ML19247A445

Fr Notice Re NRC Regulation of Medical Uses of Radioisotopes & Statement of General Policy

ML19247A445
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Issue date:	02/09/1979
From:	Chilk S NRC OFFICE OF THE SECRETARY (SECY)
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Text

8240 RULES AND REGULATIONS or:ented toward assistm Nnerany

[759%C1-M]

L Sr4meer r GunAa PotJc'r anfied physicians m c:scharr.n; ng* y"'*

- ha NRC pct:r statement is m-the:r responsteilities to pat:e lis. Hort-wnac w :r.:m-- NRC.::ensees. oth" c;er, regulat:en by AEC,NRC has a:

o agenc2es and IOe CH APTIR l-NUCtEAR REGULATCRY

[yg.;n.1 an[- Smee C P T1on's EeDeTal *;

M-ly every aspect of IP dehrer t:

c

, time or another encompasser ge g; ;

COMM1SSICH wnuon recarc;n; tne regulation rac:01sotope medical :e.x.ces to pa-the mettical uses of rad 20:sotoDes-the broadest regulation oc-PART 10-HUMAN USES CF lt ts eroceted inat future NRC acuv-

~M between 1962 and 1975, when BYPRCDUCT MATERIA 1.5 ttles in the med: cal ares. such as pro-mulgation of new resulat ons and de-the Food and Drug Mmtmttrat:en Regulation of the Mealcol Uses of vel pment of cooperaun relanonships pted from its require-menet for tiew drugs All Radioisotopes; Statement of Gener. $u w t$ vtatem M NC b.y radiopharmaceuticals regulated by al PoGcy Based on past expenence and the AEC. Dur:ng this pen,od AEC regulat-comments and advice of t.he public, ed 122e radiation safety of workers and AGENCY: Nuclear Regulatcry Com-other Federal agencies. the States, and the general public and the safety and mMm NRC's Addsory Committee on the efficacy of radioactive drugs and de-ACTION: Final Policy Statement.

Meal Uses M Isotopes, the Commm vic e with respect to paMs. E.

sion has deveJoped the following state-regulMion included production of the

SUMMARY

The Nuclear Regulatory ment of general policy to guide its reg-radamsotope. manufacture of the final Co*=n (NRC) has the fonowmg uiztfon of the medical uses of radiono-radacractive drug product or device, dis-policy enfament regardmg NRC's topes:'

tnbution, use and disposal of the prod-future role in regnintfnf the medical

1. The NRC will continue to regulate ucts. In 1975. the FDA termmnied the uses of radioisotopes. This NRC policy the medical uses of radiompes as ese=ption for radiopharmacentenh-statement is intended to inform NRC nece ry t provide for the radiation staung that it would now regulate the licensees, other Federal and State safety of w rkers and the general safet,y and eficacy of radioactive p%The NRC wul reguists the radi-agencies and the public of the Coma dzs wh respect to patzents. (As mission.s,n*enW *teth m ncteci later in this semre-nt. FDA g

the regn n of the medical uses of ation safety of patients where justified does not regulate the phytw an's rou-by the risk to patients and where vol*

radioisotopes. It is expected that tine use of radiopharmaceuticals.) At untary <*nMseds, or compliance with the sa.me time. NRC withcrew from future NRC acuvices in the medical these standards. are inadequate.

area, such as promulgation of new rez-

3. The NRC will mW* intrusion regu.:.ating radioactive drug safety.and effic ry, statmg that it would regulate ulacons and development of coopera-into medical judgments affectmg pa-the radiation safety of the workers tive relsuonships with other Federal tienta and into cther areas traditional-and' the public. The 1976 Medical agreet win follow this statement of ly considered to be a part of the prac-NRC policy.

t:ce of meM"'

Der:ce Amendments to the Food. Dn:g and rw etic Act extended FDA's au-EFFECTIVE DATE: February 9.1979.

II. RAnoNatz thority over medical dcrices (including devices contstmg radioactive materi-POR r m uw.

INFORMATION The NRC and its predecessor the als) in a way emnnr to its authonty CONTACT:

Atnmie h*gy Committmn have regu-over Cirugs.

Mr. Edward Podolak. Office of lated the medical uses of radioisotopes NR.C's authority to regulate domes.

SenMneds Development. U.S. Nt.cle-smce 1946. AEC recognized that phys!- tirsnv the medical uses of byproduct ar Regulatory Commktion. Wash-cians have the prhnary respcnsibinty e-me,-ial is found in the Atomic ington. D.C. t0555 (Phone: 301-44b for the or tee +.lon of their patients Energy Act of 1954, as amended. For 58601.,

and designed us reguladons accordn8-emple. section 81 of that Act autho-ly. The physicians were required to be rt:es NRC **to issue general or specific SUFFT W7'YTAL INFORMATION: licensed by the State, and their appil-Heenses to applicants seeking to use The NRC has developed the following cable trWnt and experience were by,:roduct material for * *

• medical three part policy statement regarding evaluated in censultation with the Ad*

t.Wy * * * " Section 81 directs NRC NRC's future role in regnin*mg the visory Committee on the Medical Uses me&x! uses of radioisotopes. On of Isotopes. This regmation has been to regulate the manufacture, produe-tion. transfer, receipt in interstate March 17.1978 the three part policy comZneret, acquisition. ownership, pos-statement was published in the Froz2-

'NRc itreenae radioisotopes in three cate.

sesszen. import and export of byprod-ar. Bettra M3 FR 11:08) for public sones: byproduct. source and special nucle-uct material. Fm2Hy. Section 81 also co-ant. Copies of the polley state. ar material. The NRC does not regulate nat.

direens that:

men ** were sent to an NRC medical li-urally occurrins or emelarator produced ra-censees, the States and 25 profeafnnst diotnotopes. The term Dyproduct matertag he M*on ahmM Dot permit the dis.

societies. Federal agencies, and indi-means any radme mar-em1 weept spe.

tribucon of any Woroduct matenal to any cial nuclest materian rielded m or made r heensee. and shan recall or oreer the recan viduals. The comment period expired dioacuve by expos:re to the rm*= Men ind.

of anse dumbuted mf t, rial from any Ucen.s-May 16.197& Twenty-two enmmenta dent to the process of producing or utumns ee. wrzo is not equipped to observe or fans to were received. Nine commenters fa.

special nucicar matensL The term soure, observe such safety st=m*=nts to protect vored all three parts of the policy metsrsc2 men" (1) uranium. thomm or any heants as may k WW W the Com.

m.****

staterm*. four corameters opposed therect, b any physical or nussion or who uses such mater.11 in viola.

one part of the policy statement and ehemtral form or (t) cres wtuch contam by tion of law or regulauen of the Comm-n weight one-twent:eth of one percent (0.05%)

or in a rnamner other than as mewed in nine commenten addressed specific or more of (1) uranium. (11) thonum or (111) the appt cauon therefor or approved by the issues discussed in the March 17. 1978 any e== nan thereof. Source c:atera! * "*" on-FrpraAr. Rzctstra notice. The com. coes not include special nuciear materia:-

Commission regulations, for the ments are ciscussed in Sect!cn II.

specscJ nucleu matenaJ means (1) piutcru.

most part set fcrth m 10 CF". Partr, N 36 Copies of the comments may be exam. Q{.,Qy Qeh througn 35. were prc=ulcated to car med m the NR Public Document materal arc:Ite:.cly ennenec er any cf tne out tne broad recum:o y seneme en.

Recm at 1717 H Street, N.W., Wash-toresoms. but coes not taciude soure. mate-nsag ed by section El. For exnmp;e.

m Eten. D.C.

nal.

Pr. 35 estabMnes regulations spec:fic btortAI'UG:!rt:. vol 44. HC.'29 41t1DM' FIBU:A2v 9.1979

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E M 33

RULIS AND REGULATIONS 8243 r

to human uses of byproduct matenal.

The NAS-BEIR 8 report discusses The rerulations try to find a balance FDNs statutory suthority (Federal limiting the exposure of the popula-between adequate controls and avoid-l Food. Drug and Cosmette Act. as tion to meccal appi: cations of :en nns anee of undue interference in rnedical amended. *1 U.S.C.101 et seca das radisuon. That report, wn:en ecluces Jud gments. A consequence of too not diminish NRC's authority. Whe e au niedical uses of ion 2=ng race.non. much reguhtion could be poorer NRC's and FDA's authorities overlap, shows an average dose rate from health care delivery to patients. A con-the respective autnorttles can be har-radicpharmaceut*m a of 1 mrem / year sequeneg. of leanng to physicians the monized by interagency agreement.

and an average dose,2 mre=/ year :n rate Irots c:ag-ma;ont7 of the decisions concern.mg The ten:ral ouesnon is a que=cn of nos,1c racioicgy or.

gg.r padents is that the pnrsic:ans poltry not cuvtortry, namely-

.970.

w 11 de mistakes. The tightest regu-To what extent should the protee-The fodowing quotauon is from the tion of the patient be conndered in. AS-Br R repert.

12 tion of physicians' dec:sfons by Fed-NRC's regulation of the medical use of e

State and professional groups will byproduct material?

is the foreseeable future, the major con-not be a.hle to prevent future inmdents tributors to radat2on exposure of the popu-in the metiical uses of radfoisotopes.

From the standpo:nt of cu.. ort'y. it 12 tion wn! continue to be natural baca-The ~ Commfuton recognizes that is clear that NRC can regulate the ground with an average whole body dose of medical uses of byproduct matenal to about 100 miem/ year. and med: cal applica-FDA res.lates the manufacture and protect the health and safety of users tions shien now ecstr:bute cocparable ex-interstate distnbution of dn.ss. includ-of this material, for instance, padents. posures to various ussues of the body. Med5-ing t h na.aa that are radioactive. FDA In licensing the possession and use of cal expmures are not ure control or ruas. also regulates the investigado=al and byproduct material. NRC est'hif thes ance by ng** or law as msem m researett uses of drugs a.s well a.s the limits wit.hin which phy:icians exer-use d wm >=% in me is d spec!Ile guidans on doses and proce-LM mend u8 'Elu* Dut it 18 '" tial t cise Drofessional discretion. Frots the dures found in the product IW"7 reduce exposures since this can be accom.

standpoint of policy, these 11mit3 ptished without loss of benent and as reis.

em N does not h me au-depend upon bow NRC views the po-c vely imr cost. rhe aim is not only to thonty to restrict the reutine use of tential hamd to the patient's health reduce the r=rm inn exposure to the ind.i.

drugs to procedures (desenbed in the and safety in the uses of the byprod-ridual but also to have procedures carried product labeling) FDA has approved uct matenal The greater the potential out with mamum emeiency so tnaz there as safe and effective. Indeed. ImC is hazard to a patient from the byprod. can be a conunorr t: crease in med: a1 the only Federal Agency that is cur-uct material or its use by a phyr.ician, beems accommed b, s -

m rac1 rently author 2:ed to regulate the rou-the more NRC may elect to circum-anon expmure.

tine use ctf radioactive drugs from the scribe areas that might otherwise be NRC will act to help ensure tnm. a-standpoi= of reducing unneceuary ra-regarded as within the discretion of d'auon exposure to patients is as l aw distinn exposu~ to patients.

the physiron-as is reasonably achievable. consistent The f'r*---M

_n believes that the The first part of NRC's policy state-with competent medical care and vith dia pecac use of radioactive drugs 12 ment indicates that NRC will continue r-in t" d intrusion into medical Judg. in most c:ases, clearly an area of low to regulate the medical uses of radioi-ments. NRC W111 not exercise.tgula-r#N risk to patienta. Therefore.

Jotopes as necessary to provide for the tory control in those arest wcere.

NRC EU not' control pnysic:an's pre-radiadon safety of workers and the upon Careful

• T--

Wf*Gn. It deter.

rogativt$ on patient selection. Instru-general public.8 This is the traditional cunes that there a.e adequate reguia-ment selection. procedure selecuan.

regulatory functon of NRC for all tions by other Fedtral or State 2:en-uses of byproduct, source and spec.21 cies or well + -"tered professional drug selecalon and dose level for most nuclear material. It is a regt:.tatory strndartis. Wherever possible. NRC daw.x uses of radotsotopes. N role that was not questioned by any of will work clos *17 with Federal and au theracem uses of radicar.We the commenters but, rather, it was State agenciec and professional g oups dmss. aM in certain diagnosuc usew consistently recognl:ed as a necessary in designtag new voluntary guidann for example, the use of pnosphorus42 role in the medical uses of radio!so. for practitioners to li=ut unnecessary for l W - e'=

of eye tu=2crs-the

topes, patient r2micon x osure.

rirJc to pn:1ents is not low. The nar of NRC's regulation of the radiation The thi.-d 7 art r i NRC's policy state. nssue or a:rpan <*~-are (or even death) safety of worters and the general ment indicases.nat NRC r.11 c.=2 ts inherent :n the use of therapeuce puolle in the medzal uses of r:u11c;so.,

.=e its intrus;on into medical ju:tg. levels of radioactive drugs. NRC nil topes :.s relin::uished by NRC to Agree. cents affecting the patient and into contmue to restnct the uses of therae Cent States" does not overlap T.th Cther area.s traditicnally con.ndered to DeutC 3md certain dimostic radioac-FDA's actir. ties; i.s in harmony with be a part of the prac.:ce of medic:ne. cve drus:s to the indicated procedures regulation by the Departnlent CI The Cornmmion recogn: es that ph7-that have Deen approved by FDA. The

~'ransportation. Social Secunty Ad.

sicians have the prim = y re:ponsibility NRC will not control the ptye-e ministration and the Joint Co

. for the protection of their padents. Drerogauwes on nudent selection and slon on Accreditation of IIospital:; and The Corru11ssion believes that basic mstru=mt selection for therapy pro.

dovetails with Occupational Safety decisions concerning the diagnos:s a=d cectres. ::ecause these procedures are and Health ANi-tration retuladon ceaunent of disease are a part of the so spechd and patient specfic.

or the work-place for the use of natu.

physician.panent relatonst:p and am Congres-s recently gave FDA anrMnrt-rally-occurring and accelerator-p*0- traditionally considered to be a part of ty to TWute medical devtets, s:zailtr duced radioactive materiais.

the or2cuce of meen, NRC reguia.

to 7oy,,ut3,nt, t,,,,c12t, e,u,,,

a p on ass =Wn The second part of NRC's policy but Tt*h-additional authonty to re-statement indicans that NRC will reg-r{d m the rotune use M medimi de-w-

-- e C ulate the ad.auon safety of patient.s W

W d&W r.ces as :=27 be nec*=7 to provide where justified by the ris4 to patients tien a, reasonshie assurance of their safety and where voluntary sis.ndard.2 or and effecniveness. FDA has not yet compliance Tith these standards. are had suff:=:ent ttme to implement its

nadequate. As noted be' ore. NRC has

' National Acade=r of Sctences Adescr7 full authority to regulate medical de-the authonty to regulate the radiation Cocumstee on the B.o:crical Effect.s of loo.

% g.Pmn2 byproduct, source or safety of patients, f.,fla*CLJ O*t Par'dCnOTLS Q.

WOhrt @e [# ;pe ;2] n,,; lear Insterial. T he*e!cre.

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.,.01D tMelJ Cf lo'tt.tN R2dL1&;TL Nc

• t t"" c2 NRC r.'.I continue to restnct physt.

C.e 9""'i eeCe*21 PODl!O In this S; ate-ACEOt97/* Of' SC*t*CPT-.W.".0 Cl Af f ee":3 Can s uses of these C*niOsl der 1Ces.

Gent Sr%CM.7 eZ".;Ce5 DCie"1L.3.

C I.T.C*.I. T14h10g100 D.C. uCC.

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fcr d'ag"osts and therapy. to y

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. RULES AND REGULATIONS tnose :: ocecures inat NP.C has d7ter.

Two ce=mente s objected to NRC's As noted m the proposed policy

=med (= consuaanon w:th its Adviso-re;uisuon of panent rad 2 anon safet.

statem ent NRC ts studying the V:

ry Ccre.=:uee en the Siedienf Uses of bmuse they beheve that NRC coes tous alhed health ceruf! canon pro-Isotopes) to be 511e and effecuve.

not have the author:ty to regulate pa-grams currently in effect or bem; The Commiss:en coes not censider tient safety. They note that NRC's en-drafte:d by other Fedenl. State and equipment cancrauon. cualificauons abung legislation coes not specifically profesmonal groups. If the coverage of paramecical personnel or reporting mention the radiauon safety of pa-proviced by these programs is not ade-to NRC misar+mmatrauons of radioac-tients. They beheve that patient quate to protect the patient from un.

tive ma:enal to be exclusively the safety is the responsibility of the phy.

necessary radiaton exposure. NRC practice of medicme or a part of physi-sictan. a responsibility that cannot be will wc:rt with these croups to d*velop a ner NRC proposed rule for the clan-panent re120cnships. The Com* shared. They believe that the Cc==is.

mmion intends to regulate these areas ston is in error to equate patients w".th trum e of allied health personnel.

There were five comments on the of padent radiation saf tty where Pasti-the public and to consider patients as fled by the rist to patients and where users rather than recipients of radio. specific subject of nuclear pharmanes (radiossharmacies).

voluntary stancarda, or compliance acuve mate rial One commenter urged NRC to dis-with these standards, are inadequate.

As noted in the analysis of the simi.

guish w

p ac comm abo e.

NRC ove III. Drscrsstos or Pt'suc Couvrm g

worti=4 in a retail environment (com-

{

A. CoWUTs ON Uu: rouCT srArNT teC: the health and safety of the n

[

One commenter opposed the use of pub!!c. The patient is a member of the p@He mcumstan_ the Cc

- the problem of definition wuen the j

the general te m " radio:sotopes" in 1

the first part of the policy statement. sion s recogniuon of physicians pn=a-hospit:al based radiopharmacy pro-This co=menter was concerned that, ry responsibility for protection of j

if taken out cf the contert of the foot.

their padents. The pohey statement hospitals and practitioners in its area.

i

{

note. it could be interpreted to include and. inceed. all of the Co-suon's

^8 Cted po poh naturally occurnng and nn ele stor. acnons in reg *Mnr the medical uses

,g,

of radiolsotopes, acknowledge the sec-Food z$1d Drug Administrauon tFDA) produced radioisotopes.

The Co-won believes that the ondary but nece"nry role of NRC in regardi:ng a determmndon of those ac-general term " radioisotopes" is alain reg?'1stine the ruinMon safety of pa-Mes of nuclear pharmacies that will F.nghsh and eas:17 recognned by the tients. The Cr-"*on also considers be comsidered manufacme and those pubDc. It was property footnoted in panents to be both users and recipt-activitaes that will be considered the the policy sintement to include the ents of radioactive matertaL However, ordman prack of pharmacy (com-more cumberso=e but speedic terms; the distinction between receipt and Foundi 1g and dispenegL byproduct. source and special nuclear use of radioactive materials is nct Pcur unmenters oW.ed to NRCs matenal and to exclude naturally oc-me*Mnrful in this case because NRC Iferer nuclear pharmames to dis-curnng and accelerator produced ra-regulates, accng other thmgs, receip*

te only those pMum that @.c dioactive matenal.

possession, use and transfer of byprod-have : prepared from FDA-approved One commenter. In opposition to uct, source and special nuclear materi-NRC's regulallon of patient radiation alin protecting the health and safety One mmmenter cited be pmcuce of safety, suggested that NRC limit its of the public.

nuclear pharmne?es supplying radio-role to the radi20cn safety of the-hos-1 pital staff and the general patient

3. conzrrrs os srtcric Issus che~ tra it to researchers who use them on hitmans under their own population. He believes that patient m.,e e ere six comments on the FDA " Notice of Claimed Investigation-dosimetry is a responsibility of the in-qu'esti n cf rep rting "HW "".ra-11 Dtennption for a New Drug" (IND).

dividual insutution and not NRC. This i

a e materia. Three One commenter noted that FDA per-commenter feels that NRC shculd cc"-ws opposed any mW'-h mits nulelear pha.~acles to operate in first remnre adequate staffing, includ-tra n reporting and three ecm-the absience of a final determination of ing a board certified physician or ra-Inenters offered suggestions on how their wtatus, providing they meet all diapha.m and a radlaucn safety they should be reported. All of the State az.nd local pharm.aceutical regula-officer, and then essentially leave the comments will be considered'in dealing tions. The two other commenters institution alone regarding dosimetry, with NRC"s newly proposed

• min-charactenzed the NRC's restrictions instrumentation, calibration, drug pro-istration reporting requirement that on the distnbution of cure =2ent or any other function con-was puhl!thed in the FEDERA2. Rectsizz radienmarmaceuticals by nuclear phar-sidered to be the practice of medicine.

for public comment on July 7, 1978 (43 mares as an unwarranted intrusion NRC does reqture the licensee to into thle practice of pharmacy which is FR 29297L staff its operation with a radiation There were six comments on the spe-regula ted by the States.

I safety officer and a phy*hn (not cific issue of paramedical tru tnin g.

NRC licenses nuclear pharmacles to nece"srily board certined) trained to Wmm radicactive material or rs.

Three commenters believe that it is distritute radioactive drugs that have diation to patients. However, the Com.

""w y for NRC to beco=le in.

been : approved by FDA. This includes mtwon ea not li=!t its regulatory role volved in paramedical training because radion;cuve drugs subject to an FDA-to protecung the hespital staff and several art-tr**uons are already pro-aDproved "New Drug Appucadon" the general pauent populauen and at viding or developing minimum stand. (NDA-) or " Notice of Claimed Investi.

ar'.+.s. guidelines or certificauon. One gational Fxemption for a New Drug" the same time fulfill its ecngressional mandate to protect the health and cc=menter believed that NRC should (INDE. NRC relles on FDA approval of safety of the public as regards source, be involved in this area because the radics.ctive drugs because NRC has byproduct and special nuclear maten. technologist. not the physician, does not re-gulated the safety and effective-at The patient being treated or diag. most of the werk with radioisotopes. ness of radioactive drugs since 1975.

Also. there are not many Sates that ncsed v.mn ramoscine matenal, s.t Two ec=mente-s believe that radicio;s are ec;u:pped to re;rclate radicacme weil as tue generni pubbe no may be !caJ physicists should be separated out crug s alety and eff ecnveness.

ex;csed to radiatics as a result of that from other para:nedical personnel and treatment. are a'l =lembers of the one of these ec=nenters offered a Daaed at L~r.ahincen. D.C. this 1st pubuc to be protected by NRC.

definition of radiological phys:cist.

day c f February 19'73.

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NOTIGS l

[7590-01-M]

ered for future vacancies as they de-Fcr the Nuclear Regula:czy ' ~,. -

9 velop. Nom: nations should be sent,o r:ussion.

NUCLEAR REGULATORY the:

S.e.: r:. J. Cm COMMI5510N Seentc-,r c/!!!c Co-tmtssti i Secretary of the Ccmmiuton. ATTN: Advt.

ti R DOC-79-414 3 ' "ed 2-3-79: 3 4 *=. M ADVl!ORY COMMITTEI ON THE MEDICAt sory Committee Management. Officer. Nu-ya

- n.Wmp ear U5ES oF ISOTCPE5 ten. D.C. 0555.

Nesunstions b New Memows Dated at Washington. D.C. this 7th The Nuclear Regulatory Commktion day of February 1979.

(NRC) is anticipating three vnenneies For the Nuclear Regulatory Com-on its Advisory Committee on the m Rtion.

Medical Uses of Isotopes ( ACMUI) and 13 inviting nominations from members Jo n C.Ho m of the medic *1 community and from

'idmm Commme other interested groups or individuals.

Ma ON.

The purpo e and function of the TR Doc. 79-4590 FUed 2-t2-79: 5:45 am)

ACMUI is to advise the NRC staff on problems or questions that arise in 11-cendnr the use of radioactive material for human diagnosis and therapy.

Duties and responsibilities include evaluating the trufnfnr aM experience requirements for phyticiant who re-Quest authornn?Mn to use radioactive mater:als for medical purposes; provid-ing guidance and comments concern-ing emnges in NRC rules, regulations p

and gnides concerning medical uses:

Lt 4 C f

and eratuating certain nontoutine uses "u

of radioactive m2fertals for human di-k._ _

J agnosis and therapy. Additional de.

~

tails regarding the duties and func-

.Z l

tions of the committee and its mem-bers can be obtamed by telephomng

f. _.

Mrs. Patric:a C Vacca at (301) 427-

~1 C32.

-.[

The eight member ACMUI consists f

of CWo physic 2An specialists in Thera-(

' y) peutic Radiology, one physician a spe-c:111st in Nuclear Medicine with a c.?

be.ckground in Pathology, two physi-

-l.

e-cian speciahsts in Nuclear Medicme

~3 7

rith a background in Radiology, two 1

physician spec:alists in Nuclear Medi-

- yI g'

c:ne with a bactground in Internal

..O Medicme, and a specialist in Medical

(' c _

Physics. It is intended that this 1al.

ance of medical spec:ahsts re -m n con-

[m.

stant.

in Accordance with established pro-Eh ~"[

eedures, the three committee members

.1'

.J Mth the greatest length of service will

? '" k be retired. creating v2emnef es for two h' N d N

spec:111sts in Nuclear Medicme who have backgrounds in Radiology and f* G c,-

spec allst in Nuclear Medicine who has

&~

i2 a background in Internal Medicine.

,,DMY Nominations must inrlude a resume e-D describing the ednentional and profes-I% I_D sional qualf fications of the nominee and his or her current address. Canda-dates must be U.S. cirnent and be able to devote approaimately 150 hours0.00174 days <br />0.0417 hours <br />2.480159e-4 weeks <br />5.7075e-5 months <br /> per Ieir to Commit **te business.

All qualified nomines will receive ft:1 consideration. Appointments are for four year terms. Compensation for services of the members is provided in kcordance with government policies.

Nominations recesved by Mr.rch 15 1979 'Mll be consicered for the forth-coming vacancies. Nominstions re-Cetved after that date W111 be consid-FfDERAt 2IGISTER. VOL 44, NO. 31--TUE50AY. FtatuAar 13. 1777 hy.

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