responsibility of the managerial and supenisory staff Vice Presidents, Deans, Directors, Chairpersons, heads of offices, laboratory supenisors and other supenisory personnel will be held accountable for the health and safety of employeca engaged in actisities under their supenision. Supervisors must insist that employees comply wth health and safety rules and work in a safe and considerate manner. Fostering a positive attitude towards heahh and safety shall be the responsibility of the supenisory staff. Employees and faculty must understand their responsibility is to comply with health and safety iules issued by the University, their departments and their supenisors. Employees and faculty are encouraged to report all unsafe conditions to their supenisors. As a member of the University community, you have a Right-To.Know about the hazardous materials that you may work with on the j% or in a laboratory. This right is a matter of federal law. Under regulations promulga:cd by the f. cral Occupational Safety and Health Administration you are required to be trained in: The University's written Hazard Communication Plan. How to access information about the hazardous materials that you may be using at any time during the day or r.ight. What to do in the case of a hazardous material spill or accidental release. How to protect yourself from personaliniury while using hazardous materials. The Office of Environmental Safety has responsibility for assurir.g compliance with this policy. The Office of Emironmental Safety is staffed by the Director of Emironmental Safety and a Hazardous Material Speciahst. The Emirenmental Safety Office also functions in an adsisory and consultative capacity prosiding a wide variety of iccupational health and safety senices. Supenisors should seek immediate assis'ance from the Environmental Safety Office if an occupational health or safety problem, or an emironmental safety incident is experienced.

cumer g TAllLE OF CONTIWTS ~. - ~ ~. -_ n CllEMICAL M ATERI ALS January 11,1989 iv SAFETY MANUAL TAllLE Ol' CONTENTS EMERGENCY TELEPHONE NUMBERS. i A CKN OWLE D G EM ENT....................... il S A FETY P O LI CY........................................ iii 8.1 HAZARD COMMUNICATION STANDARD.. I 8.1.1 Background of the lla7ard Communication Standard 1 3 8.1.2 Requiremems of the Hazar ! Communication Standard... 1 I 8.1.3 Implementation of the Hazard Communication Standard at CUA 2 8.2 F.DUCATION PROGRAMS .4 8.2 IIAZARDOUS CHEMICALS ............ 5 8,4 LABELS .6 8.5 MATERIAL SAFETY DATA SilEETS.. .....,,....... 7 8.6 HANDLING CHEMICALS. ...... 8 8.7 P E RSO NAL PR OTECI'lO N............................................ 9 8.7.1 Protection Against inhalation Hazards.........,....................... 9 8.7.2 Protection of Skin and Body...... 10 8.8 CHEMICA L STO RAG E............................... 12 8.9 CHEMICAL STABILITY............................. 13 8.10 INCOMPATI.I E CIIEMICALS.... 14 8.11 SHOCK. SENSITIVE CHEMICALS................... 16 8.12 S O LVENTS................................................... 18 8.13 COMPRESSED GASES. 19 8.14 RADIOACDVE MATERIAL..... 20 8.15 RESTRICTED AREAS................... 21 8.16 WASTE DISPOSAL...... 22 8.17 CHEMICAL SPILLS........ 23 8.17.1 Low Hazard Material Spills...... 23 8.17.2 Volatile, Flammable or Toxic Material Spills 24 8.17.3 Acid / Base 5 pills 24 8.17.4 Mercury Spills........ 24

o o..ym CLA '^" " orc " = 's Dee of hwe of Manu.al Date of RcEn of thn Pap Pege CilEMICAL M ATERIALS January 11,1989 January 30,1991 y SAFE'lY MANUAL l 8.17.5 Alkali M e tal Spills.............................................. 25 1 8.17.6 White Phosphorus............................ 25 8.18 INJ U R Y AND ILLNESS................................. 26 4 8.19 PERSONAL CONTAMINATION.................................., 27 8.19.1 Chemicals Spilled Over a Large Area of the Body......................... 27 8.19.2 Chemicals on the Skin in Small Areas...............,......... 27 8.193 Ch :micals in t he Eycs.......................................... 13 8.19.4 S m ok e a nd Fum es.................................................. 23 8.19.5 Burning Chemicals on Clot hing............,,...................,...,,. 28 8.19.6 Ingestion of llazardous Chemicals.,.........,.......,....,,.,,...... 23 8.20 M I N O R FI R ST-AI D.......................................... 30 831 FIRE AND FIRE.RELATED EMERGENCIES............................. 31 8.22 TOXICO LOGY O VERVIEW........................................... 32 8.22.1 Che mical Toxicity.............................................. 32 8.22.2 Dose. Response Relationships........... 32 8223 Routes of Entry into the Body....................................... 32 8.22.4 Types of Effects............................................. 32 8.22.5 Other Factors Affecting Toxicity...,,............................... 33 8.23 CLASSIFICATION OF TOXIC MATERIALS............................. 34 8.23.1 Physical Classifications...........................................,.. 34 8 23.2 Physiological Classilications......................................... 34 8.24 TARGET ORGAN EFFECTS........................................... 37 8.25 HYGIENIC STANDARDS............................................. 39 826 THE MSDS - SECTION DY SECTION..................................... 40 827 SAMPLE MATERIAL SAFETY DATA SHELT (MSDS).,... .................43 8.2S EXCEPTIONS TO Tile HAZARD COMMUNICATION STANCARD............. 45 8.29 NOTICES TO EM PLOYEES...................................... 46 830 EMPl OYEE RIG HTS................................................. 4 7 831 WORKPLACE CHEMICAL LISTS.,...................................,. 48 ' 832 CHEMICAL H YGIENE PROG RAM....................,................. 49 832.1 Background of the OSHA Regulation on Occupational Exposure to Hazardoas Chemicals in Laboratories 49 832.2 Requirements of the OSHA Regulation on Occupational Expmure to Hazardous Chemicals in Laboratories............ 19 50 833 EXPOSURE REDUCTION... 833.1 Environmental Monitoring. 50

l over { TABLE OF CONTENT 3 Date of bsue of Manual Date of kemon of th bge bge CIIEMICAL MATERIALS January 11,1989 January 30,1991 vi SAFETY MANUAL 833.2 Inspections, Maintenance, and liousekeeping............................. 50 8333 Protective Apparel and Equipment 50 83 3.4 Signs a n d Labe ls................................................ 51 833.5 A ccide nts and Spills............................................... 51 8 34 VENTIl ATI O N....................................................... 52 834.1 General Laboratory Ventilation.......................... 52 834.2 Che mical Fume Hoods................................... 52 8343 Other local Ventilation Devices...................................... 52 834.4 Glove Boxes and Special Ventilation Areas........................... 52 834.5 M odifica t io ns............................................. 53 834.6 New I nst allations................................... 53 834.7 Pe rform a nce........................ 53 4 834.8 Evaluation................................................. 53 835 EMPLOYEE INFORMATION AND TRAINING PROGRAM... 54 836 REVIEW OF LABORATORY ACTIVirlES................................ 55 837 MEDICAL P ROG RAM............................... 56 837.1 Conditions Obliging Medical Attention 56 837.2 Information Provided to the Physician,................. 56 8373 Physician's Written Opinion................................. 56 8 37.4 First Aid.........................,......................... 37 83S CHEMICAL HYGIENE ~ RESPONSIBILITIES................ 58 838.1 Executive Vice President........................................ 53 838.2 Department Head / Building Administrator.........................,..... SS 8383 Laboratory Supervisor /Research Scientist 59 838.4 Laboratory Worker................................................ 59 838.5 Chemical Hygiene Offi er.............,.................. 59 839 BASIC RULES AND PROCEDURES FOR WORKING WITH CHEMICALS........ 61 8 3 9.1 G e n e r al R ules......,...................................... 61 839.2 Working with Allergens and Embryotoxins...................... 64 8393 Working with Chemicals of Moderate Chronic or High Acute Toxicity.,... 64 839.5 Animal Work with Chemicals of liigh Chronic Toxicity..... 67 8.40 G LOSSAR Y................................. 69 8.41 REFER ENCES............................ .......................76 APPENDIX A - OSHA SUBPART Z... . A.1

1 i ihJPNI g 8.1 IIAZARD COhlh1UNICATION STANDARD pm on awe or sim.a oaw ni u n.on ni inn e.,g esg CllEhtlCAL 51ATERIAl.S January 11,1989 1 i SAFETY AlANUAL 8.1 IIAZ.ARD COhth1UNICATION STANDARD 8.1.1 Background ollhe linnd Communication Standard The Federal Occupational Safety and Heahh Administration (OSHA) adopted a llazard Communication Standard (HCS) in 1935 which was aimed at reducing hazardous materials injuries in the workplace. This Standard, commonly referred to as the Right To Know law, initially applied to industries in the msnufacturing sector only. Subsequent to this rulemaking, severallabor unions pres 3ed OSHA to extend the HCS to the remaining workers in the United States. hiaking their rase before a Federal Appeals Court in 1987, the court ordered OSHA to take immediate steps to extend the llCS throughout the remaining workplaces in the United States. All employers outside of the manufacturing sector that are subject to regulation by OSilA are responsible for meeting this strict performance standard. The Catholic Universilj of America WUA) was one of the institutions which came under the umbrella of this Standard. The HCS was implemented hiay 23,1988. In addition to the regulations promulgated by OSHA, the huperfund Amendments and Reauthorization Act of 1986 (SARA) became bw in 19S7. Title ill of this Act describes each local community's Right To-Know about the hazards invohing materials located within that community's jurisdiction. SARA specifically mandates that emptopts who are required to maintain hiaterial Safety Data Sheets (htSDSs) to comply with OSHNr rules must ulto provide cophs of the h1SDSs (or an inventory of maydals regning h1SDSs) to the local community for use by emergency personnel. 8.1.2 Brguirements of the Harar:1 Communication Standard Each employee must be made aware that Federal Law mandates that he or she is entitled to know of the hazards which exist in the workplace; Employers must inventory and evaluate materials used in the workplace to determine whether or not they fall within the scope of the HCS; hiaterials are deemed to be hazardous if they are specifically named in the Federal Regulations, have a Threshold Lin.it Value assigned by the American Conference of Governmental Industrial Hygienists (ACGlH), have been named by the National Toxicology Program or the International Agency for Research on Cancer as a carcinogen, or if they meet the specific laboratory standards for flammab!cs, corroswes, toxins, and irritants defined j. in the Federal Regulations (sce OSHA Subpart Z, Appendix A of this manual); Each material deemed hazardous must be labeled to identify it and the label must also indicate how the material is harmful to a person should he or she be exposed to it without proper protection; Employers must obtain or produce an htSDS for each hazardous material used at the workplace, The h1SDS must identify the product, explain its nature and the hazards involved in its use, the recautions to be taken for its safe use, and the procedures required in the case of inadvertent contact with the material or accidental release from ils container; The htSDS must be available at all times for use by employees who may be exposed to the hazardous material during the course of their employment. Employees must know how to interpret the technicallanguage used to describe the material and fully understand what to do if they are accidentally exposed to it; and,

L hapter 4 8,1 HAZARD COMMUNICATION STANDARD oee a i,we a mns oee a urin mn,a inn r y rare CllEMICAL MATERIALS January 11,1989 2 SAFETY M ANUAL Each employer is required to develop and conduct a training program to achieve the objectives of the Standard. Implicit in this requirement is the need to fully document and maintain a record of such training activities. 8.1.2 Imrilementation offhe Ha7ard CommuniciLion Stadard at CUA

8. L3.1 Each department head at the University:

is responsible to know if the materials in use in his or her department fall within the scope of the federal Hazard Communication Standard; is responsible for insuring that emergency phone numbers are posted in each area wheie employees handle hazardous chemicals and in the office of each supervisor whose section employees handle hazardous chemicals; thall cause a semi-annualinventory of hazardous materials used within the department to be taken prior to the start of the fall and spring semesters; shall Ssure that all hazardous material storage containers are labeled to show their conte 1ts, the nature of the hazard represented, and the anticipated results of unpri tected contact with the material; shall maia:a a wrrent file of the copics of the Material Data Safety Sheets in each room or laboratory n which hazardous materials are used or stored and send the originals to the Hazarde'as Material Specialist; shall forward a copy of the. semi. annual inventory to the Hazardous Material Specialist; shall insure that all employees under his or her supervision are trained in the requirements ol'the Hazard Communication Standard; and, shall maintain a record of this training in the department's files and notation of each individual receiving the training will be maintained in the department's personnel records. Departmental training records shall, at a minimum, indicate: the date the training was conducted; + the name of the person conducting the training; + the name(s) of the person (s) trained with their signature (s); and, + an outline of the training syllabus followed. + 8,1.3.2 Each research scientist: shall insure that all research empk.yees who are associated with his/her research efforts are familiar with the Hazard Communication Standard and laboratory safety procedures as detailed above for department heads; shall post appropriate Safety instructions and phone numbers in the laboratory,

own { 8.1 IIAZARD COMMl]NICATION STANDARD =,,, use ia n,ue in wnue t w oi k a nn ni um is u Ng CllEMICAL MATERIALS January 11,1989 3 sal'ETY MANUAL shall insure that proper safety equipment is on hand; and, shallinform the llaeardous Material Specialist of the acquisition of any hazardous materials obtained by standing orders, donations, and other methods not specifically coordin>ted through the Purchasing Department. 8.1.3.3 The Purchasing Department: shall advise the Hazardous Material Specialist whenever chemicals are purchased by departments and provide an inventory list of chemicals ordered; and, shall forward to the llazardous Material Specialist all MSDSs received by the Purchasing Department from manufacturers and suppliers for hazardous materials ordered by University departments. 8.1.3.4 The Hazardous Material Specialist: shall assist department heads in meeting the requirements of the llazard Communication Standard by: maintaining currency with the Standard and advising department heads of changes affecting them and the way in which they carry out their responsibilities; 1 prosiding each department, where haza dous materials are used or stored with a + suitable means for prominently displaying Material Safety Data Sheets for hazardous materials used at the University; prmiding copies of Material Data Safety Sheets to department heads to allow the departments to update their MSDS files as changes in inventories of hazardous materials warrant; determining which of their materials fall within the scope of the Hazard Communication Standard when requested to do so; maintaining audio-visual and written training materials that can be made available + to departments up(m request; providing training to department heads in the reqairements of the Standard and assisting department heads in meeting their training responsibilities when requested to do so; maintaining a supply of materials such as label forms which can be made available to department heads upon request; and, establishing and distributing the appropriate ph.cedures for the disposal of hazardous waste.

I* ucci { 8.2 EDUCATION PROGRASIS n j oa.< oi hsu vi m.at pee ei un uum or inm r.g care CilEMICAL M ATERIA!Ji january 11,19S9 4 SAFETY M ANUAL f S.2 EDUCATION PROGRAMS The University must provide an education and training program for employees using or handling chemicals. Additionalinstruction is required whenever the potential for exposure to hazardous chemicals is altered or whenever new information concerning a chemical is recelved. New or newly assigned employees must be provided training before working with or in a work area containing hazardous chemicals. Training programs shall include, as appropriate, the following: interpreting labels and MSDSs locatic. u '.idous chemicals acute and chronic effects of chemicals where the University's Hazard Communication Plan is kept a where htSDSs are kept safe chemical handling procedures a persons' protective equipment first aid a clean up procedures waste dtsposal procedures In the event a large variety of huardous chemicals is stored or in use, the University may substitute generic training for chemical. specific training. The contents of this manual meet,in part, the generic training requirements. Supenisors shall provide additional training as necessary. The University is required to keep a record of training sessions p ovided to ernployees. You may be required to sign a ledger verifying your attendance at a training session. If you do not understand the material r *ded or discussed la this manual, contact your supervisor or the Environmental Safety b, 2. 4

charner = F 3 IIAZARDOUS CIIEMICAlli >.o i6"iha, ou okcm.n4oin,, % CllEMICAL MATERIALS January 11,1989 5 sal'E1Y MANUAL 8.3 ilAZARDOUS CilEMICALS i The OSHA liar.ard Communication Standard defines a bazardous chemical as any element, chemical compound or ruixture of elements and/or compounds whic.h is a p! ysical hua -I or a i beahh hazard. The Standard applies to all hazardous che icals regardless of quantity. m A chemical is a nk,yscal hard if there is statistically significant esidence that it is a combustible liquid, a compressed gas, an explosive, a flarnmable, an organic peroxide, an oxidizer, a pyrophoric compound, an tmstable material (reactive) or water reactive substance. A chemical is a hgahh,1utrud if there is statistically significant esidence based on at least one study conducted in accordancc with established scientific principles that neute or chronic health effects may occur in exposed empicyces. locluded are: carcinogens irritants + reproductive toxins corrosives sensi izers radioactive material t neurotoxins hepatotoxins neplu otoxins + bichazards teratogens hematopoietic system agents e A chemical is considered a careirveen or potential carcinocen if it is listed in any of the following: National Toxicology Program, Annaal Remttpf,Carcinotetu (latest edition) International Agency for Research on Cancer, Monocraphs (latest edition) ,C;grinocens in thdygriJltg A chemical is considered haLEdnus if it is listed in any of the following OSHA Regulations,29 CFR Pstt 1910, Subpart Z, Toxic and lla7ardous Substances

• Threshnld Limit Values for Chemig;tljabstances and Physical Avenis in th.; Wori limironment. American Conference of Governmental Industrial flygienists (ACGlH) (latest edition)

In most cases, the label will indicate if the chemicalis harardous. Look for Ley words like caution, hazardnos. to31g, d;weerom, corrosive. Et.utti, garcinocen. etc. i If you are not sure a chemical you are using is hazardous, review the MSDS or contact your supervisor or the Environmental Safety Office.

~ c n+c, CUA " '^" tue w i,..uc oi sCnua; um..i kn i-n u om es,e me CilEMICAL AIATTRIAL.S January 11,1989 6 .SA.f f.TY MANUAL 8.t LABELS A labelis any written, printed, or graphic material displayed on or affixed to containers of hazardous chemicals. Existing labels on new containers of hazardous chemicals or containers in storage shat! not be removed or defaced. Employees are not required to work with a hazardous chemical from an untabeled container except for a portable container intended for the immediate use by the employee who performs the transfer. However, hazard information may not be withheld. Labels or other forms of ha ard warnings, such as tags or placards, preside immediate warning of potential danger. They may be used to warn of a variety of potential physical hazards or health hazards. In addition to the hazard information on the label, m inufacturers of hazardous materials are required to generate a MSDS. Read carefully all of the information on the label. If you Jo not unders.tand something, contact your supenisor for an explarmtion or request t::e MSDS. j Labels must contain the following information-contents of the container name and address of the manufacturer physical and health hazards recommended personal protective equipment

( napin

== 8.5 blATERIAL sal'EW DATA SilEETS 1 Iw oi nsu o, sonu.a tw oi keum.n oi ii.., e.,pc eace CilEhtl CAL htATEkl ALS January ll,1989 7 sal'ETY htANUAL 8.5 MAYERIAL sal'ETY DATA Sif EETS A Material Safety Data Sheet (MSDS) is a document containing chemical hazard and safe handling information and is prepared in accordance with the OSilA liarard Communication Standard. 1 Chemical manufacturert, and distributort, must prmide purchasers of hazardous chemicals with the appropriate MSDS for each hazardous chernicai purchased. If an MSDS was not prmided with the shipment of a hazardous chemical, the University must request one in writing from the manufactt.rcr or distributor in a timely manner. The University rnust assure the MSDSs on file are current. 1 Upon request, the University must mal.: MSDSs available to employees or designated representatives. Every laboratory and chemical storeroom on campus is being provided with the MSDSs for all chemicals known to be there by the Environmental Safety Office staff. The MSDSs are filed alphabetically in a clearly identified vinyl binder in each room. The Emironmental Safety Office,is the central repository for MSDSs on campus. If you find that a MSDS is missing from the vinyl binder in your laboratory or work area, contact your supervisor or call the Emironmental Safety Office. l l

Charder 11.6 IIANDLING CllEMICALS ou ne n,uc w mna on ne ueuu.m oi i% e;g esg CilEhllCAL MATERIALS January 11,1989 8 SAFETT MANUAL S6 HANDLING CilEMICALS Carefully read the label brfnt.g using a chemical. The MSDS will prmide any special handling information. Do not work alone in the laboratory. i Use required personal protective equipment. Label all containers with appropriate hazard information. Keep your hands and face clean. Wash thoroughly with soap and water after handling any chemical. Avoid direct contact with any chemical, j Keep chemicals off your hands, face and clothing, including shoes. i Never smell, inhale, or taste any chemical. Smoking, drinking, eating and the application of cosmetics is forbidden in areas where hazardous chemicals are in use. Do not dispense more of a hazardous chemical then is needed for immediate use. Always use chemicals with adequate ventilation or in a chemical fume hood, biological safety cabinet, or in a glove box, as appropriate. Refer to the MSDS. Use hazardous chemicals only as directed or for their mtended purpose. Inspect equipment or apparatus for damage before adding a hazardous chemical. Do not use damaged equipment. Never use mouth suction to fill a pipet. Use a pipet bulb or other filling device. Electrically grour.J and bond containers using approved methods before transferring or dispensing a flammable liquid from a large container. In the case of cleaning solvents, use them at the strength specified by the manufacturer. Far specific information regarding chemical handling, contact your superssor or the Emironmental Safety Office.

ower 8.7 l'ERSONAL PROTLCTION ou on 8,ue i.i mnuai noe ne ke-n ei i,m Page este CilEMICAL MATERIA 11s January 11,1999 9 S Al'ETY MANUAL 8.7 PERSONAL. PROTECTION Personal protective desices are to be used only where engineering and administrative conttels cannot be used or made adequate, or while controls are being implemented. Engineering and administrative controh to reduce or climmate exposures to hazardous chemicah include: Subetitution of r, less hazardous substance Sybstitution of less hazardous ec,uipment or process (e.g., sa ety cans for glass bottles) Isolation of operator or the process Local and general mntibtion (e.g., use of fume hood) Hazard education Job rotatian The MSDS will list the personal protective equipment recommended for use with the chemical. The MSDS addresses ' worst case" conditions. Therefore, all the equipment shown may not be necessary for a specific job. Your supervisor or the Environmental Safety Of6ce will determine which personal protecthe desices are required for each task. However, use common sense; there is no harm in being overprotected. Departments mcst provide personal protective equipment to ernployees. Check the MSDS for special ventilation requirements, such as: Use with adequate ventilation Use in a fume hcul

• Avoid inhalation of vapors Provide local ventilation Ventilation recommendations must be adapted to the workplace and the sp2cific process.

8.7.1 Protection Against inhalation Harqd3 Respirators are designed to protect only against certain speci6c types of substances and in certain concentration ranges, depending on the type of equipment used. Respirator selection is based on the hazard and the protection factors required. Types of respiratory protective equipment include: particle-remosing air purifying respirators

cncer { 8.7 PERSONAL PROTECTION

=

Er a Noe m mna vac s acomon ni inn eage e,pc CllEMICAL M ATERI ALS January 11,1989 10 SAFETY MANUAL gas and vapor removing air purifying trspirators atmosphere supplying respirators You should familiarize yourself with the limitations of each type of respiratory protective equipment used and the signals for respirator failure (odor breakthrough, filter clogging, etc.). Respirators are not to be used except in conjunction with a complete respiratory protection program. If your work requires the use of a respirator, you will receive special training from youi supenisor or the Emironmental Safety Office. Do not use respiratory protective equipment until you have received proper training. S.7.2 ErpJrnian of Skin and liody Skin and body protection involves protective clothing and includes protection of various parts of the whole body either completely or partially a may be required. Eye and face injurias arc prevented by the use of the following: safety glasses with side shields for dust and flying object protection chemical splash goggles for chemical splash, spray and mist protection face and neck shields for head and neck protection from Sarious hazards (must be used with safety glasses or goggles) Lab coats, coveralls, aprons or protective suits shall be utilized where there is immediate danger to the skin from contact with a hazardous chemical, and where it is undesirable to have the employee attired in street clothes. General categories of contaminants include: dirt and grease toxic dust !ab chemicals radioactive materials bacteriological agents + Protective garments are not to leave the workplace. For heavily centcmmated work, special attention must be given to sealing all openings in the clothing. Tape can be used for this purpose. Caps should be worn to protect hair from contamination. Exposure to 3:rong acids, acid gases, organic chemicals, oxidizing agents, radioactive material, etiological agents, carcinogens, and mutagens requires the use of protective equipment that

~ charner n 8.7 PERSONAL PROTECTION om niawe,e m ui taenikesmonorinne,g esu CIIEhllCAL 51ATERIAlli january 11,1999 11 SAFETY h1ANUAL prevents skin contamination. Impervious protective equipment must be used. Examples include: rubber gloves a rubberized suits rubber boots special protective equ'pment Protective garments are not equally effectise for every hazardous chemical. Some chemicals will" break through" the garment in a very short time. Therefore, garment selection is based on the specific chemical utilized. General selection criteria are as follows: Chemical Vinyl Rubber Syn. Natural Besistance Ecorrene flagiq Lqin EiLrik Jain };,tn akohols E E G E E G caustics E E E E E E chlorinated sokents G F NR E G NR ketones G NR G G G G petroleum selvents C G F S E F organic acids E E E E E E inorganic acids E E E E E E non. chlorinated solvents G F NR G G NR insecticides E E F S E F inks E E F S E F formaldehyde E E E S S E acrylonitrile E G E S E E hydraulic fluid E E F S E F carbon disulfide NR F G G NR G paint remover F F NR E F NR S - Superior E - Excellent G Good F - Fair NR - Not Recommended Determine what chemicals are to be used, then contact your supervisor or the Environmental Safety Office for information regarding chemical protective clothing.

e 4 t h.ipter

== 8.8 CllEMICAL STORAGE o.u o, issu os mna i vee ni un m,..o oi on, Ng Ng CilEMICAL MATERIAIS January 11,1989 12 S AFETY M ANUAL 8.8 CHEMICAL STORAGE Carefully read the label before storing a ha7ardous chemical. The MSDS will proside any special storage information and incompatibilities. Label the chemical with the date when received. Chemicals should not always be stored in alphabetical order, Do not store incompatible chemicals in close proximity to each other. Separate hazardous chemicals in storage as fallows: 1 Sn@h: oxid' ers flammable solids e n + water reactive others + + Liquids: acids caustics + oxidize:4 perchloric acid + flammables/ combustibles Gaws toxic flammable + cxidizers and inert + Once separated into hazard classes, chemicals may be stored alphabetically. Use approved storage containers and safety cans for flammable liquids. Use spill trays under containers of strong reagents. Dispose of old chemicals promptly. See waste disposal section of this pamphlet. Do not store liquids above eye level. Assure that all containcts are properly labeled. For more information on chemical storage, contact your supenisor or the Environmental Safety Office.

( n piu { 8,9 CllEMICAL STAllll.lTY ou in su.c.a wnua ou.a weumon ci inn eag eg CllEMICAL MATERI ALS January 11,1989 13 S AITIY MANUAL 8,9 CllEMICAL STAllit.lTY Stability refers to the susceptibility of the chemical to dangerous decomposition. Ethers, liquid parafGns, and olenns form peroxides on exposure to air and light, Since these chernicals are packaged in an air atmosphere, peroxides can form even though the containers have not been opened. Unless an innibitor was added by the manufacturer, closed containers of ethers should be discarded after one (1) year. Open containers of ethers should be dir. carded within six (6) months of opening. The label and MSDS will indicate if a chemicalis unstable, The following are examples of materials which may form explosive peroxides: acetal cvcichexene ( decahydrouaphthalene butadiyne l dicyclopentadiene diethyl ether dictbylene glycol dimethyl ether dioxane divinyl acetylenc a glycodimethyl ether tnrahydronaphthalene I isopropyl ether methyl acetylene sodium amide tetrahydrofuran a vinylidene chloride vinyl ethers a For additional information on chemical stability, contact your supenisor er the Environmental Safety Office. I t

~ ( Nrin ~ m 8.10 INCOMPATillLE CllEMICALS o.u m 1,,e m mnaa twe io m *n a mn eye eye CllEMICAL MATERIALS January 11,1989 14 SAFETY M ANUAL i 8.10 INCOMPATIBLE CFIEMICALS Certain hazardous chemicals cannot be safely mixed or stored with other chemicals because a severe reaction can take place or an extremely toxic reactive product can result. The label and MSDS will centain information on incompatibilities. The following is a table contaiub ca.amples of incompatible chemicals: Chemical Ettp Out of ContEc1}Vitb acetic acid chromic acid, nitric acid, hydroxide compounds, perchloric acid, peroxides, permanganates acetylene chlorine, bromine, copper, Duorine, siher, mercury alkali meuls water, carbon tetrachloride or other chlorinated hydrocarbons, carbon dioxide, the halogens ammonia, anhydrous mercury, chlorine, calcium hypochlorite, iodine, $romine, hydronuoric acid ammonium nitrate acids, metal powders, Dammable liquids, chlorates, nitrites, sulfur, - finely dhided organic or combustible meterials aniline nitric acid, hydrogen peroxide bromine same as chlorine \\ carbon, activated calcium hypochlorite, all oxidizing agents chlorates ammonium salts, acids, metal powders, sulfur, Gncly dhided organic or combustible materials ehromic acid acetic acid, naphthalene, camphor, glycerin, turpentine, alcohol, flammable liquids in general chlorine ammonia, acetylene, butadiene, butane, methane, propane (or other petroleum gases), hydrogen, sodium carbide, turpentine, benzene, finely dhided metals chlorine dioxide ammonia, methane, phosphine, hydrogen sulfide copper acetylene, hydrogen peroxide cumene hydroperoxide acids, organic or inorganic flaramable liquids ammonium nitrate, chromic acid, hydrogen peroxide, nitric acid, sodium peroxide, halogens hydrocarbons fluorine, chlorine, bromine, chromic acid, sodium peroxide

(, h Jpif f eessamma { fl.10 INCOMPATilit E CilEMICAIS ~ tw i.e awe,o wns nec.. 9 0,......i in., i.,ve e ge CilEMICAL M ATERI AIM January 11,1989 15 SAFETY M ANUAL Chemical Errit.Dut of.Ceni;irt With-hycrocyanic acid nitric acid, alkali hydronuoric acid ammonia, aqueous or anhydrous hydrogen peroxide copper, chromium, iron, most metals or their salts, alcohols, acetone, organic materials, aniline, nitromethane, flammable liquids, oxiditing gases hydrogen sulfide fuming nitric acid, oxidizing ga<,es iodine acetylene, ammonia (aqueous or anhydrous), hydrogen tuercury acetylene, fulminic acid, ammonia nitric acid acetic acid, aniline, chromic acid, hydrocyanic acid, hydrogen sulfide, flammable liquids, Hammable gases oxalic acid silver, mercury perchloric acid acetic anhydride, bismuth and its alloys, alcohol, paper, wood pota.ssium carbon tetrachloride, carbon dioxide, water potassium chlorate sulfuric and other acids potassium permanganate glycerin, ethylene glycol, ben 7 aldehyde, sulfuric acid silver acetylene, oxalic acid, tartaric acid, ammonium compounds sodium carbon tetrachloride, carbon dioxide, water sodium p raxide ethyl or methyl alcohol, glacial acetic acid, acetic anhydride, benzaldehyde, carbon disulude, glycerin, ethylene glycol, ethyl acetate, methyl acetate, furfural sulfuric acid potassium chlorate, potassium perchlorate, potassium permanganate (or compounds with similar lignt metals, such as sodium, lithium, etc.). (Based on the Manufacuring Cnemist's Association, Guide for %ferv in the Qemica] Laheratory, pp. 215-217.)

L hapser ~ ft.11 SilOCK SENSITIVE CllEMICALS ou.a nwe a uma on u animir.aG~e p.,g Cill311 CAL MATERIAL.S January 11,1989 M sal'ETY M ANUAL 8.11 SilOCK SENSITIVE CIIEMICALS J Shock sensithe refers to the susceptibility of the che mical to rapidly decompose or explode when struck, sibrated c.t otherwise agitated. Some chemicals become increasingly shxk sensitive with age, Always write the date received and date opened on at: containers of sbock sensithe chemicals. Unless an inhibitor was added by the manufacturer, closed containers of shock sensitive materials should be discarded after one (1) year. Open containers of shock sensithr materials should be discarded within six (6) moaths of opentng. The label and MSDS will indicate il a chemical is shock sensitive. Wear appropriate personal protective equipment when handling shock sensitive chemicals. The following are examples of materials which can be shock-sensitive. acetylides of heavy metals hexanitria aluminum ophorL cxplosive hexanitrodiphenylamine amatol hexanitrostubene ammonal hyrazoic acid ammonium nitrate lead a7ide ammonium perchlorate lead marnite ammonium picrate lead mononitroresorcinate ammonium salt lattice Lad picrate butyl tetryl lead styphnate calcium nitrate magnesium ophorite copper acetylide mannitol hexanitrate cyanurie triazide mercury oxalate cyclonite (hexogen) n.acury tartrate cyclotetramethylenetrinitramine mononitrotoluene dinitroethy'encurea nitrated carbohydrate dinitroglycerine nitrated glucoside dinitrophenol nitrated polyhydric alcohol dinitrophenolates nitrogen trichloride dinitrophenyt hydrazine nitrogen tri iodide dinittotoluene nitioglycerin dipicryl sulfone nitroglyciA dipicrylamine nitroglycol crythritol tetranitrate nitroguanidine fulminate of gold nitroparaffins fulminate of mercury nitronium perchlorate fulminate of platinum nitrourca fulminate of siher organic amine nitrates gelat;nized nitroce!! ulose organic nitramines germane organic peroxides guanyl nitrosaminoguanylidene hydrazine picramic acid hydrazine nitrate picramide heavy metal azides picratol

" " ~ o neer { 8.11 SilOCK SENSITIVE C!lEh!!CALS "~ ou on asue ei mrua Dae ci un n on ne. m em em CllEMICAL htATERI A!.S January 11,1989 17 SAFETY M ANUAL (Esamples of materir.ls which can be shock sensitive, continued from presious page.) pictic acid picryl chloride picryl 11uotide polynitro aliphatic compounds potassium nittoaminotetratole silver acetylide silver azide silver styphnate silver tetrazene sodatol extium amatol sodium dinitroorthocresolate sodium nitrue potassium explosive mixtures sodium picramate styp!mic acid tetrazene tetranitrocarbazole tetryl trimonite trinitroanisole trinitrobentene trinitrobenzoic acid trinitrocresol trinitt 0-meta-cresol rinitronaphthalene trinitrophenetol trinitrophloreglucinol trin:troresorcinol tritonal urca nitrate

(wn.cr CUA = s==s om u wemsuna twe ei neu a.n.. mn oc r.,g CilEMICAL hlATERIAUi january 11,19N 18 SAFETY hlANUAL 8.12 SOLVENTS Many of the commonly used solvents are volatile and are hartnful when relatively small amounts are inhaled. Most are readily absorbed through the skin. Most are flammable. Flammable liquids are more hazardous at e:levated ternperatures due to more rapid vaporization. Electrically ground and bond containcts using approved methods before transferrine or dispensing a flammable liquid from a large containct or drum. Purchase only the amount necessary for immediate use. Use approved Gammable liquid containers and storage cabinets. Keep flammable liquids from heat, flame, and direct sunlight. Do nu store Hammable liquids near oddizing agents such as chromic acid, permanganates, chlorates or perchlorates. Avoid skin contact and inhalation of solvents. Use assigned personal protective equipmeret. Do not dispose of solvents down sinks or drains. Use with ad:.quate ventilation or in a fume hood. Common sohents that are relatively toxic include: aromatic hydrocarbons, especially benzene esters of acetic or other organic acids + glycols, glycol esters and glycol ethers halogenated hydrocarbons methyl alcohol a nitrogenous bases such as amines = carbon disulfide a The label and MSDS will indicate any special hazards involving a schent. For additional information, contact your supenisor cr the Environmental Safety Office.

umer z,, 8,13 COMPRESSED GASES na oi i,we vi mon t w o, xen,...n os ou, Nye ee n CilEMICAL MATERI A!,5 January 11,1989 19 SAFETY MANUAL 8.13 COMPRESSED GA5ES Carefully read the label before using or storing compressed gas. The MSDS will prmide any special hazard information. Always use the minimum size cylinder requ: red to perform the work. Cylinders of compressed gases must be handled as high energy sources. Do not expose cylinders to temperature extremes. When storing or mosing a cylinder, have the cap securely in,-! ace to protect the stern. (A pressurized cylinder can become a rocket when its stem is broken.) Always use the correct regulator, Do not use a regulator adaptor. Use suitable racks, straps, chains or stands to support cylinders, Cylinders of toxic, flammable or reactive gases should be stored and used in a fume hood or l with local vemilatica. Usc an appropriate cart to move c%inders. Never bleed a cylinder completely empty, Leave a slight pressure to keep contaminants out. Oil or grease on the high pressure side of an oxygen c>linder can cause an explosion. ffn. net l lubricate an oxygen regulator or use a fuel gas regulator on an oxygen cylinder, Always wear safety glasses when handling compressed gases. For more information, contact your supervisor or the Enviroamental Safety OfFce,

i { cwper 7, = 4,14 RADIOACTIVE STATERIAL t Daic w 1 ue or slanwa: Dev ei ko neon ia inn Nge Nge CIIEMICAL MATERIALS January 11,1989 20 SAFETY M ANUAL S.14 RADIOACTIVE MATERIAL Only persons, projects and facilities approved by the Radiation Safety Office are authorized to use radioactive material or other sources of ionizing radiation. Indisiduals interested in using radioactive material or other sources of ionizing radiation should contact the Radiation Safety Office at ext. 5206, Radioactive material utili7ed in undergraduate and graduate teaching laboratories rhil be.inder the direct supenision of an indisidual approved by the Radiation Safety Office. Indhiduals rathorized to use sources of ionizing radiation will receive specific training from their supenism or the Radiation Sabry Office, A Radiation Safety Manualis pubbshed by the Radia: ion Safety Office and distributed to authorized users of radioactive material. 1

T cn.cer { 8.15 RESTRICTED AREAS oxe on n,ue ci mna osie.o eeusn n.a in,, can em CllEMICAL MATERIALS January 11,1989 21 SAFE 1Y MANUAL 815 RESTRICTED AREAS Facilities placarded with following warning sipts are restricted areas: CAUTION.1310llAZARDS CAUTION-CANCER llAZARD CAi! TION RADIOACTIVE MATERIAL CAUTION RADIATION AREA CAUTION / DANGER LASER CAUTION ASilESTOS The names and phone numbers of resrc;osible personnel shall be posted on the dooi(s) to all facilities where hazardous mater %. 'ored or utilized. Faculty, staff and administrators shall not enter a restricted area, except when accompanied by an authorized user of the facility. Housekeeping personnel are permitted to enter restricted areas to perform routine tasks. Ilowever, these persons shall not touch labeled waue con:ainers, other research equipment or materials. Other support personnel, such as Campus Police and Physical Plant Department personnel, etc., are permitted to enter restricted areas prosided the work to be performed does not invoke disturbing a use area within the facility, equipment or materials. Examples include: fume hoods biological safety cabinets + + sinks placarded equipment + chemicals or materials on lab benches a Support personnel shall contact an authorized user of the facility or the Environmental Safety OfGee before performing work which may invoNe any of the above items. Contact the Erwitorreantal Safety OfGce if emergency response or senice is required in a restricted area. Immediately report any unusual conditions to the Environmental Safety OfGce or the Campus Police, such as: spills - leaks + Gres injuries contamination For additionalinformation regarding restricted areas, contact your supenisor or the Environmental Safety OfGce.

cncer g,, 8.16 WASTE DISPOSAL TTie os hwe ce Manuai u m oi xcus,,,n oiin,r.,rc Pne CHEMICAL MATERI AIS January 11,1989 22 SAFETY MANUAL 8.16 WASTE DISPOSAL llazardous chemical disposal must be in accordance with procedures established by the Emiroranental Safety Office. Unless approved by the Emironmentel Safety OfGee, disposal of chemicals via the sanitary sewer system is not permitted. The MSDS will contain special disposal inforrrution, if applicable. Your department rnay also have procedures you are required to follow. Disposal of radioactive material and etiological agents / cultures requires special procedures. Contact the Emironmental Safety Office before proceeding. Contact your supenisor or the Emironmental Safe y Of6ce before disposing of any hazardous

hemical.

cn.mier

== 8.17 C!!EMICAL SPILLS om,e hwe m wnua iw m ko-n ni nm ran ee w CilEMICAL MATERIALS January 11,1989 23 SAFETY M ANUAL 8.17 CHEMICAL SPILLS Anticipate spills by having the proper safety equipment on hand. Alert personnel in the area that a spill has occurred. Do what is necessary to protect life, if the spill is too large for you to handle, is a threat to personnel or the public, involves an infectious agent or a corrosive, highly toxic or reactive chemical, call the C.impus Police for nssistance. Campus Police.xt. 5111 The MSDS will contain special spill clean up inforrration, if applicable. Con!ine the spill with sorbents, if possible. The Emironmental Safety Office is equipped to handle most spills that can occur at the University. If there is the slightest doubt as to how to proceed, do not hesitate to call for assistance. Emironmental Safety Office ext 6112 If a spill involves radioacthe materials, also contact the Radiation Safety Office. Radiation Safety Office ext. $206 For specific spill c!can.up information, contact your supervisor or the Emironmental Safety Office. 8.17.1 Low Hazard Material Spills No lire hazard; not particularly volatile, toxic or corrosive (e.g., salt solutions). Use a sorbent material that will neutralize the spill if available. trisodium phosphate sand sodium bicarbonate for acids powdered citrie acid for bases ' Oil Dri," *Zorb-All," "Speedi Dri," flentonite, etc. paper towels A dustpan and brush should be used and rubber gloves and goggles should be worn. Decontaminate area with soap and watcr after clean up.

u.mes Q.17 Clll;hilCAL SPil.LN vor,o so,e % g) o.ac.o kn m..n..i on. Ng, Tap CilDilCAL hl ATERI ALS January 11,1989 24 S Al'ETY SI ant!AL [_ L Flace residue in a containct for waste collection. ~ Contact your supenisor or the Envittnmental Safety Office for disp %alinformation. 8.17.2 Volatile. Flanimable or T.mitJJA1.ttlaihjlh w ly all personnel in the atea. Ihtinguish flames ar,d all sources of ignition wh a, brush type motors. Maintain fume hood ventilation. Vacate the area and call for assistance. The following compounds are very hatardcius. y.ctuhauld not clean them uPJeuntlL aromatic amines nitro vmpounds bromine carbon disulfide a hydrazine cyanides nitriles ethers organic halides 11 you spill a highly toxic material, immediately contact the dmironmental Safety Office (ext. 6112) o-1 e Campus Police (ext $111). l f.17.3 Athill.aK hjlli Absorb spill witi,' Oil Dri,Zorb All,Speedi Dri,' Dentonite or other clay type sorbent. Avoid contact with Akin, Place residue in container for waste collection. g I l For specific clean up information, contact your supenisor or the Emironmtntal Safety

Office, 8.17.4 Mtmity.jipjlla j

Call th Radiation Safety Office for prompt chanup of spilled mercury (or disposal of surg.lus rnercury). Only if assistance is unavailable from Radiation Srfety, the following procedure should be used to minimite the extent of air ev: amination resulting from the

t. pill.

Use a trapped vacuum line attached to a tapered glass or plastic tube, similar to a medicine dropper, to pick up mercury droplets. (in order to minimize waste disposal costs, as much of the mercury as possible should be recovered by vacuum.) Da not use a domestic or commercial vacuum cleaner.

( no,,in ({ 8.17 Cill:hilCAL SPil.tS ., d o., io n,u,.a %a o ie.o k....,,, n, e.y, ~7, CllEhllCAl. hl ATI:lll41.S January 11,1989 25 S AI 1.'IY hl ANUAl, After vacuuming there will remain mercury droplets too smiill to be visible to the naked eye. Cover the area of the spill with one of the following-sodiurn polysulfide solut on i powdered Sulfur silver metal compounds a Clean up the residue in a separate container for waste collection. For specifie escan up information, contact your i,upenisor, the !!rnironmental Safety Office, or the Itadiation Safety Office. j 8.17.5 6J121]J1 eta 15tilb Smother with powdered graphite or ' Met L X.* Call for assistante, for specibe clesn up information, contact your supenisor or the Ernironmental Safety Office. 8.17.6 Ehim.I,hosphorm Smother with wet sand or wvt sorbents. Call for assistance, for specific clean up information, contact your supenisor or the Ernironmental Safety Office.

4 ( b spitt { h 116 INJURY ANilILLNESS tw eii~ru u.,ui tw u koiu..n u m, r a og Clll3tlCAL hl ATEHl AIM Jannry 11,1989 M SM ETY$1ANUAi, j 8.18 INJURY AND ILLNESS Employees muit notify their immediate supenisor of all illnei.scs and injuries related to exposure to hatardous chemicals. Supenisors are responsible for trporting any injury or occupational illness to the OfG(e of Perr.onnel Senices by completing the Tirst Iteport of injury or Occupational lilness' form. Ernployees injured on the job should request an ambulance by dialing 9 911 and report to the i nearest emergency room for m6 dical treatment. (Contact the Emironmental Safety OIG(e for further details.) The Carnpus Police (ext. $111) should be notified of the accident and that oInce will make l arrangernents for transportation of the victim,if required. Use emergency phone or dial 6tect. Do not move a scriously injured person unless he or she is in further danger, in cases of serious injury or il! ness, it is imperative that appropriate actions be followed immediately. When in doubt as to what should be done, call the Campus Police (ext. 3111). Tell (mergency and medical personnel: your name your tocation and nature of the emergency name and amount or chemical involved area of the body affected symptoms what Erst aid sten- >u have stready taken If you have any questions regarding injury and illnen procedures, contact your supenisor or the Environmental Safety Of6ce.

( bptt f (( Q.19 PERSONAL CONTAh11 NATION "ILT i b e w u.inue tw wkon.oi % ey< ry, I CilEhtl CAL htATERI ALS January 11,1959 27 i SAirIT A1ANUAL 8.19 PERSONAL CONTAh11 NATION Do what is necessary to protect hfe. Remain calm. The htSDS will contain special first. aid information. Do not mose a seriously injured person unless they are in further dangt,. A blanket should be used immediately to protect the victim from shm,k and exter,ure. Get medical attention promptly by dialing: Campus Police 5111 Ambulance 9 911 (then describe the emergency to Campus Police) Student lleahh Senice $m En.ironmental Safety Office 6112 Poit n Control Center 625 3.133 For specific instruction regarding personal contamination, contact your supenisor or the Environmental Safety Office. 8.19.1 Ch tnicaltJIllied.0yer a large Arett chUndy Quictly remove all contaminated clothing while using the safety shower or other available source of water, immediately flomi the affected body area in cool water for at least 15 minutes. Wash off chemical with water but do not ur.e neutralizing chemicals, engnents, creams, lotions or salves. Get medical attention promptly. 8.19.2 Chemicaken the Skin in Small Arqn immediately flush with cool water. If there is no sisible burn, remove jewelry to facilitate removal of any residual material and scrub area with warm water and soap. Soap at:a remming any additional jewelry as necessary, if a delayed reaction is rued (often the next day), report immediately for medical attention and explain carefully what chemicals were involvr.d. If the incident involves Imlrefloorie acid (fin, seek immediate medical attention. DO NOT WAIT UNTIL Tile NEXT DAY! If there is any doubt, seek immediate medical attention.

u..no e A.19 l'l:ltSONAL CONTAhllNATION p.i.<,.e i, m i. sim.a um is k ri.~n.o a.. c.ig r.,g CillhllCAI, h1ATDIIAlli january 11,1989 23 S AFF/IY hl ANUAI, 8.193 CtGdGh.J.rttt!tJbn irrigate with plenS of r "r for at least 13 minutes. the cycwash of other water source. Simultaneously check for and remove contact lenses. Wash thoroughly, but gently under eyelids. Get medical attention promptly, 8.19.4 Smds_twd Fumn Anyone overcome with smoke or chemical fumes should be removed to uncontaminated air and treated for shock. Do not enter the area if a life threatening ecndition still exists: oxygen depletion explosive vapors a cyanide gas a hydrogen sulfide a nitrogen oxides e carbon monoxide e if rescuer is certified, follow standard CPP. procedures. Get medical attention promptly, 8.19.5 PJirnine Chemicals on clothinf, Extinguish burning clothing by using the drop and roll technique, douse with cold water or use an emergency shower or emergency blanLet. Remove contaminated clothing; however, avoid further damage to the burned area. If possible, s:nd clothing with the sictim. Remove heat with cool water or ice packs until tinue cround burn feels nor.nal to the touch. Cover injured person to prevent shock. Get medical attention promptly. 8.19.6 jagudeln of Hn7ardous Chemicab Identify the chemical ingested. Call for an ambulance (ext. 9 911).

an,c, { 8.19 IT.RSONAL CONTAhllNATION =g iuri to.uci.i uc.ui u.nc,e no....n.,i n,,, r# r,g CllEallCAL htVIIRIAIS January 11, W89 29 SAf t"IT 51ANUAL l Call the Poit,on inic-tmation (enter (623 3333) Cover injured permn to g,tevent thock. I Proside the ambulance crew and physician with the themical name and any other relevant information. If punible, tend the containct or the labs! with the sittim.

~~ s n ruce 8.20 hilNOR FIRST. AID om.. i m on mnui v a ei eo s.on o,oi., N g ny CilES11 CAL $1ATERI ALS January 11,1989 y) S AI ElY N1ANUAl. l 8.20 b11NOR FIRST AID Departments should obtain a first aid Lit for treatment of minor first aid cases (cuts, scratches, minor burns). first aW Lits must bc scadily accessible, if the Lit is not visible, the area where it is stored mue.t be clearly marked. First aid Lits must be fully stocked at all times. Do not dispense or administer any medications, including aspirin. Do not put any ointments or creams on wounds or burns. Use ice, cold pack or cold water. The htSDS contains special firt.t.ald information. After giving first, tid. notify the Campus Police (ext. 5111) for tra:aportation of the victim to a medical facility for esaluation. For specific first aid information, contact your supervisor or the Erwironmental Safety Office. essen.

( %pu 11.81 l'lHI: AND l~lHl:.iti:l ATI:D 1311:ltGl;NCll;S om a im a m. a o.ac ni S n ni.n m am, c.s e rm Clll3flCAl. M ATEHl AIS January 11,1989 31 S Al1:TY M ANUAL 8.21 IIRE AND l' IRE.RELATED EMER(iENCIES 8.21.1 If you discover a fire or fire rel.ited emergency such as abnormal heating of rnalerial, hazardous gas leah, harardous material or flammable liquid spill, smeke, or odor of burning. immediately follow these procedures: Activate the building alarm (fire pull station). If not available or operational, verbally notify persons in the building. Notify the Campus police (ext. 5111). lsolate the area and evacuate the building. Shut down equipment in the immediate area,ilnaniM, but DO NOT turn off fume hood blowers. Close doors to isolate the area. the the proper portabic fire crtinguir.her to: as.sist oneself to evacuate assist another to evacuate e contrc.! a small fire,iLpmph e Proside the fire /pt. lice team. with the details of the problem upon their arrival. Special hazard information you may Inow is essential. 8.21.2 If the fire alarms are ringing in your building: evacuate the building move at least 2to feet away from the building stay clear of driveways, sidewalks and other access ways to the building a if you are a supenisor, try to account for your employees and report any missing persons to the emergency personnel at the scene. Assist emergency personnel as may be requested. Do not re enter the building until directed to do so. Follow any special procedures established for your unit.

- ' ~ ~ " " ~ ~ s wpv 1 CUA " " " = = " = " " o.oc a sm,.i %u n.m m %.~nm %,ry em CllEMICAL M A'1EHI AIS January 11,1W9 32 S AII1Y M ANUAL K22 TOXICOLOGY OVLitVIEW 822.1 C}gmipt Toxicity Toxicology is the study of the nature and action of poisons, Toxicity is the ability of a chemical molecule or compound to produce injury once it reaches a susceptible site in or on the body. ' Toxicity harard is the probability that injury will occur considering the rnanner in whkh the substance is used. K22.2 12 cit.EITemLEIla1lonthics The potential toxicity (harmful action) inherent in a r.ubstance is manifest only when that substance comes in contact with a lising biological system. A chemical normally thought of as 'hatmless" will evoke a toxic response if added to a biological system in a sufficient amount. The totic potency of a chemicalis thus ultimately definto by the relationship between the dose (the amount) of the chemical and the response that is produccd in a biological system. 8.22.3 Eng. lex of lintry intn the uody There are three main toutes by whi:h hantdous chemicals enter the body-Absorption through the tricitatory tract through inhalation. Most important in terms of severity. Absorption through the dio. Runs first in the production of occupational disease (dermatitis). Absorption throuch the djgnlive trati. Can occur through eating or smoking with contaminated h:,nds or in contaminated work areas. Most expomte standards, Threshold Limit Values (TLVs) and permissible Exposure Limits (pELs), are based on the inhalation route of exposure. They are normally expressed in terms of parts per million (ppm) or milligrams per cubic rneter (mg/m') concentration in air, if a significant route of expmure for a substance is through skin contact, the MSDS will have a

• skin' notation. Examples: pesticides, carbon disulfhie, carbon tetrachloride, dioxane, mercury, thallium compounds, xylene, hydrogen cyanide,

&22A T.yr;s of Effects Acute onisoning is characterized by rapid absorption of the substance and the exposure it, sudden and severe. Normally, a single large exposure is involved. Examples: carbon monoxide or cyanide poisoning. Chronic paistmin.g is characterized by prolonged or repeated low level exposures of a duration measured in days, months or years. Symptoms may not be immediately apparent. Examples: lead or mercury poisoning, pesticide poisoning.

( user it.2: TOXICOLOGY OVLitYll'W 1,.,a.. m,.c.. wa tur : %,,...n. % em eg Cill:SilC AL hl4TI:lil AL'i January 11,1989 'l3 S41'l:1Y SITNt'AL ! sal rt:frrs to the site of action of an agent and rncans the action tales place at the point or area of contact. The site may be skin, rutaous membranes, the respiratory tract, g o.trointet,tinal syrtern, eps, etc. Absorption does not necessarily occur. Exarnple*: strong acids or a!Lalis and war gases. hils.mic refers to a site of action other than the point of contact and presupposes absorption has taken place l'or example, an irhaled material may act on ths liver. Othcr exarnples: arsenic effects the blood, nervous systern,liwr, Lidneys and skin; benzene affects bone m arrow. Q1muktlixt_MiLas are characterlicd by materials that tend to build up in the body as a retult qf nutnerous chronic crposurcs. The effects aie not scen until a critical body burden is teached. Example: heasy metals. S.uhitance in Combinnd.en: When twc or more harardous rnaterials are present at the same time, the.tsalting effnt can bc. greater than the effect predicted based on the individual substances. Th's i. called a gnetgisijs or pntr.D11adra.t!hti. Example: exposure to alcohol and chloriaated solvents. 8.22.5 Ctbct FDCl0D AffectingInsich itate of entry and route of ex;xnure; that is, how fast the toxic dose is delivered and by what means. Age can effect the capacity to repair tissue damage. Previous exposure can lead to tolerance, increased sens'tivity or make no difference, State of health, physical condition and life style can atin ct ti.e toxic response. Preexisting disease can result in increased sen;ithity. Ensironmental factors such as tempe.ature and pi*,sure. 11ost factors including genetic predisposition and t' e gendst of the exposed indhidual.

( wna = 823 CLASSiflCATION Of TONIC AIATERIAIS i v i .,e w,o %,o o,u oi k n..n.n oi mm t, g em CllEhllCAL 51ATI:HIAIM January 11,1989 M SAILTT MANUAL 8.23 CLAS$1FICATION OF TOXIC hlATERIALS 8211 11xd gI Cla W n tiOW u (h3 applies to a substance which is in the gaseous state at room ternperature and pressure. i A Y2rnt s the gaseous phase of a material which is ordinarily a solid or a bquid at room ternperature. When considering the toxicity of gases and vapors, the solubility of the substance is a Ley factor, liighly soluble materials ble ammonia irritate the upper respiratory tract. On the other hand, relatively insoluble materials like nitrogen dioxide penetrate deep into the hing, I at soluble materials,like pc..ticides, tend to have longer residence times in the body. An n,r.g3pj is composed of solid or liquid particler, of t.icroscopic size dispersed in a gaseous medium. The toxic potential of an acrosolis only partially described by its conccettation in milligrams per cubic meter (mg/rn ). For a proper assenment of the toxie hazard, the size of the acrosol's particles is important. Particles above one (1) microrneter diameter tend to deposit in the upper respiratory tract. Below one (1) micrometer, particles enter the lung. Very small particles (<0.2pm), in general, are not deposited. 8.23 2 Physiolneical Chnificatkm itI.uania are materials that cause innammation of mucous membranes with whicii they come in contact, innammation of tissue results from concentrations far below those needed to caur.c corrosion. Examples include: ^ ammonia o!Latine dusts and mists hydrogen cHoride hydrogen fluoride a halogens e orone phosgene diethyl/ dimethyl sulfate nitrogen dioxide phosphorus chlorides arsenic trichloride a Irritants can also cause changes in the mechanics of respiration and lung function. II.xamples include: sulfur dioxide acetic acid formaldehyde formic acid sulfuric acid acrolein a iodine Long term exposure to irritants can result in increased mucous secretions and chronie bronchitis.

TCs n o { lt.23 CIASSilICATION Of TOXIC AIATIltlAl.S useosum.a mua owe sa k e. ~,.n.a nu. v. g v.,n CilEStl CAL StATIlllAl.S January 11,1939 33 i SWi"IT NtANUAL A climary irritant exerts no systemic toxic action either because the products formed on the l tissue of the respiratory trat are non todc or because the irritant action is far in excess of any systemic tode action. Exarnple: hydrogen chloride. A grendity_inilAnd effect on mucous membrancs is overshadowed by a systemic effect resulting from absorption. Examples include: hydrogen sulfide aromatic hydrocarbons e Exposure to a secondary irritant can result in puhuonary edema, hemorrhage and tistue necrosis. &rhniants have the abihty to deprive tissue of oxygcn. Simt'le alphnittu are inert gases that displace oxygen. Examples include: nitregen nitrous odde carbon dioxide hydrogen e helium Ocmical uphydaub have as their specific toxic action rendering th: body incapable of utilidng an adequate oxygen supply. They are active at very low concentrations (few ppm). Examples include: carbon monoxide cyanides e Primary anesti. tics have a depressant effect upon the central nenuus system, particularly the tt brain. Examples include: alcohols halogenated hydrocarbons lhratotodt agtDu cause damage to the liver. Examples include: carbcin tetrachloride

• tetrachloroethane nitroamines b'rphrotode pgton damage the kidneys. Examples include:

uranium compounds

• halogenated hydrocarbons Neurotode agents damage the nervous sptem. The nervous systen is especially sensitive to organometallic compounds and certain sulfide compounds. Examples include:

tetraethyl lead trialkyl tia compounds a methyl mercury carbon disulfide a a manganese

• thallium a

organic phosphorus insecticides i

o. r.ici

{ lt.23 CLANSii'ICAllON Ol' TOXIC SIATI:ltlALS o.a..i am a u.nu. i t v, n m,...n.o a-n %, y CilEhllCAL $1ATI:ltl ALS January 11,1989 SAIELTY AIANUAL Somt, toxic agents act on the ido2icLhtmMern).tlittnitm. The bked rells can be disectly affected or boric marrow can be damaged, lharnples include: nitrites

• aniline toluidine nitrobenzene bentene There are toxic agents that produce damage of the pylmenny tissue (turigs) but not by immediate irritant action. I-ibrotic changes can be caused by free silica and utbestos. Other dusts can cause a restrictive disease called eneumotenknis. Examples include:

coal dust cotton dust wood dust A carcinocen commonly der.cribes any agent that can initiate or speed the development of m:lignant or potentially malignant tumors, malignant neoplastic proliferatio'a of cells, or that possesses such material. Known human carcinogens include: asbestos &nitroNphenyl alpha naphthylamine

• rnethyl chloromethyl ether inorganic arsenic

.3,3"-dichlorobentidine vinyl chloride bis.chloromethyl ether cthylene oxide 1,2.dibromo4-chloropropane (DIICP) N. nitrosodimethylamine coal tar pitch volatiles A mutacen affects the chromosome chains of esposed cells. The effect is hereditary and becomes part of the genetic pool passed on to futu.c generations. A terategt.0 (embryotoxic or fetotoxic agent) is an agent which interferes with normal embryonic development without damage to the mother or lethal effect on the fetus. Effects are not hereditary. Examples include: lead dibromodichloropropane A tend 11tcI causes a substantial proportion of exposed people to develop an allergie reaction in normal tissue after repeated exposure to the chemical. The reaction may be as rnild as a rash (contact dermatitis) or as serious as anaphylactic shock. Ihamples include: epoxies toluene diisocyanate nickel compounds chromium compounds = poison ivy chlorinated hydrocarbons

s u grr Q R.84 TARGlTI' ORGAN l'lTir!S 'o n ei ser ei w,.i i w.., u,,,s,,,;... iim e,,y r.,n j Clll311CAI. ht 4TI:HI All. January 11,1%9 37 SAI I.1Y hl ANUAl., 1 1 1 824 TARGET ORGAN EITirTS The following is a target organ categoritation of effetts which may occur, including examples of signs and symptoms and chemicals which hasc been found to cause such cifrets, ) h:02Lultsic causes liser damage l signs and symptorns jaundice; liver enlargement example chemicals carton tetrarhloride, nitrosamines, chloroform, toluene, perchloro. ethylene, cresol, dimethylsulfate nsplante3Jn produce kidney damage signs and symptoms edema; prottinuria example chemicals halogenated hydrocarbons, uranium, chloroform, mercury, dimethylsulfate nuttetoxins affect the nervous system signs and symptoms nascosis; behavioral changet; decreased muscle u> ordination exarnple chemicals mercury, carbon disulfide, benzene, carbon tetrachloride, lead, nitrobenzene htautepoittir.mtnis decreased blood functions l signs and symptoms cyanosis; loss of consciousness example chemicals carbon monoxWe, cyanides, nitrobenzene, aniline, arsenic, benzene, toluene py!monary acents irritate or damage the lungs signs ar.d symptoms cough; tightness in chest, a.hortness of breath example chemicals silica, asbestos, orone, hydrogen sulfide, chromium, nickel, alcohols terledvIt ve toxins affect the reproductive system (mutations and teratogenesis) i signs and symptoins birth defects; sterility exampic chemicals lead, dibromodichloropropane din bends affect the dermallayer of the body signs and symptoms defatting of skin; rashes; irritation example chemicals Letones, chlorinated compounds, nickel, phenol, trichloroethylene

~ I ~ Owpues a e: 834 TARGET ORGAN LITiriS tue,,e us,e vi si,,nui o.,te vi k o,a,,n,,i m, n ye eye CllEhllCAL M ATI:RI ALS January 11,1989 38 S Al'lTlY hlANUAL l = l (Target organ categoritation, contirr.d from prnious page.) nthnu.ta affect the e)c or vision l signs and symptoms conjunctivitis; corneal damage crample chemicals organic solvents, acids, cresol, quinone, hydroquinene, benrol chloride, butyl akohol, base; i I ( l

u,rm { 8.25 IlYGil:NIC STAND 4RDS

== use a wue a mous vor e veu.un s n., r.e v.v n CllEhllCAL A1ATERIALS January 11,1989 39 SAFFTY $1ANUAL l 8.:'5 llYGIENIC STANDARDS l ILy: the thmhchtlimlLula is a recommended occupational exposure standard published by the American Conference of GovernmentalIndustrial flygienists. TLVs are expressed as parts of vapor or gas per million parts of air by volume (ppm) or as approximate milligrams of particulate per cubic meter of air (mg/m ). The TLY is the average concentration of a chernical that is thought most people can be exposed to for a working lifetirne with no ill effects. The TLY is an advisory guideline. If applicable, a Eti!!re concen.tr.atjan (C) which shoeM not be exceeded or a Llin hatard (S) will be indicated with the TLV. EEL: the Prminihl. exoo ure limit is a legal standard issued by OSilA. Unless specified, the e PEL is a time weighted average (TWA). TWA: time weichted averagg is the basis for most exposure standards. The TWA is based on the average exposure weighted for an 8. hour work day. Ceiling (c) limits and acceptable maximum peaks above the average must be considered when exposures are evaluated. The htSDS will list the hygienic standard for the ha7.ardous chemical or each component of a mi.tt ure. The Erwironmental Safety Office has a complete listing of published TLV5 and PELs and other works concerning the subject of industrial toxicology, if you would like to conduct a more thorough review of a particular compound, contact the Emironmental Safety Office. The h1ullen Library subscribes to an on.line computer. based abstract senice. lla7ard information is available through the senice. Also, many manufacturers and distributors have developed on line hazard information for their products; contact your sales represenu.tive for more ir formation. Check the reference list in this manual for selected works on toxicology.

t unwr it.26 Tile MSDS

• SECTION llY SECTION per 4.i i, ue.. ma o ie ei uo un.., sem est, es,e CilEMICAL MATERIA!.S January 11,1989 40 sal'LTs' M ANUAL 8.26 Tile MSDS. SECrlON BY SECTION The following is a description of the MSDS which has been adopted by the Emitonmental Safety Of6cc to comply with the federal llazard Communication Standard. There is no pres.cribed form to be used, therefore, you may see some MSDS 5 in a different format than that i

which is described here. Whateves their form, MSDSs are to have the same information co atained in them. kttinn_1 of the MSDS lists information identifymg the product and its manufacturer, j manufacturer's name, address and telephone number

r. umber to callin case of emergency chemical name and synonyms trade name and synonynn chemical family and formula

+ l CAS number (Chemical Abstract Senice) for pure materials if your work requires an understanding of this chernical information, contact your supenisor or the Emironmental Safety Office, f kctjen )) describes the various hazardout ingtedients contained in the product, the l l per:entages, and expo.ture limits when,ippropriate. l pigments, catalysts, schkle, solvents, additives, others l base metal, alloys, metallic coatings, fillers hazardous mixtures of other liquids, solids or gases l CAS number of components All hazardous chemicals which comprise 1% or greater of the mixture will be identified. l Carcinogens will be listed if the concentrations are 0.1% or greater. Sntion.llJ describes the physical properties of the rnaterial. boiling point specific grasity melting point vapor pressure l l vapor density cvaporation rate 1 solubility in water appearance and odor l kt!!cn IV describes the fire and explosion hazard data for the material. Based on the flash point and other fire and explosion data, the appropriate extinguishing agent for fires invohing I

umer P "A s.26 Tiin Msos. sirrlos iiv si:CTION v ti Dair of hour el Manusi l8sle of Hri twm of ihn..s r Page e CilEMICAL $1ATEltl ALS hnuary 11,1989 4 SA)CTYhlANUAL l the materials will be listed. Special procedures may also le listed. flash point lower and upper explosive limits (1.EIJUEL)

• extinguishing agent water, dry chemical, foam, balon, etc.

Special fire fighting procedures unusual fira and explosion harards, toxie fumes Section V describes reactivity data: that is, the materiaPs ability to react and release energy or heat under certain conditions or when it comet in contact with certain substances. stability: stable, unstable, conditions to avoid incompatibility: materials to avoid hazardous decomposition products hazardous polymerizations: conditions in avoid Sn. tion _YJ describes the known health hazard d.ita for the material and erposure limits. Symptoms or the heahh effects of an overexposure are listed. This information will help the user and medical personnel recognize if an overerposure has occurred. thicshold limit value effects of overexposure: headache, nausea, narcosis, irritation, weakness, etc.

• primary routes of exposure: inhalation, skin, ingestion cancer or other special heahh hazards emergency and first aid procedures for: ingestion, inhalation, skin contact, eye contact e

Sution VII gives instructions for the steps to be taken in case of an accidental release or spill. The steps normally include information on containment, evacuation procedures nnd waste disposal as appropriate. The statements on the MSDS are general; more specific information is available from your supervisor. steps to be taken in case material is released or spilled waste disposal methods handling and storage procedures to be taken with the material a special precautions or miscellaneous information regarding the material Sutien Vill describes the protective equipment for the individual who might have to work with the substance. This section normally describes worst case conditions; therefore, the

k, hdj'lf f enemmen 8.26 Till: htSI)S. SECTION llY StrilON g= om.o i,,a,,, mnu i om. x o n...n,o n.. Ng r, Clllh11 CAL htATrill ALS January 11,1989 4: SAFE 1T h1ANUAL extent to which personal protective equipment is required is task dependent. Contact your supenisor for instructions. respiratory equipment: dust mask, chemical cartridge respirator, self contained breathing apparatus ventilation: local, general, special protectisc gloves: type eye protection: glasses, goggles, shield other protective equipment in sorne cases, manufacturen may choose to withhold certain information if the information is considered to be a trade secret, llowever, the htSDS must still contain all relevant hazard, protection and health information. Some htSDSs are more complete than others. Do not assume everphing that you need to know is contained on the h1SDS.

u.ar v' g PTT A it.27 s Asti t i: SirTT.itirL sriiriv iirTA siiri:T <hisi>s) v L.)M l Dee H N oe ni ht.s.w.i Du on k c .u...i ;,i inn, t,,p p,,, e CllEhllCAL htAT1;RI A13 January 11,1989 o sal'l:1YhtW UAL 8.27 SAhlPl.E MATERIAL SAFETY DATA SilEET (hisDs) thown below is an exampic of the hiatorial Safety Data $hect used tiy the U.S. Department of Labot Explanation of the information contained in thit form can be found in Section 8.26 of this inanual. MMertal $alety ()ata Sheet U.S. Department of Labor ue, t met io amar e ie, o,.uoene,,,ei seiei, one ne.* wiinosoca OSH4 s Has sett Communwee stervives t,en n u..oemy I om)

1. 9 08 84 Ilio IPE sinesia1 nuit te

,,,m Ag,i ,,,,o tes@ed he tierdic msverniee*: 090 4o itis (m77 a*tutitv ps vesse ni tenn av ten a*= tie,ia.es **e.e+ =,w **e'en e ea, ne m w e#ve s,w e ac s e* a v. m... sw weie mew 4

w se me ee via e==

8et tiren i kewense e he*e t m,.pwy i s p.m e 9,,mi., edrerese pentsp, Atw (Ay &#ees peg fsp (osN Ioicteerg H#e1[ka k+.yft ten (ice P e,w ~~~ ~f. vie #e es b..pe,e, mv.mj Sectkin 11 - Herafdous Brigtedlents/1dentity infotmahon w 6mm ,6tassenrue C.reverwma l'. tech Chemca Henwy Ceetnewi Namswan 0944 l'tt ACOfH TLV th erwew) %famej e. Ge*e este ge g

• e6 ese epup**

M WS DeCitort lli - Phyllc8UChe,wical Characteristics M4 0088 Speohc Gee F4 0 e il 3

• st== henwe tmm tyi use ig es.n vasvu (>eresiy p#1 e 1)

(4mse Haw (Duhe Acessia

• 9 Lombery ei vveier

~ Appee,sttre anus (A3ar _SectioriIV - Fire end Eeplosion Hatara Data tegen Pont in4e9ms Unee hammaces Laws Lt.L utL ImW.@se8vg Moe. Space f e. Fywsq F%, wee kl8%Sv5 IWe We La4Wesun WatOs N" h*N O$HA 174. Sep4 19M

m,,,, 7._ { 8.89 SAhll'LE $1ATrillAL SAFETY DATA Slirl:T (SISDS) g t;u i s.sov i,i uino i o a io ui, n...n o um r.ig r.,g CllE511 CAL MATERI ALS January ll,1989 44 sal LTT MANUAL.a. (Sample of the Material Safety Data Sheet, page 2.) secuen v ne.oiony o.i. L.w=*y pewia4*e Lerusuems e Aw=J Mates km ein io, w,,e,.e,. se 4..w ~ Fiass+ sus (+ww=*mm a bytesate.te Hawac.4 Us, v.s.se Gew=ns to Awas Perw+>a stam 9'ad $4J1 (k%w = tiettlon VI a. Hepith Hatard Data 6mse si os 4 tsey w s.aiemy !.m > invp194e

• Heenh Hssacos ekvte eM vvww)

La.tnigerus e, telP P nu d han.9,gnet Q%4a stegue eat bg<.a s+us (r.ftactne at !apsews ueo.te Comave.1 Ger+aN Ane. red byjetwowe incipenry ord rygt Ani Pentedwn OmWm.e M $ection Yll.* Precautlofit for Sett Handling and Use Sept to Be Imarti en Cana hteieos is 6tenessed or 6 pupa 4.mm.D Wreste OttVssN heetPingt om me Pene.mano e be f amen m Howwgp swt $4emg Orwe erecomms 1 B.D E Section vit! - Control Measures Feesweewy Petsettum (#wtsy Irpe/ . NNe .I h h 6decha<w.ai m weg (ver ~ ~ Praecieve Go.es f re Pattactwm ~,_ e<_,., _ vvwWyperne P>wwes Pepe I e voe p s io. si.uvatern

u,, pin { NJN I XCol"flONS TO Till; ll A7.ARD COMMUNICATION S TANI)Alti) o.,i, os i,,,,, a u.in u t w,.4 u om.n..i o,.. N r N, j Cill:MICAL MATI: RIALS January 11,1939 15 l S Al~I"IY M ANUAl. i 828 EXCEP110NS TO Tile IIAZARD COMMUNICATION STANDARD The llaard Commurtication Standard dces not apply to chemicals in the fellowing categories: any article formed to a specific rhape that does not release hazardous chemicah under l normal u.se 1 any food, food additive, drug or cosmetie distilled spiriti, wines or malt bescrages e products intended for personal use and consumption a (Ernployees using products of this type are exempted from the prmisions of the Standard so long as the products are used in the same way and to the same depce that they are used by the general consumer. As an example, housekeepers would not be exempted from tht: provtsions when using a strong industrial cleanser that is available to the general contumer t>ecame of the greater time each day that they spend ut.ing it.) If you are not sure a chemicalin your work area is exempted, contact your surenisor or Emironmental Safety Office. amps aumeuse

1 l t lid l9tt { N.29 NOTICE TO Ehli LOYl:ES s o i,..i hw os maa tiu..i k n.s,. n,,, a., e.,g rye CllEMICAL MATI:R1AtS January 11,1999 4/, .%I ETY MANUAL 8.29 NOTICES TO EMI'LOYEES The Unisersity is required to advise you of your..gnts regarding the llanrd Communic-* Standard. This manual rncels the requirement in part.

t over CUA "a ""onx "'""" tw oi t..a os si na o ie ni un,uo.,,,,,,m e.,g e., g, CllDllCAL M ATT.HI AIA January 11,1989 47 S AITIY M ANU AL 00 EMPLOYEE RIGifTS Employees who may be exposed to hatardous chemicah are guarantec 1 access to the following-

• Chemical exposure informat en Workplace Chemical Lists Material safety Data Shects in addition, employees shall receive training on the harards of chemicals and on the measures that they can take to protect themsches.

The Univer ity must proside employees with appropriate personal protective equipment. You have the right to file a complaint against the University regarding alleged violations of the 11arard Communkation Standard. If you file a complaint, you are protetted from: discharge l cause for di<. charge discipline discrimination a loss of pay, position, seniority or benefits a Al'eged violations of the Standard should be referred to ynur supervisor or the Environmental Safety Office. Ilowner, you always have the right to file a complaint with the Occupational Safety and llealth Administration. Providing you with hazardous chemical information does not affect the liability of the University with regard to the heahh and safety of employees. The University still has the responsibility to tale action to prevent the occurr.:nce of occupational disease and unnccessary ex}wsure.

t vinie r 8Ji WOltKPIACI: Cill.AllCAL LIS1S o.at,a i,,,,..i u.,n w o ie,o kr ,,,,.n.. n.. Ng e n. Cill:ht! CAL AIAT1:HIAIS January 11,1W9 44 S 41't"lY ht ANtfAL 8.31 WOIElt\\CE CilEMICAL LISTS The UrdverUty li, required to compile ai.d maintain a Worlplate Chemical List for all chemicals that require a Material Safety Data Shett. Tbc Workplace Chemical List contains the follcming information: the c.htmical name of the ccmrnen name the work area where the chemicalls normally used or stored the typical amount of the chemical that is generally on hand The Wortplace Chernical List provider. you with information regarding large quantitlcs of hansdous chemicah,in your work arcs. New or newly auigned employees will be made aware of the Workplace Chemical List before working with hantdous chemicals or in a work atra containing large quantities of haardous j chemicals. i De artments will update the list as necessary but not leu than semi annually. p l

t hqwrt { 832 Cill htlCAl,llVGilMC PROGRAht s 'twe..: h,oe vi Manut tune 6: An mm a:L Nee brs Clli.;htlCA!, hiA*IERIAtA January 11,1989 January 30,1991 49 SAITTY htANUAL 832 CilEh11 CAL llYGIENU PROGRAh! 832.1 lhulgtcuniellbrEllA.llegulation,DILQif.VMth2nallwunt_la.lluantenLChrmki.10 labetalents The l'ederal Occupadonal Safety and llealth Adminhttation (OSilA) enacted the Occupathsnal Exposure to Chemicah in Laloratories Standard in 19M. This standard applies to all employees eagaged in the laboratory use of hazardous chemicah at CUA. 832.2 Requitnaculu.01hcEllAlimulallarLntLQtturatinnd15pesutt_10 lhtrulenLChrfainh inlabsteries A palmary requirement of the standard is the formulation and implementation of a Chemical llygiene Plan (CllP). The CllP Indudes work practices, procedures and polides to ensure that emplayees are protected from all potentially hazardous chemicah in their work area. Alany of the specific required elements of the CilP are already contained in this manual. Additic'nal elements not necesarily addressed by earlier sections of this manual are listed below in Sections 833 through fi39, The Laboratory Safety h1anual for the University includes the Chemical hinterials Salety hir.nual, the Radiation Salety bianual and the IJiologleal Safety blanual. Respomibility for the implernentation of the policy contained in the Laboratoiy Safety hianual falls primarily up(m the laboratory supemsor/research scientht. Compliance of individual laboratori:s with this policy h monitored by the Environmental l Safety Office, the Internal Auditor and, externally, by OSilA, EPA and NRC. 1 1 l l l

/ ~ ~ - ' " ~ ~ i i,ym { 533 EXpOSURI: REDULTION 1w w hwe os sinnu ' o m on k n n,nn ni % h re Ng CllEM iCAl, htATERIAlli January 11,1989 January 30, l'h1 $0 SAITW MANUAL 8331%POSURE REDUCTION 833.1 EnxiframtnLitllteniterior, Regular instrumental monitoring of airborne concentrations of chemicals is not usually , ustified or practicalin laboratories but may be appropriate when testing or ieder.igning m3s or other ventilation dnices or wien a highly toxic substance b stored or used regularly (e.g.,3 times /wcek). If a taloratory meets thesn testing criteria or the laboratory supenisor bu reason to believe that a laboratory area is chemically contaminated, contact the Erwitonmental Saft ty Office to coordmate the; ptovhion of emitonmentti monitoring. 833.2 ImpudenL).lalutwsnee. anttiens;}nxing Formal chemleal bygiene and houscleeping inspections should be performed by the laboratory Safety Committec semi.nnnually. Informal irapections should be centinual and should be perfe,rmed by the laboratory supeniwr. Eye wash fountains chould be tested at intervals of not less than 3 mouths. A written record of these irapections shall be maintained on inspection tags attached to the eye wash fountain. Safety showers should be tested at intervals of not let.s than 3 months. A written record of these inspections shall be maintained on inspection tags nttached to the safety showers. j Other safety equipment, such as reusable gloves, fnce shields, liquid waste cans, etc., should be inspected regulaily (e.g., every 3-6 months) by the laboratory supenisor. Stairways and hallways shall not be used as storage areas. Access to crits, emergency equipment (fire extingukhers, eyewash fountains, etc.) and utility controls shall never be bh>cked. 1% cts and laboratory benches should be cleaned regularly. 8333 hnttrda.ernatti and Equkuntnt Protective apparel compatible with the required degree of protection for substances being handled should be purchased by the department and used in each laboratory.

• There should be at least one easily accessible drench t>pe safety shower within 10 seconds and not more than 100 feet away from laboratories using chemicah in concentrations that pose skin hazards. The debered water flow should be a rainimum of 30 gallons per minute at a temperature range of 15' to 35'C.

An eyewash fountain should be available within each laboratory using chemicals in concentrations that pose eye haards. The eyewash should deliver a continuous 110w for 15 minutes at a temperature range of 15' to 35'C. A fire extinguhher compatible with the fire hazards in the laboratory should be available within each laboratory, Muhipurpose dry chemical extinguishers, Icaturing an ammoni.im phosphate base, can be used on Class A:B:C lires and are pnerally preferred for installation in laboratories.

l k DR(Wf { fl33 1:XpOSUlti; lti:DUUI10N ,7 -.m.. _ om. _,,,_..

r...

CllP..',1ICAL MATI: RIAL.9 January 11,1989 January 30,1991 51 SAlrlY MANUAL A fire alarm and telephone for ricergency use should be available nearby each laboratory, Other items designated by the laboratory supenhor or by the !!nvironmental Safety Office should be prmided. 833.4 $gt1Landbhth Prominent signs and labels of the following types should be posted: ) On the laboratory entrance post names and emergency telephone numbers of laboratory supenitors and names and telephone numbers of emerga.ncy personnel / facilities. Names of supenhors are kept on file in the Environmental Safety Office and the Departrnent of Pubbe Safety, This hst is snaintained by the thismanental Safety Office annually. J Ident.ity labels, showing contents of chemical containers (inch. ding wrcte receptacles) and associated harards should be on all chemical containers. Labels on incoming containers of harardous chemicals shall not be removed or defaced. Pos.t location signs for s.afety showers, eyewash r,tations, fire extinguishers, other safely and first aid equipment, exits and areas where food and beverage consumption and storage are permitted or prohibited. Post warnings at areas or equipment where special or unusual hazards exist (e.g., bicharards, lasers, radio isotopes, high voltage equiprnent, etc.). A 'NO SMOKING' sign should be posted in each laboratory. 833.5 MddentLand S"4 A University. wide emergency plan has been established and is regularly reviewed. A copy is maintained in the files of the Environmental Safety Office and is available to all indhiduals wishing to use it to develop their own laboratory plan to be reviewed by the Ensironmental Safety Office. + A written emergency plan shall be established and communicated to all personnel by the supenhor of each laboratory;it should include procedures for ventilation failure, evacuation, medical care, reporting, and daills. Appropriate portions of this plan shall be posted in each laboratory. There should be an alarm system to alert people in all parts of the facility including isolation areas such as cold rooms. A University-wide spill control policy has been developed, See section 8.17.1 to 8.17.6 of this manual. All accidents or significant near accidents r.hould be communicated to Ibe Environmental Safety Office by the Idioratory Supenhor to be carefully analyzed as appropriate with the results distributed to all who might benefit. Copies of the renective report forms to be used by injured students and employees are found in the appendix.

Cha}hef CUA '34 "-" " Date of Inue of Manual l' ate of Revision et this Page Pape CllEMICAL SIATERIALS January 11,1939 Je.nuary 30,1991 $2 SAFEW A1ANUAL ) 834 VENTILATION 834.1 General 1 abgnterv Veritilation The central HVAC system should provide a sontce of fresh air for breathing and for in; ut to local wotilation devices, it should not be relied on for protection from toxic substances released itto the laboratory. Its purpor.e is to ensure that laboratory air is continually replaced, preventing increase of air concentrations of toxic substances during the working day. It should direct air flow into the laboratory from non-laboratory areas and out to the exterior of the building. 834.2 Chemical Fume Hoods in a laboratory where workers run the nsk of significant exposure to potentially hazardous chemicals there should be at least one chemical fume hood for every 2 workers, and the hoods.i.ould be large enough to provide each person with 2.5 linear feet of working space at [ the face, if this is not possible, work with substances of unknown toxicity should be avoided -) or other types of local ventilation dcvices, approved by the Emironmental Safety Office, should be provided. Each hood should have a continuous monitoring device to allow convenicut confirmation af adequate hood performance before use. This device can be as sophisticated as a static pressure manometer or as simple as a length of tissue paper taped to the sash bottom. Chemical fume hoods whict recirculate exhaust air back to the laboratocy em>ironment should not be used. The serbents and filters used may not adequately remove contamin.nts from the ex% us< air. 8343 Other Inal Ventilation Dnien Ventilated storege cabinets, canopy hoods, snorkels, etc. should be provided as needed. Canopy hoods, snorkels and other large local exhaust devices vuld not be installed on pre-existing ventilation systems without the approval of the Enviiontaental Safety Office. 834.4 Gsjonsg %rgial Ventilalon Areas Glove boxes have mtdtiple ports in which arm-length rubber gloves are mounted, and the operator works through these. They are generally operated under negative pressute, so that any air leakage is into the box. If the material being used is sufficiently toxic to require the use of a negative pressure glove box,it is obvious that exhaust air will require treatment. Exhaust air from giove boxes and isolation rooms should be passed through scrrbbers or q given other treatment before it is released into the emironment. Glove boxes, us~1 for experiments where protection from atmcspheric humidity or oxygen is desired, commonly operate under ambient or positive pressure. If positive pressure g;ove boxes must be used with highly toxic chemicals, they should be thoroughly tested for leaks before each use, and there should be a method of monitoring the integrity of the system such as a pressure gauge. I Cold rooms and warm rooms and similar isolated areas should have provisions for rapid and safe escape in the event of electrical failure.

Chapter l CUA. " " = " " " l Date el h,ue of Manual Date til Reviwn of this Page Pqe CllEMICAL MATERIAIS January 11,1989 January 30, M1 53 sal'E'IY MANUAL 8M.$ Modifications Any alteration el the ventilation system, including both general ventilation systems and local hood exhaust systems, should be made only if thorough testing indicates that worker protection from airborne toxic substances will continue to be adequate. Contact the Emironmental Safety Office to authorize any proposed modificatiora. 8M.6 New Installati2.!d Prior to the purchase of any new local exhaust system, contact tio Environmental Safety Office for authorization and confirmation that the proposed system meets federal and local safety, health. and pollution regulations. 834.7 ht/;c >ance A ventilation rate of 4-12 room air changes / hour is normally adequate general ventilation if local exhaust systems such as hoods are used as the primary method of control. General air flow should not be turbulent and should be relatively uniform throughout the laboratory, with no high velocity or static areas. Airflow into and within a hood should not be excessively turbulent. liood face velocity should be adequate (typically 60-100 linear feet per minute). Ilowever; if radioactive materials are invohrd, the Radiation Safety Manual should be consulted as to face velocity. 834,8 Evaluation Performace should be evaluated on installation, regularly monitored (at least eve y six months), and reevaluated whenever a change in local ventilation devices is made. Contact the Emi.ronmental Safety Office to arrange for ventilation testing. l

. ~.. .~ ,n-.- - _,. _,. -~..... ,a. .. ~. j ., e c 4-d iM m '4 8J5 EMPIAWEE ISTORMATION AND TRAINING PROGRAhi ) Daw of laue of Manual Date of Revuum of ttus Page j _ Pap CllEMICAL MNERIALS ~ January 11,1989 January 30,1991 54 i Fifk'.tY MANUAL l 835 EMPLOYEE INFORMATION AND TRAINING PROGRAM An employee safety information and training program is in existence at the University and is reviewed regularly. The purpose of this trainmg is to assure that employees covered under this ee-program are adequately informed about the work in the laboratory, its risks, and what to do if i an acddent occurs,- The laboratory supervisor shall provide this training at the time of an employee's initial assignment to a work area where hazardous chemicals or equipment are present and prior to . j assignments involving new exposure situations, j i The training and education program should be a regular, continuing actinty. - 1 i Every laboratory worker should know the location and proper use of available protective . apparel, emergency equipment and procedures. Receiving and stockroom / storeroom personnel should know about hazards, handling equipment, j ~ protective apparel, and relevant regulations. ] - Literature and consulting advice concerning chemical hygiene ase readily available from the : Environmental Safety. Office. Laboratory personnel should be encouraged to use these. Information resources.

4 4 ChalHef (( 836 RINII3V OF IABORATORY ACTIVITIES g D4tc of hwe of Wnual Daic of Reuuon of this Page Page CilEhllCAL htATERIALS January 11,1989 January 30,1991 35 sal'En MANUAL 836 REVIEW OF LABORATORY AC11VITIES Certain laboratory operations, procedures, or activities require approval from the laboratory supcivisor prior to implementation. This includes working with particularly hazardous substances including reproductive toxins, chemicals which have a high degree of acute toxicity and chemicals considered as select carcinogens. A select carcinogen is a chemical (1) regulated by OSIIA as a carcinogen, or (2) listed as a known carcinogen in the latest edition of the Annual ReppJt on Catsinggtm published by the National Toxicology Program, or (3) listed in - groups 2A or 2B of the International Acency for Research_pfL ancer Monocranh. C The laboratory supervisor is itivited to ask for assistance from the Chemical flygiene Officer in instances where there are questions about the safety of conducting high risk operations and experiments. When necessary, the Chemical llygiene Officer will seek assistance from the Laboratory Safety Committee, as this committee is charged with reviewing procedures for high risk operations and experiments brought to its attention, in instances where the laborrtory activity may pose extremely hazardous conditions, the supervisor shall alert the Cheanical Ilygiene Officer.

3 = -1 Ompter. lCUA '""'c^="*" Dec of luue of Manual Dee of Revmon of this l'agt l' age ! CHEMICAL MATERIAIS January 11,1989 . January 30,1991 36 SAFETY MANUAL 837 M13 DICAL PROGRAM 837.1 Conditions Oblicine Medical Attention The University shall provide all employees who work with hazardous chemicals in laboratories as defined in Section 832,1 of this manual an opportunity to receive medical i attention, including any follow up examinations which the examining physician determines to -be necessary, under the circumstances listed in this Section 837.1. Such medical j examinations and consultations shall be performed by or under the direct supervision of a 'l licensed physician and shall be provided without cost to the employee, without loss of pay, and at a reasonable time and place, If an employee develops signs or symptoms associated with a hazardous chemical to which the employee may have been exposed in the laboratory, the cmployee shall be provided an opportunity to receive an appropriate medical examination. l 4

• Where exposure monitoring reveals an exposure level routinely above the action level (or in absence of an action level, the PEL) for an OSHA regulated substance for which there-are exposure monitoring and medical surveillance requirements, medical surveillance shall be established for the affected employee as prescribed by the particular standard.

If an event takes place in the work area such as a spill, leak, explosion, or other- + occurrence resuhing in the likelihood of a hazardous exposure, the affected employee ' shall be provided an opportunity for a medical consultation. Such consultation shall be for the purpose of determining the need for a medical examination. t + - All employees seeking any medical consultation, treatment or examination under this section must Cle a Workers' Compensation First Report of injury Form with the Office of ' Personnel Senies within 5 days after seeking such medical attention. 837.2 Information Prmided to the Physician Any release of information m the physician must be approved by the Chemical Hygiene Officer. The University shall provide the following information_ to the physician:

• The identity of the hazardous chemical (s) to which the employee may have been exposed;
• A description of the conditions under which the exposure occurred including quantitative exposure data,if available; and
• A description of any signs and symptoms of the exposure that the employee may be -

8373 :- Physician's Written Oriinion For examination or consultation required under this standard, the University shall obtain a written opinion from the examining physician which shall include the followmg: Any recommendation for further medical follow-up; - The results of the medical examination and any associated tests; l s"

~ Chapict CUA """'c^""=" Date of taue el Manua' Dec of Russmn of thu Page Page CllEMICAL h1ATERIAIS January 11,1989 January 30,1991 57 SAFETYhtANUAL

• Any medical condition which may be revealed in the course of the examination which may place the employee at increased risk as a result of exposure to a hazardous chemical found in the workplace; and
• A statement that the employee has been informei by the physician of the results of the consultation or medical examination and any medical condition that may require further examination or treatment.

+ The written opinion shall not reveal spedfic findings of diagnoses unrelated to occupationai exposure. S.37A First Aid An emergency room with medical personnelis available n' nearby hospital (s). To anange for emergency transport to these hospitals, dial 9-911 and untify the dispatcher of the incident. Then, dial ext. 5111 to notify the CUA Department of Public Safety for assistance in directing the ambulance to the scene.

i Chapter CUA "3" c " a"= "*' =" ""=""""'s J Date of Inue of Manual Date of RevNon of thn Page Page CllEk11 CAL M ATERIAIE January 11,1989 January 30,1991 58 SAFETY MANUAL 838 CHEMICAL HYGIENE RESPONSIBILITIES Responsibility for chemical hygiene rests at all levels. Specific responsibilities are as follows. 838.1 Executive Vice President The Executive Vice President has the ultimate legal responsibility and accountability for chemical hygiene within the institution. The Executive Vice President shall: Appoint a chemical hygiene officer. + Designate a signatory person for the University in safety, health, and emironmental matters relating to proposals for funds from an outside agency for sponsored work Provide University legal counsel to the Chemical Hygiene Officer and other University + employees who have need to consult with counsel on matters related to chemical hygiene. Include provisions for appropriate storage and disposal of chemicals in the long range + plans for facilitics development. Inform the University community of the chemical hygiene plan. Provide adequate support for institutional chemical hygiene. Respond to reports and or requests regarding matters of chemical hygiene to the appropriate individual. 838.2 Denartment Head /I}xijdine Administrator In University departments or buildings containing laboratories where potentially hazardoas chemicals are used, the Department Head and Building Administrator shalb Provide list of supersisors to the Emironmental Safety Office on request. + Develop plans, in consultation with the Emironmental Safety Office for the appropriate stcrage of chemicals within the Department / Building. Develop a departmental plan, in consultation with the Emironmental Safety Ifice, for + the appropriate collection and delivery of any chemical waste to the Environmental Safety Office. Ensure that all new faculty members, researchers, student employees and other departmental employees as appropriate are informed of the hygiene plan. Ensure that the supervisors of all undergraduate students be informed of and + knowledgeable in basic rules of chemical safety and that these rules be followed in all undergraduate laboratory courses. Inform the Environmental Safety Office of all chemically-related facility deficiencies which + are known to him/her. l,

i Chaplet (( 838 CilEMICAL llYGIENE RESPONSlHILITIES Date of laue of Manual Date of Revmon ul :hin hge Pm CllEMICAL MATERIAlli January 11,1989 Janusy 30,1991 $9 SAFETY MANUAL Investigate and forward any reports of unsafe chemical practiar, to the Environmental Safety Office. Ensure that all common areas of the building are free of chemic:d harnds, i 8333 LaboratoJ1Smachor /ResearIlLSI!CMill The laboratory supervisor /research scientist has overall responsibility for chemical t ygiene in the 1:.boratory which includes the responsibility to: Ensure that laboratory workers know and follow the chemical hygiene rules, that + protective equipment is available and in working order, and that appropriate training has been provided; Provide regular, chemical hygiene and housekeeping inspections including routine inspections of ernergency equipment; Be aware of the current legal requirements concerning regulated substances used in her/his laboratories; Determine the required levels of protective apparel and equipment and ensure that workers utilize the equipment and wear the apparel, including eye protection. Ensure that facilities and training for use of any material being ordered are adequate. Ensure that appropriate signs and notices of hazards and restricted activities are posted in the laboratory. Report any chemically-related problems to the appropriate department head and the Environmental Safety Office. 838.4 Laboratory Worker The laboratory worker is responsible for: Planning and conducting each operation in accordance with the institutional chemical + hygiene procedures; and Developing good personal chemical hygiene habits. Informing bis /her supervisor of any incident or irregularity regarding the use of dny chemical. 838.5 Chemica! Hwiene Officci The Chemical Hygiene Officer shalk Work with the Laboratory Safety Committee, administrators and other employees to + develop and implement appropriate chemical hygiene policies and practices; Monitor procurement, use, and disposal of chemicals used in the laboratories;

~ chapter { 838 CllEMICAL llYGIENE RESPONSilllLITIES Dele of luue at Manual Date of Revmon of this Page Page CilEMICAL MATERIALS January 11,1989 January 30,1991 60 SAFETY MANUAL See that appropriate audits are conducted and records maintained; licip project directors develop adequate facilities and precautionary tecimiques; = Know the current legal requirements concerning regulated substances; Seek ways to improve the chemical bygiene program; Ensure that appropriate sections of the Laboratory Safety Marmal are reviewed annually. = 1 l l l l

ChJfCf 839 IIASIC RULES AND PROCEDURES ~ FOR WORKING WITil CIIZhllCALS Date of hwe of Manual Date of Rewon of tha Pye Page CIIEh11 CAL h1ATERIALS ,',anuary 11,1989 January 30,1991 61 SAFETY 51ANUAL 839 BASIC RULES AND PROCEDURES FOR WORKING WITil CilEhilCAI.S CUA reauires that all employces working in laboratories and other departmental employees who work in ch:mical hboratory areas know and follow the rules and procedures of the Chemical liygiene Plan. In addition to the procedures in Sections 832-833 of this Chemical Ilygiene Plan, employees should follow the rules listed below. 1 j l 839.1 CttnnaljLti,tg l The following should be used for essentially all laboratory work with chemicals; l 839.1.1 Accidents and spills 1 The topic of chemical spills is addressed in detail in Section 8.17 of this manual. The top!c of penc.c ! contmination with chemicals is addressed in detail in Section 8.19 c this manual. r l 839.1.2 Avoids. 2cc of " routine" exposure l Develop und encourage safe habits; avoid unne:essary exposure to chemicals by any routc. Do not smell or taste chemicak Apparatus which may discharge toxic chemicals (vacuum pumps, distillation columns, etc.) j should be vented into local exhaust devices. l Inspect gloves and test glove boxes before use. Do not allow release of toxic substances in cold rooms and warm rooms, since they contain recirculated air. 839.13 Choice of chemicals Use only those chemicals for which the quality of the available ventilation sprem is appropriate. Wherever practical, use existing chemical stocks before purchasing new l' stock. Avoid bulk purchase of chemicals and ordu th r,mallest amount needed for the project. 839.1.4 Eating, smoking, etc. Avoid eating, drinking, smoking, gum chewing, or application of cosmetics in areas where hboratory chemicals are present; wash hands before conducting these activities. Avoid storage, bandling or consumption of food or beverages in Morage areas, l refrigerators, glassware or utensils which are also used for laboratory operation.s. l l I i l l

~ Chapter 839 UASIC RULES AND PROCEDUP.ES ,y FOR WORKING WITil CllEMICALS Dee of !aue of Manual Dae of Revmon of tha PAge rMge CllEMICAL MA'ITRIAIS January 11,1989 Januaiy 30,1991 62 SAFEn* MANUAL 839.1.5 Equipment and glassware Handle rad store laboratory glassware with care to awid damage; do not use damaged glassware. Shield or wrap Dewar flasks and ather evacuated glass apparatus to contain chemicals and fragments should implosion occur. Use equipment only for its designed purpose. 839.L6 Exiting Wash areas of exposed skin well before leming the laboratory. 339.1.7 llorseplay Avoid practical jokes or other behavior which might confuse, startle or distract another worker. 8,39.1.8 Mouth suction Do not use mouth suction for pipetting or starting a siphon. 839.1.9 Personal appare! Confine long hair and loose clothing. Wear appropriate shoes at all times in the laboratomy. 839.1.10 Personal work station Keep the work area clean and unduttered, with chemicals and equipment being properly hbeled and stored; clean up the work area on completion of an operation or at the end of each day, 839.1.11 Personal protection Assure that appropria!e eye protection is worn by all persons, induding visitors, where chemicals are stored or handled. Wear appropriate gloves when the potential for contact with toxic materials exists; when using reusable gloves, inspect before each use, wash before removal, and replace periodically. (A table of resistance to chemicais of common glove materials is given in Section 8.7.2 of this manual.) Use appropriate respiratory equipment when air contaminant concentiations are not sufficiently restricted by engineering controls, inspecting the respirator before use. Many types of respirators are available. 'I~ne choice of an appropriate respirator depends on many factors including type of contaminant and its air concentration, legal exposure limits, and warning properties (i.e., eye irritation, odor detection threshold, etc.). Before using any respirator, obtain approval from the laboratory supervisor or the Environmental Safety Office. Use other protective and emergency apparel and equipment as appropriate.

chapter 839 IIASIC RULES AND PROCEDURES FOR WORKING WITil CllEMICAIS Date of hsue of Manual Ibie of Revmon ut um Page Nge CIIEMICAL htATERIAIS January 11,1989 January 30,1991 63 SAFETY MANUAL Avoid use of contact lenses in the laboratory unless necessary; if they are used, inform supenisor so special precautions can be taken. Since contact lenses by themselves afford no protection from chemical splashes or projectiles, appropriate eye protection shall also be worn. Rernove laboratory coats immediately on significant contamination. 839.1.12 Planning Seek information and adsice about hazards, plan appropriate protective precedures, and plan positioning of equipment before beginning any new operation. 839.1.13 Unattended operations Leave lights on, place an appropriate sign on the door, and provide for contalument of toxic substances in the event of failure of a utility senice (such as cooling water) to an unattended operation. 839.1.14 Use of hood Use the hood for operations which might result in release of tox4 chemical vapors or dust. As a rule of thumb, use a hood or other local ventilation device when working with any appreciably volatile substance with a TLV of less than $0 ppm. Confirm adequate bood performance before use; keep hood sash under the 100 feet per minute indicator at all times except when adjustments within the hood are being made; keep materials retained in hoods to a minimum and do not allow them to block vents or air flow. Leave the hood 'ON' in the following circumstances: if toxic substances are retained in it; or if it is uncertain whether adequate general laboratory ventilation will be maintained when it ia "OFF.' 839.1.15 Vigilance Be alert to unsafe conditions and see that they are corrected when detected. 839.1.16 Waste disposal Assure that the plan for each laboratory operation includes plans and training for waste disposal Deposit chemical waste in appropriately lah: led receptacles and follow all other waste disposal procedures of the Chemical Hygiene Plan. Do not discharge to the. sewer concentrated acids or bases; highly toxic, malodorous, or lachrymatory substances; or any substances which might interfere with the biological activity of waste water treatment plants, create fire or explosion hazards, cause structural damage or obstruct Ihw.

Oopte: {~ 839 'IIASIC RULES AND PROCEDURES - FOR WORKING WITil CilEMICALS - ~ ~ Date of issue of Manual Date of Remum of this Page Page =

CllEMICAL MATERIALS January 11,1989 January 30,1991 -

64 -. SATE'IY MAhTAL 839.L17 Working alone Avoid working alone in a building; do not work alone in a laboratory if the procedures being conducted are hazardous. - 839.2 Workinn with Allergens and Embryotoxins 839.2.1-Allergens Examples include the following: diammethane, isocyanates, bichromates.) Wear suitable gloves to prevent hand contact with allergens or substances of unknown allergenic activity. j 839.2.2 Embryotoxins. Examples include the following: organomercurials, lead compounds, formamide.) If you are a woman of childbearing age, handle these suStances only in a beod whose satisfactory performance has been confirmed, using appropriate protective apparel _ (especially gloves) to prevent skin contact. Review each use of these materials with the research supervisor and review continuing - uses annually or whenever a procedural change is made. Store these substances, properly labeled, in an adequately ventilated area in.an unbreakable secondary container. Notify supervisors of all incidents of exposure or spills; consult a qualified physician when appropriate.. -8393 : Workine with Chemicals of Moderate Chronic or Hich Aegte Toxicity Examples include the following: diisopropyl fluorophosphate, hydrofluoric acid, hydregen cyanide.) The particular rules listed below supplement those mentioned above and are to be followed. 8393.1. Aim To minimize exposure to these toxic substances by any route using all reasonable - _ precautions. 8393.2 Applicability ' These precautions are appropriate for substances with moderate chronic or high acute toxicity used in significant quantities. '83933 Location - Use and store these substances only in areas of restricted access with special warning signs. . ~ -, s m_ _, _ _ _ _ _. _ _ _ _ _ - - m c .ws

oren p 839 IIASIC RULES AND PROCEDURES FOR WORKING WITil CIIEhllCALS ~ tur of twm of Manual Date of Remen of thu Page l' age CllEh11 CAL AIATERIALS January 11,1989 January 30,1991 65 SAFETY h1ANUAL Always use a heal (previously evaluated to confirm adequate performance with a face velocity of at least (0 linear icct pc: minute) or olber containment device for procedurcs which may result in the generation of acrosols or vapors containing the substance. 8393 4 Personal protection Always avoid skin contrct by use of gloves and long sleeved laboratory coat (and other protective apparel as appropriate). Always wash hands and arms immediately after working with these materiais. 8393.5 Records hiaintain records of the amounts of these materials on hand, amounts used, and the names of the workers involved. 839.3.6 Prevention of spills and accidents Be prepared for accidents and spills. Assure that at least 2 people are present at all times if a compound in use is highly toxic or of unknown toxicity. Store breakable containers of these substances in chemically resistant trays; also work and enount apparatus above such trays or cover work and storage surfaces with removable, absorbent, plastic backed paper, if a major spill occurs outside the hood, evacuate the area. Inform the Environmental Safety Office immediately. Assure that cleanup personnel wear suitable protective apparel and equipment. 839.3.7 W aste Thoroughly decontaminate or incinerate contaminated clothing or shoes. If possible, chemically decontaminate by chemical conversion. These senices can be arranged through the Emironmental Safety Office. Store waste and contaminated materials in closed, suitably labeled, impenious containers. Workiuc with Chemis2 s of High Chron.ic Todri y 1 l 839.4 (Examples include the following dimethylmercury and nickel carbonyl, benzo-a pyrene, N-nitrosodiethylamine, other human carcinogens or substances with high carcinogenic potency in animals.) Further supplemental rules to be followed, in addition to all these mentioned above, for work with substances of known high chronic ioxicity (in quantities above a few milligrams to a few grams, depending on the substance). 839.4.1 Access Conduct all transfers and work with these substances in a " controlled area" which includes a restricted access hood, glove box, or portion of a laboratory, designated for use of

a x ~ Chquer _ 839 BASIC RULES AND PROCEDURES - FOR WORKING WITH CilEMICAIS Date of suue of Manual Date of llevmon of this f%ge Page = Ci!EMICAL MATERIALS - ~ January 11,1989 January 30,1991 66-SAFETY MANUAL highly toxic substances. All people with access to controlled areas must be aware of the substances being used and must take necessary precautions. 839,4.2 Approvah - Prepare a written plan for use and disposal hLese materials and obtain the approval of - the laboratory supervisor and the Emironmuel Safety Office. 839.43 ' Non-contamination / decontamination = -Protect vacuum pumps against contamination by scrubbers or llEPA filters and vent them into the hood. Decontaminate vacuum pumps or other contaminated equipment, - including glassware, in the hood before removing them from the controlled area. l Decontaminale the contro!!cd area before normal work is resumed there. 839.4.4 Ex t L On ! caving a controlled area, remove any protective apparel (placing it in an appropriate, labeled container) and thoroughly wash hands, forearms, face, and neck. -839.4.5 Housekeeping - Use a wet mop or a vacuum cleaner equipped with a HEPA fiker instead of dry sweep!ag if the toxic substance was a dry powder. ~ E 839.4.6 -Medic surveillance + I . If using toxicologically significant _ quantities of chemicals of high chronic toxicity on a regular basis (c.g.,3 times per week), consult a qualified physician concerning desirabili_tyx of regular medical surveillance. 839.4.7 Records : - Keep accurate records of the amounts of these substances stored and med, the dates of me, and names of users. 839.4.8-. Signs and labels Assure that the controlled area is conspicuously marked with warning and restricted access signs and that all containers of these substances are appropriately labeled v ith - i identity and waining labels. ' 839.4.9; Spills Assure that contingency plans, equipment, and materials to minimize exposures of people ^ -and property in case of accident are availabic. '839.4.10 Storage-Store containers of chemicals of high chronic toxicity only in a ventilated, limited access area in appropriately labeled, unbreakable, chemically resistant, secondary containers. x

7 _ _ _. _ _ ~ ~ _ Chaptet 839 BASIC RULES AND PROCEDURES { 1. FOR WORKING WITH CilEMICALS H Date of luE of Manual. Date of Revmon of tho Page Page ' CIIEMICAL MATERIAIS January 11,1989 _ ' January 30,1991 67 SAFE'lY MANUAL 'l 839.4.11 Glove boxes - For a negative pressure glove box, ventilation rate shall be at least 2 volume changes / hour and pressere at least 0.5 inches of water. For a positive pressure glove box, thoroughly check for lesis before each use, la cither case, trap the exit gases or filter them through a HEPA filter and then release thern into the hood. _J 839,4.12 Waste Use chemical decontamination whenever possible; ensure that containers of contaminated waste (including washings from contaminated flasks) are transferred from the controlled area in a secondary container under the supenision of authorized personnel. 339.5 Animal Work with CJgmicah of Hich Chronic Toxici y t 839.5.1 Supervision of the animal care facilities is administered by the lastitutional Animal Care j - and Use Cotamittee appointed ty the Executive Vice President. This committee should be consulted prior to use of any animal for research or teaching purposes. Care and use of certain animals use i for teaching or research and covered by the Animal Welfare Act (7USC2143) should strictly adhere to the guidelines described in that Act.' - Facilities housing animals covered by this act must be registered with the U.S.- Department of Agriculture's AnimalInspection Senice. Such facilities must fde an ennual report (US 18-23) with the USDA and should be inspected at least twice a year by the University's Consulting Veterinanan. s The University's Consulting Veterinarian must be licensed to practice in either the State of Maryland or Virginia or the District of Columbia. The Veterinarian receives an adjunct appointment in the Department of Biology. This appointment is re-evaluated on ar. annual basis, and can be renewed upon satisfactory reevaluation. The rules of Section 839.4 also apply to animal work with chemicals of high chronie

toxicity, i S39.5.2 Access For large scale studies, special facilities with restricted access are preferable.

L 839.53 Administration of the toxic substance When possibic, administer the substance by injection or gavage instead of in the diet. If administration is in the diet, use a' caging system under negative pressure or under. laminar air flow directed toward HEPA fdters. - 839.5.4- =. Aerosol suppression Devise procedures which minimize formation and dispersal of contaminated acrosols, including those from food, urine, and feces (e.g., use HEPA filtered vacuum equipment for cleaning, moisten contaminated bedding before removal from the cage, mix diets in closed containers in a hood). a

ti cncer _. 4 -{- 8.39 EASIC RULES AND PROCEDURES ' FOR WORKING WTril CHEMICA15 Date of issue of Manual. Date of Revision of this Page Pagt - CllEMICAL MATERIA 13 - ' January 11,1989 January 30,1991 68-SAFETY MANUAL - 839.5.5-Personal protection - When working in the animal room, wear plastic or rubber gloves, fully buttoned laboratory coat or jumpsuit and,if needed because ofincomp!cte suppression of aerosols - 4 other apparel and equipment (shoe and head coverings, respirator). 839.5.6 Waste disposal Dispose of contaminated animal tissues and excreta by incineration if the available incinerator can convert the contaminant to non toxic products; otherwise, package the waste appropriately for burialin an EPA approved site. These services can be coordinated through the Emironmental Safety Office. 9\\ F 1 if e r-.. + - -

.m .. _.. m. m_ m. ,m.... ~ Chapter. { 8.40 GLOSSARY' hdte Of lMuc of Manual Date of Reymon of ms Page Page ' CHEMICAL MATERIALS January 11,1989-January 30,1991 69 SAFT'IT MANUAL 8.40 GLOSSARY ACGlH: The American Conference of GovernmentalIndustrial Hygienists is a voluntary rnembership organization of professional industrial hygiene personnel in governmental or educationalinstitutions. The ACGlH develops and publishes recommended occupational exposure limits each year called Threshold Limit Values (TLVs) for hundreds of chemicals, physical agents, and biological exposure indices. ACUTE. Severe, often dangerous conditions in which relatively rapid changes occur. ACUTE EXPOSURE An intense exposure over a relatively short period of time. ANSI The American National Standards Institute is a voluntary membership organization (privately fur.ded) that develops consensus standards nationally for a wide variety of devices and procedures. ASPHYX1 ANT A chemical (gas or vapor) that can cause death or unconsciousness by suffocation. Shnple asphyxiants, such as nitrogen, either use up or displace oxygen in the air. They become especially dangerous in confined or enclosed spaces. Chemical asphyxiants, such as carbon monoxide and hydrogen sulfide, interfere with the body's ability to absorb or transport oxygen to the tissues. BOILING POINT The temperature at which the vapor pressure of a liquid equals atmospheric - pressure or at which the liquid changes to a vapor, The boiling point is usually expressed in degrees Fahrenheit. If a flammable material has a low boiling point, it indicates a special fire

hazard.

'C' or. CEILING A description usually seen in connection with a published exposure hmk. It refers to the concentration that should not be exceeded, even for an instant. It may be written as TLV C or Threshold Limit Value-Ceiling. (See also THRESHOLD LIMIT VALUE.) CARCINOGEN A substance or physical agent that may cause cancer in animals or humans. C.A.S. NUMHER Identifies a particular chemical by the Chemical Abstracts Service, a service. of the American Chemical Society that indexes and compiles abstracts of worldwide chemical literature called " Chemical Abstracts." . CC-Cubic centimeter, a volumetric measurement which is also equal to one milliliter (mL). CHEMICAL As broadly applied to the chemical industry, an element _or a compound produced by chemical reactions on a large scale for either direct industrial and consumer use'or for reaction with other chemicals. CllEMICAL REACTION A change in the arrangement of atoms or molecules to yield substances of different composition and properties. (See also REAC11VITY.) CHRONIC Persistent, prolonged or repeated conditions. CilRONIC EXPOSURE A prolonged exposure occurring over a period of days, weeks, or

years, t

y+ sw.'rt +- ,,.,m, .-~... _.-m.,--

Chapter CUA "a " ss*"' Date of twuc of Manual D#c of Reituon of this Page Page CllEMICAL MATERIALS January 11,1989 January 30,1991 70 SAFETY MANUAL COMBUSTIBLE According to the DOT and NFPA, combustible liquids are those having a flash point at or above 100

• F (37.8* C), or liquids that will burn. They do not ignite as easily as flammable liquids. However, combustible 1: quids can be ignited under certain circumstances, and must be handled with c.,xtion. Substances such as wood, paper, etc., are termed " Ordinary Combustibles."

CONCENTRATION The relative amount of a materialin combination with another material. For exunple,5 parts (of acetone) per million (parts of air). CORROSIVE A substance that, according to the DOT, causes visible destruction or permanent changes in human skin tissue at the site of contact or is highly corrosive to steel. CUBIC METER (m') A measure of volume in the metric system. CUTANEOUS Pertaining to or affecting the skin. DECOMPOSITION The breakdown of a chemical or substance into different parts or simpler compounds. Decomposition can occur due to heat, chemical scaction, decay, etc. DERMAL Pertaining to or affecting the skin. DERMATITIS An inflammation of the skin. DILUTION VENTILATION See GENERAL VENTILATION. DOT The U.S. Department of Transportation is the federal agency that regulates the labeling and transportation of hazardous materials. DYSPNEA Shortness of breath; difficult or labored breathing. EPA The U.S. Environmental Protection Agency is the federal agency that is responsible for administration of laws to control and/or reduce pollution of air, water, and land systems. EPA NUMBER The number assigned to chemicals regulated by the EPA. EPIDEMIOLOGY The study of disease in human populations. ERYTilEMA A reddening of the skin. EVAPORATION RATE The rate at which a materialis converted to vapor (evaporates) at a given temperature and pressure when compared to the evaporation rate of a given substance. Heakh and fire hazard evaluations of materials involve consideration of evaporation rates as one aspect of the evaluation.

• F Degree, Fahrenheit; a temperature scale.

FLAMMABLE LIQUID According to the DOT and NFPA, a flammable liquid is one that has a flash point below 100

• F. (Sce also FLASH POINT.)

FLASil POINT The lowest temperature at which a liquid gives off enough vapor to form an ignitable misure and burn when a source of ignition (sparks, open flames, cigarettes, etc.) is

Chapter CUA = " "ss^"' l Date of loue of Manual Date ut Revien et tha hge Page CIIEMICAL MATERIALS January 11,1989 January 30,1991 71 SAFETY MANUAL present. Two tests are used to determine the flash point: open cup and closed cup. The test method is indicated on the MSDS after the Dash point. g See GRAM. GENERAL VENTILATION Also known as general exhaust untilation, this is a system of ventilation consisting of either natural or mechanically induced fresh air movements to mix with and dilute contaminants in the workroom air. This is not the recommended type of ventilation to control contaminants that are higidy toxic, when there may be corrosion problems from the contaminant, when the worker is close to where Lbc contaminant is being generated, and where fire or explosion hazards are Eencrated close to sources of ignition. (See also LOCAL EXHAUST VENTILATION.) g/Kg See GRAMS PER KILOGRAM. GRAM (g) A metric unit of weight. One ounce equals 28.3 grams. GRAMS PER KILOGRAM (g/Kg) This indicates the dose of a substance given to test animals in toxicity studies. For example, a dose may bc 2 grams (of substance) per kilotvam of body weight (of the experimental animal). IIAZARDOUS MATERIAL Any substance or compound that has the capability of producing adverse effects on the health and safety of humans. IGNITAllLE A solid, liquid or compressed gas that has a flash point of less than 140' F. Ignitable material may be regulated by tbc EPA as a hazardous waste, as well. INCOMPATillLE The term applied to two substances to indicate that one material can not be mixed with the other without the possibility of a dangerous reaction. INGESTION Taking a substance into the body through the month as food, drink, medicine, or unknowingly as on contaminated hands or cigarettes, etc. INilMATION The breathing in of an airborne substance that may be in the form of gases, fumes nists, vapors, dusts, or aerosols. INililllTOR - A substance that is added to another to prevent or slow down an unwanted reaction or change. IRRITANT A substance that produces an irritating effect when it contacts skin, eyes, nose, or respiratory system. KILOGRAM (Kg) A unit of weight in the metric system equal to 2 2 pounds. LC,, See LETHAL CONCENTRATION 33 LD, See LETIIAL DOSE 3 LEL See LOWER EXPLOSIVE LIMIT. LFL Sec LOWER EXPLOSIVE LIMIT.

~ . ~. > - - - -,.. -., ~. .- ~ -. - - -.--. 'C Chyter CUA a * = ss = Date of hwe of Manual Date t) Reuwm of thn Page lage CilEMICAL MATERIALS January 11,1989 January 30,1991 72 i SAFETY MANUAL. 1 LETilAL CONCENTRATION, The concentration of an air contaminant that will kill 50 percent of the test animals in a group during a singic exposure.

1 LETHAL DOSE The dose of a sulr.tance or chemical that will kill 50 percent of the test animals in a group within the first 30 days following exposure.

~ LITER (L) A measure of capacity - One quart equals approximately 0.9 liter and one liter i ? equals approximately 34 fluid ounces, j LOCAL EXHAUST VENTILATION Also knomi as exhaust ventilation.) A ventilation system l ' that captures and removes the contam(mants at the point they are being produc I escape into the workroom air. -The system consists of hood, ductwork, a fan and possibly an air-cleaning device? Advantages of local exhaust ventilation over general ventilation include: it i J removes the contaminant rather than dilutes ill it requires less airflow and thus is more : economical mer the long term; and the system can be used to conserve or reclaim valuable - materials. Howeverlthe system must be properly designed with the correctly shaped and placed hoods, and correct!y sized fans and ductwork. - LOWER EXPLOSIVE LIMIT (LEL) (Also known as the Lower Flammable Limit.) The lowest concentration of a substance that will produce a fire or flash when an ignition source (flame, spark, etc.) is present. It is expressed in percent of vapor or gas in the air by volume. Below the LEL or LFL, the air contaminant mixture is theoretically too " lean' to burn. (See-also UEL); j 8 m. See CUBIC METER. MELTING POINT The temperature at which a solid changes to a liquid.- A melting range a may be given for mixture, 'mg See MILLIGRAM. mg/kg; See MILLIGRAMS PER KILOGRAM. 2 mg/m See MILLIGRAMS PER CUBIC METER. - MILLIGRAM (mg)- A unit of weight in the metric system. One thousand milligrams equal one gram. . MILLIGRAMS PER CUHIC METER (mg/m') Units used to' measure air concentrations of

dusts, gases, mists, and fumes.

MILLIGRAMS PER KILOGRAM (mg/kg) This indicates the dose of a substance (mg/kg) given to test animals in toxicity studies. For example, a dose.may be 2 milligrams (of substance) per kil.ogram of body weight (of the experimental animal). MILLILITER (mL) A metric unit used to measure capacity.- One tuilliliter equals one cubic centimeter. One thousand milliliters equal one liter.-

MS11A The M!ac Safety and Health Administration; a federal agency that regulates the mining industry in the United States. Respirators are designed to meet standards set by this agency.

v W i

~. - -... Chapter l { 8.40 GLOSSARY Pac of Nue of Manwl Daic of Remma of ihn Page P. ige CllEMICAL MATERIALS January II,1989 January 30,1991 73 SAFETY MANUAL ' MUTAGEN Anything that can cause a change (or mutation)in the genetic material of a thing . cell. - - NARCOSIS Stupor or unconsciousness caused by exposure to a chemical. NFPA The National Fire Prevention Association is a voluntary membersh'p organization whose l aims are to promote and improve fire protection and prevention. NFPA has published 16 volumes of codes known as the National Fire Codes. Within these codes is Standard No. 704,

• Identification of the Fire Hazards of Materials.' This is a system that rates the hazard of a -

l material during a fire. These hazards are divided into heahh, flammability, and reacthity hazards and appear in a well-known diamond symbol using numerals zero through four to i indicate severity of the hazard. Zero indicates no special hazard and four indicates a severe: hazard. . NIOSil The National Institute for Occupational Safety and Heakh is a federal agency that, among its various responsibilities, trains occupational heahh and safety professionals, conducts research on health and safety concerns, and tests and certifies respirators for workplace use. ODOR TIIRESilOLD.The minimum concentration of a tubstance at which a majority of test subjects can detect and identify the substance's characteristic odor. ORAL Hasing to do with the mouth, q OSilA-The Occupational Safety and Health Administration (or Act - depending upon usage) is the federal agency under the Department of Labor that promulgates and enforces safety and - health regulations for businesses having 10 or more employees in the United States, OX1DATION The process of combining oxygen with some other substance or a chemical s - change in which an atom loses clertrons. . OXIDIZER A substance that gives up oxygen easily to stimulate combustion of material, e.g., orgnnic. OXYGEN DEFICIENCY An atmosphere having less than the normal percentage of oxygen found in normal air. Normal air contains 21% oxygen at sea level. PERMISSIBLE EXPOSURE LIMIT (PEL) An exposure limit that is published and enforced by OSHA as a legal standard. PEL may be either a time-weighted-average (TWA) exposure limit (8-hour), a 15-minute short term exposure limit (STEL), or a ceiling (C). T'ne PELs are found in Tables Z 1, Z-2, or Z-3 of OSifA regulations (29 CFR 1910,1000). (See also TLV.).

PERSONAL PROTECTIVE EQUIPMENT Any desices or clothing worn by the worker to protect against hazards in the emironment, Examples are respirators, gloves, and chemical splash goggles.

POLYMERIZATION A chemical reaction in which two or more small molecules combine to form larger molecules that contain repeating structural units of the original molecules. A huardous polymerization is the above reaction with an uncontrolled release of energy. ppm - Parts (of vapor or gas) per million (parts of air) by volume.

i 4 Ot4['tff I 8,50 GLOSSARY y ou o saw ci M.nu um ot anmon w am em sge r CllEMICAL MATERIAL S January 11,1989 January 30,1991 74 SAFTlY MANUAL REACTIVITY A substance's susceptibility to undergoin; a chemical reaction or change that may result in dangerous side effera. nd. ;_ W~ie. he:ning, and corrosive or toxie emissions. The conditions **.ot cause the reaction,

• ach as heat, other chemicals, and dropping, will usually be speci% as
• Conditions to Avoid' when a chemical's reactivity is discussed on a MSDS.

RFSPIRATOR A device which is designed to protect the wearer frorn inhaling harmful contaminants. RESPIRATORY HAZARD A particular concentration of an airborne contaminant that, when it enters the body by way of the respiratory system or by being breathed into the lungs, results in some bodily function impairment. SENSITIZER A substance that may cause no reaction in a person during initial exposures, but afterwards, further exposures will cause an allergic response to the substance. SilORT TERM EXPOSURE LIMIT (STEL) Represented as STEL or TLV-STEL, this is the maximum concentration to which workers can be exposed for a short period of time (15 minutes) for only four times throughout the day with at least one hour between expc*ures. Also the daily TLV TWA must not be exceeded. ' SKIN" This designation sometimes appears alongside a TLV or PEL lt refers to the possibility of absorption of the particular chemical through the din and eyes. Thus, protection of large surface areas of skin should be considered to prevent skin absorption so that the TLV is not invalidated. STEL Short Term Exposure Limit. SUBSTANCE Any chemical entit". SYNONYM Another name by which the same chemical may be known. SYSTEMIC Spread throughout the body; affecting many or all body systems or organs; not localized in one spot or area. TERATOGEN An agent or substance that may cause physical defects in the developing embryo or fetus when a pregnant female is exposed to that substance. TilRESilOLD LIMIT VALUE Airborne concentrations of substances devised by the ACGlH that represent conditions under which it is believed that nearly all workers may be exposed day after day with no adverse effect. TLVs are advisory exposure guidelines, not legal standards,- that are based on evidence from industrial experience, animal studies, or human studies when they exist. There are three different types of TLVs: Time Weighted Average (TLV TWA), Short Term Exposure Limit (TLV-STEL) and Ceiling (TLV-C). (See also PEL) TIME WEIGitTED AVERAGE The average, over a given work period (e.g.,8-hour workday), of a person's exposure to a chemical or an agent. The average is determined by sampling for the contaminant throughout the time period. Represenied as TLV TWA. TIN See THRESHOLD LIMIT VALUE. l

Chapict CUA "a " ss^"' o m o#isme or Manua ou or Revmon at this Pare Pare CIIEMICAL MATERIALS January 11,1989 January 30,1991 75 SAFE 1Y M ANUAL TOXICITY The potential of a substance to exert a harmful effect on humans or animals and a description of the effect and the conditiens or concentration under which the effect that, when it enters the body by way of the respiratory system or by being bicathed into the lungs, results in some bodily function impairment. TRADE NAME The commercial name or trademark by which a chemicalis known. One chemical may have 1 variety of trade names depending on the manufacturers or distributors involved. 'DVA See TIME WEIGliTED AVERAGE. UEL Sec UPPER EXPLOSIVE LIMIT. UFL See UPPER EXPLOSlVE LIMIT. UNSTABLE LIQUID A liquid that,in its pure state nr as commercially produced, will react vigorously in some hazardous way under shock conditions (i.e., dropping), certain ternperatures, or pressures. UPPER EXPLOSIVE LIMIT Also known as Upper Flammable Limit (UFL). Is the highest concentration (expressed percent of vapor or gas in the air by voLme) of a substance that will burn or explode when an ignition t.ource is present. Theoretically above this limit the mixture is said to be too

• rich" to support combustion. The difference between the LEL and UEL constitutes the flammable range or explosive range of a substance. That is,if the LEL is 1 ppm and the UEL is 5 ppm, then the explosive range of the chemical is 1 ppm to 5 ppm. (See also LEL)

VAPOR The gaseous form of substances which are normally in the liquid or solid state (at normal room temperature and pressure). Vapors evaporate into the air from liquids such as solvents. Solvents with low boiling points will evaporate, e

e ChJptfl S.41 REI'ERENCES Date of hsue of Man at Date of Revtuon of thn Page Pape CilEMICAL MATERIALS Januarv U,1989 January 30,1991 76 ) SAFETY MANUAL j 8,41 REIT:.RENCES

1. Altman, P.L, Dittmer, D.S., Dielc.igy. Rata.D. col Yfl.1 III,2nd ed., Fed. of Am. Societies for Experimentrl Biology; Bethesda, MD,1972,

2. Anon.,Ierie and Ita7ardous Industrial Chemicals Safety Manual, laternational Technical Information Institute: Tokyo, Ja;3an,1979.

3. Bretherick, L,11andbook cLPeactive Chemical lla7 anis,2nd printing, Uuucrworths:

Boston, MA,1980.

4. Brodsky, A., edhor, CRC Handbook of Radiation Measurement arid Protection, CRC Press Inc: West Palm Beach, FL,1978.

5. Cg.r.sinectns, U.S. Department of IIcalth and lluman Senices, Public Health Senice, National Toxicology Program, U.S. Government Printing Office, Washington, DC, latest edition.

6. Casarett, A., Radiationfielegy, Prentice-Hall, Inc.: Englewocxl Cliffs, NJ,1968.

7. Casarett, l J., Doult, J., Eds., Toxicolor v. Macmillan: New York,1975.

8. Cember, II.,In1Indyction to Health Physics, Pergamon Press: New York,1%9.

9. Deichmann, W.B., Gerarde, H.W., Toxicolocv of Drucs and Chemicals,4th ed., Academic Press: New York,199.

10, Dessmentation of the Threshold 1.imit Values for Subs 11 mees in the Workroom Air nmi SupplementalDocumentatifB. American Conference of GovernmentalIndustrial Hygienists: Cincinnati, OH, (latest edition).

11. Fawcett, H.fl., Hazardous and Toxic Materials: Safe llandlinjti.,Disoosal. John Wiley &

Sons: New York,1984

12. Fire Protection Guide on Hazardous Materials. 7th ed., National Fire Protection Association: Boston, MA.

13. Gocximan, LS., Gilman, A., The Pharnucolocical Basis of Thernoeutics, Macmillan: NY, 1975.

14. Gosselin, R.E., et al., Clinical Tc5ign[ggy rLCommercial Products Acute Poisoninc. 4th ed., Williams and Wilkins: Baltimore,1976.

15. Green, M.E., Turk, A., Safety in Workine Mth Chemicak Macmillan: New York, NY, 1978.

16. Ihg Jh7anl.Cepmunigntien Standard - A Guiddeel National Safety Council: Chicago, IL,6061L

17. Hilado, CJ., Clark, S.W.,6.PJpjgnition TemocratmetgLQigmis.laly.e_nts, Chem. Eng.:

(NY),1972, 79 (19), 75-80.

t (hcpter (( 8AI REFEIENCES pm. w iswe u MannaT o.oe c ken,,on of ihu hge f.nc CilE4tlCAL MATElllALS January 11,1989 January 30,1991 77 SAFETY MANUAL

18. Tis.IndmitiaLEndtfaltal.J.ts Evaluation and Control. U.S. Department of Heahh, Education and Welfare, Public Heahh Service, NIOSH, U.S. Printmg Officc: Washington, DC, Stock Number 0174301-003%4,1973.

19. lad.tutdaLWntiloJiei, American Conference of covernmentalIndustris!Ilygienists, Committee ou industrial Ventilation: lansing, MI, (latest edition).

20. Knoll, G., Radiation.Iktulian.and.hituuttmt.nl, John Wiley & Sons, NY,1979.

21. Lederer, W.H., Regulatory Chemin.l.s of Heall)Lanifnvironmental.fcatgrn, Van n

r Nostrand Reir3old Company: New York,1985.

22. Lewis, RJ., Ed., Fecistry of Toxic Effects et Chemical.S.uhMat'.ta, DilEW (NIO511), Publ.

Microfiche issucJ r;uarterly.

23. Loomis, T.A., Eisraki l pf Toxicolocv,3rd ed., Lea and Febigen Philadelphia,1978.

At

74. Martin, A, Harbison, S., Radratin.R.Etatution, Chapman and Hall, Ltd.: London, England, 1979.

25. Moe, Lasuk, Schumacher, and liunt, Radiation Safety Technicidftal: tine Coursc, Argonne National Laboratory, ANL 7291 Rev,1. He.ahh and Safety, May ID7. available from NTIS, USDC, $pringfield, VA 22151.

26. Morgan, K., Turner, J., Etntiglu of.Rin 'ation Protection, Robert E, Krieger Publishing i

Co., Huntington, NY,1973.

27. Murr, G.D., Ed., liaratds in the Chemigl I.aboratory. 2nd ed., Chemical Society Lond.m, 1972.

28. NIOSH/ OSHA ProducLGuide terC.btqd.cd,litoards. DHEW (NIOSH): Sept.1978, Publ.

No. 78-210.

29. Olishifski,.Iulian D., McElroy, Frank Es Eunda.tnentals of In:iustrial Hvciene. National Safety Cotmcil: Chicago, IL,1976.

30. DSHA Safety and He:dth.S.tand.DL4LG2CER1210), United Etates Department of Labor, OSHA, Government Printing Office; Washington, DC,(latest edition).

3L Patty, F.A.,In!!astrial Hvciene and.Toxicolocv Volume H-Testelogy,Interscience Wiley-New York,1980.

32. Proctor, N., Hughes, J. Chemical Hazards in the Workplace, Lippincott: Philadelphia, 1978.

k

33. Prudent Practitts for Handline Ha7ardp.33 Chemicab in Labe.r.atatic, National Rescaich Council, National Academy Press: Washington, DC,198L

% Safety in A_.gademic Chem _i_5tn LaboraL0riu,4th ed., Committee on Chemical Safety, American Chemical Society: Washington, DC,198.3.

O gier CUA " " = ""c Dow of lu,ue el Manual D4.+ rif Revnum of thu l' age Page CllEMICAL MATERIAIS January 11,1989 January 30,1991 78 SAFETY MANUAL

35. Sax, N.I., Dancerous Prooerties ofIndustrial Materiah,7th ci, Van Nostrand-Reinhold:

New York,1988.

36. Shapiro, J., Radial.icnAntcIlion, Ilarvard Univasity Pren: Cambridge, MA,1)S.

37. Shleien, B., Terpilak, M.S.,Iht.]Iealth Physiss.and Radinlocical llealth IIAndbook, Nuc! con Lecturn Associates, Olacy, MD,19S4.

38. Sittig, M., }.larardous and Tode E[f sts of Industrial Chemicals. Noyes Data Corp Park t

Ridge, NJ,1979.

39. Steere, N.V., Ed.Cf:Uh;#mok of Laboratory Saltty,2nd ed., CRC Press: West Palm Deach, FL,1971.

40. TINS ThreshoQ.J.imit W1ues for Chemical substances and Physical.Aggnts in ths Workronmfoyironment withJntended Chances. TLV Alttorne Contaminants Committee,

] American Conference of Governmental Indu:, trial flygienists: Cincinnati, Oli, (latest edition).

41. Walters, D.C., Ed., S.nfc IlandliDC 0LChemical carcinocensdfutacens. Teratogsmad

}Jichiv Toxic Substantes, Ann Arbor Science Publishers, Inc.: Arm Arbor, MI,1980, Vol 1.

42. Winhoir, M., Ed., The Merck IndgA 10th ed., Merck and Company: Rahway, NJ,1933.

43. Zabetakis, M.G., Flammsble Churcteristics of Comtyustible (lases and Vanors, U.S.

Bureau of Mines Bulletin 627,1%5.

8 Chaptet APPENDIX A. OSilA SUllPART Z ome us us,ic on Manui Dee o' keuwon o' ihn Pne Pac CIIEMICAL MATERIALS January 11,1989 14ebruary 22,1989 A-1 SAFETY MANUAL APPENDIX A OSilA SUBPART Z llazardous & Toxic Chemicals List of Regulated Substances Each supenisor will be issued as a part of this Chemical Materials Safety Manual, a copy of the publication " Air Contaminants Permissible Exposure Limits (Title 29 Code of Federal Regulations Part 1910.1000),' published by the U.S. Department of L. abor, Occupational Safety and llealth Administration (OSHA),1989. The Environmental Safety OfGce will also have available to any employee or supenisor, for review, a copy of 29 CFR 1910,' Air Contaminants; Final Rule,' published on January 19,1989, in the Federal Register. Any employee with specific questions about hazardous materials or who wishes to receive a copy of these air contaminant tables should ask his supenisor or the Environmental Safety Office for such infore ation. I l ,}}